Philip T Cagle

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Localized malignant mesothelioma
    Timothy Craig Allen
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Am J Surg Pathol 29:866-73. 2005
  2. ncbi request reprint Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies
    Philip T Cagle
    Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
    Arch Pathol Lab Med 129:1421-7. 2005
  3. ncbi request reprint Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Patho
    Neal I Lindeman
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115 6110, USA
    J Thorac Oncol 8:823-59. 2013
  4. ncbi request reprint Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Patho
    Neal I Lindeman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115 6110, USA
    Arch Pathol Lab Med 137:828-60. 2013
  5. ncbi request reprint Review and update of uncommon primary pleural tumors: a practical approach to diagnosis
    Laura Granville
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Arch Pathol Lab Med 129:1428-43. 2005
  6. ncbi request reprint Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group
    Aliya N Husain
    Department of Pathology, University of Chicago, Chicago, IL 60631, USA
    Arch Pathol Lab Med 133:1317-31. 2009
  7. doi request reprint p16 Deletion in sarcomatoid tumors of the lung and pleura
    Naobumi Tochigi
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 137:632-6. 2013
  8. doi request reprint Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group
    Aliya N Husain
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Arch Pathol Lab Med 137:647-67. 2013
  9. doi request reprint Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging
    Liang Gao
    Cornell University, The Methodist Hospital Research Institute, Weill Cornell Medical College, Department of Systems Medicine and Bioengineering, Houston, Texas 77030, USA
    J Biomed Opt 17:066017. 2012
  10. doi request reprint Tissue-preserving antibody cocktails to differentiate primary squamous cell carcinoma, adenocarcinoma, and small cell carcinoma of lung
    Alan F Brown
    Department of Pathology, University of Texas Health Science Center at San Antonio, 78229, USA
    Arch Pathol Lab Med 137:1274-81. 2013

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Localized malignant mesothelioma
    Timothy Craig Allen
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Am J Surg Pathol 29:866-73. 2005
    ..Localized malignant mesotheliomas should be separated from diffuse malignant mesotheliomas because of their localized presentation, quite different biologic behavior, and far better prognosis...
  2. ncbi request reprint Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies
    Philip T Cagle
    Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
    Arch Pathol Lab Med 129:1421-7. 2005
    ....
  3. ncbi request reprint Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Patho
    Neal I Lindeman
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115 6110, USA
    J Thorac Oncol 8:823-59. 2013
    ....
  4. ncbi request reprint Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Patho
    Neal I Lindeman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115 6110, USA
    Arch Pathol Lab Med 137:828-60. 2013
    ....
  5. ncbi request reprint Review and update of uncommon primary pleural tumors: a practical approach to diagnosis
    Laura Granville
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Arch Pathol Lab Med 129:1428-43. 2005
    ..Primary pleural tumors are divided according to their behavior and are discussed separately as benign tumors, tumors of low malignant potential, and malignant neoplasms...
  6. ncbi request reprint Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group
    Aliya N Husain
    Department of Pathology, University of Chicago, Chicago, IL 60631, USA
    Arch Pathol Lab Med 133:1317-31. 2009
    ..Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose...
  7. doi request reprint p16 Deletion in sarcomatoid tumors of the lung and pleura
    Naobumi Tochigi
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 137:632-6. 2013
    ..Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as the most common genetic alteration in malignant mesotheliomas that is of potential diagnostic and prognostic significance...
  8. doi request reprint Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group
    Aliya N Husain
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Arch Pathol Lab Med 137:647-67. 2013
    ..Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose...
  9. doi request reprint Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging
    Liang Gao
    Cornell University, The Methodist Hospital Research Institute, Weill Cornell Medical College, Department of Systems Medicine and Bioengineering, Houston, Texas 77030, USA
    J Biomed Opt 17:066017. 2012
    ....
  10. doi request reprint Tissue-preserving antibody cocktails to differentiate primary squamous cell carcinoma, adenocarcinoma, and small cell carcinoma of lung
    Alan F Brown
    Department of Pathology, University of Texas Health Science Center at San Antonio, 78229, USA
    Arch Pathol Lab Med 137:1274-81. 2013
    ..The limitations of small sample size and the need to conserve tissue for additional molecular studies necessitate the use of sensitive and specific marker panels on a single slide...
  11. ncbi request reprint MUC4 expression in non-small cell lung carcinomas: relationship to tumor histology and patient survival
    Kun Y Kwon
    Department of Pathology, Baylor College of Medicine, Houston, Tex, USA
    Arch Pathol Lab Med 131:593-8. 2007
    ..Although its tissue distribution has been studied, its utility in predicting prognosis in NSCLC is unknown...
  12. ncbi request reprint Expression of renal cell carcinoma-associated markers erythropoietin, CD10, and renal cell carcinoma marker in diffuse malignant mesothelioma and metastatic renal cell carcinoma
    Kelly J Butnor
    Department of Pathology, University of Vermont Fletcher Allen Health Care, Burlington, VT 05401, USA
    Arch Pathol Lab Med 130:823-7. 2006
    ..Standard panels of immunohistochemical markers are of limited benefit...
  13. doi request reprint Differential diagnosis of lung carcinoma with coherent anti-Stokes Raman scattering imaging
    Liang Gao
    Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Houston, Texas, USA
    Arch Pathol Lab Med 136:1502-10. 2012
    ..Finally, we also introduce the potential of a coherent anti-Stokes Raman scattering-based endoscopy system to support intraoperative applications at the cellular level...
  14. doi request reprint Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray
    Bradley M Turner
    Department of Pathology, University of Texas Health Science Center, San Antonio, USA
    Arch Pathol Lab Med 136:163-71. 2012
    ..TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic proteinase that may be an alternative marker for primary lung ACA...
  15. doi request reprint Revolution in lung cancer: new challenges for the surgical pathologist
    Philip T Cagle
    Department of Pathology and Laboratory Medicine, 6565 Fannin Street, The Methodist Hospital, Houston, Texas 77030, USA
    Arch Pathol Lab Med 135:110-6. 2011
    ....
  16. doi request reprint Pulmonary epithelioid hemangioendothelioma mimicking mesothelioma
    Armita Bahrami
    Baylor College of Medicine and Methodist Hospital, Houston, Texas, USA
    Pathol Int 58:730-4. 2008
    ....
  17. ncbi request reprint Well-differentiated Papillary Mesothelioma With Invasive Foci
    Andrew Churg
    Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada Department of Pathology, The University of Texas Medical Branch Galveston Department of Pathology and Genomic Medicine, Houston Methodist Hospital Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY PhenoPath Laboratories, Seattle, WA Department of Laboratory Medicine and Pathology, Mayo Clinic in Arizona, Scottsdale, AZ Department of Pathology, University of Virginia Health System, Charlottesville, VA Department of Pathology, CHU Caen, Caen, France Department of Clinical Pathology, Ospedale dell Angelo Venezia, Mestre, Italy
    Am J Surg Pathol 38:990-8. 2014
    ..We suggest that these lesions be called WDPM with invasive foci to alert clinicians to the possibility of recurrence. ..
  18. doi request reprint Lung cancer genotype-based therapy and predictive biomarkers: present and future
    Philip T Cagle
    Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas, USA
    Arch Pathol Lab Med 136:1482-91. 2012
    ..The advent of genotype-based therapy and predictive biomarkers for lung cancer has thrust the pathologist into the front lines of precision medicine for this deadly disease...
  19. ncbi request reprint Pleuropulmonary desmoid tumors: immunohistochemical comparison with solitary fibrous tumors and assessment of beta-catenin and cyclin D1 expression
    Lizmarie Andino
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston Medical School, Houston, Tex, USA
    Arch Pathol Lab Med 130:1503-9. 2006
    ..Alterations of the adenomatous polyposis coli/beta-catenin pathway have been detected in sporadic desmoid tumors and have been associated with nuclear accumulation of beta-catenin and overexpression of cyclin D1...
  20. doi request reprint Basic concepts of molecular pathology
    Timothy Craig Allen
    Department of Pathology, The University of Texas Health Science Center at Tyler, TX 75708 3154, USA
    Arch Pathol Lab Med 132:1551-6. 2008
  21. doi request reprint Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas
    Simion Chiosea
    Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
    Mod Pathol 21:742-7. 2008
    ..A discrepancy between p16 protein expression and homozygous deletion suggests that other molecular mechanisms may play a role in p16 protein expression in mesothelial proliferations...
  22. ncbi request reprint Lung adenocarcinoma biomarker incidence in Hispanic versus non-Hispanic white patients
    Elizabeth McQuitty
    From the Department of Pathology, University of Texas Health Sciences Center, San Antonio Drs Zhang and Jagirdar the Department of Anatomic and Clinical Pathology, South Texas Veterans Health Care System, San Antonio Dr Tio and the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas Drs McQuitty, Olsen, and Cagle and Ms Hendrickson Dr McQuitty is now with the Department of Pathology and Immunology, Baylor College of Medicine, Houston
    Arch Pathol Lab Med 138:390-4. 2014
    ..However, little information addresses the underlying genetic changes in lung adenocarcinoma among Hispanic patients in the United States...
  23. ncbi request reprint Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas: possible role for chemotherapeutic intervention
    Rosane de Oliveira Duarte Achcar
    Department of Pathology, University of Texas Health Sciences Center, San Antonio, USA
    Arch Pathol Lab Med 131:1350-60. 2007
    ..It appears that, although STAT3 is not absolutely required for tumor formation, tumors that develop in the presence of STAT3 become dependent on its expression for their survival, making it a potential therapeutic target...
  24. ncbi request reprint Comparison of monoclonal versus polyclonal calretinin antibodies for immunohistochemical diagnosis of malignant mesothelioma
    Laura A Granville
    U T MD Anderson Cancer Center, Houston, TX, USA
    Appl Immunohistochem Mol Morphol 13:75-9. 2005
    ..Neither antibody performed well on sarcomatous malignant mesothelioma (Zymed=2/22; DAKO=1/22). Both antibodies are useful in the diagnosis of epithelial malignant mesothelioma, although monoclonal antibody is slightly less sensitive...
  25. ncbi request reprint Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer
    Alvaro C Laga
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Arch Pathol Lab Med 129:1113-7. 2005
    ..Cyclooxygenase 2 inhibitors have been reported to effectively inhibit carcinogenesis in colon cancer experimental models...
  26. ncbi request reprint Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Patho
    Neal I Lindeman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115 6110, USA
    J Mol Diagn 15:415-53. 2013
    ..Already, new treatments targeting genetic alterations in other, less common driver oncogenes are being evaluated in lung cancer, and testing for these may be addressed in future versions of these guidelines. ..
  27. doi request reprint Pulmonary papillary adenoma: a case report and review of the literature
    Kristine M Cornejo
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Bronchology Interv Pulmonol 20:52-7. 2013
    ..The clinicopathologic features and differential diagnosis of this unusual neoplasm is discussed with a review of the English literature...
  28. doi request reprint Folate receptor in adenocarcinoma and squamous cell carcinoma of the lung: potential target for folate-linked therapeutic agents
    Philip T Cagle
    Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    Arch Pathol Lab Med 137:241-4. 2013
    ..Folate receptors can serve as targets for drugs attached to folate and are overexpressed in many cancers...
  29. doi request reprint Diffuse malignant mesothelioma
    Sergio Pina Oviedo
    Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, TX 77030, USA
    Arch Pathol Lab Med 136:882-8. 2012
    ..It was not until focal invasion into the skeletal muscle was discovered on permanent sections that a diagnosis of DMM could be established...
  30. doi request reprint Quantitative evaluation of protein expression as a function of tissue microarray core diameter: is a large (1.5 mm) core better than a small (0.6 mm) core?
    Valsamo K Anagnostou
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Arch Pathol Lab Med 134:613-9. 2010
    ..6-mm to 1.5-mm core "biopsies" of standard formalin-fixed, paraffin-embedded tissue blocks and by the processing of hundreds of cases arrayed on a single recipient block in an identical manner...
  31. ncbi request reprint Frozen section of lung specimens
    Anna Sienko
    Department of Pathology, The Methodist Hospital, Houston, Texas 77030, USA
    Arch Pathol Lab Med 129:1602-9. 2005
    ..Frozen section of lung tissue is performed to guide the surgeon in subsequent therapy...
  32. ncbi request reprint Cytomegalovirus infection masquerading as carcinoma in a lung transplant patient
    Timothy Craig Allen
    Department of Pathology, University of Texas Health Center, Tyler 75708 3154, USA
    Arch Pathol Lab Med 129:e1-3. 2005
    ..In lung transplant patients, a cytomegalovirus infection may mimic malignancy both radiographically and on initial histopathologic examination...
  33. pmc Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung
    Jie Song
    Department of Pathology, University of Chicago Medical Center, Chicago, IL, USA
    Arch Pathol Lab Med 134:1702-5. 2010
    ..The expression patterns of these functionally related proteins have not, to our knowledge, been systemically studied in neuroendocrine tumors of the lung...
  34. doi request reprint Lung cancer biomarkers: present status and future developments
    Philip T Cagle
    Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    Arch Pathol Lab Med 137:1191-8. 2013
    ..Current, unresolved issues in the precision medicine of lung cancer will be addressed by the development of new biomarker tests, new drugs, and new test technologies and by improvement in the cost to benefit ratio of biomarker testing...
  35. doi request reprint Advances in treatment of lung cancer with targeted therapy
    Philip T Cagle
    Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, TX, USA
    Arch Pathol Lab Med 136:504-9. 2012
    ..To date, 4 targeted therapies have been approved for treatment of lung cancer by the US Food and Drug Administration: gefitinib in 2002, erlotinib in 2003, bevacizumab in 2006, and crizotinib in 2011...
  36. doi request reprint On-the-spot lung cancer differential diagnosis by label-free, molecular vibrational imaging and knowledge-based classification
    Liang Gao
    Weill Cornell Medical College, The Methodist Hospital Research Institute, Department of Systems Medicine and Bioengineering, Houston, Texas 77030, USA
    J Biomed Opt 16:096004. 2011
    ..The demonstration of the strategy is also a necessary step toward in vivo point-of-care diagnosis of precancerous and cancerous lung lesions with a fiber-based CARS microendoscope...
  37. ncbi request reprint Transforming growth factor alpha and epidermal growth factor receptor in reactive and malignant mesothelial proliferations
    Yun Cai Cai
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    Arch Pathol Lab Med 128:68-70. 2004
    ..However, the comparative expression of these growth factors in mesothelioma and reactive mesothelial proliferations has been less well studied...
  38. ncbi request reprint Precision medicine for lung cancer: role of the surgical pathologist
    Philip T Cagle
    Department of Pathology and Genomic Medicine, The Methodist Hospital, 6565 Fannin St, Main Building, Room 227, Houston, TX 77030, USA
    Arch Pathol Lab Med 136:1186-9. 2012
    ..Pathologists should embrace the innovations described at the Houston Lung Symposium but must recognize that their traditional expertise will be an important component of precision medicine for the foreseeable future...
  39. ncbi request reprint Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: an immunohistochemical approach
    Hong Zhang
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    Mod Pathol 18:111-8. 2005
    ..This panel also facilitates diagnosis of combined small cell and non-small cell carcinomas...
  40. ncbi request reprint Silicone thorax due to a ruptured breast implant
    Robert L Levine
    Department of Neurosurgery, The University of Texas School of Medicine, Houston, USA
    Chest 127:1854-7. 2005
    ....
  41. pmc Significance of overexpression of alpha methylacyl-coenzyme A racemase in hepatocellular carcinoma
    Wei Li
    Department of Pathology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Exp Clin Cancer Res 27:2. 2008
    ..This study aims to evaluate immunohistochemical expression of the AMACR in neoplastic and nonneoplastic liver lesions, and assess its value in the diagnosis of hepatocellular carcinoma (HCC)...
  42. pmc Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates
    Randall J Olsen
    Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, The Methodist Hospital, and University of Houston, B490, 6565 Fannin Street, Houston, TX 77030, USA
    Am J Pathol 176:1346-54. 2010
    ..We conclude that PVL does not contribute to lower respiratory tract infection in this nonhuman primate model of human CA-MRSA pneumonia...
  43. ncbi request reprint Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells
    Avedis Kazanjian
    Institute for Cellular Therapeutics and Departments of Surgery, Biochemistry, and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Cancer Res 64:6874-82. 2004
    ..In addition, mice with a mutation in GFI1 display abnormal development of pulmonary neuroendocrine cells, indicating that GFI1 is important for neuroendocrine differentiation...
  44. ncbi request reprint Nitric oxide and tuberculosis infection
    Patricio Escalante
    Am J Respir Crit Care Med 167:1718; author reply 1718. 2003
  45. ncbi request reprint Expression of telomerase reverse transcriptase (TERT) in malignant mesotheliomas
    Fumiyuki Kumaki
    Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Surg Pathol 26:365-70. 2002
    ..This study demonstrates the usefulness of immunohistochemical staining for the evaluation of mesotheliomas. The required immunostaining can be performed using paraffin sections of formalin-fixed tissues...
  46. ncbi request reprint Specificity of MOC-31 and HBME-1 immunohistochemistry in the differential diagnosis of adenocarcinoma and malignant mesothelioma: a study on environmental malignant mesothelioma cases from Turkish villages
    Derya Gumurdulu
    Department of Pathology, Ukurova University, Faculty of Medicine, Adana, 01330, Turkey
    Pathol Oncol Res 8:188-93. 2002
    ..HBME-1 should be included in this panel; MOC-31 can be used where CEA is not available or to doublecheck the reactivity of this antibody...
  47. ncbi request reprint The 100-year anniversary of the description of the frozen section procedure
    Anthony A Gal
    Department of Pathology and Laboratory Medicine, Emory University Hospital, Room H171, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
    JAMA 294:3135-7. 2005
  48. ncbi request reprint Interpreting the histopathology of chronic cough: a prospective, controlled, comparative study
    Richard S Irwin
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Chest 130:362-70. 2006
    ..Trauma from chronic coughing produces airway inflammation similar to diseases causing cough...