JANET BUTEL

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Cell and molecular biology of simian virus 40: implications for human infections and disease
    J S Butel
    Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    J Natl Cancer Inst 91:119-34. 1999
  2. ncbi request reprint Detection of antibodies to polyomavirus SV40 in two central European countries
    J S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM385, Houston, TX 77030, USA
    Cent Eur J Public Health 11:3-8. 2003
  3. ncbi request reprint Increasing evidence for involvement of SV40 in human cancer
    J S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dis Markers 17:167-72. 2001
  4. ncbi request reprint Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease
    J S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM 385, One Baylor Plaza, Houston, TX 77030, USA
    Carcinogenesis 21:405-26. 2000
  5. ncbi request reprint Association between SV40 and non-Hodgkin's lymphoma
    Janet S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM385, One Baylor Plaza, Houston, TX 77030, USA
    Leuk Lymphoma 44:S33-9. 2003
  6. ncbi request reprint Molecular evidence of simian virus 40 infections in children
    J S Butel
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 180:884-7. 1999
  7. pmc Variable frequency of polyomavirus SV40 and herpesvirus EBV in lymphomas from two different urban population groups in Houston, TX
    Sonia Toracchio
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    J Clin Virol 46:154-60. 2009
  8. ncbi request reprint SV40-positive brain tumor in scientist with risk of laboratory exposure to the virus
    Amy S Arrington
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 23:2231-5. 2004
  9. ncbi request reprint Simian virus 40 tumor antigen expression and immunophenotypic profile of AIDS-related non-Hodgkin's lymphoma
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 342:38-46. 2005
  10. ncbi request reprint Polyomavirus SV40 infections in Kazakhstan
    Zhannat Z Nurgalieva
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    J Infect 50:142-8. 2005

Research Grants

  1. Hamster Model for AIDS Lymphomas
    JANET BUTEL; Fiscal Year: 2003
  2. SV40 Pathogenesis of Human Infections
    JANET BUTEL; Fiscal Year: 2007
  3. Baylor-UTHouston Center for AIDS Research
    JANET BUTEL; Fiscal Year: 2007
  4. SUPPRESSOR GENES AND BREAST CANCER
    JANET BUTEL; Fiscal Year: 1993
  5. TUMOR VIRUSES, ONCOGENES AND MAMMARY EPITHELIAL CELLS
    JANET BUTEL; Fiscal Year: 1991
  6. TUMOR VIRUS EFFECTS ON MOUSE MAMMARY EPITHELIAL CELLS
    JANET BUTEL; Fiscal Year: 1980
  7. Hamster Model of SV40 Infection and Disease
    Janet S Butel; Fiscal Year: 2010

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Cell and molecular biology of simian virus 40: implications for human infections and disease
    J S Butel
    Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    J Natl Cancer Inst 91:119-34. 1999
    ..Critical assessment of virologic and epidemiologic data suggests a probable causative role for SV40 in certain human cancers, but additional studies are necessary to prove etiology...
  2. ncbi request reprint Detection of antibodies to polyomavirus SV40 in two central European countries
    J S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM385, Houston, TX 77030, USA
    Cent Eur J Public Health 11:3-8. 2003
    ..These data suggest that SV40 may be present in these populations and emphasize the importance of follow-up studies to determine the pathogenesis of infections by this emerging human agent...
  3. ncbi request reprint Increasing evidence for involvement of SV40 in human cancer
    J S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dis Markers 17:167-72. 2001
    ..It is concluded that SV40 should be considered a candidate human tumor virus and that vigorous efforts to clarify the role of the virus in human disease should be supported...
  4. ncbi request reprint Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease
    J S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM 385, One Baylor Plaza, Houston, TX 77030, USA
    Carcinogenesis 21:405-26. 2000
    ..The difficulties in establishing an etiologic role for a virus in human cancer are discussed, as well as the different approaches that proved viral links to cancer. Future directions for tumor virus studies are considered...
  5. ncbi request reprint Association between SV40 and non-Hodgkin's lymphoma
    Janet S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM385, One Baylor Plaza, Houston, TX 77030, USA
    Leuk Lymphoma 44:S33-9. 2003
    ..We conclude that SV40 is significantly associated with some types of NHL and that lymphomas should be added to the types of human cancers associated with SV40...
  6. ncbi request reprint Molecular evidence of simian virus 40 infections in children
    J S Butel
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 180:884-7. 1999
    ..Sequence variation among SV40 regulatory regions ruled out laboratory contamination of specimens. This study shows the presence of SV40 infections in pediatric patients born after 1982...
  7. pmc Variable frequency of polyomavirus SV40 and herpesvirus EBV in lymphomas from two different urban population groups in Houston, TX
    Sonia Toracchio
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    J Clin Virol 46:154-60. 2009
    ..Studies have reported differing frequencies of detection of polyomavirus simian virus 40 (SV40) in association with human lymphomas...
  8. ncbi request reprint SV40-positive brain tumor in scientist with risk of laboratory exposure to the virus
    Amy S Arrington
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 23:2231-5. 2004
    ..This case suggests a link between viral exposure and tumor development...
  9. ncbi request reprint Simian virus 40 tumor antigen expression and immunophenotypic profile of AIDS-related non-Hodgkin's lymphoma
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 342:38-46. 2005
    ..2/12, 17%; P = 0.05). This study shows that SV40 gene expression occurs in a fraction of cells in some B-cell lymphomas among patients with HIV/AIDS...
  10. ncbi request reprint Polyomavirus SV40 infections in Kazakhstan
    Zhannat Z Nurgalieva
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    J Infect 50:142-8. 2005
    ..To examine the prevalence of polyomavirus SV40 infections in Kazakhstan, a central Asian country known to have used potentially contaminated SV40 poliovaccines before 1962...
  11. pmc Polyomavirus shedding in the stool of healthy adults
    John A Vanchiere
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Clin Microbiol 47:2388-91. 2009
    ..001). These findings support the hypothesis that the gastrointestinal tract may be a site of polyomavirus persistence, and they suggest a fecal-oral route of viral transmission...
  12. pmc Detection of polyomavirus SV40 in tonsils from immunocompetent children
    Niraj C Patel
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, United States
    J Clin Virol 43:66-72. 2008
    ..BK and JC viruses establish persistent infections in humans, and evidence suggests that SV40 can infect humans, as well. Whether persistence occurs in the lymphoid system is unknown...
  13. ncbi request reprint Detection of BK virus and simian virus 40 in the urine of healthy children
    John A Vanchiere
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA
    J Med Virol 75:447-54. 2005
    ..These results suggest that the timing of SV40 infections in humans may be similar to that of BKV and that urine from healthy children could contribute to the ubiquity of BKV infection early in life...
  14. ncbi request reprint Specific and quantitative detection of human polyomaviruses BKV, JCV, and SV40 by real time PCR
    Adrienne L McNees
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM 385, Houston, TX 77030, USA
    J Clin Virol 34:52-62. 2005
    ..Advancements in detection of these viruses may contribute to improved diagnosis and treatment of affected patients...
  15. ncbi request reprint Simian virus 40 in human cancers
    Regis A Vilchez
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, BCM 286, Room N1319, One Baylor Plaza, Houston, TX 77030, USA
    Am J Med 114:675-84. 2003
    ..However, the small samples and lack of control groups in some reports have made it difficult to assess their reliability...
  16. ncbi request reprint Conventional epidemiology and the link between SV40 and human cancers
    Regis A Vilchez
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Lancet Oncol 4:188-91. 2003
    ..In this essay, we consider the unique features of SV40 infection in humans and examine the limitations of conventional studies that seek to disprove the aetiological link with human cancer...
  17. ncbi request reprint Frequent detection of polyomaviruses in stool samples from hospitalized children
    John A Vanchiere
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 192:658-64. 2005
    ..Conclusions. Polyomaviruses are frequently present in stool samples from hospitalized children. These findings suggest that fecal-oral transmission of BKV may play a role in the ubiquity of infection...
  18. ncbi request reprint Detection of polyomavirus simian virus 40 tumor antigen DNA in AIDS-related systemic non-Hodgkin lymphoma
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Acquir Immune Defic Syndr 29:109-16. 2002
    ..None of the S-NHL samples were positive for both Epstein-Barr virus DNA and SV40 DNA. Further studies of the possible role of SV40 in the pathogenesis of S-NHL are warranted...
  19. ncbi request reprint AIDS-related systemic non-Hodgkin's lymphoma at a large community program
    Regis A Vilchez
    Department of Medicine, Baylor Center for AIDS Research, Baylor College of Medicine, Houston, Texas 77030, USA
    AIDS Res Hum Retroviruses 18:237-42. 2002
    ..In addition, this opportunistic malignancy is associated with significant mortality. Therefore, it is necessary to develop a better understanding of the pathogenesis of this disease...
  20. ncbi request reprint The clinical epidemiology of Hodgkin lymphoma in HIV-infected patients in the highly active antiretroviral therapy (HAART) era
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Medicine (Baltimore) 82:77-81. 2003
    ..These results suggest that Hodgkin lymphoma has a low incidence in HIV-infected patients receiving HAART, but the malignancy is an aggressive disease with unfavorable clinical outcome in these patients...
  21. ncbi request reprint Association between simian virus 40 and non-Hodgkin lymphoma
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Lancet 359:817-23. 2002
    ..We aimed to identify which one of the three polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma...
  22. pmc Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters
    Niraj C Patel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM385, Houston, TX 77030 3411, USA
    Virology 386:94-101. 2009
    ..These results indicate that SV40 replicates in hamsters, vertical transmission of SV40 can occur, and the viral regulatory region influences transmission...
  23. pmc Influence of the viral regulatory region on tumor induction by simian virus 40 in hamsters
    Vojtech Sroller
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM385, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:871-9. 2008
    ..This study shows that SV40 strains differ in their biological properties, suggests that SV40 replicates to some level in hamsters, and indicates that the outcome of an SV40 infection may depend on the viral strain present...
  24. pmc Emergent human pathogen simian virus 40 and its role in cancer
    Regis A Vilchez
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM 385, One Baylor Plaza, Houston, TX 77030, USA
    Clin Microbiol Rev 17:495-508, table of contents. 2004
    ..quot; This review analyzes the accumulating data that indicate that SV40 is a pathogen which has a possible etiologic role in human malignancies. Future research directions are considered...
  25. ncbi request reprint SV40 in human brain cancers and non-Hodgkin's lymphoma
    Regis A Vilchez
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Oncogene 22:5164-72. 2003
    ....
  26. pmc SV40 lymphomagenesis in Syrian golden hamsters
    Adrienne L McNees
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 384:114-24. 2009
    ....
  27. ncbi request reprint Polyomavirus SV40 and AIDS-related systemic non-Hodgkin's lymphoma
    Regis A Vilchez
    Department of Molecular Virology and Microbiology and Baylor UTHouston Center for AIDS Research, Baylor College of Medicine, Houston, TX, USA
    Cancer Treat Res 133:215-40. 2007
  28. ncbi request reprint Effects of radiation and latent virus on immune responses in a space flight model
    William T Shearer
    Department of Pediatrics, Section of Allergy and Immunology, Baylor College of Medicine, Houston, TX, USA
    J Allergy Clin Immunol 115:1297-303. 2005
    ..The immunosuppressive effects of space flight radiation and reactivation of latent virus infections in human beings are largely unknown...
  29. ncbi request reprint Simian virus 40 and its association with human lymphomas
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Mail Stop BCM 385, One Baylor Plaza, Houston, TX 77030, USA
    Curr Oncol Rep 5:372-9. 2003
    ..This review examines the data implicating SV40 in the pathogenesis of human lymphomas and discusses future directions to define the causative role for SV40 in these malignancies...
  30. pmc The history of tumor virology
    Ronald T Javier
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:7693-706. 2008
    ..This rich history promises that tumor virology will continue to contribute to our understanding of cancer and to the development of new therapeutic and preventive measures for this disease in the 21st century...
  31. ncbi request reprint Differential ability of two simian virus 40 strains to induce malignancies in weanling hamsters
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 330:168-77. 2004
    ....
  32. ncbi request reprint Re: Lack of serologic evidence for prevalent simian virus 40 infection in humans
    Regis A Vilchez
    J Natl Cancer Inst 96:633; author reply 633-4. 2004
  33. ncbi request reprint A prospective longitudinal study of polyomavirus shedding in lung-transplant recipients
    Lora D Thomas
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Infect Dis 195:442-9. 2007
    ..Polyomavirus infection causes renal dysfunction after kidney transplantation, but it has not been thoroughly investigated in nonrenal solid-organ transplantation...
  34. ncbi request reprint The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study
    Paul D Ling
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 187:1571-80. 2003
    ..50). Thus, adults independently control persistent viruses, which display discordant, sporadic reactivations...
  35. ncbi request reprint SV40 multiple tissue infection and asbestos exposure in a hyperendemic area for malignant mesothelioma
    Manola Comar
    Department of Public Medicine Sciences, University of Trieste, Trieste, Italy
    Cancer Res 67:8456-9. 2007
    ..045). This survey shows that SV40 sustains infections in multiple tissues in malignant mesothelioma patients from a geographic area affected with asbestos-related mesothelioma...
  36. ncbi request reprint Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapy
    John A Lednicky
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    AIDS 17:801-7. 2003
    ..To assess the frequency of shedding of polyomavirus JC virus (JCV) genotypes in urine of HIV-infected patients receiving highly active antiretroviral therapy (HAART)...
  37. pmc Evidence of simian virus 40 exposure in a colony of captive baboons
    Landon W Westfall
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, 3601 4th Street STOP 6591, Lubbock, TX 79430, USA
    Virology 377:54-62. 2008
    ..DNA sequence analysis of the PCR products confirmed that SV40 Tag specific sequences were detected in baboons...
  38. ncbi request reprint SV40 and human tumours: myth, association or causality?
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Centre, Dallas, Texas 75390, USA
    Nat Rev Cancer 2:957-64. 2002
    ..How did a simian virus infect humans and is the virus a passenger in tumours or is it important in their pathogenesis?..
  39. ncbi request reprint Polyomaviruses in solid-organ transplant recipients
    Regis A Vilchez
    Transplantation 74:579-80; author reply 580-1. 2002
  40. ncbi request reprint Lymphoproliferative disorders in Costa Rica and simian virus 40
    Armando Meneses
    Department of Pathology, Hospital San Juan de Dios, San Jose, Costa Rica
    Haematologica 90:1635-42. 2005
    ....
  41. ncbi request reprint Re: Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccines
    Regis A Vilchez
    J Natl Cancer Inst 95:687; author reply 689. 2003
  42. pmc Phylogenetic analysis of polyomavirus simian virus 40 from monkeys and humans reveals genetic variation
    Zac H Forsman
    Department of Biology and Biochemistry, University of Houston, Texas, USA
    J Virol 78:9306-16. 2004
    ....
  43. ncbi request reprint Quantification of vertical transmission of Murine polyoma virus by real-time quantitative PCR
    Shaojie Zhang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM385, Houston, TX 77030, USA
    J Gen Virol 86:2721-9. 2005
    ..It should be considered that there is a possibility that other polyomaviruses, including those in humans, may be vertically transmitted...
  44. ncbi request reprint Polyomavirus simian virus 40 infection associated with nephropathy in a lung-transplant recipient
    Aaron Milstone
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Transplantation 77:1019-24. 2004
    ..Recent data suggest that some individuals may develop renal dysfunction related to SV40 infection, including individuals too young to have received contaminated vaccines...
  45. ncbi request reprint Epstein-Barr virus DNA loads in adult human immunodeficiency virus type 1-infected patients receiving highly active antiretroviral therapy
    Paul D Ling
    Department of Molecular Virology and Microbiology, Baylor Center for AIDS Research, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 37:1244-9. 2003
    ..Additional studies are needed to determine whether EBV-specific CD4+ and CD8+ cells play a role in the pathogenesis of EBV in HIV-1-infected patients receiving HAART...
  46. ncbi request reprint Polyomavirus SV40 infection and lymphomas in Spain
    Regis A Vilchez
    Int J Cancer 107:505-6; author reply 507-8. 2003
  47. ncbi request reprint Re: Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40
    Regis A Vilchez
    J Natl Cancer Inst 95:1249; author reply 1250. 2003
  48. ncbi request reprint An overview of the biology and viral pathogenesis of lymphoproliferative disorders in HIV-infected patients
    Regis A Vilchez
    Res Initiat Treat Action 9:14-8. 2003
  49. ncbi request reprint Pathogenesis and management of polyomavirus infection in transplant recipients
    Eun Jeong Kwak
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 35:1081-7. 2002
    ..Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed...
  50. ncbi request reprint Simian virus 40 infection in lymphoproliferative disorders
    Regis A Vilchez
    Lancet 361:1565; author reply 1565-6. 2003
  51. ncbi request reprint Polyomaviruses in kidney transplant recipients
    Regis A Vilchez
    Am J Transplant 2:481. 2002
  52. pmc PCR detection and DNA sequence analysis of the regulatory region of lymphotropic papovavirus in peripheral blood mononuclear cells of an immunocompromised rhesus macaque
    John A Lednicky
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Clin Microbiol 40:1056-9. 2002
    ..A lymphotropic papovavirus (LPV) archetypal regulatory region was amplified from DNA from the blood of an immunocompromised rhesus monkey. We believe this is the first nonserological evidence of LPV infection in rhesus monkeys...

Research Grants33

  1. Hamster Model for AIDS Lymphomas
    JANET BUTEL; Fiscal Year: 2003
    ..In addition, this project may provide new insights into lymphomagenesis in general and may lead to the development of new diagnostic and therapeutic approaches to this malignancy. ..
  2. SV40 Pathogenesis of Human Infections
    JANET BUTEL; Fiscal Year: 2007
    ..This new information will allow better understanding of the biology of SV40 human infections and may provide insights into the mechanisms of SV40 involvement in human malignancies. ..
  3. Baylor-UTHouston Center for AIDS Research
    JANET BUTEL; Fiscal Year: 2007
    ..The major policy-making body of the CFAR is the Internal Advisory Committee; management is assisted by External Advisory and Developmental Grants Scientific Review Committees. ..
  4. SUPPRESSOR GENES AND BREAST CANCER
    JANET BUTEL; Fiscal Year: 1993
    ..These tools allow us to experimentally address molecular genetic mechanisms responsible for early stages of breast disease, which we believe will have profound implications toward understanding the development of human breast cancer...
  5. TUMOR VIRUSES, ONCOGENES AND MAMMARY EPITHELIAL CELLS
    JANET BUTEL; Fiscal Year: 1991
    ..this project will provide insights into the cell biology of breast cancer and epthelial cell transformation in general...
  6. TUMOR VIRUS EFFECTS ON MOUSE MAMMARY EPITHELIAL CELLS
    JANET BUTEL; Fiscal Year: 1980
    ..The response of BALB/c murine mammary gland cells to SV40 and mouse mammary tumor virus (MMTV) is the system under study. ..
  7. Hamster Model of SV40 Infection and Disease
    Janet S Butel; Fiscal Year: 2010
    ..This project will provide new understandings of mechanisms relevant to polyomaviruses and human cancer and may identify novel targets for therapeutics to treat polyomavirus infections and prevent disease. ..