Robert C Burghardt

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Oxytocin-induced Ca2+ responses in human myometrial cells
    R C Burghardt
    Departments of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843 4458, USA
    Biol Reprod 60:777-82. 1999
  2. ncbi request reprint Integrins and extracellular matrix proteins at the maternal-fetal interface in domestic animals
    Robert C Burghardt
    Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
    Cells Tissues Organs 172:202-17. 2002
  3. doi request reprint Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estradiol
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Endocrinology 150:936-45. 2009
  4. ncbi request reprint Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation
    Rebecca M Simmons
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Endocrinology 150:4295-305. 2009
  5. ncbi request reprint Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration
    David W Erikson
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 81:814-25. 2009
  6. doi request reprint Select nutrients in the ovine uterine lumen. IX. Differential effects of arginine, leucine, glutamine, and glucose on interferon tau, ornithine decarboxylase, and nitric oxide synthase in the ovine conceptus
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, USA
    Biol Reprod 84:1139-47. 2011
  7. ncbi request reprint Galectin 15 (LGALS15): a gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment
    Shaye K Lewis
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 77:1027-36. 2007
  8. doi request reprint Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Biosciences, and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 82:854-64. 2010
  9. doi request reprint Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843, USA
    Matrix Biol 29:369-82. 2010
  10. ncbi request reprint Uterine MHC class I molecules and beta 2-microglobulin are regulated by progesterone and conceptus interferons during pig pregnancy
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    J Immunol 181:2494-505. 2008

Research Grants

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Oxytocin-induced Ca2+ responses in human myometrial cells
    R C Burghardt
    Departments of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843 4458, USA
    Biol Reprod 60:777-82. 1999
    ....
  2. ncbi request reprint Integrins and extracellular matrix proteins at the maternal-fetal interface in domestic animals
    Robert C Burghardt
    Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
    Cells Tissues Organs 172:202-17. 2002
    ....
  3. doi request reprint Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estradiol
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Endocrinology 150:936-45. 2009
    ..The temporal and cell type-specific expression of STC1 makes this gene a unique marker for implantation in pigs...
  4. ncbi request reprint Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation
    Rebecca M Simmons
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Endocrinology 150:4295-305. 2009
    ..These studies reveal that IGFBP1 is a common endometrial marker of conceptus elongation in sheep and cattle and most likely regulates conceptus elongation by stimulating migration and attachment of the trophectoderm...
  5. ncbi request reprint Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration
    David W Erikson
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 81:814-25. 2009
    ....
  6. doi request reprint Select nutrients in the ovine uterine lumen. IX. Differential effects of arginine, leucine, glutamine, and glucose on interferon tau, ornithine decarboxylase, and nitric oxide synthase in the ovine conceptus
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, USA
    Biol Reprod 84:1139-47. 2011
    ....
  7. ncbi request reprint Galectin 15 (LGALS15): a gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment
    Shaye K Lewis
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 77:1027-36. 2007
    ..These results support the hypothesis that LGALS15 is uniquely expressed in Caprinae endometria and functions as an attachment factor important for peri-implantation blastocyst elongation...
  8. doi request reprint Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Biosciences, and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 82:854-64. 2010
    ..Cysteine proteases and their inhibitors may also specifically modify proteins for successful utilization and fluid-phase transport across uterine, placental, and neonatal gut epithelia...
  9. doi request reprint Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843, USA
    Matrix Biol 29:369-82. 2010
    ..These cell signaling pathways, acting in concert, mediate adhesion, migration and cytoskeletal remodeling of Tr cells essential for expansion and elongation of conceptuses and attachment to uterine LE for implantation...
  10. ncbi request reprint Uterine MHC class I molecules and beta 2-microglobulin are regulated by progesterone and conceptus interferons during pig pregnancy
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    J Immunol 181:2494-505. 2008
    ....
  11. ncbi request reprint Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 68:1951-8. 2003
    ..Results suggest that uterine stromal decidualization is common to species with different types of placentation, but the extent is variable and correlates with the depth of trophoblast invasion during implantation...
  12. ncbi request reprint Pig conceptuses increase uterine interferon-regulatory factor 1 (IRF1), but restrict expression to stroma through estrogen-induced IRF2 in luminal epithelium
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 4458, USA
    Biol Reprod 77:292-302. 2007
    ....
  13. ncbi request reprint Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at maternal-conceptus interface and uterine wall during ovine pregnancy
    Robert C Burghardt
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Reproduction 137:567-82. 2009
    ....
  14. ncbi request reprint An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis
    Lisa M Sanders
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr 134:3233-8. 2004
    ..These results suggest that the enhancement of apoptosis associated with fish oil and pectin feeding may be due to a modulation of the redox environment that promotes ROS-mediated apoptosis...
  15. doi request reprint Mechanistic mammalian target of rapamycin (MTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, TX, USA
    Mol Cell Endocrinol 354:22-33. 2012
    ..Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation...
  16. doi request reprint The influence of estrogen on hepatobiliary osteopontin (SPP1) expression in a female rodent model of alcoholic steatohepatitis
    Atrayee Banerjee
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Toxicol Pathol 37:492-501. 2009
    ....
  17. ncbi request reprint Pig conceptuses secrete estrogen and interferons to differentially regulate uterine STAT1 in a temporal and cell type-specific manner
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Endocrinology 148:4420-31. 2007
    ..The interactions of estrogen and interferons to regulate cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation...
  18. ncbi request reprint Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface
    Dana A Massuto
    Departments of Veterinary Integrative Biosciences Veterinary Large Animal Clinical Sciences Animal Science, Texas A and M University, College Station, Texas 77843 4458, USA
    Reproduction 139:465-78. 2010
    ..Results suggest that functional LAP-ITG adhesion complexes support conceptus attachment and promote TGFB activation leading to TGFB interaction with TGFBR supporting events of porcine implantation...
  19. pmc The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep
    Kathrin A Dunlap
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas
    Biol Reprod 82:876-87. 2010
    ..Thus, S1P signaling may be crucial for proper fetal-placental development...
  20. doi request reprint Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy
    Daniel W Bailey
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Reproduction 140:583-94. 2010
    ..Furthermore, LE and vascular development are highly responsive to the effects of progesterone...
  21. ncbi request reprint Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation
    Frankie J White
    Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Reproduction 132:919-29. 2006
    ..We suggest that Spp1 at the apical surface of LE provides a mechanism to bridge conceptus to LE during implantation, and that Spp1-positive macrophages within the stroma may be involved in uterine remodeling for conceptus invasion...
  22. ncbi request reprint Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
    ....
  23. doi request reprint Effects of long-term progesterone exposure on porcine uterine gene expression: progesterone alone does not induce secreted phosphoprotein 1 (osteopontin) in glandular epithelium
    Daniel W Bailey
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Reproduction 140:595-604. 2010
    ..We hypothesize that a servomechanism involving sequential effects of multiple hormones and cytokines, similar to those for sheep and humans, is required for GE differentiation and function, including the synthesis and secretion of SPP1...
  24. ncbi request reprint Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways
    Fuller W Bazer
    Texas A and M University, College Station, TX 77843 2471, USA
    Reprod Biol 8:179-211. 2008
    ..The magnitude of the LH surge was reduced in cows receiving endotoxin...
  25. doi request reprint Comparative aspects of implantation
    Fuller W Bazer
    Department of Animal Science Veterinary Integrative Biosciences, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
    Reproduction 138:195-209. 2009
    ....
  26. ncbi request reprint Galectin 15 (LGALS15) functions in trophectoderm migration and attachment
    Jennifer L Farmer
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, TX 77843 2471, USA
    FASEB J 22:548-60. 2008
    ..Collectively, these results support the hypothesis that LGALS15 stimulates trophectoderm cell migration and attachment via integrin binding and activation which are critical to blastocyst elongation and implantation...
  27. doi request reprint Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell Signaling pathways, and stimulates migration of ovine trophectoderm cells
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 149:3085-94. 2008
    ..Collectively, these results support the hypothesis that IGF-II coordinately activates multiple cell signaling pathways critical to survival, growth, and differentiation of the ovine conceptus during early pregnancy...
  28. ncbi request reprint Galectin-15 in ovine uteroplacental tissues
    C Allison Gray
    Center for Animal Biotechnology and Genomics and Department of Animal Science and Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Reproduction 130:231-40. 2005
    ....
  29. pmc Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors
    Jone A Stanley
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Reprod Toxicol 32:112-23. 2011
    ..Vitamin C mitigated the effects of CrVI. This study shows that CrVI causes cell cycle arrest in granulosa cells by altering cell cycle regulatory proteins with potential intervention by vitamin C...
  30. ncbi request reprint Progesterone and placentation increase secreted phosphoprotein one (SPP1 or osteopontin) in uterine glands and stroma for histotrophic and hematotrophic support of ovine pregnancy
    Kathrin A Dunlap
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 79:983-90. 2008
    ..Collectively, P(4) induces and the conceptus further stimulates SPP1 in uterine GE and stroma, where SPP1 likely influences histotrophic and hematotrophic support of conceptus development...
  31. pmc Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 88:77. 2013
    ....
  32. ncbi request reprint Glycosylation dependent cell adhesion molecule 1-like protein and L-selectin expression in sheep interplacentomal and placentomal endometrium
    Jésus J Muniz
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Reproduction 131:751-61. 2006
    ..These data suggest that GlyCAM-1 assumes distinct functions in compartment-specific regions of the sheep uterus...
  33. ncbi request reprint Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells
    Rola Barhoumi
    Depatrment of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Toxicol Lett 165:133-41. 2006
    ....
  34. pmc Proline and hydroxyproline metabolism: implications for animal and human nutrition
    Guoyao Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
    Amino Acids 40:1053-63. 2011
    ..Further research is warranted to develop effective strategies of dietary supplementation with proline or hydroxyproline to benefit health, growth, and development of animals and humans...
  35. ncbi request reprint Osteopontin: roles in implantation and placentation
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 69:1458-71. 2003
    ..OPN has the potential to profoundly impact pregnancy, and investigators are now challenged to focus on the mechanistic nature of the functions of this multifaceted and major component of the uterine-placental microenvironment...
  36. doi request reprint Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines
    Jin Young Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 84:70-8. 2011
    ..These results indicate that L-Arg enhances production of polyamines and NO and activates the MTOR/FRAP1-RPS6K-RPS6 signaling pathway to stimulate proliferation and migration of oTr cells...
  37. doi request reprint Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration
    Jin Young Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 84:62-9. 2011
    ....
  38. ncbi request reprint Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8. 2003
    ....
  39. ncbi request reprint Regulation of expression of fibroblast growth factor 7 in the pig uterus by progesterone and estradiol
    Hakhyun Ka
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 77:172-80. 2007
    ....
  40. pmc Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring
    Kirthiram K Sivakumar
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, TAMU 4458, Texas A and M University, College Station, TX 77843, USA
    Dev Biol 388:22-34. 2014
    ..As a result of the above events, CrVI induced early reproductive senescence and decrease in litter size in F1 female progeny...
  41. doi request reprint Dietary supplementation with L-arginine between days 14 and 25 of gestation enhances embryonic development and survival in gilts
    Xilong Li
    Department of Animal Science, Texas A and M University, College Station, 77843, TX, USA
    Amino Acids 46:375-84. 2014
    ..Reproductive performance of gilts did not differ between the 0.4 and 0.8 % L-arginine groups. Thus, dietary supplementation with 0.4 or 0.8 % L-arginine between days 14 and 25 of gestation enhances embryonic/fetal survival in swine...
  42. doi request reprint Impacts of arginine nutrition on embryonic and fetal development in mammals
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, 77843, USA
    Amino Acids 45:241-56. 2013
    ..Collectively, enhancement of uterine as well as placental growth and function through dietary arginine supplementation provides an effective solution to improving embryonic and fetal survival and growth...
  43. ncbi request reprint Dietary supplementation with 0.8% L-arginine between days 0 and 25 of gestation reduces litter size in gilts
    Xilong Li
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 140:1111-6. 2010
    ..These results indicate that dietary supplementation with 0.8% L-arginine between d 0 and 25 of gestation, while increasing placental vascularity, adversely affects the reproductive performance of gilts...
  44. doi request reprint Non-covalent delivery of proteins into mammalian cells
    Aurore Loudet
    Department of Chemistry, Texas A and M University, Box 30012, College Station, TX 77841, USA
    Org Biomol Chem 6:4516-22. 2008
    ..At 37 degrees C, import into endocytic compartments dominates, but at 4 degrees C weak, diffuse fluorescence is observed in the cytosol, indicative of a favorable mode of action...
  45. ncbi request reprint Analysis of osteopontin at the maternal-placental interface in pigs
    Jane E Garlow
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 66:718-25. 2002
    ..e., integrins) on conceptus and uterus to promote conceptus development and signaling between these tissues as key contributors to attachment and placentation in the pig...
  46. ncbi request reprint Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 148:3922-31. 2007
    ..The continuous presence of tight and adherens junctions in the uterine glands would allow for vectorial secretion of trophic substances required for conceptus elongation and survival...
  47. ncbi request reprint Functional effects of transforming growth factor beta on adhesive properties of porcine trophectoderm
    Laurie A Jaeger
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Endocrinology 146:3933-42. 2005
    ..These results suggest multiple effects of TGFbeta at the porcine conceptus-maternal interface, including integrin-mediated conceptus-maternal communication through LAP...
  48. ncbi request reprint Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Endocrinology 146:675-84. 2005
    ....
  49. ncbi request reprint Steroid regulation of cell specific secreted phosphoprotein 1 (osteopontin) expression in the pregnant porcine uterus
    Frankie J White
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, 77843, USA
    Biol Reprod 73:1294-301. 2005
    ..We conclude that, in pregnant pigs, SPP1 is induced by conceptus estrogen in uterine LE and is regulated in GE in a manner coincident with CL/placental progesterone production...
  50. doi request reprint Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans
    Sakhila K Banu
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Fertil Steril 91:2199-209. 2009
    ..To determine whether a mixed population of immortalized human endometriosis epithelial and stromal cells is able to induce peritoneal endometriosis in nude mice...
  51. pmc 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    BMC Cancer 10:669. 2010
    ..The main purpose of this study was to investigate the pathways of C-DIM-induced cell death...
  52. ncbi request reprint Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility
    Lisa M Sanders
    Faculty of Nutrition, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
    Cancer Lett 208:155-61. 2004
    ..Thus the colon responds to oxidative stress less effectively than the small intestine, possibly contributing to increased cancer incidence at this site...
  53. ncbi request reprint Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14)
    Marisa D Covington
    Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station, Texas, USA
    Am J Physiol Renal Physiol 290:F43-51. 2006
    ..These results demonstrate that ischemia induces increased expression of active MT1-MMP and subsequent disruption of cadherin/catenin complexes, implying that MT1-MMP plays a role in ischemia-induced ARF...
  54. pmc Fluorescent cassettes for monitoring three-component interactions in vitro and in living cells
    Liangxing Wu
    Department of Chemistry, Texas A and M University, Box 30012, College Station, Texas 77841, USA
    J Am Chem Soc 131:9156-7. 2009
    ....
  55. ncbi request reprint Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney
    Adebayo D Akintola
    Department of Systems Biology and Translational Medicine, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Am J Physiol Renal Physiol 294:F170-6. 2008
    ....
  56. ncbi request reprint Progesterone and placental hormone actions on the uterus: insights from domestic animals
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 71:2-10. 2004
    ..Strategic manipulation of these physiological mechanisms may offer therapeutic schemes to improve uterine capacity, conceptus survival, and reproductive health of domestic animals and humans...
  57. pmc Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    J Toxicol Sci 34:13-25. 2009
    ..These results demonstrate the feasibility of analyzing BaP metabolism in situ by multiphoton spectral analysis and also identifying cell-type differences in BaP accumulation and metabolism...
  58. ncbi request reprint Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Brain Res 1145:11-8. 2007
    ..These data suggest that voltage operated Ca(2+) channels, mitochondrial Ca(2+) and K(+)-ATP channels may be targets of propofol action in astrocytes...
  59. pmc Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm
    C Allison Gray
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 101:7982-7. 2004
    ..Galectins may be useful as cellular and molecular markers for endometrial function and receptivity, to enhance conceptus survival and development, and to evaluate and enhance fertility...
  60. pmc Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Toxicol Appl Pharmacol 253:45-56. 2011
    ..Therefore, the combination of the two-photon acquisition with the unmixing process should provide important insights into the cellular and molecular mechanisms by which BaP and other PAHs alter cellular homeostasis...
  61. pmc Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model
    Sarah G Black
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    J Virol 84:9078-85. 2010
    ..The essential role played by enJSRVs in sheep reproductive biology could also be played by endometrium-derived viral particles that influence development and differentiation of the trophectoderm...
  62. pmc Novel pathways for implantation and establishment and maintenance of pregnancy in mammals
    Fuller W Bazer
    Departments of Animal Science, Texas A and M Health Sciences Center, College Station, TX 77843, USA
    Mol Hum Reprod 16:135-52. 2010
    ..Understanding the roles of the variety of hormones, growth factors and endogenous retroviral proteins in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals...
  63. pmc Endogenous retroviruses regulate periimplantation placental growth and differentiation
    Kathrin A Dunlap
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 103:14390-5. 2006
    ..This work supports the hypothesis that ERVs play fundamental roles in placental morphogenesis and mammalian reproduction...
  64. pmc Image analysis of Ca2+ signals as a basis for neurotoxicity assays: promises and challenges
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Neurotoxicol Teratol 32:16-24. 2010
    ..Each of the methods described and appropriately used results in reliable and reproducible measurements which may be applied in a high-throughput fashion to individualize in vitro assessment of cellular responses caused by toxicants...
  65. ncbi request reprint Using quantitative structure-activity relationships (QSAR) to predict toxic endpoints for polycyclic aromatic hydrocarbons (PAH)
    Erica D Bruce
    Department of Civil Engineering, Texas A and M University, College Station, Texas, USA
    J Toxicol Environ Health A 71:1073-84. 2008
    ..Accurate toxicity predictions are made by examining each type of endpoint important to the process of carcinogenicity, and a clearer understanding between composition and toxicity can be obtained...
  66. pmc Uterine biology in pigs and sheep
    Fuller W Bazer
    Department of Animal Science, 442D Kleberg Center, 2471 TAMU, Texas A and M University, College Station, TX, 77843 2471, USA
    J Anim Sci Biotechnol 3:23. 2012
    ....
  67. pmc Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase
    Alan R Parrish
    Department of Systems Biology and Translational Medicine, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843, USA
    Cell Biol Toxicol 25:217-25. 2009
    ..This is the first report of the use of sEH inhibitors to protect against acute nephrotoxicity and suggests a therapeutic potential of these compounds...
  68. ncbi request reprint Implantation mechanisms: insights from the sheep
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics, Animal Science and Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
    Reproduction 128:657-68. 2004
    ....
  69. ncbi request reprint The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: a potential biomarker
    Atrayee Banerjee
    Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX, 77843 4467, USA
    Toxicol Pathol 34:373-84. 2006
    ..The data indicates that OPN is transcribed and translated within the biliary epithelium. These findings suggest a potential role of OPN as an early biomarker in predicting inflammatory liver diseases such as ASH...
  70. ncbi request reprint Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinases
    Marisa D Covington
    Department of Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station, 77843 1114, USA
    Am J Physiol Renal Physiol 289:F280-8. 2005
    ..These results demonstrate that ischemia induces a selective metalloproteinase-dependent cleavage of E-cadherin and decrease in N-cadherin that are associated with a disruption of junctional contacts...
  71. ncbi request reprint Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells
    Rola Barhoumi
    Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
    Toxicol Sci 68:444-50. 2002
    ..This was confirmed by showing that inhibition of the K+ channel opening by tetraethylammonium chloride can reverse the effect of BaP on oxytocin-induced Ca2+ oscillations, and potentially decrease the toxicity of BaP...
  72. ncbi request reprint Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function
    Robert S Chapkin
    Department of Veterinary Anatomy and Public Health, Center for Environmental and Rural Health, Texas A and M University, College Station 77843 2471, USA
    Lipids 37:193-9. 2002
    ..026) were positively correlated with caspase 3 activity. These data provide evidence in vivo indicating that dietary EPA and DHA induce compositional changes in colonic mitochondrial membrane phospholipids that facilitate apoptosis...
  73. pmc Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53
    Sakhila K Banu
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Toxicol Appl Pharmacol 251:253-66. 2011
    ..Our study, for the first time provides a clear insight into the effect of CrVI on multiple pathways that lead to apoptosis of granulosa cells which could be mitigated by vitamin C...
  74. ncbi request reprint Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats
    Sakhila K Banu
    Reproductive Endocrinology and Cell Signaling Laboratory, Texas A and M University, TAMU 4458, College Station, Texas 77843, USA
    Toxicol Appl Pharmacol 232:180-9. 2008
    ..Therefore, Cr(VI) toxicity could be a potential risk to the reproductive system in developing females, and vitamin C plays a protective role against Cr(VI)-induced ovotoxicity...
  75. ncbi request reprint Uterine receptivity to implantation of blastocysts in mammals
    Fuller W Bazer
    Department of Animal Science, Texas A and M, University CollegeStation, TX 77843 2471, USA
    Front Biosci (Schol Ed) 3:745-67. 2011
    ....
  76. ncbi request reprint The IGF system in the neonatal ovine uterus
    Kanako Hayashi
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Reproduction 129:337-47. 2005
    ..These results support the hypothesis that an intrinsic IGF system in the uterus regulates epithelial-stromal interactions important for postnatal uterine growth and endometrial gland morphogenesis in the sheep...
  77. ncbi request reprint Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds
    Marjorie S Hong
    Department of Chemical Engineering, Texas A and M University, College Station, TX 77845, USA
    Toxicol Appl Pharmacol 186:110-8. 2003
    ..The effects of OPs that cause or do not cause OPIDN were clearly distinguishable, not only by their effects on neurite length, but also by their effects on Ca(2+) homeostasis in differentiated SY5Y cells...
  78. pmc Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells
    Katrina L Mealey
    Department of Veterinary Physiology and Pharmacology, Texas A and M University College of Veterinary Medicine, College Station, Texas 77843 4466, USA
    Antimicrob Agents Chemother 46:755-61. 2002
    ..Doxycycline, a drug that has been used for treatment of bacterial infections in cancer patients, can induce functional P-gp expression in cancer cells, resulting in multidrug resistance...
  79. ncbi request reprint Cloning of GJA1 (connexin43) and its expression in canine ovarian follicles throughout the estrous cycle
    Lauri A Willingham-Rocky
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX, USA
    Gene Expr Patterns 7:66-71. 2007
    ....
  80. pmc Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2
    Brian Laffin
    Department of Integrated Biosciences, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Mol Cell Biol 28:1936-46. 2008
    ..Together, our results suggest that SIM2s is a key regulator of mammary-ductal development and that loss of SIM2s expression is associated with an invasive, EMT-like phenotype...
  81. ncbi request reprint Integrin activation in bovine placentomes and in caruncular epithelial cells isolated from pregnant cows
    Philip S Bridger
    Institute for Hygiene and Infectious Diseases of Animals, Justus Liebig University, 35392 Giessen, Germany
    Biol Reprod 79:274-82. 2008
    ..Thus, this in vitro model provides excellent potential for further mechanistic studies designed to elucidate feto-maternal interactions in the bovine placentome...
  82. ncbi request reprint Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes
    Mee Young Hong
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
    Carcinogenesis 23:1919-25. 2002
    ....
  83. ncbi request reprint Loss of N-cadherin and alpha-catenin in the proximal tubules of aging male Fischer 344 rats
    Ki Yoon Jung
    Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Mech Ageing Dev 125:445-53. 2004
    ..Taken together, these data suggest that aging is associated with decreased expression of N-cadherin and alpha-catenin and is associated with a loss of cell polarity...
  84. ncbi request reprint Ischemia-induced cleavage of cadherins in NRK cells is not sufficient for beta-catenin transcriptional activity
    Gang Chen
    Department of Systems Biology and Translational Medicine, College of Medicine, Texas A and M University System Health Science Center, Texas, USA
    Cell Commun Adhes 14:111-23. 2007
    ..These results suggest that ischemia-induced disruption of cadherin/catenin complexes is not sufficient to stimulate beta-catenin transcriptional activity in NRK cells...
  85. ncbi request reprint Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity
    Jing Jiang
    Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station 77843 1114, USA
    Toxicol Sci 80:170-82. 2004
    ..Taken together, these data suggest that alterations in cadherin and catenin expression, localization, and interaction are associated with nephrotoxicity...

Research Grants1

  1. Acquisition of a Confocal/Multiphoton Microscopy System
    Robert Burghardt; Fiscal Year: 2006
    ..This new technology will provide faculty, postdoctoral fellows and students with access to a state-of-the-art imaging facility and will facilitate the ongoing research of the major and minor users. [unreadable] [unreadable] [unreadable]..