Nathan S Bryan

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. doi request reprint Acute effects of hemodialysis on nitrite and nitrate: potential cardiovascular implications in dialysis patients
    Nathan S Bryan
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Free Radic Biol Med 58:46-51. 2013
  2. doi request reprint Pharmacological therapies, lifestyle choices and nitric oxide deficiency: a perfect storm
    Nathan S Bryan
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine at The University of Texas Health Sciences Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 1825 Pressler St SRB 530C, Houston, TX 77030, USA
    Pharmacol Res 66:448-56. 2012
  3. doi request reprint Ingested nitrate and nitrite and stomach cancer risk: an updated review
    Nathan S Bryan
    Texas Therapeutics Institute, Houston, TX 77030, USA
    Food Chem Toxicol 50:3646-65. 2012
  4. ncbi request reprint Application of nitric oxide in drug discovery and development
    Nathan S Bryan
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences at Houston, Department of Integrative Biology and Pharmacology, 1825 Pressler St 530C, Houston, TX 77030, USA 1 713 500 2439 1 713 500 2447
    Expert Opin Drug Discov 6:1139-54. 2011
  5. ncbi request reprint Nitrite in nitric oxide biology: cause or consequence? A systems-based review
    Nathan S Bryan
    Institute of Molecular Medicine, University of Texas at Houston Health Sciences Center, 1825 Pressler, Houston, TX 77030, USA
    Free Radic Biol Med 41:691-701. 2006
  6. ncbi request reprint Cardioprotective actions of nitrite therapy and dietary considerations
    Nathan S Bryan
    Brown Foundation Institute of Molecular Medicine, The University of Texas Houston Health Sciences Center, 1825 Pressler St, Houston TX 77030, USA
    Front Biosci (Landmark Ed) 14:4793-808. 2009
  7. doi request reprint Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway
    Kalpana Mujoo
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, TX 77030, USA
    Protein Cell 3:535-44. 2012
  8. pmc Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
    Sandesh C S Nagamani
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 90:836-46. 2012
  9. pmc Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice
    Nathan S Bryan
    The Brown Foundation Institute of Molecular Medicine, University of Texas Houston Health Sciences Center, Houston, TX 77030, USA
    Free Radic Biol Med 45:468-74. 2008
  10. doi request reprint Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, Brown Foundation Institute of Molecular Medicine, The Univ of Texas Houston Health Science Center, 1825 Pressler St, SRB 530B, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 296:H1281-8. 2009

Collaborators

Detail Information

Publications39

  1. doi request reprint Acute effects of hemodialysis on nitrite and nitrate: potential cardiovascular implications in dialysis patients
    Nathan S Bryan
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Free Radic Biol Med 58:46-51. 2013
    ..89 to 95.08±24.64 μM; P=0.01). Chronic and persistent depletion of plasma and salivary nitrite and nitrate probably reduces NO bioavailability and may explain in part the increased cardiovascular mortality in the dialysis patient...
  2. doi request reprint Pharmacological therapies, lifestyle choices and nitric oxide deficiency: a perfect storm
    Nathan S Bryan
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine at The University of Texas Health Sciences Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 1825 Pressler St SRB 530C, Houston, TX 77030, USA
    Pharmacol Res 66:448-56. 2012
    ..Understanding NO homeostasis in each patient and how treatments and procedures affect NO homeostasis should allow for better medical care and improved outcomes...
  3. doi request reprint Ingested nitrate and nitrite and stomach cancer risk: an updated review
    Nathan S Bryan
    Texas Therapeutics Institute, Houston, TX 77030, USA
    Food Chem Toxicol 50:3646-65. 2012
    ..This new and growing body of evidence calls for a reconsideration of nitrite and nitrate safety...
  4. ncbi request reprint Application of nitric oxide in drug discovery and development
    Nathan S Bryan
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, The Graduate School of Biomedical Sciences at Houston, Department of Integrative Biology and Pharmacology, 1825 Pressler St 530C, Houston, TX 77030, USA 1 713 500 2439 1 713 500 2447
    Expert Opin Drug Discov 6:1139-54. 2011
    ..Understanding and utilizing dietary and nutritional strategies to restore NO homeostasis could allow for safer, quicker marketing of products that may be just as efficacious as drugs designed against specific targets...
  5. ncbi request reprint Nitrite in nitric oxide biology: cause or consequence? A systems-based review
    Nathan S Bryan
    Institute of Molecular Medicine, University of Texas at Houston Health Sciences Center, 1825 Pressler, Houston, TX 77030, USA
    Free Radic Biol Med 41:691-701. 2006
    ....
  6. ncbi request reprint Cardioprotective actions of nitrite therapy and dietary considerations
    Nathan S Bryan
    Brown Foundation Institute of Molecular Medicine, The University of Texas Houston Health Sciences Center, 1825 Pressler St, Houston TX 77030, USA
    Front Biosci (Landmark Ed) 14:4793-808. 2009
    ..Here the state of the art of nitrite in cytoprotection as well as maintenance of steady state blood and tissue nitrite is reviewed...
  7. doi request reprint Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway
    Kalpana Mujoo
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, TX 77030, USA
    Protein Cell 3:535-44. 2012
    ..These studies demonstrate that polyphenol curcumin may be involved in differentiation of ES cells partly due to manipulation of nitric oxide signaling...
  8. pmc Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
    Sandesh C S Nagamani
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 90:836-46. 2012
    ..Hence, NO supplementation should be investigated for the long-term treatment of this condition...
  9. pmc Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice
    Nathan S Bryan
    The Brown Foundation Institute of Molecular Medicine, University of Texas Houston Health Sciences Center, Houston, TX 77030, USA
    Free Radic Biol Med 45:468-74. 2008
    ..Dietary nitrite and nitrate may serve as essential nutrients for optimal cardiovascular health and may provide a novel prevention/treatment modality for disease associated with NO insufficiency...
  10. doi request reprint Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, Brown Foundation Institute of Molecular Medicine, The Univ of Texas Houston Health Science Center, 1825 Pressler St, SRB 530B, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 296:H1281-8. 2009
    ..These data reveal novel anti-inflammatory properties of nitrite and implicate the use of nitrite as a new natural therapy for microvascular inflammation and endothelial dysfunction associated with hypercholesterolemia...
  11. doi request reprint Nitric oxide bioactivity of traditional Chinese medicines used for cardiovascular indications
    Yaoping Tang
    Brown Foundation Institute of Molecular Medicine, Health Science Center, The University of Texas at Houston, Houston, TX 77030, USA
    Free Radic Biol Med 47:835-40. 2009
    ..Repletion of biological nitrite and nitrate by these extracts and providing a natural system for NO generation in both endothelium-dependent and -independent mechanisms may account for some of the therapeutic effects of TCMs...
  12. doi request reprint Concentration- and stage-specific effects of nitrite on colon cancer cell lines
    Hong Jiang
    Texas Therapeutics Institute at Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States
    Nitric Oxide 26:267-73. 2012
    ..Taken together, our data indicate nitrite inhibits cancer cell progression at low concentrations and early stage but promotes cancer cell progression at higher concentrations in cells representing stage 4 colon carcinomas...
  13. doi request reprint Urinary nitrate might be an early biomarker for pediatric acute kidney injury in the emergency department
    Asad I Mian
    Department of Pediatrics, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatr Res 70:203-7. 2011
    ..Thus, low urinary nitrate is associated with AKI in the pediatric ED even when SCr is normal. Predictive potential of this putative urinary biomarker for AKI needs further evaluation in sicker patients...
  14. doi request reprint Nitrite and nitrate: cardiovascular risk-benefit and metabolic effect
    Yaoping Tang
    Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    Curr Opin Lipidol 22:11-5. 2011
    ....
  15. doi request reprint Sodium nitrite: the "cure" for nitric oxide insufficiency
    Deepa K Parthasarathy
    Texas Therapeutics Institute, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States
    Meat Sci 92:274-9. 2012
    ..Foods or diets enriched with nitrite can have profound positive health benefits...
  16. pmc Requirement of argininosuccinate lyase for systemic nitric oxide production
    Ayelet Erez
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Med 17:1619-26. 2011
    ..Our data demonstrate a previously unappreciated role for ASL in NOS function and NO homeostasis. Hence, ASL may serve as a target for manipulating NO production in experimental models, as well as for the treatment of NO-related diseases...
  17. pmc Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
    Nathan S Bryan
    Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:19144-9. 2007
    ..Therefore, nitrite and nitrate may serve as essential nutrients for optimal cardiovascular health and may provide a treatment modality for cardiovascular disease...
  18. ncbi request reprint Discovery of the nitric oxide signaling pathway and targets for drug development
    Nathan S Bryan
    Institute of Molecular Medicine, The University of Texas Houston Health Sciences Center, Houston, TX 77030, USA
    Front Biosci (Landmark Ed) 14:1-18. 2009
    ....
  19. pmc Natural product nitric oxide chemistry: new activity of old medicines
    Hong Jiang
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, TX 77030, USA
    Evid Based Complement Alternat Med 2012:873210. 2012
    ..We will review the current state of science behind NO activity of herbal medicines and their effects on CVD...
  20. pmc Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells
    Kalpana Mujoo
    Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center, 1825 Pressler Street, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:18924-9. 2008
    ..These studies demonstrate that cGMP-mediated NO signaling plays an important role in the differentiation of ES cells into myocardial cells...
  21. doi request reprint Dietary sources of nitrite as a modulator of ischemia/reperfusion injury
    Harsha K Garg
    Brown Foundation Institute of Molecular Medicine, The University of Texas Houston Health Sciences Center, USA
    Kidney Int 75:1140-4. 2009
    ..Here, we review the current body of knowledge regarding dietary sources of nitrite and its modulation of cytoprotection in an I/R injury...
  22. pmc Methods to detect nitric oxide and its metabolites in biological samples
    Nathan S Bryan
    Institute of Molecular Medicine, The University of Texas Houston Health Sciences Center, Houston, TX 77030, USA
    Free Radic Biol Med 43:645-57. 2007
    ....
  23. pmc Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly
    Ashley C Torregrossa
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St 530C, Houston, TX 77030, USA
    J Geriatr Cardiol 8:230-42. 2011
    ..Implementing strategies to diagnose and treat NO insufficiency may provide enormous benefit to the geriatric patient...
  24. pmc Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide
    John W Elrod
    Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:11430-5. 2008
    ..This study presents clear evidence for an endocrine role of NO generated endogenously from eNOS and provides additional evidence for the profound cytoprotective actions of NO in the setting of I/R injury...
  25. ncbi request reprint Concomitant presence of N-nitroso and S-nitroso proteins in human plasma
    Tienush Rassaf
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 33:1590-6. 2002
    ..Our findings may not only have important implications for the transport of NO in vivo, but also for cardiovascular disease diagnostics and the risk assessment of nitrosamine-related carcinogenesis in man...
  26. pmc Chemical nature of nitric oxide storage forms in rat vascular tissue
    Juan Rodriguez
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Proc Natl Acad Sci U S A 100:336-41. 2003
    ..We conclude that intravascular nitroso species and nitrite both have the potential to release physiologically relevant quantities of NO independent of enzymatic control by NO synthase...
  27. ncbi request reprint Nitrosative stress in an animal model of necrotizing enterocolitis
    Ruben Zamora
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Free Radic Biol Med 39:1428-37. 2005
    ..Whether nitrite plays a protective or deleterious role remains to be investigated...
  28. ncbi request reprint NO adducts in mammalian red blood cells: too much or too little?
    Tienush Rassaf
    Nat Med 9:481-2; author reply 482-3. 2003
  29. ncbi request reprint Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
    Petra Kleinbongard
    Department of Medicine, Division of Cardiology, Pulmonary Diseases, Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 35:790-6. 2003
    ..These results provide evidence for a uniform constitutive vascular NOS-activity across mammalian species...
  30. pmc Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo
    Nathan S Bryan
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 101:4308-13. 2004
    ..The findings also raise the intriguing possibility that N-nitrosation is directly involved in the modulation of protein function...
  31. ncbi request reprint Bound NO in human red blood cells: fact or artifact?
    Nathan S Bryan
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Nitric Oxide 10:221-8. 2004
    ....
  32. pmc Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]
    Ling Tao
    Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:11471-6. 2004
    ..In the case of hTrx, these effects are further potentiated by S-nitrosation, but this posttranslational modification is not essential for protection...
  33. pmc Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo
    David R Janero
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 101:16958-63. 2004
    ..These findings provide insight into the global in vivo metabolism of GTN at pharmacologically relevant doses and offer an additional experimental paradigm for the NObonomic analysis of NO-donor metabolism and signaling...
  34. ncbi request reprint Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
    Nathan S Bryan
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Chem Biol 1:290-7. 2005
    ..Thus, nitrite homeostasis may be of great importance to NO biology...
  35. ncbi request reprint N-Nitroso products from the reaction of indoles with Angeli's salt
    Fabienne Peyrot
    Institut de Chimie des Substances Naturelles, C N R S, Avenue de la Terrasse, F 91198, Gif sur Yvette, France
    Chem Res Toxicol 19:58-67. 2006
    ..It is intriguing to speculate that the particular efficiency of nitroxyl to form N-nitroso species in the heart may account for the positive inotropic effects observed with AS earlier...
  36. ncbi request reprint Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Arterioscler Thromb Vasc Biol 26:1517-23. 2006
    ..We reported previously that systemic genetic overexpression of eNOS attenuates MI-R injury. The purpose of the current study was to investigate tissue-specific genetic overexpression of the human eNOS gene...
  37. ncbi request reprint Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment
    Xunde Wang
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 281:26994-7002. 2006
    ....
  38. ncbi request reprint Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury
    Mark R Duranski
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 291:H2980-6. 2006
    ..These results suggest that hepatic protection in eNOS-TG mice may be mediated in part by NO signaling via the sGC-cGMP pathway and is independent of HO-1 signal transduction pathways...
  39. ncbi request reprint Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo
    Martin Feelisch
    Department of Molecular and Cellular Physiology, LSU Health Sciences Centers, Shreveport, Louisiana 71130, USA
    FASEB J 16:1775-85. 2002
    ....