Joseph Bryan

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint ABCC8 and ABCC9: ABC transporters that regulate K+ channels
    Joseph Bryan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Pflugers Arch 453:703-18. 2007
  2. ncbi request reprint Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channels
    J Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX, USA
    Biochim Biophys Acta 1461:285-303. 1999
  3. ncbi request reprint Toward linking structure with function in ATP-sensitive K+ channels
    Joseph Bryan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Diabetes 53:S104-12. 2004
  4. ncbi request reprint Insulin secretagogues, sulfonylurea receptors and K(ATP) channels
    J Bryan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Pharm Des 11:2699-716. 2005
  5. ncbi request reprint Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement
    Alvaro Munoz
    Departments of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 146:5514-21. 2005
  6. ncbi request reprint Activating mutations in the ABCC8 gene in neonatal diabetes mellitus
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
    N Engl J Med 355:456-66. 2006
  7. ncbi request reprint Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 268:423-6. 1995
  8. ncbi request reprint Adenosine diphosphate as an intracellular regulator of insulin secretion
    C G Nichols
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 272:1785-7. 1996
  9. ncbi request reprint Sur domains that associate with and gate KATP pores define a novel gatekeeper
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza 112C, Houston, TX 77030, USA
    J Biol Chem 278:41577-80. 2003
  10. ncbi request reprint Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channels
    Wanda H Vila-Carriles
    Department of Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 21:18-25. 2007

Research Grants

Collaborators

Detail Information

Publications42

  1. ncbi request reprint ABCC8 and ABCC9: ABC transporters that regulate K+ channels
    Joseph Bryan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Pflugers Arch 453:703-18. 2007
    ..2 polymorphism has been suggested as a predisposing factor in type 2 diabetes mellitus. Studies on K(ATP) channel null mice are clarifying the roles of these metabolically sensitive channels in a variety of tissues...
  2. ncbi request reprint Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channels
    J Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX, USA
    Biochim Biophys Acta 1461:285-303. 1999
    ..K(ATP) channels are a unique example of the physiologic and medical importance of a transport ATPase and provide a paradigm for how other members of the family may interact with other ion channels...
  3. ncbi request reprint Toward linking structure with function in ATP-sensitive K+ channels
    Joseph Bryan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Diabetes 53:S104-12. 2004
    ....
  4. ncbi request reprint Insulin secretagogues, sulfonylurea receptors and K(ATP) channels
    J Bryan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Pharm Des 11:2699-716. 2005
    ..The model has a central chamber which could serve as a multifaceted binding pocket...
  5. ncbi request reprint Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement
    Alvaro Munoz
    Departments of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 146:5514-21. 2005
    ..The results indicate that loss of alpha-cell K(ATP) channels uncouples glucagon release from inhibition by beta-cells and reveals a role for K(ATP) channels in the regulation of glucagon release by low glucose...
  6. ncbi request reprint Activating mutations in the ABCC8 gene in neonatal diabetes mellitus
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
    N Engl J Med 355:456-66. 2006
    ..We hypothesized that activating mutations in ABCC8, which encodes SUR1, cause neonatal diabetes...
  7. ncbi request reprint Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 268:423-6. 1995
    ..The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release...
  8. ncbi request reprint Adenosine diphosphate as an intracellular regulator of insulin secretion
    C G Nichols
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 272:1785-7. 1996
    ..Thus, by binding to SUR NBF2 and antagonizing ATP inhibition of KATP++ channels, intracellular MgADP may regulate insulin secretion...
  9. ncbi request reprint Sur domains that associate with and gate KATP pores define a novel gatekeeper
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza 112C, Houston, TX 77030, USA
    J Biol Chem 278:41577-80. 2003
    ..The results explain and predict pathologies associated with alteration of the 5' ends of clustered ABCC8 (9)/KCNJ11 (8) genes...
  10. ncbi request reprint Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channels
    Wanda H Vila-Carriles
    Department of Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 21:18-25. 2007
    ..These studies indicate that the B site involves L0 and the K(IR) amino terminus, elements that are critical for control of channel gating...
  11. ncbi request reprint Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels
    Alvaro Munoz
    Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Stroke 34:164-70. 2003
    ..To evaluate the role of neuronal/beta-cell-type K(ATP) channels, SUR1 null (Sur1KO) mice lacking (K(IR)6.x/SUR1)(4) K(ATP) channels were subjected to a preconditioning protocol with the use of double carotid occlusion...
  12. ncbi request reprint SUR-dependent modulation of KATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactions
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:43997-4004. 2002
    ....
  13. ncbi request reprint cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets
    Mitsuhiro Nakazaki
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Diabetes 51:3440-9. 2002
    ..We hypothesize that a reduced release of insulin in response to incretins may contribute to the unexpected normoglycemic phenotype of Sur1KO mice versus the pronounced hypoglycemia seen in neonates with loss of K(ATP) channel activity...
  14. ncbi request reprint Toward understanding the assembly and structure of KATP channels
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
    Physiol Rev 78:227-45. 1998
    ..The availability of cloned KATP channel genes opens the way for characterization of this family of ion channels and identification of additional genetic defects...
  15. pmc Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2
    David Ortiz
    Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:17985-95. 2012
    ..NBD2, but not NBD1, has a higher affinity for ATP (and ADP) in mutant versus wild type (with or without Mg(2+)). Thus, the mutants spend more time in nucleotide-bound conformations, with reduced affinity for GBC, that activate the pore...
  16. ncbi request reprint Cloning and expression of a murine fascin homolog from mouse brain
    R A Edwards
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 270:10764-70. 1995
    ..Electron cryomicroscopy images show that the reconstituted bundles are highly ordered. However, their fine structure differs from that of echinoid fascin-actin bundles. This structural difference can be attributed to fascin...
  17. ncbi request reprint Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion
    V Seghers
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:9270-7. 2000
    ....
  18. ncbi request reprint A conserved inhibitory and differential stimulatory action of nucleotides on K(IR)6.0/SUR complexes is essential for excitation-metabolism coupling by K(ATP) channels
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:49083-92. 2001
    ....
  19. ncbi request reprint Hetero-concatemeric KIR6.X4/SUR14 channels display distinct conductivities but uniform ATP inhibition
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:31563-6. 2000
    ..We propose that SUR-dependent, inhibitory ATP-enhanced interactions of the cytoplasmic domains of both K(IR)6.1 and K(IR)6.2 stabilize a closed form of the M2 bundle in the gating apparatus...
  20. ncbi request reprint Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes
    B E Tubb
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Genomics 65:146-56. 2000
    ..The likely function of retinal fascin, in light of known fascin roles in other cell types, is to assemble actin microfilaments in support of photoreceptor disk morphogenesis...
  21. ncbi request reprint Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:717-20. 2000
    ..These data are incorporated into a functional topology model for the regulatory SUR subunits of K(ATP) channels...
  22. ncbi request reprint The tolbutamide site of SUR1 and a mechanism for its functional coupling to K(ATP) channel closure
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS Lett 459:367-76. 1999
    ..These findings uncover a molecular basis for an inhibitory influence of SUR1, an ATP-binding cassette (ABC) protein, on K(IR)6.2, a ion channel subunit...
  23. ncbi request reprint Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoforms
    A P Babenko
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 274:11587-92. 1999
    ..This is the first identification of parts of an ABC protein that interact with an ion channel subunit to modulate the spontaneous activity and ATP sensitivity of the heteromeric channel...
  24. ncbi request reprint The N-terminus of KIR6.2 limits spontaneous bursting and modulates the ATP-inhibition of KATP channels
    A P Babenko
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 255:231-8. 1999
    ..The results identify the N-terminus of KIR6.2 as a determinant of the interburst kinetics of KATP channels and suggest that the two cytoplasmic domains of KIR6.2 participate in ATP-inhibitory gating through distinct mechanisms...
  25. ncbi request reprint Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells
    A P Babenko
    Departments of Cell Biology and Medicine, Baylor College of Medicine, Houston, TX, USA
    Circ Res 83:1132-43. 1998
    ....
  26. ncbi request reprint Sulfonylurea receptors set the maximal open probability, ATP sensitivity and plasma membrane density of KATP channels
    A P Babenko
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS Lett 445:131-6. 1999
    ..2 modification. The results demonstrate allosteric interaction(s) are essential for normal intrinsic activity, ATP inhibition, and trafficking of KATP channels...
  27. ncbi request reprint Of mice and men: K(ATP) channels and insulin secretion
    L Aguilar-Bryan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Recent Prog Horm Res 56:47-68. 2001
    ....
  28. ncbi request reprint Cloning of cDNAs encoding human caldesmons
    M B Humphrey
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Gene 112:197-204. 1992
    ..Examination of the 'junctions' at either end of the deleted central domain gives a clear indication of the splice sites and suggests that the nonmuscle form is generated by exon skipping.(ABSTRACT TRUNCATED AT 250 WORDS)..
  29. pmc Fascin, an echinoid actin-bundling protein, is a homolog of the Drosophila singed gene product
    J Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030 3498
    Proc Natl Acad Sci U S A 90:9115-9. 1993
    ..No extensive similarities were found with other known actin-binding/bundling proteins, indicating that this is a separate gene family...
  30. ncbi request reprint Molecular biology of adenosine triphosphate-sensitive potassium channels
    L Aguilar-Bryan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocr Rev 20:101-35. 1999
    ....
  31. ncbi request reprint Cloning and expression of a smooth muscle caldesmon
    J Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 264:13873-9. 1989
    ..A tentative map of the major binding domains is proposed on the basis of available data...
  32. ncbi request reprint Sequence of an avian non-muscle caldesmon
    J Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    J Muscle Res Cell Motil 12:372-5. 1991
    ..This central segment is thought to be helical, suggesting that non-muscle caldesmon is approximately 35 nm shorter, about 40 nm overall length, than smooth muscle caldesmon...
  33. ncbi request reprint Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels
    Andras Szollosi
    Unit of Endocrinology and Metabolism, University of Louvain Faculty of Medicine, UCL 55 30, Avenue Hippocrate 55, B 1200 Brussels, Belgium
    J Biol Chem 282:1747-56. 2007
    ..It is suggested that unidentified potassium channels are sensitive to glucose and subserve the acute and long-term metabolic control of [Ca(2+)](c) in beta-cells without functional K(ATP) channels...
  34. ncbi request reprint The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells
    Martina Dufer
    Institute of Pharmacy, Department of Pharmacology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 20:65-74. 2007
    ..The change in Ca(2+) sequestration in beta cells treated with insulinotropic antidiabetics may have implications for beta cell survival and the therapeutic use of these drugs...
  35. ncbi request reprint Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroD
    Ji Won Kim
    Department of Anatomy, Ajou University, School of Medicine, Suwon, 442 749, Korea
    Mol Endocrinol 16:1097-107. 2002
    ..These results also suggest that E3 is specific for BETA2/NeuroD, and the stimulatory effect of ngn3 in HIT cells may require factors specifically expressed in HIT cells...
  36. ncbi request reprint Epinephrine-induced hyperpolarization of islet cells without KATP channels
    Andrea Sieg
    Institut fur Neurophysiologie, Universitat zu Koln, Cologne, Germany
    Am J Physiol Endocrinol Metab 286:E463-71. 2004
    ..We conclude that epinephrine can hyperpolarize beta-cells in the absence of KATP channels via activation of low-conductance BaCl2-sensitive K+ channels that are regulated by pertussis toxin-sensitive G proteins...
  37. ncbi request reprint Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism
    Khalid Hussain
    The London Centre for Pediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children National Health Service Trust, University College London, UK
    Diabetes 54:2946-51. 2005
    ..Other possible mechanisms such as the suppressive effect of prolonged hyperinsulinemia on alpha-cell secretion should be considered...
  38. ncbi request reprint Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
    Tony K T Lam
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 701, Bronx, New York 10461, USA
    Nat Med 11:320-7. 2005
    ..These findings indicate that a physiological elevation in circulating lipids can be sensed within the hypothalamus and that a defect in hypothalamic lipid sensing disrupts glucose homeostasis...
  39. ncbi request reprint Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells
    Myriam Nenquin
    Unité d Endocrinologie et Métabolisme, University of Louvain Faculty of Medicine UCL 55 30, Ave Hippocrate 55, B 1200 Brussels, Belgium
    J Biol Chem 279:32316-24. 2004
    ....
  40. ncbi request reprint Hypothalamic K(ATP) channels control hepatic glucose production
    Alessandro Pocai
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 434:1026-31. 2005
    ..These findings suggest that activation of hypothalamic K(ATP) channels normally restrains hepatic gluconeogenesis, and that any alteration within this central nervous system/liver circuit can contribute to diabetic hyperglycaemia...
  41. ncbi request reprint Docking and fusion of insulin secretory granules in SUR1 knock out mouse beta-cells observed by total internal reflection fluorescence microscopy
    Toshiteru Kikuta
    Department of Biochemistry, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    FEBS Lett 579:1602-6. 2005
    ..fusion with the plasma membrane. Thus, the impaired docking and fusion results in decreased insulin exocytosis from Sur1KO beta-cells...
  42. ncbi request reprint Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo
    Huarong Zhou
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Diabetes 56:1107-12. 2007
    ..We conclude that zinc atoms, not the insulin molecule itself, provide the switch-off signal from the beta-cell to the alpha-cell to initiate glucagon secretion during hypoglycemia...

Research Grants2

  1. Studies of Sulfonylurea Receptors and KATP Channels
    Joseph Bryan; Fiscal Year: 2007
    ..x interacts with the L0 linker of SURs to control bursting. (3) To define further the sulfonylurea/glibenclamide binding pocket of SUR1, specifically to identify amino acids in proximity to the meglitinide head group. ..