Eric L Brown

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection
    Eric L Brown
    Center for Infectious Diseases, University of Texas School of Public Health, Houston, Texas 77030, USA
    J Biol Chem 287:9940-51. 2012
  2. pmc Pretreatment of epithelial cells with rifaximin alters bacterial attachment and internalization profiles
    Eric L Brown
    The University of Texas School of Public Health, 1200 Herman Pressler, Houston, TX 77030, USA
    Antimicrob Agents Chemother 54:388-96. 2010
  3. pmc Pediatric antibody response to community-acquired Staphylococcus aureus infection is directed to Panton-Valentine leukocidin
    Eric L Brown
    Center for Infectious Disease, University of Texas School of Public Health, 1200 Herman Pressler Dr, Houston, TX 77030, USA
    Clin Vaccine Immunol 16:139-41. 2009
  4. ncbi request reprint Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia
    Maria Labandeira-Rey
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Science 315:1130-3. 2007
  5. ncbi request reprint Multicomponent Lyme vaccine: three is not a crowd
    Eric L Brown
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, 2121 W, Holcombe Blvd, Suite 603, Houston, TX 77030, USA
    Vaccine 23:3687-96. 2005
  6. ncbi request reprint Virulence potential of the staphylococcal adhesin CNA in experimental arthritis is determined by its affinity for collagen
    Yi Xu
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Institute of Biosciences and Technology, Houston, Texas 77030, USA
    J Infect Dis 189:2323-33. 2004
  7. ncbi request reprint Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb)
    Lawrence Y L Lee
    Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030 7552, USA
    J Biol Chem 279:50710-6. 2004
  8. ncbi request reprint Inhibition of complement activation by a secreted Staphylococcus aureus protein
    Lawrence Y L Lee
    Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030 7552, USA
    J Infect Dis 190:571-9. 2004
  9. doi request reprint Seroprevalence of the enteroaggregative Escherichia coli virulence factor dispersin among USA travellers to Cuernavaca, Mexico: a pilot study
    David B Huang
    Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    J Med Microbiol 57:476-9. 2008
  10. ncbi request reprint Decorin-binding sites in the adhesin DbpA from Borrelia burgdorferi: a synthetic peptide approach
    Dagmar Sandback Pikas
    Center for Extracellular Matrix Biology, Albert B Alkek Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 278:30920-6. 2003

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection
    Eric L Brown
    Center for Infectious Diseases, University of Texas School of Public Health, Houston, Texas 77030, USA
    J Biol Chem 287:9940-51. 2012
    ..These data suggest a potential defense function for constitutively produced catalytic antibodies to a putative superantigenic site of Efb, but an adaptive catalytic response appears to be proscribed...
  2. pmc Pretreatment of epithelial cells with rifaximin alters bacterial attachment and internalization profiles
    Eric L Brown
    The University of Texas School of Public Health, 1200 Herman Pressler, Houston, TX 77030, USA
    Antimicrob Agents Chemother 54:388-96. 2010
    ..The study provides evidence that rifaximin-mediated changes in epithelial cell physiology are associated with changes in bacterial attachment/internalization and reduced inflammatory cytokine release...
  3. pmc Pediatric antibody response to community-acquired Staphylococcus aureus infection is directed to Panton-Valentine leukocidin
    Eric L Brown
    Center for Infectious Disease, University of Texas School of Public Health, 1200 Herman Pressler Dr, Houston, TX 77030, USA
    Clin Vaccine Immunol 16:139-41. 2009
    ..The data show that patients infected with Panton-Valentine leukocidin (PVL)-positive strains developed a dominant immunoglobulin G anti-PVL antibody response that correlates with markers of inflammation...
  4. ncbi request reprint Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia
    Maria Labandeira-Rey
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Science 315:1130-3. 2007
    ....
  5. ncbi request reprint Multicomponent Lyme vaccine: three is not a crowd
    Eric L Brown
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, 2121 W, Holcombe Blvd, Suite 603, Houston, TX 77030, USA
    Vaccine 23:3687-96. 2005
    ....
  6. ncbi request reprint Virulence potential of the staphylococcal adhesin CNA in experimental arthritis is determined by its affinity for collagen
    Yi Xu
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Institute of Biosciences and Technology, Houston, Texas 77030, USA
    J Infect Dis 189:2323-33. 2004
    ..CNA, a collagen adhesin of S. aureus, was shown to be a virulence factor in several animal models. However, the precise molecular mechanism by which CNA contributes to virulence remains unclear...
  7. ncbi request reprint Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb)
    Lawrence Y L Lee
    Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030 7552, USA
    J Biol Chem 279:50710-6. 2004
    ....
  8. ncbi request reprint Inhibition of complement activation by a secreted Staphylococcus aureus protein
    Lawrence Y L Lee
    Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030 7552, USA
    J Infect Dis 190:571-9. 2004
    ..These data suggest that Efb is a virulence factor involved in facilitating persistent S. aureus infections by interfering with complement activity in vivo...
  9. doi request reprint Seroprevalence of the enteroaggregative Escherichia coli virulence factor dispersin among USA travellers to Cuernavaca, Mexico: a pilot study
    David B Huang
    Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    J Med Microbiol 57:476-9. 2008
    ..Further studies are needed to characterize in more detail the host clinical and immunological responses to the dispersin protein...
  10. ncbi request reprint Decorin-binding sites in the adhesin DbpA from Borrelia burgdorferi: a synthetic peptide approach
    Dagmar Sandback Pikas
    Center for Extracellular Matrix Biology, Albert B Alkek Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 278:30920-6. 2003
    ..All of these peptides were active in our decorin-binding assay, and consensus decorin binding motifs are discussed...
  11. pmc Rifaximin-mediated changes to the epithelial cell proteome: 2-D gel analysis
    Caroline Schrodt
    Center for Infectious Diseases, The University of Texas School of Public Health, Houston, Texas, United States of America
    PLoS ONE 8:e68550. 2013
    ..These data suggested that in addition to its antimicrobial properties, rifaximin may alter host cell physiology that provides cytoprotective effects against bacterial pathogens. ..
  12. pmc Microbial etiology of travelers' diarrhea in Mexico, Guatemala, and India: importance of enterotoxigenic Bacteroides fragilis and Arcobacter species
    Zhi Dong Jiang
    Center for Infectious Diseases, University of Texas School of Public Health, 1200 Herman Pressler Room 741, Houston, TX 77030, USA
    J Clin Microbiol 48:1417-9. 2010
    ..S. and European travelers with acute diarrhea acquired in Mexico, Guatemala, and India. Arcobacter butzleri and ETBF were detected in 8% and 7% of diarrhea cases, respectively...
  13. pmc The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    BMC Med Genet 10:56. 2009
    ..The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants...
  14. ncbi request reprint Genetics of diabetic retinopathy
    Craig L Hanis
    Human Genetics Center, The University of Texas Health Science Center at Houston, PO Box 20186, Houston, TX 77225, USA
    Curr Diab Rep 6:155-61. 2006
    ..Elucidating the susceptibility genes and pathways should permit strategies to slow and reverse the troubling trends for the population, families, and individuals...
  15. ncbi request reprint A genome-wide linkage scan for diabetic retinopathy susceptibility genes in Mexican Americans with type 2 diabetes from Starr County, Texas
    D Michael Hallman
    University of Texas Health, Science Center at Houston, P O Box 20186, Houston, TX 77225, USA
    Diabetes 56:1167-73. 2007
    ..Candidate genes were identified in most implicated regions...
  16. pmc Physiological IgM class catalytic antibodies selective for transthyretin amyloid
    Stephanie A Planque
    From the Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030
    J Biol Chem 289:13243-58. 2014
    ..Excess misTTR was dissolved by a hydrolytic mIgM. The studies reveal a novel antibody property, the innate ability of IgMs to selectively degrade and dissolve toxic misTTR species as a first line immune function. ..
  17. pmc The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses
    Lawrence Y Lee
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030 7552, USA
    J Clin Invest 110:1461-71. 2002
    ..These data suggest a role for Map as an immunomodulatory protein that may play a role in persistent SA infections by affecting protective cellular immunity...
  18. pmc Bile salt inhibition of host cell damage by Clostridium difficile toxins
    Charles Darkoh
    The University of Texas School of Public Health, Division of Epidemiology, Human Genetics and Environmental Sciences, Center for Infectious Diseases, Houston, Texas, United States of America The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America
    PLoS ONE 8:e79631. 2013
    ..difficile growth and toxin production. These findings open up a new avenue for the development of non-antibiotic therapeutics for CDI treatment. ..
  19. ncbi request reprint Familial aggregation of severity of diabetic retinopathy in Mexican Americans from Starr County, Texas
    D Michael Hallman
    Human Genetics Center, The University of Texas Health Science Center at Houston, P O Box 20186, Houston, TX 77225, USA
    Diabetes Care 28:1163-8. 2005
    ..To determine whether retinopathy itself or only its severity aggregates in families, we examined the occurrence and severity of diabetic retinopathy in Mexican-American siblings with type 2 diabetes...
  20. pmc Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans
    May E Montasser
    Human Genetics Center, School of Public Health, University of Texas Health Science, Center at Houston, Houston, Texas 77030, USA
    J Hypertens 27:491-501. 2009
    ....
  21. ncbi request reprint Lack of genetic linkage evidence for a trans-acting factor having a large effect on plasma lipoprotein[a] levels in African Americans
    Ruth Ann Barkley
    Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Lipid Res 44:1301-5. 2003
    ..60), 14 (LOD 2.56), and 19 (LOD 2.52). No linkage evidence was found to support the hypothesis of another single gene with large effects specifically segregating in African Americans that may account for their elevated Lp[a] levels...
  22. pmc Adverse association between diabetic retinopathy and cardiac structure and function
    David Aguilar
    Winters Center for Heart Failure Research and Section of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am Heart J 157:563-8. 2009
    ..Our objective was to assess the relationship between retinopathy and cardiac structure and function in a cohort of individuals with type 2 diabetes mellitus...
  23. pmc Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure
    Charles C Chung
    Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Hermann Pressler, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 94:268-76. 2009
    ..Thus, GR gene variation may influence interindividual differences in blood pressure in human populations...
  24. ncbi request reprint Corticotropin releasing hormone (CRH) gene variation: comprehensive resequencing for variant and molecular haplotype discovery in monosomic hybrid cell lines
    Lawrence C Shimmin
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
    DNA Seq 18:434-44. 2007
    ..6), likely reflecting disruptive selection in CRH evolution. Network analysis showed that AA have retained an ancestral CRH haplotype, while the most common EA haplotype is derived from a single recombination event...
  25. ncbi request reprint Serotonin 2a receptor T102C polymorphism and impaired impulse control
    James M Bjork
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Am J Med Genet 114:336-9. 2002
    ..These preliminary data suggest that the T102C 5-HT2a receptor polymorphism may be a marker for impaired behavior control-perhaps in the context of psychiatric disorder history...

Research Grants1

  1. Genome-wide association to Staphylococcus carriage
    Craig L Hanis; Fiscal Year: 2010
    ..aureus carriage as means of identifying novel genes or pathways associated with carriage/disease. This information may then be used to develop novel treatment and prevention strategies. ..