Jan Bressler

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Global DNA methylation and risk of subclinical atherosclerosis in young adults: the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, United States
    Atherosclerosis 219:958-62. 2011
  2. pmc The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    BMC Med Genet 10:56. 2009
  3. pmc Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region
    Yong hui Jiang
    Department of Molecular, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Genomics 9:50. 2008
  4. doi request reprint Seafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders
    Mohammad H Rahbar
    Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health at Houston, Houston, TX 77030, USA
    Neurotox Res 23:22-38. 2013
  5. pmc Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study
    Jan Bressler
    Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, USA
    Neurology 80:92-9. 2013
  6. ncbi request reprint Epigenetics and human disease
    Yong hui Jiang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Genomics Hum Genet 5:479-510. 2004
  7. pmc Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 5:e10521. 2010
  8. ncbi request reprint Mouse imprinting defect mutations that model Angelman syndrome
    Mei Yi Wu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 44:12-22. 2006
  9. pmc Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, P O Box 20334, Houston, TX 77225 0334, USA
    Am J Epidemiol 171:14-23. 2010
  10. ncbi request reprint A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A
    Yong hui Jiang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Am J Med Genet A 131:1-10. 2004

Collaborators

Detail Information

Publications13

  1. pmc Global DNA methylation and risk of subclinical atherosclerosis in young adults: the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, United States
    Atherosclerosis 219:958-62. 2011
    ..PDAY is a bi-racial investigation of the natural history of atherosclerosis and its risk factors involving 3013 individuals aged 15-34 years who underwent autopsy after dying of unrelated causes in 1987-1994...
  2. pmc The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    BMC Med Genet 10:56. 2009
    ..The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants...
  3. pmc Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region
    Yong hui Jiang
    Department of Molecular, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Genomics 9:50. 2008
    ..Taking advantage of the human genome sequence, we have performed extensive sequence analysis and molecular studies for the PWS candidate region...
  4. doi request reprint Seafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders
    Mohammad H Rahbar
    Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health at Houston, Houston, TX 77030, USA
    Neurotox Res 23:22-38. 2013
    ..Based on our findings, we recommend additional education to Jamaican parents regarding potential hazards of elevated blood mercury concentrations, and its association with seafood consumption and type of seafood...
  5. pmc Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study
    Jan Bressler
    Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, USA
    Neurology 80:92-9. 2013
    ....
  6. ncbi request reprint Epigenetics and human disease
    Yong hui Jiang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Genomics Hum Genet 5:479-510. 2004
    ..The MEGDI model may apply to some complex disease traits and could explain negative results in genome-wide genetic scans...
  7. pmc Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 5:e10521. 2010
    ..03). Adjustment for BMI did not eliminate any of the observed associations with diabetes. Significant statistical interaction between race and the FTO variants suggests that the effect on diabetes susceptibility may be context dependent...
  8. ncbi request reprint Mouse imprinting defect mutations that model Angelman syndrome
    Mei Yi Wu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 44:12-22. 2006
    ..A second mutation, an 80-kb deletion extending upstream of the first mutation, caused a similar imprinting defect with variable penetrance. These results suggest that there is a mouse functional equivalent to the human AS-IC...
  9. pmc Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, P O Box 20334, Houston, TX 77225 0334, USA
    Am J Epidemiol 171:14-23. 2010
    ..This study demonstrates that genetic variants revealed in a case-control genome-wide association study enriched for early disease onset may play a role in the genetic etiology of CHD in the general population...
  10. ncbi request reprint A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A
    Yong hui Jiang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Am J Med Genet A 131:1-10. 2004
    ..A mixed epigenetic and genetic and mixed de novo and inherited (MEGDI) model could be relevant to other "complex disease traits"...
  11. pmc Interaction between the NOS3 Gene and Obesity as a Determinant of Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study
    Jan Bressler
    Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 8:e79466. 2013
    ..These results suggest that interaction between obesity and NOS3 genotype may be a determinant of diabetes case status in whites in the ARIC cohort. Replication in other populations will be required to confirm these observations. ..
  12. pmc Maternal and paternal age are jointly associated with childhood autism in Jamaica
    Mohammad H Rahbar
    Division of Epidemiology, Human Genetics, and Environmental Sciences EHGES, School of Public Health, The University of Texas Health Science Center at Houston UTHealth, Houston, TX 77030, USA
    J Autism Dev Disord 42:1928-38. 2012
    ..6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM...
  13. ncbi request reprint Disruption of the genomic imprint in trans with homologous recombination at Snrpn in ES cells
    Ting Fen Tsai
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Genesis 37:151-61. 2003
    ....

Research Grants2

  1. DNA Methylation Profiles in a Polygenic Mouse Model of Diet-Induced Obesity
    Jan Bressler; Fiscal Year: 2007
    ..This will be studied first in mice to see whether this type of change could help to explain the increased risk for non-insulin dependent diabetes mellitus (NIDDM) and coronary heart disease (CHD) with obesity. ..