Affiliation: Texas Medical Center
- Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RFAgathe Bourgogne
Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
Genome Biol 9:R110. 2008..Enterococcus faecalis has emerged as a major hospital pathogen. To explore its diversity, we sequenced E. faecalis strain OG1RF, which is commonly used for molecular manipulation and virulence studies...
- Bicarbonate enhances expression of the endocarditis and biofilm associated pilus locus, ebpR-ebpABC, in Enterococcus faecalisAgathe Bourgogne
Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, 6431 Fannin, Houston, Texas 77030, USA
BMC Microbiol 10:17. 2010..However, there is no report relating to the environmental conditions that affect expression of the ebpR-ebpABC locus...
- EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RFAgathe Bourgogne
Division of Infectious Diseases, Department of Medicine, Center for the Study of Emerging and Re Emerging Pathogens, MSB 2 112, University of Texas Medical School, 6431 Fannin St, Houston, TX 77030, USA
J Bacteriol 189:6490-3. 2007..An ebpR deletion (DeltaebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation...
- Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine proteaseAgathe Bourgogne
Division of Infectious Disease, Center for the Study of Emerging and Re Emerging Pathogens, MSB 2 112, University of Texas Medical School, 6431 Fannin St, Houston, TX 77030, USA
J Bacteriol 188:2875-84. 2006....
- Library screen identifies Enterococcus faecalis CcpA, the catabolite control protein A, as an effector of Ace, a collagen adhesion protein linked to virulencePeng Gao
Center for Molecular Imaging, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, Division of Applied Biologics, The University of Texas Health Science Center at Houston, Houston, Texas, USA
J Bacteriol 195:4761-8. 2013..faecalis carbohydrate uptake and utilization. Our discovery is the first to associate CcpA with the production of a major E. faecalis virulence factor, providing new insights into the regulation of E. faecalis pathogenesis. ..
- Multiple posttranscriptional regulatory mechanisms partner to control ethanolamine utilization in Enterococcus faecalisKristina A Fox
Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 106:4435-40. 2009..Gene expression appears to be directed by overlapping posttranscriptional regulatory mechanisms, each responding to a particular metabolic signal, conceptually akin to regulation by multiple DNA-binding transcription factors...
- Further characterization of the epa gene cluster and Epa polysaccharides of Enterococcus faecalisFang Teng
Center for the Study of Emerging and Re Emerging Pathogens, The University of Texas Medical School, Houston, Texas77030, USA
Infect Immun 77:3759-67. 2009..faecalis virulence in a mouse peritonitis model...
- Diversity of the fsr-gelE region of the Enterococcus faecalis genome but conservation in strains with partial deletions of the fsr operonJessica R Galloway-Peña
Division of Infectious Disease, Department of Medicine, University of Texas Medical School, Houston, TX 77030, USA
Appl Environ Microbiol 77:442-51. 2011..However, strains lacking the fsrC-EF_1841 region show a distinct conservation of the sequence surrounding this deletion and in gelE, suggesting that the deletion may result from horizontal transfer and recombination...
- Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomesXiang Qin
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
BMC Microbiol 12:135. 2012..faecium strains in clinical environments. Systematic study of the molecular epidemiology and pathogenesis of E. faecium has been hindered by the lack of closed, complete E. faecium genomes that can be used as references...
- A family of fibrinogen-binding MSCRAMMs from Enterococcus faecalisJouko Sillanpaa
Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, TX, USA
Microbiology 155:2390-400. 2009..Thus, E. faecalis contains a family of MSCRAMMs that structurally and functionally resemble the Fg-binding MSCRAMMs of staphylococci...
- atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpBMelissa Drysdale
Department of Microbiology and Molecular Genetics, The University of Texas Houston Health Science Center, Houston, Texas 77030, USA
J Bacteriol 186:307-15. 2004..The data suggest that, in a strain containing both virulence plasmids, atxA is the major regulator of capsule synthesis and controls capBCAD expression indirectly, via positive regulation of acpA and acpB...
- Transcriptional analysis of the Bacillus anthracis capsule regulatorsMelissa Drysdale
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, 6431 Fannin St, MSB 1 206 Houston, TX 77030, USA
J Bacteriol 187:5108-14. 2005....
- Isolation of a minireplicon of the virulence plasmid pXO2 of Bacillus anthracis and characterization of the plasmid-encoded RepS replication proteinEowyn Tinsley
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, East 1240 Biomedical Science Tower, Pittsburgh, PA 15261, USA
J Bacteriol 186:2717-23. 2004..Competition DNA binding experiments showed that the 5' and central regions of the putative origin were important for RepS binding. MBP-RepS also bound nonspecifically to single-stranded DNA with a lower affinity...
- Global effects of virulence gene regulators in a Bacillus anthracis strain with both virulence plasmidsAgathe Bourgogne
Department of Microbiology and Molecular Genetics, The University of Texas Houston Health Science Center, 77030, USA
Infect Immun 71:2736-43. 2003..anthracis, previous assumptions regarding reduced virulence of strains harboring single plasmids must be reassessed and the potential roles of newly identified atxA-regulated genes should be investigated...