Research Topics
Genomes and Genes | George W BoozSummaryAffiliation: Texas A and M University Country: USA Publications
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Detail Information
Publications
Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failureGeorge W Booz
The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
J Mol Cell Cardiol 34:1443-53. 2002..The central focus of this review is on recent studies suggesting that modulation or activation of JAK-STAT signaling by ANG II has pathological consequences for heart function...- Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferationJena J Steinle
Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, Temple, Texas 76504, USA
J Biol Chem 278:20681-6. 2003..These results support the hypothesis that beta3-adrenergic receptors play a role in proliferation and migration of cultured human retinal endothelial cells... - Cytokine G-protein signaling crosstalk in cardiomyocytes: attenuation of Jak-STAT activation by endothelin-1George W Booz
The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
Mol Cell Biochem 240:39-46. 2002..Overall our findings indicate that endothelin-1 acts to temper IL-6-related cytokine signaling in cardiomyocytes, in particular STAT3 activation... - Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylationGeorge W Booz
Texas A and M University System, Health Science Center, College of Medicine, Cardiovascular Research Institute, Division of Molecular Cardiology, 1901 South 1st Street, Bldg 162 Temple 76504, USA
Basic Res Cardiol 98:33-8. 2003..We propose that Erk serves as a scaffolding protein in recruiting either a protein tyrosine or MAP kinase phosphatase to STAT3... - Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROSMazen Kurdi
The Division of Molecular Cardiology, The Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Scott and White, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
J Cell Physiol 212:424-31. 2007..The finding that signaling by the IL-6-type cytokine may be redox-sensitive defines a novel mechanism of regulation that has implications for exploiting their therapeutic potential... - Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signalingMazen Kurdi
Division of Molecular Cardiology, Cardiovascular Research Institute, College of Medicine, The Texas A and M University System Health Science Center, College Station, TX 76504, USA
J Cardiovasc Pharmacol 50:126-41. 2007..Understanding how IL-6-type cytokine signaling is regulated in cardiac myocytes has great significance for exploiting the therapeutic potential of these cytokines and the phenomenon of preconditioning... - Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytesMazen Kurdi
Division of Molecular Cardiology, Texas A and M University System Health Science Center, Temple, TX, USA
Free Radic Biol Med 42:474-81. 2007..Parthenolide may be a useful tool for studying the roles of oxidative stress and mitochondrial dysfunction in the pathogenesis of cardiac hypertrophy and failure... - Working outside the system: an update on the unconventional behavior of the renin-angiotensin system componentsMazen Kurdi
Department of Medicine, The Cardiovascular Research Institute of the Texas A and M University System Health Science Center, College of Medicine, Scott and White Hospital, Temple, TX 76504, USA
Int J Biochem Cell Biol 37:1357-67. 2005..A greater understanding of these extra-system functions of the RAS components may aid in the development of novel treatments for hypertension, myocardial ischemia, and heart failure... - Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophyKenneth M Baker
Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, 1901 S 1st Street, Building 205, Temple 76504, USA
Regul Pept 120:5-13. 2004..These data demonstrate a previously unknown growth mechanism of Ang II in the heart, which should be considered when designing therapeutic strategies to block Ang II actions... - Putting the brakes on cardiac hypertrophy: exploiting the NO-cGMP counter-regulatory systemGeorge W Booz
Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, Temple, Tex, USA
Hypertension 45:341-6. 2005..Understanding the function and regulation of the antihypertrophic NO-cGMP system offers the promise of novel therapeutic strategies for treating cardiac hypertrophy and heart failure... - Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cellsMazen Kurdi
Division of Molecular Cardiology, Department of Internal Medicine, Scott and White, The Texas A and M University System Health Science Center, College of Medicine, Central Texas Veterans Health Care System, Temple, TX 76504, USA
J Interferon Cytokine Res 27:23-31. 2007..Our findings suggest that the proapoptotic actions of IFN-gamma in A549 cells occur downstream of Jak1 activation by a noncanonical pathway that does not involve the Jak1 target, Stat1... - G-CSF-based stem cell therapy for the heart--unresolved issues part B: Stem cells, engraftment, transdifferentiation, and bioengineeringMazen Kurdi
Department of Chemistry and Life Sciences, College of Sciences and Computer Engineering, Holy Spirit University of Kaslik, Jounieh, Lebanon
Congest Heart Fail 13:347-51. 2007..The convergence of bioengineering and molecular biology on stem cell therapy would seem to make what was once unimaginable, cardiac regeneration, a clinical reality in less than one generation... - G-CSF-based stem cell therapy for the heart-unresolved issues part A: paracrine actions, mobilization, and deliveryMazen Kurdi
Department of Chemistry and Life Sciences, College of Sciences and Engineering, Holy Spirit University of Kaslik, Jounieh, Lebanon
Congest Heart Fail 13:221-7. 2007..Such knowledge could be readily exploited to make G-CSF-based therapy a reality for the clinician... - Cardiac angiotensin AT2 receptor: what exactly does it do?George W Booz
Hypertension 43:1162-3. 2004 - Growing old, angiotensin II, cardiac hypertrophy, and death: making the connection with p66ShcGeorge W Booz
Hypertension 46:259-60. 2005 - Agonist-dependent internalization of the angiotensin II type one receptor (AT1): role of C-terminus phosphorylation in recruitment of beta-arrestinsChris E Kule
Science Department, Cabrini College, Radnor, PA, USA
Regul Pept 120:141-8. 2004..In conclusion, this study shows that the high affinity binding of beta-arrestins to the phosphorylated C-terminus is the predominant mechanism of agonist-induced beta-arrestin recruitment to the cell surface and AT1 receptor... - Growing hearts by the bushelMazen Kurdi
Department of Chemistry and Life Sciences, College of Sciences and Computer Engineering, Holy Spirit University of Kaslik, Jounieh, Lebanon
Congest Heart Fail 14:95-6. 2008