George W Booz

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure
    George W Booz
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
    J Mol Cell Cardiol 34:1443-53. 2002
  2. ncbi request reprint Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation
    Jena J Steinle
    Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    J Biol Chem 278:20681-6. 2003
  3. ncbi request reprint Cytokine G-protein signaling crosstalk in cardiomyocytes: attenuation of Jak-STAT activation by endothelin-1
    George W Booz
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
    Mol Cell Biochem 240:39-46. 2002
  4. ncbi request reprint Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation
    George W Booz
    Texas A and M University System, Health Science Center, College of Medicine, Cardiovascular Research Institute, Division of Molecular Cardiology, 1901 South 1st Street, Bldg 162 Temple 76504, USA
    Basic Res Cardiol 98:33-8. 2003
  5. ncbi request reprint Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS
    Mazen Kurdi
    The Division of Molecular Cardiology, The Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Scott and White, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    J Cell Physiol 212:424-31. 2007
  6. ncbi request reprint Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signaling
    Mazen Kurdi
    Division of Molecular Cardiology, Cardiovascular Research Institute, College of Medicine, The Texas A and M University System Health Science Center, College Station, TX 76504, USA
    J Cardiovasc Pharmacol 50:126-41. 2007
  7. ncbi request reprint Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes
    Mazen Kurdi
    Division of Molecular Cardiology, Texas A and M University System Health Science Center, Temple, TX, USA
    Free Radic Biol Med 42:474-81. 2007
  8. ncbi request reprint Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components
    Mazen Kurdi
    Department of Medicine, The Cardiovascular Research Institute of the Texas A and M University System Health Science Center, College of Medicine, Scott and White Hospital, Temple, TX 76504, USA
    Int J Biochem Cell Biol 37:1357-67. 2005
  9. ncbi request reprint Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy
    Kenneth M Baker
    Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, 1901 S 1st Street, Building 205, Temple 76504, USA
    Regul Pept 120:5-13. 2004
  10. ncbi request reprint Putting the brakes on cardiac hypertrophy: exploiting the NO-cGMP counter-regulatory system
    George W Booz
    Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, Temple, Tex, USA
    Hypertension 45:341-6. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure
    George W Booz
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
    J Mol Cell Cardiol 34:1443-53. 2002
    ..The central focus of this review is on recent studies suggesting that modulation or activation of JAK-STAT signaling by ANG II has pathological consequences for heart function...
  2. ncbi request reprint Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation
    Jena J Steinle
    Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    J Biol Chem 278:20681-6. 2003
    ..These results support the hypothesis that beta3-adrenergic receptors play a role in proliferation and migration of cultured human retinal endothelial cells...
  3. ncbi request reprint Cytokine G-protein signaling crosstalk in cardiomyocytes: attenuation of Jak-STAT activation by endothelin-1
    George W Booz
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
    Mol Cell Biochem 240:39-46. 2002
    ..Overall our findings indicate that endothelin-1 acts to temper IL-6-related cytokine signaling in cardiomyocytes, in particular STAT3 activation...
  4. ncbi request reprint Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation
    George W Booz
    Texas A and M University System, Health Science Center, College of Medicine, Cardiovascular Research Institute, Division of Molecular Cardiology, 1901 South 1st Street, Bldg 162 Temple 76504, USA
    Basic Res Cardiol 98:33-8. 2003
    ..We propose that Erk serves as a scaffolding protein in recruiting either a protein tyrosine or MAP kinase phosphatase to STAT3...
  5. ncbi request reprint Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS
    Mazen Kurdi
    The Division of Molecular Cardiology, The Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Scott and White, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    J Cell Physiol 212:424-31. 2007
    ..The finding that signaling by the IL-6-type cytokine may be redox-sensitive defines a novel mechanism of regulation that has implications for exploiting their therapeutic potential...
  6. ncbi request reprint Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signaling
    Mazen Kurdi
    Division of Molecular Cardiology, Cardiovascular Research Institute, College of Medicine, The Texas A and M University System Health Science Center, College Station, TX 76504, USA
    J Cardiovasc Pharmacol 50:126-41. 2007
    ..Understanding how IL-6-type cytokine signaling is regulated in cardiac myocytes has great significance for exploiting the therapeutic potential of these cytokines and the phenomenon of preconditioning...
  7. ncbi request reprint Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes
    Mazen Kurdi
    Division of Molecular Cardiology, Texas A and M University System Health Science Center, Temple, TX, USA
    Free Radic Biol Med 42:474-81. 2007
    ..Parthenolide may be a useful tool for studying the roles of oxidative stress and mitochondrial dysfunction in the pathogenesis of cardiac hypertrophy and failure...
  8. ncbi request reprint Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components
    Mazen Kurdi
    Department of Medicine, The Cardiovascular Research Institute of the Texas A and M University System Health Science Center, College of Medicine, Scott and White Hospital, Temple, TX 76504, USA
    Int J Biochem Cell Biol 37:1357-67. 2005
    ..A greater understanding of these extra-system functions of the RAS components may aid in the development of novel treatments for hypertension, myocardial ischemia, and heart failure...
  9. ncbi request reprint Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy
    Kenneth M Baker
    Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, 1901 S 1st Street, Building 205, Temple 76504, USA
    Regul Pept 120:5-13. 2004
    ..These data demonstrate a previously unknown growth mechanism of Ang II in the heart, which should be considered when designing therapeutic strategies to block Ang II actions...
  10. ncbi request reprint Putting the brakes on cardiac hypertrophy: exploiting the NO-cGMP counter-regulatory system
    George W Booz
    Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, Temple, Tex, USA
    Hypertension 45:341-6. 2005
    ..Understanding the function and regulation of the antihypertrophic NO-cGMP system offers the promise of novel therapeutic strategies for treating cardiac hypertrophy and heart failure...
  11. ncbi request reprint Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells
    Mazen Kurdi
    Division of Molecular Cardiology, Department of Internal Medicine, Scott and White, The Texas A and M University System Health Science Center, College of Medicine, Central Texas Veterans Health Care System, Temple, TX 76504, USA
    J Interferon Cytokine Res 27:23-31. 2007
    ..Our findings suggest that the proapoptotic actions of IFN-gamma in A549 cells occur downstream of Jak1 activation by a noncanonical pathway that does not involve the Jak1 target, Stat1...
  12. ncbi request reprint G-CSF-based stem cell therapy for the heart--unresolved issues part B: Stem cells, engraftment, transdifferentiation, and bioengineering
    Mazen Kurdi
    Department of Chemistry and Life Sciences, College of Sciences and Computer Engineering, Holy Spirit University of Kaslik, Jounieh, Lebanon
    Congest Heart Fail 13:347-51. 2007
    ..The convergence of bioengineering and molecular biology on stem cell therapy would seem to make what was once unimaginable, cardiac regeneration, a clinical reality in less than one generation...
  13. ncbi request reprint G-CSF-based stem cell therapy for the heart-unresolved issues part A: paracrine actions, mobilization, and delivery
    Mazen Kurdi
    Department of Chemistry and Life Sciences, College of Sciences and Engineering, Holy Spirit University of Kaslik, Jounieh, Lebanon
    Congest Heart Fail 13:221-7. 2007
    ..Such knowledge could be readily exploited to make G-CSF-based therapy a reality for the clinician...
  14. ncbi request reprint Cardiac angiotensin AT2 receptor: what exactly does it do?
    George W Booz
    Hypertension 43:1162-3. 2004
  15. ncbi request reprint Growing old, angiotensin II, cardiac hypertrophy, and death: making the connection with p66Shc
    George W Booz
    Hypertension 46:259-60. 2005
  16. ncbi request reprint Agonist-dependent internalization of the angiotensin II type one receptor (AT1): role of C-terminus phosphorylation in recruitment of beta-arrestins
    Chris E Kule
    Science Department, Cabrini College, Radnor, PA, USA
    Regul Pept 120:141-8. 2004
    ..In conclusion, this study shows that the high affinity binding of beta-arrestins to the phosphorylated C-terminus is the predominant mechanism of agonist-induced beta-arrestin recruitment to the cell surface and AT1 receptor...
  17. ncbi request reprint Growing hearts by the bushel
    Mazen Kurdi
    Department of Chemistry and Life Sciences, College of Sciences and Computer Engineering, Holy Spirit University of Kaslik, Jounieh, Lebanon
    Congest Heart Fail 14:95-6. 2008