M R Blackburn

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency
    M R Blackburn
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 273:5093-100. 1998
  2. pmc Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction
    M R Blackburn
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston Medical School, Houston, Texas 77030, USA
    J Exp Med 192:159-70. 2000
  3. ncbi The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities
    M R Blackburn
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 275:32114-21. 2000
  4. ncbi Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice
    J L Chunn
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston Medical School, Houston, TX 77030, USA
    J Immunol 167:4676-85. 2001
  5. ncbi Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice
    H Zhong
    Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Pharmacol Exp Ther 298:433-40. 2001
  6. ncbi Diverse genetic regulatory motifs required for murine adenosine deaminase gene expression in the placenta
    D Shi
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 272:2334-41. 1997
  7. ncbi Metabolic and immunologic consequences of limited adenosine deaminase expression in mice
    M R Blackburn
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 271:15203-10. 1996
  8. pmc Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice
    M Wakamiya
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 92:3673-7. 1995
  9. ncbi Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development
    M R Blackburn
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA
    Development 124:3089-97. 1997
  10. ncbi Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice
    M R Blackburn
    Verna and Mars McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 270:23891-4. 1995

Collaborators

  • J R Fozard
  • W Chen
  • L F Thompson
  • Scott Rivkees
  • J L Chunn
  • C P Turner
  • R E Kellems
  • S G Apasov
  • H Zhong
  • D Shi
  • S K Banerjee
  • M V Sitkovsky
  • H W Young
  • G N Colasurdo
  • P T Smith
  • J B Volmer
  • M Wakamiya
  • X Gao
  • J H Winston
  • G Hanten
  • S K Datta
  • T B Knudsen
  • K Mitani
  • R Jurecic
  • S Vaishnav
  • J W Belmont
  • R S Geske
  • J Cartwright
  • M J McArthur
  • M J Airhart
  • J M Chinsky

Detail Information

Publications15

  1. ncbi Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency
    M R Blackburn
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 273:5093-100. 1998
    ..ADA-deficient mice also exhibited severe pulmonary insufficiency, bone abnormalities, and kidney pathogenesis. These mice have provided in vivo information into the metabolic basis for the immune phenotype associated with ADA deficiency...
  2. pmc Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction
    M R Blackburn
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston Medical School, Houston, Texas 77030, USA
    J Exp Med 192:159-70. 2000
    ..These data suggest that disturbances in purinergic signaling mediate the lung inflammation and damage seen in ADA-deficient mice...
  3. ncbi The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities
    M R Blackburn
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 275:32114-21. 2000
    ..This model will be useful in examining the efficacy of ADA enzyme therapy and studying the mechanisms underlying the immunodeficiency and pulmonary phenotypes associated with ADA deficiency...
  4. ncbi Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice
    J L Chunn
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston Medical School, Houston, TX 77030, USA
    J Immunol 167:4676-85. 2001
    ..Collectively, these findings suggest that elevations in adenosine can directly impact lung inflammation and physiology...
  5. ncbi Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice
    H Zhong
    Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Pharmacol Exp Ther 298:433-40. 2001
    ....
  6. ncbi Diverse genetic regulatory motifs required for murine adenosine deaminase gene expression in the placenta
    D Shi
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 272:2334-41. 1997
    ..These findings indicate that multiple protein binding motifs are necessary for Ada expression in the placenta...
  7. ncbi Metabolic and immunologic consequences of limited adenosine deaminase expression in mice
    M R Blackburn
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 271:15203-10. 1996
    ..These mice represent the first genetic animal model for ADA deficiency and provide insight into the tissue-specific requirements of ADA...
  8. pmc Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice
    M Wakamiya
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 92:3673-7. 1995
    ..The results presented here demonstrate that ADA is important for the homeostatic maintenance of purines in mice...
  9. ncbi Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development
    M R Blackburn
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA
    Development 124:3089-97. 1997
    ..These experiments provide genetic evidence that Ada expression at the maternal-fetal interface is essential for early postimplantation development in mice...
  10. ncbi Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice
    M R Blackburn
    Verna and Mars McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 270:23891-4. 1995
    ..Our findings suggest that placental ADA is important for murine fetal development and illustrate a general strategy for the tissue specific correction of phenotypes associated with null mutations in mice...
  11. pmc Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling
    S G Apasov
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 108:131-41. 2001
    ..Experiments with thymocytes ex vivo confirmed that ADA deficiency reduces tyrosine phosphorylation of TCR-associated signaling molecules and blocks TCR-triggered calcium increases...
  12. pmc Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures
    L F Thompson
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, University of Oklahoma, Oklahoma City, 73104, USA
    J Clin Invest 106:1149-57. 2000
    ..Thus, ADA substrates accumulate and disrupt thymocyte development in ADA deficiency. These substrates derive from thymocytes that undergo apoptosis as a consequence of failing to pass developmental checkpoints, such as beta selection...
  13. ncbi Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies
    T B Knudsen
    Department of Anatomy, East Tennessee State University, James H Quillen College of Medicine, Johnson City 37614
    Biol Reprod 44:171-84. 1991
    ..Thus, maternal expression of ADA in the antimesometrial decidua may play a role during establishment of the embryo in the uterine environment, whereas fetal expression of ADA in the trophoblast might be important to placentation...
  14. ncbi Activation of apoptosis in early mouse embryos by 2'-deoxyadenosine exposure
    X Gao
    Department of Anatomy and Developmental Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107
    Teratology 49:1-12. 1994
    ..Exposure to this metabolic toxin activates apoptosis in day 7-8 embryos through an adenosine-sensitive, NAD-dependent mechanism...
  15. ncbi A1 adenosine receptors mediate hypoglycemia-induced neuronal injury
    C P Turner
    Department of Pediatrics, Yale Child Health Researh Center, 464 Congress Avenue, New Haven, Connecticut 06520, USA
    J Mol Endocrinol 32:129-44. 2004
    ..Collectively, these data show that hypoglycemia induces A1ARs activation leading to alterations in [Ca2+]i, which plays a prominent role in leading to hypoglycemia-induced neuronal death...