Tadhg Begley

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase
    Abhishek Chatterjee
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 478:542-6. 2011
  2. pmc Thiamin biosynthesis: still yielding fascinating biological chemistry
    Tadhg P Begley
    Department of Chemistry, Texas A and M University, College Station, TX 77843, U S A
    Biochem Soc Trans 40:555-60. 2012

Collaborators

  • Abhishek Chatterjee
  • Pei Jing Pai
  • David H Russell
  • Steven E Ealick
  • Pieter C Dorrestein
  • N Dinuka Abeydeera
  • Shridhar Bale

Detail Information

Publications2

  1. pmc Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase
    Abhishek Chatterjee
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 478:542-6. 2011
    ....
  2. pmc Thiamin biosynthesis: still yielding fascinating biological chemistry
    Tadhg P Begley
    Department of Chemistry, Texas A and M University, College Station, TX 77843, U S A
    Biochem Soc Trans 40:555-60. 2012
    ..cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase...

Research Grants22

  1. MECHANISTIC ENZYMOLOGY OF THIAMIN BIOSYNTHESIS
    Tadhg Begley; Fiscal Year: 2002
    ..Once we have identified specific reactions in the sulfur transfer and in the thiazole formation, we will initiate systematic mechanistic studies on each of the enzymes involved. ..
  2. The mechanistic enzymology of thiamin biosynthesis
    Tadhg Begley; Fiscal Year: 2003
    ....
  3. MECHANISTIC ENZYMOLOGY OF THIAMIN BIOSYNTHESIS
    Tadhg Begley; Fiscal Year: 2001
    ..Once we have identified specific reactions in the sulfur transfer and in the thiazole formation, we will initiate systematic mechanistic studies on each of the enzymes involved. ..
  4. MECHANISTIC ENZYMOLOGY OF THIAMIN BIOSYNTHESIS
    Tadhg Begley; Fiscal Year: 2001
    ..Once we have identified specific reactions in the sulfur transfer and in the thiazole formation, we will initiate systematic mechanistic studies on each of the enzymes involved. ..
  5. MECHANISTIC ENZYMOLOGY OF THIAMINE BIOSYNTHESIS
    Tadhg Begley; Fiscal Year: 1992
    ..The annual production of thiamine is 2,000 tons, of which is produced by total synthesis. Cloning of the thiamine biosynthetic genes therefore has potential applications in the commercial production of thiamine fermentation...
  6. The mechanistic enzymology of thiamin biosynthesis
    Tadhg Begley; Fiscal Year: 2006
    ....
  7. Mechanistic enzymology of quinolinic acid biosynthesis
    Tadhg Begley; Fiscal Year: 2007
    ..Mechanistic studies on the quinolinic acid biosynthetic enzymes will facilitate the identification of small molecule inhibitors to control these disease states. ..
  8. The mechanistic enzymology of thiamin biosynthesis
    Tadhg Begley; Fiscal Year: 2004
    ....
  9. Mechanistic enzymology of quinolinic acid biosynthesis
    Tadhg Begley; Fiscal Year: 2006
    ..Mechanistic studies on the quinolinic acid biosynthetic enzymes will facilitate the identification of small molecule inhibitors to control these disease states. ..
  10. Mechanistic enzymology of quinolinic acid biosynthesis
    Tadhg Begley; Fiscal Year: 2005
    ..Mechanistic studies on the quinolinic acid biosynthetic enzymes will facilitate the identification of small molecule inhibitors to control these disease states. ..
  11. The mechanistic enzymology of thiamin biosynthesis
    Tadhg Begley; Fiscal Year: 2005
    ....
  12. The mechanistic enzymology of thiamin biosynthesis
    Tadhg Begley; Fiscal Year: 2007
    ....
  13. The mechanistic enzymology of thiamin biosynthesis
    Tadhg Begley; Fiscal Year: 2003
    ....
  14. MECHANISTIC ENZYMOLOGY OF THIAMIN BIOSYNTHESIS
    Tadhg Begley; Fiscal Year: 2000
    ..Once we have identified specific reactions in the sulfur transfer and in the thiazole formation, we will initiate systematic mechanistic studies on each of the enzymes involved. ..
  15. MECHANISTIC ENZYMOLOGY OF THIAMINE BIOSYNTHESIS
    Tadhg Begley; Fiscal Year: 1993
    ..The annual production of thiamine is 2,000 tons, of which is produced by total synthesis. Cloning of the thiamine biosynthetic genes therefore has potential applications in the commercial production of thiamine fermentation...
  16. MECHANISTIC ENZYMOLOGY OF THIAMINE BIOSYNTHESIS
    Tadhg Begley; Fiscal Year: 1991
    ..The annual production of thiamine is 2,000 tons, of which is produced by total synthesis. Cloning of the thiamine biosynthetic genes therefore has potential applications in the commercial production of thiamine fermentation...
  17. MECHANISTIC ENZYMOLOGY OF THIAMIN BIOSYNTHESIS
    Tadhg Begley; Fiscal Year: 1999
    ..Once we have identified specific reactions in the sulfur transfer and in the thiazole formation, we will initiate systematic mechanistic studies on each of the enzymes involved. ..