Fuller Bazer

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi Contributions of an animal scientist to understanding the biology of the uterus and pregnancy
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Reprod Fertil Dev 25:129-47. 2012
  2. ncbi Select nutrients, progesterone, and interferon tau affect conceptus metabolism and development
    Fuller W Bazer
    Department of Animal Science, Texas A and M University, College Station, TX, USA
    Ann N Y Acad Sci 1271:88-96. 2012
  3. ncbi Uterine biology in pigs and sheep
    Fuller W Bazer
    Department of Animal Science, 442D Kleberg Center, 2471 TAMU, Texas A and M University, College Station, TX, 77843 2471, USA
    J Anim Sci Biotechnol 3:23. 2012
  4. ncbi Select nutrients in the uterine lumen of sheep and pigs affect conceptus development
    Fuller W Bazer
    Department of Animal Science and Center for Animal Biotechnology, Texas A and M University, Texas 77843 2471, USA
    J Reprod Dev 58:180-8. 2012
  5. ncbi Mechanistic mammalian target of rapamycin (MTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, TX, USA
    Mol Cell Endocrinol 354:22-33. 2012
  6. ncbi Uterine histotroph and conceptus development: select nutrients and secreted phosphoprotein 1 affect mechanistic target of rapamycin cell signaling in ewes
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas, USA
    Biol Reprod 85:1094-107. 2011
  7. ncbi Growth and development of the ovine conceptus
    F W Bazer
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    J Anim Sci 90:159-70. 2012
  8. ncbi Differential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens
    Whasun Lim
    Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul 151 921, Korea
    Reprod Biol Endocrinol 9:137. 2011
  9. ncbi Conceptus signals for establishment and maintenance of pregnancy
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Reprod Biol Endocrinol 2:49. 2004
  10. ncbi Effects of the estrous cycle, pregnancy and interferon tau on expression of cyclooxygenase two (COX-2) in ovine endometrium
    Seokwoon Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, Texas 77843 2471, USA
    Reprod Biol Endocrinol 1:58. 2003

Research Grants

  1. OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTOR
    Fuller Bazer; Fiscal Year: 2005
  2. Bridges to the Doctorate in Reproductive Biology
    Fuller Bazer; Fiscal Year: 2007

Collaborators

Detail Information

Publications84

  1. ncbi Contributions of an animal scientist to understanding the biology of the uterus and pregnancy
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Reprod Fertil Dev 25:129-47. 2012
    ..g. fibroblast growth factors and hepatocyte growth factor) that regulate uterine epithelial cells and conceptus trophectoderm, and roles of toll-like receptors expressed by uterine epithelia and conceptus trophectoderm in pregnancy...
  2. ncbi Select nutrients, progesterone, and interferon tau affect conceptus metabolism and development
    Fuller W Bazer
    Department of Animal Science, Texas A and M University, College Station, TX, USA
    Ann N Y Acad Sci 1271:88-96. 2012
    ....
  3. ncbi Uterine biology in pigs and sheep
    Fuller W Bazer
    Department of Animal Science, 442D Kleberg Center, 2471 TAMU, Texas A and M University, College Station, TX, 77843 2471, USA
    J Anim Sci Biotechnol 3:23. 2012
    ....
  4. ncbi Select nutrients in the uterine lumen of sheep and pigs affect conceptus development
    Fuller W Bazer
    Department of Animal Science and Center for Animal Biotechnology, Texas A and M University, Texas 77843 2471, USA
    J Reprod Dev 58:180-8. 2012
    ..Azaserine, an inhibitor of hexosamine biosynthesis, inhibits effects of Gluc and fructose. Thus, select nutrients in the uterine lumen affect gene transcription and mRNA translation to affect conceptus development...
  5. ncbi Mechanistic mammalian target of rapamycin (MTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, TX, USA
    Mol Cell Endocrinol 354:22-33. 2012
    ..Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation...
  6. ncbi Uterine histotroph and conceptus development: select nutrients and secreted phosphoprotein 1 affect mechanistic target of rapamycin cell signaling in ewes
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas, USA
    Biol Reprod 85:1094-107. 2011
    ..This minireview focuses on components of histotroph that affect conceptus development in the ewe...
  7. ncbi Growth and development of the ovine conceptus
    F W Bazer
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    J Anim Sci 90:159-70. 2012
    ....
  8. ncbi Differential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens
    Whasun Lim
    Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul 151 921, Korea
    Reprod Biol Endocrinol 9:137. 2011
    ..Therefore, we investigated estrogen regulation of A2M gene expression during development of the chicken oviduct, and its expression in normal and cancerous ovaries from chickens...
  9. ncbi Conceptus signals for establishment and maintenance of pregnancy
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Reprod Biol Endocrinol 2:49. 2004
    ..Strategic manipulation of these physiological mechanisms can offer therapeutic schemes to improve uterine capacity, conceptus survival and reproductive health...
  10. ncbi Effects of the estrous cycle, pregnancy and interferon tau on expression of cyclooxygenase two (COX-2) in ovine endometrium
    Seokwoon Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, Texas 77843 2471, USA
    Reprod Biol Endocrinol 1:58. 2003
    ..Indeed, expression of COX-2 in the endometrial epithelia as well as conceptus is likely to have a beneficial regulatory role in implantation and development of the conceptus...
  11. ncbi Interferons and uterine receptivity
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Semin Reprod Med 27:90-102. 2009
    ..Understanding the roles of IFNs in uterine receptivity for implantation is necessary to develop approaches to enhance reproductive health and fertility in humans and domestic animals...
  12. ncbi Novel pathways for implantation and establishment and maintenance of pregnancy in mammals
    Fuller W Bazer
    Departments of Animal Science, Texas A and M Health Sciences Center, College Station, TX 77843, USA
    Mol Hum Reprod 16:135-52. 2010
    ..Understanding the roles of the variety of hormones, growth factors and endogenous retroviral proteins in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals...
  13. ncbi Comparative aspects of implantation
    Fuller W Bazer
    Department of Animal Science Veterinary Integrative Biosciences, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
    Reproduction 138:195-209. 2009
    ....
  14. ncbi Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways
    Fuller W Bazer
    Texas A and M University, College Station, TX 77843 2471, USA
    Reprod Biol 8:179-211. 2008
    ..The magnitude of the LH surge was reduced in cows receiving endotoxin...
  15. ncbi Reproductive biology in the era of genomics biology
    Fuller W Bazer
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Theriogenology 64:442-56. 2005
    ....
  16. ncbi Uterine receptivity to implantation of blastocysts in mammals
    Fuller W Bazer
    Department of Animal Science, Texas A and M, University CollegeStation, TX 77843 2471, USA
    Front Biosci (Schol Ed) 3:745-67. 2011
    ....
  17. ncbi Contributions of an animal scientist to reproductive biology
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, TX, USA
    Biol Reprod 85:228-42. 2011
    ..g., fibroblast growth factors and hepatocyte growth factor) that, in turn, regulate functions of uterine epithelial cells and conceptus trophectoderm...
  18. ncbi Strong science challenges conventional wisdom: new perspectives on ovarian biology
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, USA
    Reprod Biol Endocrinol 2:28. 2004
  19. ncbi The endocrinology and physiology of parturition: understanding the process through mining genome databases
    Fuller Bazer
    Department of Animal Science, College Station, Texas 77843-2471, USA
    Endocrinology 144:2253. 2003
  20. ncbi Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 75:289-96. 2006
    ..The advanced development of blastocysts in P4-treated ewes is hypothesized to involve early induction of specific genes in the endometrial epithelia, such as LGALS15, and undoubtedly components of uterine histotroph...
  21. ncbi Biology of progesterone action during pregnancy recognition and maintenance of pregnancy
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas AM University, College Station, Texas 77843-2471, USA
    Front Biosci 7:d1879-98. 2002
    ....
  22. ncbi Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors of mTORC1 and mTORC2 complexes in ovine uteri and conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 81:87-100. 2009
    ..These results suggest that the FRAP1 cell signaling pathway mediates interactions between the maternal uterus and peri-implantation conceptuses and that P4 and IFNT affect this pathway by regulating expression of RHEB and EIF4EBP1...
  23. ncbi Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Texas A and M University, 442 Kleberg Center, 2471 TAMU, College Station, Texas 77843 2471, USA
    Reproduction 133:285-95. 2007
    ....
  24. ncbi Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:602-9. 2009
    ..These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival...
  25. ncbi Pregnancy and interferon tau regulate major histocompatibility complex class I and beta2-microglobulin expression in the ovine uterus
    Youngsok Choi
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station 77843, USA
    Biol Reprod 68:1703-10. 2003
    ..The silencing of MHC class I alpha chain and beta2MG genes in the endometrial LE and sGE during pregnancy recognition and establishment may be a critical mechanism preventing immune rejection of the conceptus allograft...
  26. ncbi Uterine MHC class I molecules and beta 2-microglobulin are regulated by progesterone and conceptus interferons during pig pregnancy
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    J Immunol 181:2494-505. 2008
    ....
  27. ncbi Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 79:376-86. 2008
    ....
  28. ncbi Select nutrients in the ovine uterine lumen. ii. glucose transporters in the uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Departments of Animal Science and Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 80:94-104. 2009
    ....
  29. ncbi Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estradiol
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Endocrinology 150:936-45. 2009
    ..The temporal and cell type-specific expression of STC1 makes this gene a unique marker for implantation in pigs...
  30. ncbi Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements
    Joann G W Fleming
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, 77843 2471, USA
    Endocrinology 147:899-911. 2006
    ..These results support the hypothesis that the antiluteolytic effects of IFNT are mediated by direct inhibition or silencing of ESR1 gene transcription, thereby precluding ESR1/SP1 from stimulating OXTR gene transcription...
  31. ncbi Identification of endometrial genes regulated by early pregnancy, progesterone, and interferon tau in the ovine uterus
    C Allison Gray
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 74:383-94. 2006
    ..Identification and analysis of these hormonally responsive genes will help define endometrial pathways critical for uterine support of peri-implantation conceptus survival, growth, and implantation...
  32. ncbi Analysis of osteopontin at the maternal-placental interface in pigs
    Jane E Garlow
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843-2471, USA
    Biol Reprod 66:718-25. 2002
    ..e., integrins) on conceptus and uterus to promote conceptus development and signaling between these tissues as key contributors to attachment and placentation in the pig...
  33. ncbi Select nutrients in the ovine uterine lumen. V. Nitric oxide synthase, GTP cyclohydrolase, and ornithine decarboxylase in ovine uteri and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 81:67-76. 2009
    ..Thus, biosynthesis of NO and polyamines in ovine uterine endometria and conceptuses is potentially regulated at transcriptional, translational, and posttranslational levels to favor conceptus development and implantation...
  34. ncbi Prolactin regulation of neonatal ovine uterine gland morphogenesis
    Karen D Carpenter
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843-2471, USA
    Endocrinology 144:110-20. 2003
    ..Collectively, results indicate that PRL regulates endometrial adenogenesis in the neonatal ovine uterus...
  35. ncbi Progesterone and interferon-tau regulate cystatin C in the endometrium
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, 77843-2471, USA
    Endocrinology 147:3478-83. 2006
    ..These results indicate that CST3 is a novel P4-induced and IFNT-stimulated gene expressed only in the epithelial cells of the ovine endometrium and implicate CST3 in regulation of uterine cathepsin activity during conceptus implantation...
  36. ncbi Progesterone and interferon tau regulate leukemia inhibitory factor receptor and IL6ST in the ovine uterus during early pregnancy
    Gwonhwa Song
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
    Reproduction 137:553-65. 2009
    ..Thus, LIF and STAT3 may have biological roles in endometrial function and trophectoderm growth and differentiation...
  37. ncbi HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau
    Rebecca M Simmons
    Department of Animal Science, Texas A and M University, College Station, Texas, USA
    Biol Reprod 82:35-43. 2010
    ....
  38. ncbi Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Biosciences, and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 82:854-64. 2010
    ..Cysteine proteases and their inhibitors may also specifically modify proteins for successful utilization and fluid-phase transport across uterine, placental, and neonatal gut epithelia...
  39. ncbi Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, Texas 77843-2471, USA
    Endocrinology 146:4825-33. 2005
    ....
  40. ncbi Dietary supplementation with 0.8% L-arginine between days 0 and 25 of gestation reduces litter size in gilts
    Xilong Li
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 140:1111-6. 2010
    ..These results indicate that dietary supplementation with 0.8% L-arginine between d 0 and 25 of gestation, while increasing placental vascularity, adversely affects the reproductive performance of gilts...
  41. ncbi Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation
    Rebecca M Simmons
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Endocrinology 150:4295-305. 2009
    ..These studies reveal that IGFBP1 is a common endometrial marker of conceptus elongation in sheep and cattle and most likely regulates conceptus elongation by stimulating migration and attachment of the trophectoderm...
  42. ncbi Interferon regulatory factor 6 (IRF6) is expressed in the ovine uterus and functions as a transcriptional activator
    Jo Ann G W Fleming
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Mol Cell Endocrinol 299:252-60. 2009
    ..IRF6 is hypothesized to play critical roles in endometrial gene expression as well as in conceptus trophectoderm growth and differentiation...
  43. ncbi Select nutrients in the ovine uterine lumen. IV. Expression of neutral and acidic amino acid transporters in ovine uteri and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:1196-208. 2009
    ..These results document coordinate changes in expression of transporters that are likely responsible for increases in amounts of neutral and acidic amino acids in the uterine lumen to support conceptus growth, development, and survival...
  44. ncbi Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 79:1226-36. 2008
    ..Therefore, FGF10, MET, IGFBP1, and IGFBP3 are P4-regulated factors within the endometrium of the ovine uterus that have potential effects on endometrial function and peri-implantation blastocyst growth and development...
  45. ncbi Developmental changes in polyamine levels and synthesis in the ovine conceptus
    Hyukjung Kwon
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843-2471, USA
    Biol Reprod 69:1626-34. 2003
    ..Our findings may have important implications for both intrauterine growth retardation and fetal origins of diseases in adults...
  46. ncbi Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 74:913-22. 2006
    ..The data suggest that STC1 secreted by the endometrial glands is transported into the fetal circulation and allantoic fluid, where it is hypothesized to regulate growth and differentiation of the fetus and placenta, by placental areolae...
  47. ncbi Methods for studying interferon tau stimulated genes
    Fuller W Bazer
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, USA
    Methods Mol Med 122:367-80. 2006
    ..Given that ISGs are increased in the endometrium during pregnancy across diverse species, they may be important in establishment of uterine receptivity to implantation of the conceptus...
  48. ncbi Pig conceptuses increase uterine interferon-regulatory factor 1 (IRF1), but restrict expression to stroma through estrogen-induced IRF2 in luminal epithelium
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 4458, USA
    Biol Reprod 77:292-302. 2007
    ....
  49. ncbi Discovery of candidate genes and pathways in the endometrium regulating ovine blastocyst growth and conceptus elongation
    M Carey Satterfield
    Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Physiol Genomics 39:85-99. 2009
    ..This transcriptomic data provides novel insights into the biology of endometrial function and preimplantation blastocyst growth and development in sheep...
  50. ncbi Regulation of expression of fibroblast growth factor 7 in the pig uterus by progesterone and estradiol
    Hakhyun Ka
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 77:172-80. 2007
    ....
  51. ncbi Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843-4458, USA
    Endocrinology 146:675-84. 2005
    ....
  52. ncbi Progesterone and interferon tau regulate hypoxia-inducible factors in the endometrium of the ovine uterus
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Endocrinology 149:1926-34. 2008
    ....
  53. ncbi Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm
    C Allison Gray
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 101:7982-7. 2004
    ..Galectins may be useful as cellular and molecular markers for endometrial function and receptivity, to enhance conceptus survival and development, and to evaluate and enhance fertility...
  54. ncbi Galectin 15 (LGALS15): a gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment
    Shaye K Lewis
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 77:1027-36. 2007
    ..These results support the hypothesis that LGALS15 is uniquely expressed in Caprinae endometria and functions as an attachment factor important for peri-implantation blastocyst elongation...
  55. ncbi The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep
    Kathrin A Dunlap
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas
    Biol Reprod 82:876-87. 2010
    ..Thus, S1P signaling may be crucial for proper fetal-placental development...
  56. ncbi Arginine deficiency in preterm infants: biochemical mechanisms and nutritional implications
    Guoyao Wu
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr Biochem 15:442-51. 2004
    ..This new knowledge will be beneficial for designing the next generation of enteral and parenteral amino acid solutions to optimize nutrition and health in this compromised population...
  57. ncbi Proline and hydroxyproline metabolism: implications for animal and human nutrition
    Guoyao Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
    Amino Acids 40:1053-63. 2011
    ..Further research is warranted to develop effective strategies of dietary supplementation with proline or hydroxyproline to benefit health, growth, and development of animals and humans...
  58. ncbi Identification of genes in the ovine endometrium regulated by interferon tau independent of signal transducer and activator of transcription 1
    Seokwoon Kim
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 144:5203-14. 2003
    ..These IFNtau -stimulated genes may be important in establishment of uterine receptivity to the embryo and conceptus implantation given their stage-specificity in endometrium across diverse species...
  59. ncbi Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 68:1951-8. 2003
    ..Results suggest that uterine stromal decidualization is common to species with different types of placentation, but the extent is variable and correlates with the depth of trophoblast invasion during implantation...
  60. ncbi Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8. 2003
    ....
  61. ncbi Ovine placental lactogen specifically binds to endometrial glands of the ovine uterus
    Sekoni Noel
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843-2471, USA
    Biol Reprod 68:772-80. 2003
    ..Thus, effects of oPL on the endometrial glands may be mediated by receptors for oPRL and oGH...
  62. ncbi Integrins and extracellular matrix proteins at the maternal-fetal interface in domestic animals
    Robert C Burghardt
    Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
    Cells Tissues Organs 172:202-17. 2002
    ....
  63. ncbi Pharmacokinetics and safety of arginine supplementation in animals
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 137:1673S-1680S. 2007
    ....
  64. ncbi Polyamine synthesis from proline in the developing porcine placenta
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 72:842-50. 2005
    ..Our novel findings provide a new base of information for future studies to define the role of proline in fetoplacental growth and development...
  65. ncbi Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
    ....
  66. ncbi Arginine metabolism and nutrition in growth, health and disease
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 37:153-68. 2009
    ..The effect of Arg in treating many developmental and health problems is unique among AAs, and offers great promise for improved health and wellbeing of humans and animals...
  67. ncbi Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 148:3922-31. 2007
    ..The continuous presence of tight and adherens junctions in the uterine glands would allow for vectorial secretion of trophic substances required for conceptus elongation and survival...
  68. ncbi Progesterone and placentation increase secreted phosphoprotein one (SPP1 or osteopontin) in uterine glands and stroma for histotrophic and hematotrophic support of ovine pregnancy
    Kathrin A Dunlap
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 79:983-90. 2008
    ..Collectively, P(4) induces and the conceptus further stimulates SPP1 in uterine GE and stroma, where SPP1 likely influences histotrophic and hematotrophic support of conceptus development...
  69. ncbi Postnatal uterine development in Inverdale ewe lambs
    Kanako Hayashi
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Texas A and M University, 442 Kleberg Center, 2471 TAMU, College Station, Texas 77843 2471, USA
    Reproduction 135:357-65. 2008
    ....
  70. ncbi Implantation mechanisms: insights from the sheep
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics, Animal Science and Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
    Reproduction 128:657-68. 2004
    ....
  71. ncbi Galectin 15 (LGALS15) functions in trophectoderm migration and attachment
    Jennifer L Farmer
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, TX 77843 2471, USA
    FASEB J 22:548-60. 2008
    ..Collectively, these results support the hypothesis that LGALS15 stimulates trophectoderm cell migration and attachment via integrin binding and activation which are critical to blastocyst elongation and implantation...
  72. ncbi Progesterone regulation of the endometrial WNT system in the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 20:935-46. 2008
    ....
  73. ncbi Functional effects of transforming growth factor beta on adhesive properties of porcine trophectoderm
    Laurie A Jaeger
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Endocrinology 146:3933-42. 2005
    ..These results suggest multiple effects of TGFbeta at the porcine conceptus-maternal interface, including integrin-mediated conceptus-maternal communication through LAP...
  74. ncbi Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell Signaling pathways, and stimulates migration of ovine trophectoderm cells
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 149:3085-94. 2008
    ..Collectively, these results support the hypothesis that IGF-II coordinately activates multiple cell signaling pathways critical to survival, growth, and differentiation of the ovine conceptus during early pregnancy...
  75. ncbi Osteopontin: roles in implantation and placentation
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 69:1458-71. 2003
    ..OPN has the potential to profoundly impact pregnancy, and investigators are now challenged to focus on the mechanistic nature of the functions of this multifaceted and major component of the uterine-placental microenvironment...
  76. ncbi Dietary L-arginine supplementation enhances the reproductive performance of gilts
    Ronaldo D Mateo
    Texas Tech University, Lubbock, TX 79409, USA
    J Nutr 137:652-6. 2007
    ..032) and live litter birth weight of piglets by 24% (16.38 vs. 13.19 kg, P = 0.016). This exciting finding provides the first evidence for a marked increase of live-born piglets by 2 per litter through nutritional intervention in gilts...
  77. ncbi Developmental changes in nitric oxide synthesis in the ovine placenta
    Hyukjung Kwon
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 70:679-86. 2004
    ....
  78. ncbi Progesterone and placental hormone actions on the uterus: insights from domestic animals
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 71:2-10. 2004
    ..Strategic manipulation of these physiological mechanisms may offer therapeutic schemes to improve uterine capacity, conceptus survival, and reproductive health of domestic animals and humans...
  79. ncbi Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids
    Hyukjung Kwon
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 71:901-8. 2004
    ..The results have important implications for understanding the mechanisms responsible for both intrauterine growth retardation and developmental origins of adult disease...
  80. ncbi Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1
    M David Stewart
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 66:393-400. 2002
    ..Collectively, results indicate that IFNtau effect on IRF-1 expression is primarily regulated by tyrosine-phosphorylated Stat1alpha or Stat1beta dimers, whereas the decline of IRF-1 after 6 h of IFNtau treatment is regulated by IRF-9...
  81. ncbi Developmental changes of amino acids in ovine fetal fluids
    Hyukjung Kwon
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station 77843-2471, USA
    Biol Reprod 68:1813-20. 2003
    ..These novel findings of the unusual abundance of traditionally classified nonessential amino acids in allantoic fluid raise important questions regarding their roles in ovine conceptus development...
  82. ncbi Glutamine synthesis in the developing porcine placenta
    Jon T Self
    Department of Animal Science, Texas A and M University, College Station, Texas 77843-2471, USA
    Biol Reprod 70:1444-51. 2004
    ....
  83. ncbi A highly efficient method for porcine cloning by nuclear transfer using in vitro-matured oocytes
    Shawn C Walker
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843-4458, USA
    Cloning Stem Cells 4:105-12. 2002
    ..The method described here can be undertaken by a single micromanipulator at a reasonable cost, and should facilitate the broad utilization of porcine cloning technology in transgenic and nontransgenic applications...
  84. ncbi Maternal nutrition and fetal development
    Guoyao Wu
    Department of Animal Science, Texas A and M University, Health Science Center, College Station, TX 77843, USA
    J Nutr 134:2169-72. 2004
    ..Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults...

Research Grants7

  1. OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTOR
    Fuller Bazer; Fiscal Year: 2005
    ....
  2. Bridges to the Doctorate in Reproductive Biology
    Fuller Bazer; Fiscal Year: 2007
    ....