Research Topics
Genomes and Genes | Rola BarhoumiSummaryAffiliation: Texas A and M University Country: USA Publications
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Publications
Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cellsRola Barhoumi
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
Brain Res 1145:11-8. 2007..These data suggest that voltage operated Ca(2+) channels, mitochondrial Ca(2+) and K(+)-ATP channels may be targets of propofol action in astrocytes...- Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cellsRola Barhoumi
Depatrment of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
Toxicol Lett 165:133-41. 2006.... 
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell lineRola Barhoumi
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
Toxicol Appl Pharmacol 253:45-56. 2011..Therefore, the combination of the two-photon acquisition with the unmixing process should provide important insights into the cellular and molecular mechanisms by which BaP and other PAHs alter cellular homeostasis...- Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell linesRola Barhoumi
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
J Toxicol Sci 34:13-25. 2009..These results demonstrate the feasibility of analyzing BaP metabolism in situ by multiphoton spectral analysis and also identifying cell-type differences in BaP accumulation and metabolism... - Image analysis of Ca2+ signals as a basis for neurotoxicity assays: promises and challengesRola Barhoumi
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
Neurotoxicol Teratol 32:16-24. 2010..Each of the methods described and appropriately used results in reliable and reproducible measurements which may be applied in a high-throughput fashion to individualize in vitro assessment of cellular responses caused by toxicants... - Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytesSatya Sree N Kolar
Department of Nutrition and Food Science, Kleberg Biotechnology Center, MS 2253, Texas A and M University, College Station, TX 77843 2253, USA
Am J Physiol Gastrointest Liver Physiol 293:G935-43. 2007.... - Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulationSatya Sree N Kolar
Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2253, USA
Cancer Res 67:5561-8. 2007..Collectively, these data show that the combination of DHA and butyrate, compared with butyrate alone, further enhances apoptosis by additionally recruiting a Ca2+ -mediated intrinsic mitochondrial pathway... - Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growthIndira Jutooru
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
Exp Cell Res 316:2174-88. 2010.... - The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytesYeevoon Ng
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
Carcinogenesis 26:1914-21. 2005..These data indicate that DHA and butyrate potentiate mitochondrial lipid oxidation and the dissipation of MP which contribute to the induction of apoptosis... - Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell linesYongchang Qian
Department of Integrative Biosciences, Texas A and M University, College Station Center for Environmental and Rural Health, College Station, TX 77843 4458, USA
Toxicol Appl Pharmacol 219:162-71. 2007..This work further develops in vitro models that distinguish between compounds that cause OPIDN and those that induce acute neurotoxicity only. The study also exposes additional OP-induced toxicities that may be obscured in vivo... - 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancerKathy Vanderlaag
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
BMC Cancer 10:669. 2010..The main purpose of this study was to investigate the pathways of C-DIM-induced cell death... - MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cellsKyounghyun Kim
Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Veterinary Research Building 410, College Station, Texas 77843 4466, USA
J Mol Endocrinol 46:67-79. 2011.... 
Non-covalent delivery of proteins into mammalian cellsAurore Loudet
Department of Chemistry, Texas A and M University, Box 30012, College Station, TX 77841, USA
Org Biomol Chem 6:4516-22. 2008..At 37 degrees C, import into endocytic compartments dominates, but at 4 degrees C weak, diffuse fluorescence is observed in the cytosol, indicative of a favorable mode of action...- Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cellsShaheen Khan
Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, Texas 77843 4466, USA
Mol Endocrinol 20:2199-214. 2006..This represents a novel interaction between two ligand activated receptors where one receptor inhibits activation of the second receptor... - Energy transfer cassettes in silica nanoparticles target intracellular organellesJiney Jose
Department of Chemistry, Texas A and M University, College Station, TX 77842, USA
Org Biomol Chem 9:3871-7. 2011..Neither of these findings were anticipated given that silica nanoparticles of this type are generally considered to be non-porous... - Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cellsRola Barhoumi
Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
Toxicol Sci 68:444-50. 2002..This was confirmed by showing that inhibition of the K+ channel opening by tetraethylammonium chloride can reverse the effect of BaP on oxytocin-induced Ca2+ oscillations, and potentially decrease the toxicity of BaP... - n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formationWooki Kim
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
J Immunol 181:6236-43. 2008..These data imply that lipid rafts may be targets for the development of dietary agents for the treatment of autoimmune and chronic inflammatory diseases... - Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogensFei Wu
Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, United States
J Steroid Biochem Mol Biol 110:104-15. 2008.... - Interactive effects of fatty acid and butyrate-induced mitochondrial Ca²⁺ loading and apoptosis in colonocytesSatya Kolar
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas, USA
Cancer 117:5294-303. 2011.... - Determination of metal interactions with the chaperone Hspa5 in human astrocytoma cells and rat astrocyte primary culturesEvelyn Tiffany-Castiglioni
Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX, USA
Methods Mol Biol 758:29-48. 2011.... - Organelle-selective energy transfer: a fluorescent indicator of intracellular environmentAurore Loudet
Department of Chemistry, Texas A and M University, College Station, TX 77842 3012, USA
Bioorg Med Chem Lett 21:1849-51. 2011..This phenomenon may open new horizons in intracellular imaging... - Fluorescent cassettes for monitoring three-component interactions in vitro and in living cellsLiangxing Wu
Department of Chemistry, Texas A and M University, Box 30012, College Station, Texas 77841, USA
J Am Chem Soc 131:9156-7. 2009.... - Alteration of EGFR spatiotemporal dynamics suppresses signal transductionHarmony F Turk
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas, United States of America
PLoS ONE 7:e39682. 2012.... - Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calciumKuihuan Jian
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, 4458 TAMU, College Station, TX 77843 4458, USA
J Neurophysiol 102:1801-10. 2009..Mobilization of intracellular Ca2+ was required for somatostatin induced inhibition of photoreceptor L-VGCCs, suggesting that somatostatin plays an important role in the modulation of photoreceptor physiology... - n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activationTim Y Hou
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, USA
Biochem J 443:27-37. 2012..Collectively, these data demonstrate that n-3 PUFA, such as DHA, alter PtdIns(4,5)P2 in CD4+ T-cells, thereby suppressing the recruitment of WASP to the immunological synapse, and impairing actin remodelling in CD4+ T-cells... - Cationic polyfluorenes for intracellular delivery of proteinsAnyanee Kamkaew
Department of Chemistry, Texas A and M University, Box 30012, College Station, TX 77841, USA
Org Biomol Chem 9:6513-8. 2011..Once inside the cells, the quaternary amine system 1 released more of its cargo into regions outside the lysosomes. In one exploratory experiment, pyrenebutyrate was shown to accelerate import of a protein system by polymer 1... - Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIMKathy Vanderlaag
Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843-4466, USA
Cancer Lett 236:198-212. 2006.... - Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteinsJeongmin Seo
Department of Nutrition and Food Science, Chemistry, and Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843-2253, USA
FASEB J 20:770-2. 2006.... - Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compoundsMarjorie S Hong
Department of Chemical Engineering, Texas A and M University, College Station, TX 77845, USA
Toxicol Appl Pharmacol 186:110-8. 2003..The effects of OPs that cause or do not cause OPIDN were clearly distinguishable, not only by their effects on neurite length, but also by their effects on Ca(2+) homeostasis in differentiated SY5Y cells... - Intracellular imaging of organelles with new water-soluble benzophenoxazine dyesJiney Jose
Department of Chemistry, Texas A and M University, Box 30012, College Station, TX 77841, USA
Org Biomol Chem 8:2052-9. 2010..17-0.33 in pH 7.4 phosphate buffer, and at slightly shorter wavelengths and higher quantum yields in EtOH. Two dyes, 3 and 4 permeated into Clone 9 cells and selectively stained mitochondria and golgi, respectively... - Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaBRola Barhoumi
Department of Anatomy, Neuroscience Program, College of Veterinary Medicine, Texas A and M University, MS 4458 TAMU, College Station, TX 77843-4458, USA
Brain Res Mol Brain Res 122:167-79. 2004..These data indicate that Mn augments LPS-induced expression of NOS2 in C6 cells by increasing mitochondrial ROS and activation of NF-kappaB... - A comparison of two methods for fractionating complex mixtures in preparation for toxicity analysisLeslie Cizmas
Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843-4458, USA
J Toxicol Environ Health A 66:1351-70. 2003..The optimal fractionation method for a mixture of chlorophenols and PAHs may involve a refined hybrid method... - Salmonella enterica serovar Typhimurium-induced internalization and IL-8 expression in HeLa cells does not have a direct relationship with intracellular Ca(2+) levelsJosely F Figueiredo
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
Microbes Infect 11:850-8. 2009.... - A ratiometric pH reporter for imaging protein-dye conjugates in living cellsJunyan Han
Department of Chemistry, Texas A and M University, Box 30012, College Station, Texas 77841, USA
J Am Chem Soc 131:1642-3. 2009..The more acidic environment of the endosomes was conspicuous from the red fluorescence of the probe... - Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivoLan H Ly
Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
J Infect Dis 198:768-71. 2008..Furthermore, significant increases in interferon-gamma, transforming growth factor-beta, tumor necrosis factor-alpha, and interleukin-12p40 cytokine mRNA were seen in the pleural cells of the BCG-vaccinated guinea pigs... - Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transferKyounghyun Kim
Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Veterinary Research Building 409, College Station, Texas 77843 4466, USA
Mol Endocrinol 19:843-54. 2005..Results of the FRET assay are consistent with in vitro studies on ERalpha/Sp1 interactions and transactivation, and confirm that ERalpha and Sp1 interact in living breast cancer cells... - Rb localization and phosphorylation kinetics correlate with the cellular phenotype of cultured breast adenocarcinoma cellsJeannine Botos
Department of Veterinary Physiology, Texas A and M University, College Station 77843 4466, USA
In Vitro Cell Dev Biol Anim 38:235-41. 2002..We conclude that assessment of hypophosphorylated Rb may be more useful than assessment of total Rb for the evaluation of transformed breast adenocarcinoma phenotypes... - Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cellsKatrina L Mealey
Department of Veterinary Physiology and Pharmacology, Texas A and M University College of Veterinary Medicine, College Station, Texas 77843-4466, USA
Antimicrob Agents Chemother 46:755-61. 2002..Doxycycline, a drug that has been used for treatment of bacterial infections in cancer patients, can induce functional P-gp expression in cancer cells, resulting in multidrug resistance... - Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 productionYang-Yi Fan
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University Health Science Center, College Station, TX 77843-2471, USA
J Immunol 173:6151-60. 2004..Similar results were obtained when purified DHA was fed. These data demonstrate for the first time that dietary DHA alters T cell membrane microdomain composition and suppresses the PKCtheta; signaling axis... - Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and functionRobert S Chapkin
Department of Veterinary Anatomy and Public Health, Center for Environmental and Rural Health, Texas A and M University, College Station 77843 2471, USA
Lipids 37:193-9. 2002..026) were positively correlated with caspase 3 activity. These data provide evidence in vivo indicating that dietary EPA and DHA induce compositional changes in colonic mitochondrial membrane phospholipids that facilitate apoptosis... - Circulating antibodies directed against nitrosylated antigens in trypanosome-infected miceSanie Mnaimneh
Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
Exp Parasitol 105:241-7. 2003..Our results indicate the production of NO and its derivatives in trypanosomiasis. This production may potentially induce the synthesis of nitroso epitopes in vivo and favor the development of a humoral immune response...