Rola Barhoumi

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells
    Rola Barhoumi
    Depatrment of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Toxicol Lett 165:133-41. 2006
  2. pmc Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Toxicol Appl Pharmacol 253:45-56. 2011
  3. ncbi request reprint Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Brain Res 1145:11-8. 2007
  4. pmc Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    J Toxicol Sci 34:13-25. 2009
  5. pmc Image analysis of Ca2+ signals as a basis for neurotoxicity assays: promises and challenges
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Neurotoxicol Teratol 32:16-24. 2010
  6. ncbi request reprint The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes
    Yeevoon Ng
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 26:1914-21. 2005
  7. ncbi request reprint Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes
    Satya Sree N Kolar
    Department of Nutrition and Food Science, Kleberg Biotechnology Center, MS 2253, Texas A and M University, College Station, TX 77843 2253, USA
    Am J Physiol Gastrointest Liver Physiol 293:G935-43. 2007
  8. ncbi request reprint An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis
    Lisa M Sanders
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr 134:3233-8. 2004
  9. ncbi request reprint Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation
    Satya Sree N Kolar
    Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2253, USA
    Cancer Res 67:5561-8. 2007
  10. pmc 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    BMC Cancer 10:669. 2010

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells
    Rola Barhoumi
    Depatrment of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Toxicol Lett 165:133-41. 2006
    ....
  2. pmc Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Toxicol Appl Pharmacol 253:45-56. 2011
    ..Therefore, the combination of the two-photon acquisition with the unmixing process should provide important insights into the cellular and molecular mechanisms by which BaP and other PAHs alter cellular homeostasis...
  3. ncbi request reprint Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Brain Res 1145:11-8. 2007
    ..These data suggest that voltage operated Ca(2+) channels, mitochondrial Ca(2+) and K(+)-ATP channels may be targets of propofol action in astrocytes...
  4. pmc Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    J Toxicol Sci 34:13-25. 2009
    ..These results demonstrate the feasibility of analyzing BaP metabolism in situ by multiphoton spectral analysis and also identifying cell-type differences in BaP accumulation and metabolism...
  5. pmc Image analysis of Ca2+ signals as a basis for neurotoxicity assays: promises and challenges
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Neurotoxicol Teratol 32:16-24. 2010
    ..Each of the methods described and appropriately used results in reliable and reproducible measurements which may be applied in a high-throughput fashion to individualize in vitro assessment of cellular responses caused by toxicants...
  6. ncbi request reprint The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes
    Yeevoon Ng
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 26:1914-21. 2005
    ..These data indicate that DHA and butyrate potentiate mitochondrial lipid oxidation and the dissipation of MP which contribute to the induction of apoptosis...
  7. ncbi request reprint Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes
    Satya Sree N Kolar
    Department of Nutrition and Food Science, Kleberg Biotechnology Center, MS 2253, Texas A and M University, College Station, TX 77843 2253, USA
    Am J Physiol Gastrointest Liver Physiol 293:G935-43. 2007
    ....
  8. ncbi request reprint An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis
    Lisa M Sanders
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr 134:3233-8. 2004
    ..These results suggest that the enhancement of apoptosis associated with fish oil and pectin feeding may be due to a modulation of the redox environment that promotes ROS-mediated apoptosis...
  9. ncbi request reprint Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation
    Satya Sree N Kolar
    Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2253, USA
    Cancer Res 67:5561-8. 2007
    ..Collectively, these data show that the combination of DHA and butyrate, compared with butyrate alone, further enhances apoptosis by additionally recruiting a Ca2+ -mediated intrinsic mitochondrial pathway...
  10. pmc 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    BMC Cancer 10:669. 2010
    ..The main purpose of this study was to investigate the pathways of C-DIM-induced cell death...
  11. ncbi request reprint Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines
    Yongchang Qian
    Department of Integrative Biosciences, Texas A and M University, College Station Center for Environmental and Rural Health, College Station, TX 77843 4458, USA
    Toxicol Appl Pharmacol 219:162-71. 2007
    ..This work further develops in vitro models that distinguish between compounds that cause OPIDN and those that induce acute neurotoxicity only. The study also exposes additional OP-induced toxicities that may be obscured in vivo...
  12. pmc Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Exp Cell Res 316:2174-88. 2010
    ....
  13. ncbi request reprint Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes
    Mee Young Hong
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
    Carcinogenesis 23:1919-25. 2002
    ....
  14. doi request reprint Energy transfer cassettes in silica nanoparticles target intracellular organelles
    Jiney Jose
    Department of Chemistry, Texas A and M University, College Station, TX 77842, USA
    Org Biomol Chem 9:3871-7. 2011
    ..Neither of these findings were anticipated given that silica nanoparticles of this type are generally considered to be non-porous...
  15. pmc MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells
    Kyounghyun Kim
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Veterinary Research Building 410, College Station, Texas 77843 4466, USA
    J Mol Endocrinol 46:67-79. 2011
    ....
  16. doi request reprint Non-covalent delivery of proteins into mammalian cells
    Aurore Loudet
    Department of Chemistry, Texas A and M University, Box 30012, College Station, TX 77841, USA
    Org Biomol Chem 6:4516-22. 2008
    ..At 37 degrees C, import into endocytic compartments dominates, but at 4 degrees C weak, diffuse fluorescence is observed in the cytosol, indicative of a favorable mode of action...
  17. ncbi request reprint Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells
    Shaheen Khan
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, Texas 77843 4466, USA
    Mol Endocrinol 20:2199-214. 2006
    ..This represents a novel interaction between two ligand activated receptors where one receptor inhibits activation of the second receptor...
  18. ncbi request reprint Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility
    Lisa M Sanders
    Faculty of Nutrition, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
    Cancer Lett 208:155-61. 2004
    ..Thus the colon responds to oxidative stress less effectively than the small intestine, possibly contributing to increased cancer incidence at this site...
  19. ncbi request reprint Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells
    Rola Barhoumi
    Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843, USA
    Toxicol Sci 68:444-50. 2002
    ..This was confirmed by showing that inhibition of the K+ channel opening by tetraethylammonium chloride can reverse the effect of BaP on oxytocin-induced Ca2+ oscillations, and potentially decrease the toxicity of BaP...
  20. pmc n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formation
    Wooki Kim
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Immunol 181:6236-43. 2008
    ..These data imply that lipid rafts may be targets for the development of dietary agents for the treatment of autoimmune and chronic inflammatory diseases...
  21. pmc Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens
    Fei Wu
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, United States
    J Steroid Biochem Mol Biol 110:104-15. 2008
    ....
  22. pmc Interactive effects of fatty acid and butyrate-induced mitochondrial Ca²⁺ loading and apoptosis in colonocytes
    Satya Kolar
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas, USA
    Cancer 117:5294-303. 2011
    ....
  23. doi request reprint Determination of metal interactions with the chaperone Hspa5 in human astrocytoma cells and rat astrocyte primary cultures
    Evelyn Tiffany-Castiglioni
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX, USA
    Methods Mol Biol 758:29-48. 2011
    ....
  24. pmc Organelle-selective energy transfer: a fluorescent indicator of intracellular environment
    Aurore Loudet
    Department of Chemistry, Texas A and M University, College Station, TX 77842 3012, USA
    Bioorg Med Chem Lett 21:1849-51. 2011
    ..This phenomenon may open new horizons in intracellular imaging...
  25. pmc Fluorescent cassettes for monitoring three-component interactions in vitro and in living cells
    Liangxing Wu
    Department of Chemistry, Texas A and M University, Box 30012, College Station, Texas 77841, USA
    J Am Chem Soc 131:9156-7. 2009
    ....
  26. ncbi request reprint Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB
    Rola Barhoumi
    Department of Anatomy, Neuroscience Program, College of Veterinary Medicine, Texas A and M University, MS 4458 TAMU, College Station, TX 77843 4458, USA
    Brain Res Mol Brain Res 122:167-79. 2004
    ..These data indicate that Mn augments LPS-induced expression of NOS2 in C6 cells by increasing mitochondrial ROS and activation of NF-kappaB...
  27. pmc Alteration of EGFR spatiotemporal dynamics suppresses signal transduction
    Harmony F Turk
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e39682. 2012
    ....
  28. pmc Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium
    Kuihuan Jian
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, 4458 TAMU, College Station, TX 77843 4458, USA
    J Neurophysiol 102:1801-10. 2009
    ..Mobilization of intracellular Ca2+ was required for somatostatin induced inhibition of photoreceptor L-VGCCs, suggesting that somatostatin plays an important role in the modulation of photoreceptor physiology...
  29. pmc n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation
    Tim Y Hou
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, USA
    Biochem J 443:27-37. 2012
    ..Collectively, these data demonstrate that n-3 PUFA, such as DHA, alter PtdIns(4,5)P2 in CD4+ T-cells, thereby suppressing the recruitment of WASP to the immunological synapse, and impairing actin remodelling in CD4+ T-cells...
  30. ncbi request reprint Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843 4466, USA
    Cancer Lett 236:198-212. 2006
    ....
  31. pmc Cationic polyfluorenes for intracellular delivery of proteins
    Anyanee Kamkaew
    Department of Chemistry, Texas A and M University, Box 30012, College Station, TX 77841, USA
    Org Biomol Chem 9:6513-8. 2011
    ..Once inside the cells, the quaternary amine system 1 released more of its cargo into regions outside the lysosomes. In one exploratory experiment, pyrenebutyrate was shown to accelerate import of a protein system by polymer 1...
  32. ncbi request reprint Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins
    Jeongmin Seo
    Department of Nutrition and Food Science, Chemistry, and Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2253, USA
    FASEB J 20:770-2. 2006
    ....
  33. ncbi request reprint Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds
    Marjorie S Hong
    Department of Chemical Engineering, Texas A and M University, College Station, TX 77845, USA
    Toxicol Appl Pharmacol 186:110-8. 2003
    ..The effects of OPs that cause or do not cause OPIDN were clearly distinguishable, not only by their effects on neurite length, but also by their effects on Ca(2+) homeostasis in differentiated SY5Y cells...
  34. ncbi request reprint Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production
    Yang Yi Fan
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University Health Science Center, College Station, TX 77843 2471, USA
    J Immunol 173:6151-60. 2004
    ..Similar results were obtained when purified DHA was fed. These data demonstrate for the first time that dietary DHA alters T cell membrane microdomain composition and suppresses the PKCtheta; signaling axis...
  35. doi request reprint Intracellular imaging of organelles with new water-soluble benzophenoxazine dyes
    Jiney Jose
    Department of Chemistry, Texas A and M University, Box 30012, College Station, TX 77841, USA
    Org Biomol Chem 8:2052-9. 2010
    ..17-0.33 in pH 7.4 phosphate buffer, and at slightly shorter wavelengths and higher quantum yields in EtOH. Two dyes, 3 and 4 permeated into Clone 9 cells and selectively stained mitochondria and golgi, respectively...
  36. pmc Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells
    Rola Barhoumi
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 9:e90908. 2014
    ..In summary, DHA is a highly bioactive chemo-protective agent capable of modulating BaP-induced DNA adducts...
  37. ncbi request reprint Rb localization and phosphorylation kinetics correlate with the cellular phenotype of cultured breast adenocarcinoma cells
    Jeannine Botos
    Department of Veterinary Physiology, Texas A and M University, College Station 77843 4466, USA
    In Vitro Cell Dev Biol Anim 38:235-41. 2002
    ..We conclude that assessment of hypophosphorylated Rb may be more useful than assessment of total Rb for the evaluation of transformed breast adenocarcinoma phenotypes...
  38. ncbi request reprint Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivo
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
    J Infect Dis 198:768-71. 2008
    ..Furthermore, significant increases in interferon-gamma, transforming growth factor-beta, tumor necrosis factor-alpha, and interleukin-12p40 cytokine mRNA were seen in the pleural cells of the BCG-vaccinated guinea pigs...
  39. ncbi request reprint A comparison of two methods for fractionating complex mixtures in preparation for toxicity analysis
    Leslie Cizmas
    Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, Texas 77843 4458, USA
    J Toxicol Environ Health A 66:1351-70. 2003
    ..The optimal fractionation method for a mixture of chlorophenols and PAHs may involve a refined hybrid method...
  40. ncbi request reprint Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer
    Kyounghyun Kim
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Veterinary Research Building 409, College Station, Texas 77843 4466, USA
    Mol Endocrinol 19:843-54. 2005
    ..Results of the FRET assay are consistent with in vitro studies on ERalpha/Sp1 interactions and transactivation, and confirm that ERalpha and Sp1 interact in living breast cancer cells...
  41. pmc A ratiometric pH reporter for imaging protein-dye conjugates in living cells
    Junyan Han
    Department of Chemistry, Texas A and M University, Box 30012, College Station, Texas 77841, USA
    J Am Chem Soc 131:1642-3. 2009
    ..The more acidic environment of the endosomes was conspicuous from the red fluorescence of the probe...
  42. pmc Salmonella enterica serovar Typhimurium-induced internalization and IL-8 expression in HeLa cells does not have a direct relationship with intracellular Ca(2+) levels
    Josely F Figueiredo
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Microbes Infect 11:850-8. 2009
    ....
  43. pmc Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells
    Katrina L Mealey
    Department of Veterinary Physiology and Pharmacology, Texas A and M University College of Veterinary Medicine, College Station, Texas 77843 4466, USA
    Antimicrob Agents Chemother 46:755-61. 2002
    ..Doxycycline, a drug that has been used for treatment of bacterial infections in cancer patients, can induce functional P-gp expression in cancer cells, resulting in multidrug resistance...
  44. ncbi request reprint Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function
    Robert S Chapkin
    Department of Veterinary Anatomy and Public Health, Center for Environmental and Rural Health, Texas A and M University, College Station 77843 2471, USA
    Lipids 37:193-9. 2002
    ..026) were positively correlated with caspase 3 activity. These data provide evidence in vivo indicating that dietary EPA and DHA induce compositional changes in colonic mitochondrial membrane phospholipids that facilitate apoptosis...
  45. pmc Confocal fluorescence microscopy studies of a fluorophore-labeled dirhodium compound: visualizing metal-metal bonded molecules in lung cancer (A549) cells
    Bruno Peña
    Department of Chemistry, Texas A and M University, College Station, Texas 77842, United States
    J Am Chem Soc 136:7861-4. 2014
    ..This is the first study of a fluorophore-labeled metal-metal bonded compound, work that opens up new venues for the study of intracellular distribution of dinuclear transition metal anticancer complexes. ..
  46. doi request reprint Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics
    Sankar P Chaki
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    J Cell Sci 126:1637-49. 2013
    ..Thus, this study identifies Nck as a key coordinator of cytoskeletal changes that enable cell polarization and directional migration, which are crucial processes in development and disease...
  47. ncbi request reprint Circulating antibodies directed against nitrosylated antigens in trypanosome-infected mice
    Sanie Mnaimneh
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Exp Parasitol 105:241-7. 2003
    ..Our results indicate the production of NO and its derivatives in trypanosomiasis. This production may potentially induce the synthesis of nitroso epitopes in vivo and favor the development of a humoral immune response...