Antonio Baldini

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
  2. ncbi Dissecting contiguous gene defects: TBX1
    Antonio Baldini
    Center for Cardiovascular Development, Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Genet Dev 15:279-84. 2005
  3. ncbi Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development
    Zhen Zhang
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:5307-15. 2005
  4. ncbi DiGeorge syndrome: the use of model organisms to dissect complex genetics
    Antonio Baldini
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 11:2363-9. 2002
  5. ncbi The 22q11.2 deletion syndrome: a gene dosage perspective
    Antonio Baldini
    Department of Pediatrics Cardiology and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    ScientificWorldJournal 6:1881-7. 2006
  6. ncbi DiGeorge syndrome: an update
    Antonio Baldini
    Division of Cardiology, Department of Pediatrics, and Center for Cardiovascular Development, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Cardiol 19:201-4. 2004
  7. pmc Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development
    Zhen Zhang
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 133:3587-95. 2006
  8. pmc Canonical Wnt signaling functions in second heart field to promote right ventricular growth
    Di Ai
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:9319-24. 2007
  9. pmc Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21
    Huojun Cao
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
    Dev Biol 347:289-300. 2010
  10. pmc Tbx1 regulates proliferation and differentiation of multipotent heart progenitors
    Li Chen
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, TX, USA
    Circ Res 105:842-51. 2009

Collaborators

Detail Information

Publications37

  1. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
    ..Furthermore, our data link, for the first time, the function of the secondary heart field to congenital heart disease...
  2. ncbi Dissecting contiguous gene defects: TBX1
    Antonio Baldini
    Center for Cardiovascular Development, Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Genet Dev 15:279-84. 2005
    ..Tbx1 is an excellent tool to probe the genetic network governing embryonic pharyngeal development...
  3. ncbi Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development
    Zhen Zhang
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:5307-15. 2005
    ..We also thereby demonstrate conclusively that the role of Tbx1 in fourth PAA development is cell non-autonomous...
  4. ncbi DiGeorge syndrome: the use of model organisms to dissect complex genetics
    Antonio Baldini
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 11:2363-9. 2002
    ..Consistent with clinical data, experiments in mice indicate that genetics can only explain part of the phenotypic variability. The recent identification of phenotypic modifiers further underscores the complex genetics of this syndrome...
  5. ncbi The 22q11.2 deletion syndrome: a gene dosage perspective
    Antonio Baldini
    Department of Pediatrics Cardiology and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    ScientificWorldJournal 6:1881-7. 2006
    ..These experiments have revealed substantially different sensitivity to gene dosage in different tissues and at different times, underlying the importance of the developmental context within which gene dosage reduction occurs...
  6. ncbi DiGeorge syndrome: an update
    Antonio Baldini
    Division of Cardiology, Department of Pediatrics, and Center for Cardiovascular Development, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Cardiol 19:201-4. 2004
    ..This article is an update on DiGeorge syndrome research focusing on the synergy of human and model systems genetics toward the understanding of conotruncal and aortic arch defects...
  7. pmc Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development
    Zhen Zhang
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 133:3587-95. 2006
    ..Thus, the mesodermal transcription program is not only crucial for cardiovascular development, but is also key in the development and patterning of pharyngeal endoderm...
  8. pmc Canonical Wnt signaling functions in second heart field to promote right ventricular growth
    Di Ai
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:9319-24. 2007
    ..Our findings reveal that Wnt signaling plays a major positive role in promoting growth and diversification of SHF precursors into right ventricular and interventricular myocardium...
  9. pmc Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21
    Huojun Cao
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
    Dev Biol 347:289-300. 2010
    ..These data demonstrate new functional mechanisms for Tbx1 in tooth morphogenesis and provide a molecular basis for craniofacial defects in DiGeorge syndrome patients...
  10. pmc Tbx1 regulates proliferation and differentiation of multipotent heart progenitors
    Li Chen
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, TX, USA
    Circ Res 105:842-51. 2009
    ..Loss of Tbx1 results into hypoplasia of heart regions derived from the second heart field, a population of cardiac progenitors cells (CPCs). Thus, we hypothesized that Tbx1 is an important player in the biology of CPCs...
  11. ncbi In vivo response to high-resolution variation of Tbx1 mRNA dosage
    Zhen Zhang
    Institute of Biosciences and Technology, Texas A and M University Health Sciences Center, Houston, TX 77030, USA
    Hum Mol Genet 17:150-7. 2008
    ..Overall, our data suggest that there are developmental process-specific gene dosage thresholds beyond which the phenotype worsens very rapidly with very small mRNA level reductions...
  12. pmc Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants
    Francesca Vitelli
    Department of Pediatrics, Cardiology, Baylor College of Medicine, 1102 Bates St, RM FC450 03, Houston, TX 77030, USA
    Dev Biol 295:559-70. 2006
    ....
  13. pmc In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea
    Huansheng Xu
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
    Dev Biol 310:329-40. 2007
    ..This model provides a striking demonstration of the essential role played by the periotic mesenchyme in the organogenesis of the cochlea...
  14. ncbi Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:4387-95. 2005
    ..A genetic-based blueprint of crucial developmental times for organs and systems should be a valuable asset for our understanding of birth defect pathogenesis...
  15. ncbi Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract
    Joshua W Vincentz
    Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas Houston, Health Sciences Center and M D Anderson Cancer Center, Houston, Texas, USA
    Genesis 41:192-201. 2005
    ..In addition, Fgf15 and Tbx1 do not interact genetically, suggesting that Fgf15 operates through a pathway independent of Tbx1. These studies reveal a novel role of Fgf15 during development of the cardiac outflow tract...
  16. pmc Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
    Li Chen
    Program of Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 189:417-24. 2010
    ..Our findings reveal a novel pathway for the development of the lymphatic vessel network...
  17. ncbi Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle
    Feiyan Dong
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Development 133:4891-9. 2006
    ..Conditional inactivation in mice and manipulation of Pitx2 expression in chick mandible cultures revealed an autonomous function in expansion and survival of branchial arch mesoderm...
  18. pmc Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a
    Li Chen
    Texas Heart Institute, Houston, Texas, USA
    PLoS Genet 8:e1002571. 2012
    ..We speculate that this may be a general mechanism of T-box function and that Baf60a is a key component of the transcriptional control in cardiac progenitors...
  19. ncbi A genetic link between Tbx1 and fibroblast growth factor signaling
    Francesca Vitelli
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston TX 77030, USA
    Development 129:4605-11. 2002
    ..We speculate that the FGF8 locus might affect the penetrance of cardiovascular defects in individuals with chromosome 22q11 deletions involving TBX1...
  20. ncbi Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis
    Masae Morishima
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 228:95-104. 2003
    ..The latter function is likely related to the known role of the Endothelin-1 pathway in neural crest function...
  21. ncbi A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field
    Tuong Huynh
    Institute of Biosciences and Technology, Texas A and M University Health Sciences Center, Houston, Texas 77030, USA
    Genesis 45:470-5. 2007
    ..Finally, we show that Tbx1(Cre)-positive and Tbx1(Cre)-negative cell descendants occupy discrete domains in the outflow tract throughout development...
  22. ncbi TBX1 is required for inner ear morphogenesis
    Francesca Vitelli
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 12:2041-8. 2003
    ..Our data suggest that Tbx1 deletion in del22q11 patients may cause not only external and middle ear defects but also sensorineural and vestibular phenotypes observed in these patients...
  23. pmc Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8
    Francesca Vitelli
    Institute of Biosciences and Technologies, Texas A and M University, Houston, TX, USA
    J Mol Cell Cardiol 49:836-40. 2010
    ..Our data suggest a coordinated pathway modulating Fgf8 ligand expression and tissue response to it in the SHF...
  24. doi Manipulation of endogenous regulatory elements and transgenic analyses of the Tbx1 gene
    Zhen Zhang
    Institute of Biosciences and Technologies, Texas A and M University, Houston, TX 77843, USA
    Mamm Genome 21:556-64. 2010
    ..Overall, our data suggest a regulatory architecture of the Tbx1 gene made of tissue-specific modules and redundant elements that individually contribute, to a modest extent, to the expression of the gene...
  25. pmc A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice
    Y Eugene Yu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 173:297-307. 2006
    ..Therefore, we have identified a new dosage-sensitive genomic region that may be critical for normal heart development in both mice and humans...
  26. ncbi Generating and modifying DiGeorge syndrome-like phenotypes in model organisms: is there a common genetic pathway?
    Francesca Vitelli
    Department of Pediatrics Cardiology, Baylor College of Medicine, Feigin Center, 6621 Fannin Street, FC430 09, Houston, TX 77030, USA
    Trends Genet 19:588-93. 2003
  27. pmc Genetic pathways to mammalian heart development: Recent progress from manipulation of the mouse genome
    Huansheng Xu
    Institute of Biosciences and Technology, Texas A and M University System, Houston, TX 77030, United States
    Semin Cell Dev Biol 18:77-83. 2007
    ..The medical significance of these studies is not only relevant to congenital heart disease, but also to the biology of cardiac cell regeneration...
  28. pmc A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
    Min Xie
    Center for Cardiovascular Development, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17378-83. 2006
    ..Thus, by disrupting the endogenous TAK1 locus, we prove a pivotal role for TAK1 in the LKB1/AMPK signaling axis, an essential governor of cell metabolism...
  29. ncbi DiGeorge's syndrome: a gene at last
    Antonio Baldini
    Department of Pediatric Cardiology, and Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Lancet 362:1342-3. 2003
  30. ncbi Peroxisome proliferator-activated receptor-delta upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-beta
    Luca Brunelli
    Department of Pediatrics, The University of Texas at Houston Medical School, Houston, TX 77030 1503, USA
    Circ Res 100:e59-71. 2007
    ....
  31. ncbi Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways
    Francesca Vitelli
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 11:915-22. 2002
    ..We hypothesize that this is due to the lack of a guidance role from the pouch endoderm, which is missing in these mutants...
  32. ncbi Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome
    Katrina Prescott
    Molecular Medicine Unit, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
    Hum Genet 116:486-96. 2005
    ..However Crkl, another gene implicated in the 22q11DS phenotype, was found to be downregulated by microarray and RTQPCR...
  33. ncbi Fate map of serotonin transporter-expressing cells in developing mouse heart
    Luigi Michele Pavone
    Department of Biological Structures, Functions, and Technologies, University of Naples Federico II, Naples, Italy
    Genesis 45:689-95. 2007
    ..Overall, our data reveal specific and regionally restricted distribution of SERT-expressing cells in the developing heart of mouse...
  34. ncbi Tbx1 regulation of myogenic differentiation in the limb and cranial mesoderm
    Akbar Dastjerdi
    Department of Craniofacial Development, King s College London, Guy s Tower, London Bridge, United Kingdom
    Dev Dyn 236:353-63. 2007
    ..Finally, analysis of the Tbx1-mesoderm-specific knockout mouse demonstrated the cell autonomous requirement for Tbx1 during myocyte development in the cranial mesoderm...
  35. pmc Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells
    Huansheng Xu
    Institute of Biosciences and Technologies, Texas A and M University System, 2121 W Holcombe, Room 820C, TX, USA
    Dev Biol 302:670-82. 2007
    ..We conclude that the main functions of Tbx1 in the inner ear are to control, cell-autonomously, contribution, size and fate of a large population of otic epithelial cells, and, cell non-autonomously, cochlear morphogenesis...
  36. ncbi Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1
    Sarah Ivins
    Molecular Medicine Unit, Institute of Child Health, London WC1N 1EH, UK
    Dev Biol 285:554-69. 2005
    ..These experiments highlight which genes and pathways potentially affected by lack of Tbx1, and whose role may be explored further by testing for epistasis using mouse mutants...
  37. ncbi Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick
    Catherine Roberts
    Molecular Medicine Unit, Institute of Child Health, London, UK
    Hum Mol Genet 15:3394-410. 2006
    ....