Ashok Balasubramanyam

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial
    Melissa C Smart-Halajko
    Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and UCL Medical School, London, UK
    BMC Med Genet 12:89. 2011
  2. pmc Syndromes of ketosis-prone diabetes mellitus
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Room 700B, One Baylor Plaza, and Endocrine Service, Ben Taub General Hospital, Houston, Texas 77030, USA
    Endocr Rev 29:292-302. 2008
  3. ncbi request reprint Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, BCM 700B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 292:E40-8. 2007
  4. ncbi request reprint New profiles of diabetic ketoacidosis: type 1 vs type 2 diabetes and the effect of ethnicity
    A Balasubramanyam
    Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Arch Intern Med 159:2317-22. 1999
  5. ncbi request reprint Developmental changes in expression of myotonic dystrophy protein kinase in the rat central nervous system
    A Balasubramanyam
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Comp Neurol 394:309-25. 1998
  6. doi request reprint Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: a stable isotope study
    Rajagopal V Sekhar
    Translational Metabolism Unit, Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Metabolism 60:754-60. 2011
  7. ncbi request reprint Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome
    Susana D'Amico
    Translational Metabolism Unit and the Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Am J Clin Nutr 84:204-11. 2006
  8. pmc Pathogenesis of A⁻β⁺ ketosis-prone diabetes
    Sanjeet G Patel
    Translational Metabolism Unit, Diabetes Endocrinology Research Center, Baylor College of Medicine, Houston, Texas, USA
    Diabetes 62:912-22. 2013
  9. doi request reprint HLA class II alleles specify phenotypes of ketosis-prone diabetes
    Ramaswami Nalini
    Translational Metabolism Unit, Division of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA
    Diabetes Care 31:1195-200. 2008
  10. doi request reprint Impaired lipoprotein processing in HIV patients on antiretroviral therapy: aberrant high-density lipoprotein lipids, stability, and function
    Baiba K Gillard
    Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, Houston, TX, USA
    Arterioscler Thromb Vasc Biol 33:1714-21. 2013

Research Grants

  1. Viral mechanisms of adipocyte dysfuntion: Role of Vpr.
    Ashok Balasubramanyam; Fiscal Year: 2009
  2. Viral mechanisms of adipocyte dysfuntion: Role of Vpr.
    Ashok Balasubramanyam; Fiscal Year: 2010
  3. Diet/Exercise, Niacin, Fenofibrate for HIV Lipodystrophy
    Ashok Balasubramanyam; Fiscal Year: 2007
  4. Diet/Exercise, Niacin, Fenofibrate for HIV Lipodystrophy
    Ashok Balasubramanyam; Fiscal Year: 2007
  5. MOLECULAR BASIS OF HIV LIPODYSTROPHY: ROLE OF VPR
    Ashok Balasubramanyam; Fiscal Year: 2003

Collaborators

Detail Information

Publications58

  1. pmc ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial
    Melissa C Smart-Halajko
    Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and UCL Medical School, London, UK
    BMC Med Genet 12:89. 2011
    ....
  2. pmc Syndromes of ketosis-prone diabetes mellitus
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Room 700B, One Baylor Plaza, and Endocrine Service, Ben Taub General Hospital, Houston, Texas 77030, USA
    Endocr Rev 29:292-302. 2008
    ....
  3. ncbi request reprint Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, BCM 700B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 292:E40-8. 2007
    ....
  4. ncbi request reprint New profiles of diabetic ketoacidosis: type 1 vs type 2 diabetes and the effect of ethnicity
    A Balasubramanyam
    Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Arch Intern Med 159:2317-22. 1999
    ..We determined the "diabetic types," ethnic distributions, and phenotypes of patients with DKA in an urban hospital...
  5. ncbi request reprint Developmental changes in expression of myotonic dystrophy protein kinase in the rat central nervous system
    A Balasubramanyam
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Comp Neurol 394:309-25. 1998
    ..The adult localizations suggest that DMPK may function in membrane trafficking and secretion within neurons associated with cognition, memory, and motor control...
  6. doi request reprint Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: a stable isotope study
    Rajagopal V Sekhar
    Translational Metabolism Unit, Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Metabolism 60:754-60. 2011
    ..Combining rosiglitazone with agents designed to blunt lipolysis could expand depleted peripheral adipose depots in patients with HIV lipodystrophy...
  7. ncbi request reprint Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome
    Susana D'Amico
    Translational Metabolism Unit and the Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Am J Clin Nutr 84:204-11. 2006
    ..The effect of growth hormone (GH) replacement on these lipid kinetic abnormalities is unknown...
  8. pmc Pathogenesis of A⁻β⁺ ketosis-prone diabetes
    Sanjeet G Patel
    Translational Metabolism Unit, Diabetes Endocrinology Research Center, Baylor College of Medicine, Houston, Texas, USA
    Diabetes 62:912-22. 2013
    ..They highlight a novel process of defective energy production and ketosis in A⁻β⁺ KPD...
  9. doi request reprint HLA class II alleles specify phenotypes of ketosis-prone diabetes
    Ramaswami Nalini
    Translational Metabolism Unit, Division of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA
    Diabetes Care 31:1195-200. 2008
    ..Genetic factors could contribute to their distinctive phenotypes. Our aim was to specify the role of HLA class II alleles associated with susceptibility or resistance to autoimmune type 1 diabetes in determining KPD phenotypes...
  10. doi request reprint Impaired lipoprotein processing in HIV patients on antiretroviral therapy: aberrant high-density lipoprotein lipids, stability, and function
    Baiba K Gillard
    Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, Houston, TX, USA
    Arterioscler Thromb Vasc Biol 33:1714-21. 2013
    ..We tested the hypothesis that HIV/ART HDL have abnormal structures and properties and are dysfunctional...
  11. ncbi request reprint Severely dysregulated disposal of postprandial triacylglycerols exacerbates hypertriacylglycerolemia in HIV lipodystrophy syndrome
    Rajagopal V Sekhar
    Translation Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Am J Clin Nutr 81:1405-10. 2005
    ..One mechanism is accelerated lipolysis in the fasted state, but the severity of the hypertriacylglycerolemia suggests that additional underlying abnormalities may exist in the disposal of dietary fat...
  12. ncbi request reprint Association of amino-terminal-specific antiglutamate decarboxylase (GAD65) autoantibodies with beta-cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis-prone diabetes mellitus
    Christiane S Hampe
    Robert H Williams Laboratory, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 92:462-7. 2007
    ..The A+B- KPDM subgroup comprises patients with classic, autoimmune type 1 diabetes, whereas the A+B+ KPDM subgroup has only partial beta-cell loss and a distinct clinical phenotype...
  13. pmc A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome
    Wade C Haaland
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA
    Diabetes Care 32:873-7. 2009
    ....
  14. pmc Altered relationship of plasma triglycerides to HDL cholesterol in patients with HIV/HAART-associated dyslipidemia: further evidence for a unique form of metabolic syndrome in HIV patients
    Catherine N Vu
    Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Houston, TX, USA
    Metabolism 62:1014-20. 2013
    ..We investigated the relationship of TG to HDL-C in highly-active antiretroviral drug (HAART)-treated HIV patients...
  15. pmc Presence or absence of a known diabetic ketoacidosis precipitant defines distinct syndromes of "A-β+" ketosis-prone diabetes based on long-term β-cell function, human leukocyte antigen class II alleles, and sex predilection
    Ramaswami Nalini
    Translational Metabolism Unit, Baylor College of Medicine, Houston, TX 77030, USA
    Metabolism 59:1448-55. 2010
    ..Unprovoked DKA predicts long-term β-cell functional reserve, insulin independence, and glycemic control in KPD...
  16. ncbi request reprint Characteristics of ketosis-prone diabetes in a multiethnic indigent community
    Mario R Maldonado
    Division of Endocrinology, Department of Medicine, Baylor College of Medicine Houston, Texas 77030, USA
    Ethn Dis 14:243-9. 2004
    ..To compare demographic and clinical characteristics among 3 ethnic groups of indigent patients exhibiting diabetic ketoacidosis (DKA), in Houston, Texas...
  17. ncbi request reprint Re: A comparison of classification schemes for ketosis-prone diabetes
    Ramaswami Nalini
    Division of Diabetes, Endocrinology and Metabolism, N520 Alkek, One Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Clin Pract Endocrinol Metab 3:E1. 2007
  18. doi request reprint Characteristics of patients with ketosis-prone diabetes (KPD) presenting with acute pancreatitis: implications for the natural history and etiology of a KPD subgroup
    Ramiro Fernandez
    Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Endocr Pract 19:243-51. 2013
    ..This longitudinal study characterized ketosis-prone diabetes (KPD) in patients presenting with concomitant AP and DKA...
  19. pmc Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of "heart positive," a randomized, controlled trial
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 96:2236-47. 2011
    ..HIV patients on antiretroviral therapy (ART) have a unique dyslipidemia [elevated triglycerides and non-high-density lipoprotein-cholesterol (HDL-C), low HDL-C] with insulin resistance (characterized by hypoadiponectinemia)...
  20. ncbi request reprint Accuracy and predictive value of classification schemes for ketosis-prone diabetes
    Ashok Balasubramanyam
    Translational Metabolism Unit, Baylor College of Medicine, One Baylor Plaza, Room 520 N, Houston, TX 77030, USA
    Diabetes Care 29:2575-9. 2006
    ....
  21. ncbi request reprint Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes
    Mario Maldonado
    Division of Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 88:5090-8. 2003
    ..Novel, nonautoimmune causes of beta-cell dysfunction are likely to underlie the A-beta+ and A-beta- syndromes...
  22. pmc Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation
    Rajagopal V Sekhar
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA
    Am J Clin Nutr 94:847-53. 2011
    ..Aging is associated with oxidative stress, but underlying mechanisms remain poorly understood...
  23. ncbi request reprint Heart positive: design of a randomized controlled clinical trial of intensive lifestyle intervention, niacin and fenofibrate for HIV lipodystrophy/dyslipidemia
    Susan L Samson
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030, United States
    Contemp Clin Trials 27:518-30. 2006
    ....
  24. doi request reprint Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes
    Maria J Redondo
    Department of Pediatrics, Section of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Diabetes 13:564-71. 2012
    ..To examine the relationship between BMI and beta-cell function at diagnosis of autoimmune type 1 diabetes (T1D) in a large group of ethnically diverse children...
  25. doi request reprint Human monocytes accelerate proliferation and blunt differentiation of preadipocytes in association with suppression of C/EBPΑ mRNA
    Jacob Couturier
    Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Texas, USA
    Obesity (Silver Spring) 20:253-62. 2012
    ..Additionally, the levels of both IL-6 and CXCL1 were highest when preadipocytes and monocytes were cultured together, compared to each cell in culture alone. Such cross-talk amplifies the production of mediators of tissue inflammation...
  26. ncbi request reprint Presence of the metabolic syndrome distinguishes patients with ketosis-prone diabetes who have a Type 2 diabetic phenotype
    Max E Otiniano
    Division of Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    J Diabetes Complications 19:313-8. 2005
    ..This study was designed to determine if patients with ketosis-prone diabetes could be distinguished clinically on the basis of features of the metabolic syndrome (MetS)...
  27. doi request reprint HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation
    Neeti Agarwal
    Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Sci Transl Med 5:213ra164. 2013
    ..Confirmation of these mechanisms in HIV patients could lead to targeted treatment of the metabolic complications with Vpr inhibitors, GR antagonists, or PPARγ/PPARα agonists. ..
  28. doi request reprint Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndrome
    Rajagopal V Sekhar
    Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Diabetes and Endocrinology Research Center, USA
    Metabolism 61:1395-403. 2012
    ..Metreleptin does, however, improve glycemia and non-HDL-C in these patients. These results suggest a dissociation between leptin's effects on glucose metabolism compared to those on lipid kinetics in HADL...
  29. pmc Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and management
    Absalon D Gutierrez
    Translational Metabolism Unit, Diabetes and Endocrinology Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, ABBR 607, One Baylor Plaza, Houston, TX 77030, USA
    Endocrine 41:1-10. 2012
    ..In this review, we have focused specifically on a comprehensive assessment of dysglycemia in the context of HIV infection and HAART...
  30. ncbi request reprint Lipid lowering effects of statins and fibrates in the management of HIV dyslipidemias associated with antiretroviral therapy in HIV clinical practice
    Fehmida Visnegarwala
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX 77009, USA
    J Infect 49:283-90. 2004
    ....
  31. ncbi request reprint Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'
    Ashok Balasubramanyam
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Lipidol 15:59-67. 2004
    ..Identification of rationally based therapies requires an understanding of the mechanistic basis of HADL...
  32. pmc Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs
    Dinakar Iyer
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:4516-21. 2006
    ..Hence, the phosphorylation status of serine-162 in the alphaI coil may constitute a novel switch that directs target gene expression into proliferation or differentiation programs...
  33. ncbi request reprint Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability
    Abu R Vasudevan
    Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA
    Diabetes Technol Ther 6:850-63. 2004
    ....
  34. ncbi request reprint HIV-associated lipodystrophy syndrome: an accelerated form of the metabolic syndrome of insulin resistance due to altered fat distribution
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, USA
    Res Initiat Treat Action 12:5-11. 2006
  35. doi request reprint Types of pediatric diabetes mellitus defined by anti-islet autoimmunity and random C-peptide at diagnosis
    Maria J Redondo
    Department of Pediatrics, Section of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Diabetes 14:333-40. 2013
    ..To test the hypothesis that anti-islet autoantibody expression and random serum C-peptide obtained at diagnosis define phenotypes of pediatric diabetes with distinct clinical features...
  36. ncbi request reprint Short- and long-term effects of growth hormone (GH) replacement on protein metabolism in GH-deficient adults
    Jianjian Shi
    Department of Medicine, Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 88:5827-33. 2003
    ..05). GH replacement in GHD acutely improves protein balance by stimulating synthesis and inhibiting catabolism. After 6 months, protein kinetics reached a new homeostasis to maintain the net gain in FFM...
  37. ncbi request reprint Regression of acanthosis nigricans correlates with disappearance of anti-insulin receptor autoantibodies and achievement of euglycemia in type B insulin resistance syndrome
    Gilbert G Fareau
    Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Metabolism 56:670-5. 2007
    ..We have documented, for the first time, regression of AN in temporal association with disappearance of circulating anti-insulin receptor autoantibodies and achievement of euglycemia in a patient with type B insulin resistance...
  38. pmc The role of the immune system in obesity and insulin resistance
    Payal S Patel
    Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    J Obes 2013:616193. 2013
    ..Thus it is not merely an increased mass of adipose tissue that directly leads to attenuation of insulin action, but rather adipose tissue inflammation activated by the immune system in obese individuals that leads to insulin resistance...
  39. pmc Adiponectin and the mediation of HDL-cholesterol change with improved lifestyle: the Look AHEAD Study
    L Maria Belalcazar
    Department of Medicine, University of Texas Medical Branch, Galveston, TX, USA
    J Lipid Res 53:2726-33. 2012
    ..Data supported the contribution of changes in both HMW- and non-HMW-adiponectin to the improvement in HDL-C with ILI...
  40. pmc Intensive lifestyle modification reduces Lp-PLA2 in dyslipidemic HIV/HAART patients
    Joshua S Wooten
    Division of Atherosclerosis and Vascular Biology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Med Sci Sports Exerc 45:1043-50. 2013
    ....
  41. ncbi request reprint Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription
    Dinakar Iyer
    Department of Medicine, Division of Endocrinology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 42:7477-86. 2003
    ..Phosphorylation of the MADS box may constitute a novel mechanism for regulation of SRF-dependent actin gene transcription...
  42. ncbi request reprint Metabolic basis of HIV-lipodystrophy syndrome
    Rajagopal V Sekhar
    Section of Endocrinology and Department of Medicine, Children s Nutrition Research Center and US Department of Agriculture Agricultural Research Service, Baylor College of Medicine, Houston 77030, USA
    Am J Physiol Endocrinol Metab 283:E332-7. 2002
    ..02). The lipoatrophy observed in HIV lipodystrophy is associated with accelerated lipolysis. Increased hepatic reesterification promotes the hypertriglyceridemia observed in this syndrome...
  43. ncbi request reprint Improved outcomes in indigent patients with ketosis-prone diabetes: effect of a dedicated diabetes treatment unit
    Mario R Maldonado
    Section of Endocrinology, Department of Medicine, Baylor College of Medicine, and Ben Taub General Hospital, Houston, Texas 77030 3498, USA
    Endocr Pract 9:26-32. 2003
    ..To investigate whether a specialized intervention program could improve diabetes-related health outcomes in indigent patients with type 1 diabetes who were prone to occurrence of diabetic ketoacidosis (DKA)...
  44. ncbi request reprint Cardiovascular implications of HIV-associated dyslipidemic lipodystrophy
    Rajagopal V Sekhar
    Division of Endocrinology, Baylor College of Medicine, 719E, One Baylor Plaza, Houston, TX 77030, USA
    Curr Atheroscler Rep 6:173-9. 2004
    ..In this article, we review HADL in terms of metabolic, molecular, and cytokine derangements leading to cardiovascular disease...
  45. ncbi request reprint Health outcomes beyond glucose control
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, Texas, USA
    Am J Manag Care 12:S382-91. 2006
    ....
  46. ncbi request reprint Rise of plasma ghrelin with weight loss is not sustained during weight maintenance
    Jose M Garcia
    Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Obesity (Silver Spring) 14:1716-23. 2006
    ..The objective of this study was to investigate the relationship of plasma ghrelin concentrations to active WL and weight maintenance in obese subjects...
  47. doi request reprint Treatment of dyslipidemia in HIV-infected patients
    Rajagopal V Sekhar
    Translational Metabolism Unit, Diabetes and Endocrinology Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Expert Opin Pharmacother 11:1845-54. 2010
    ..Patients infected with HIV are at high risk for dyslipidemia, insulin resistance and cardiovascular disease. Therapies to reverse these risks are complex, sometimes controversial, and not uniformly effective...
  48. ncbi request reprint Fenofibrate is effective in treating hypertriglyceridemia associated with HIV lipodystrophy
    Archana Rao
    Division of Endocrinology, Baylor College of Medicine, and Endocrine Service, Ben Taub General Hospital, Houston, Texas, USA
    Am J Med Sci 327:315-8. 2004
    ..To determine the effectiveness of fenofibrate in treating hypertriglyceridemia associated with highly active antiretroviral therapy-associated HIV lipodystrophy syndrome (HLS)...
  49. pmc Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine
    Rajagopal V Sekhar
    Translational Metabolism Unit, Baylor College of Medicine, Houston, Texas, USA
    Diabetes Care 34:162-7. 2011
    ....
  50. ncbi request reprint Dysregulated energy expenditure in HIV-infected patients: a mechanistic review
    Evelyn Chang
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Infect Dis 44:1509-17. 2007
    ..Identifying unifying mechanisms will be an important step to finding effective treatments for HIV-related alterations in energy expenditure and to reversing metabolic risks in patients with HIV infection...
  51. ncbi request reprint Novel syndromes of ketosis-prone diabetes: implications for management and medical economics
    Ashok Balasubramanyam
    Endocrine Service, Ben Taub General Hospital, Baylor College of Medicine, Houston, USA
    Manag Care 13:7-10; discussion 19-21. 2004
  52. ncbi request reprint In vivo arginine production and intravascular nitric oxide synthesis in hypotensive sepsis
    Salvador Villalpando
    US Department of Agriculture, Agricultural Research Service, Children s Nutrition Research Center, Department of Pediatrics, and Medical Services, Ben Taub General Hospital, Houston, TX, USA
    Am J Clin Nutr 84:197-203. 2006
    ..Low plasma arginine is correlated with a worse prognosis in patients with sepsis, and increased NO has been implicated in the hypotension of sepsis. Data on in vivo arginine and NO kinetics are lacking in hypotensive septic adults...
  53. ncbi request reprint Developmental expression of serum response factor in the rat central nervous system
    Janet L Stringer
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Brain Res Dev Brain Res 138:81-6. 2002
    ..These data suggest that SRF has a significant function in the early post-natal development of the CNS...
  54. ncbi request reprint Cardiovascular event prevention in the person with type 2 diabetes: case examples for identifying and treating multiple risks
    Ashok Balasubramanyam
    Baylor College of Medicine, One Baylor Plaza, Room 719E, Houston, TX 77030, USA
    Diabetes Educ 32:163S-173S; quiz 174S-177S. 2006
  55. doi request reprint Genetic modifiers of cardiorespiratory fitness response to lifestyle intervention
    Inga Peter
    1Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 2Center for Statistical Sciences, Brown University, Providence, RI 3Department of Medicine, University of Texas Medical Branch, Galveston, TX 4Department of Health and Physical Activity, Physical Activity and Weight Management Research Center, University of Pittsburgh, Pittsburgh, PA 5Weight Control and Diabetes Research Center, Department of Psychiatry and Human Behavior, The Miriam Hospital and Brown Medical School, Providence, RI 6Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 7Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 8Diabetes Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 9Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC and 10Molecular Cardiology Research Institute, Center for Translational Genomics, Tufts Medical Center and Tufts University, Boston, MA
    Med Sci Sports Exerc 46:302-11. 2014
    ....
  56. ncbi request reprint Economic impact of diabetic ketoacidosis in a multiethnic indigent population: analysis of costs based on the precipitating cause
    Mario R Maldonado
    Division of Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Diabetes Care 26:1265-9. 2003
    ..Diabetic ketoacidosis (DKA) is a common complication of diabetes. We analyzed the inpatient costs of treating DKA in a multiethnic, indigent population in Houston, Texas...
  57. ncbi request reprint Long-term, randomized clinical trial of two diets in the metabolic syndrome and type 2 diabetes
    Lynne W Scott
    Diabetes Care 26:2481-2. 2003
  58. ncbi request reprint Ethnic differences in beta-cell functional reserve and clinical features in patients with ketosis-prone diabetes
    Mario R Maldonado
    Diabetes Care 26:2469. 2003

Research Grants12

  1. Viral mechanisms of adipocyte dysfuntion: Role of Vpr.
    Ashok Balasubramanyam; Fiscal Year: 2009
    ..The goal of this project is to determine how a protein made by the HIV virus, termed Vpr, can cause chronic inflammation of fat cells and lead to these disorders. ..
  2. Viral mechanisms of adipocyte dysfuntion: Role of Vpr.
    Ashok Balasubramanyam; Fiscal Year: 2010
    ..The goal of this project is to determine how a protein made by the HIV virus, termed Vpr, can cause chronic inflammation of fat cells and lead to these disorders. ..
  3. Diet/Exercise, Niacin, Fenofibrate for HIV Lipodystrophy
    Ashok Balasubramanyam; Fiscal Year: 2007
    ..Thus, this study will determine the efficacy of diet and exercise, with and without niacin and fenofibrate, in reducing the cardiovascular risk of patients with HIV lipodystrophy / dyslipidemia. ..
  4. Diet/Exercise, Niacin, Fenofibrate for HIV Lipodystrophy
    Ashok Balasubramanyam; Fiscal Year: 2007
    ..Thus, this study will determine the efficacy of diet and exercise, with and without niacin and fenofibrate, in reducing the cardiovascular risk of patients with HIV lipodystrophy / dyslipidemia. ..
  5. MOLECULAR BASIS OF HIV LIPODYSTROPHY: ROLE OF VPR
    Ashok Balasubramanyam; Fiscal Year: 2003
    ....