C J Baker

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc The frequency of genes encoding three putative group B streptococcal virulence factors among invasive and colonizing isolates
    Shannon D Manning
    National Food Safety and Toxicology Center and Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, USA
    BMC Infect Dis 6:116. 2006
  2. ncbi request reprint Immunization of pregnant women with group B streptococcal type III capsular polysaccharide-tetanus toxoid conjugate vaccine
    Carol J Baker
    Departments of Pediatrics, Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    Vaccine 21:3468-72. 2003
  3. ncbi request reprint Use of capsular polysaccharide-tetanus toxoid conjugate vaccine for type II group B Streptococcus in healthy women
    C J Baker
    Dept of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Infect Dis 182:1129-38. 2000
  4. ncbi request reprint Immune response of healthy women to 2 different group B streptococcal type V capsular polysaccharide-protein conjugate vaccines
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 189:1103-12. 2004
  5. ncbi request reprint Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Room 302A, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
    Vaccine 25:55-63. 2007
  6. ncbi request reprint Safety and immunogenicity of capsular polysaccharide-tetanus toxoid conjugate vaccines for group B streptococcal types Ia and Ib
    C J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 179:142-50. 1999
  7. ncbi request reprint Safety and immunogenicity of a bivalent group B streptococcal conjugate vaccine for serotypes II and III
    Carol J Baker
    Sections of Infectious Diseases, Department of Pediatrics, and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 188:66-73. 2003
  8. pmc Group B streptococcal conjugate vaccines
    C J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Arch Dis Child 88:375-8. 2003
  9. ncbi request reprint A 5-year review of recurrent group B streptococcal disease: lessons from twin infants
    E H Moylett
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Infect Dis 30:282-7. 2000
  10. ncbi request reprint Group B streptococcal colonization and serotype-specific immunity in pregnant women at delivery
    J R Campbell
    Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Obstet Gynecol 96:498-503. 2000

Detail Information

Publications54

  1. pmc The frequency of genes encoding three putative group B streptococcal virulence factors among invasive and colonizing isolates
    Shannon D Manning
    National Food Safety and Toxicology Center and Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, USA
    BMC Infect Dis 6:116. 2006
    ..It is not known, however, whether these genes occur more frequently in invasive versus colonizing GBS strains...
  2. ncbi request reprint Immunization of pregnant women with group B streptococcal type III capsular polysaccharide-tetanus toxoid conjugate vaccine
    Carol J Baker
    Departments of Pediatrics, Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    Vaccine 21:3468-72. 2003
    ..To determine the safety and immunogenicity of group B streptococcal (GBS) type III CPS-TT conjugate vaccine in pregnant women...
  3. ncbi request reprint Use of capsular polysaccharide-tetanus toxoid conjugate vaccine for type II group B Streptococcus in healthy women
    C J Baker
    Dept of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Infect Dis 182:1129-38. 2000
    ..Immunological responses to conjugate were dose dependent and correlated with opsonophagocytosis in vitro. These results support inclusion of II-TT conjugate when preparing a multivalent GBS vaccine...
  4. ncbi request reprint Immune response of healthy women to 2 different group B streptococcal type V capsular polysaccharide-protein conjugate vaccines
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 189:1103-12. 2004
    ..Infections caused by group B streptococcal (GBS) type V are increasingly common. Capsular polysaccharide (CPS)-protein conjugate GBS vaccines are immunogenic in healthy adults, but type V vaccines have not previously been tested...
  5. ncbi request reprint Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Room 302A, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
    Vaccine 25:55-63. 2007
    ..V-TT vaccine-induced antibodies promoted opsonophagocytic killing of type V GBS and avidity maturation of V CPS-specific IgG...
  6. ncbi request reprint Safety and immunogenicity of capsular polysaccharide-tetanus toxoid conjugate vaccines for group B streptococcal types Ia and Ib
    C J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 179:142-50. 1999
    ..Immune responses to the conjugates were dose-dependent and correlated in vitro with opsonophagocytosis. These results support inclusion of Ia- and Ib-TT conjugates when formulating a multivalent GBS vaccine...
  7. ncbi request reprint Safety and immunogenicity of a bivalent group B streptococcal conjugate vaccine for serotypes II and III
    Carol J Baker
    Sections of Infectious Diseases, Department of Pediatrics, and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 188:66-73. 2003
    ..These results support the feasibility of a multivalent vaccine for the 5 prevalent invasive disease-causing GBS CPS serotypes...
  8. pmc Group B streptococcal conjugate vaccines
    C J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Arch Dis Child 88:375-8. 2003
    ....
  9. ncbi request reprint A 5-year review of recurrent group B streptococcal disease: lessons from twin infants
    E H Moylett
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Infect Dis 30:282-7. 2000
    ..The exact pathogenesis of recurrent GBS disease remains unclear, but our data support the hypothesis that persistent mucosal colonization with the original GBS strain rather than new acquisition is a pivotal factor in disease recurrence...
  10. ncbi request reprint Group B streptococcal colonization and serotype-specific immunity in pregnant women at delivery
    J R Campbell
    Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Obstet Gynecol 96:498-503. 2000
    ..To describe the relationship between serum concentration of group B streptococcal capsular polysaccharide-specific immunoglobulin (Ig) G, colonization status, race or ethnicity, and age in pregnant women...
  11. doi request reprint Distinguishing true coagulase-negative Staphylococcus infections from contaminants in the neonatal intensive care unit
    C M Healy
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Perinatol 33:52-8. 2013
    ..To characterize true coagulase-negative Staphylococcus (CoNS) infections in infants receiving neonatal intensive care...
  12. ncbi request reprint Failure of rifampin to eradicate group B streptococcal colonization in infants
    M Fernandez
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Infect Dis J 20:371-6. 2001
    ..CONCLUSIONS: Rifampin treatment for four days utilized as a single agent after completion of parenteral therapy failed to reliably eradicate GBS colonization in infants...
  13. ncbi request reprint Clinical and laboratory characteristics of a large cohort of symptomatic, human immunodeficiency virus-infected infants and children. AIDS Clinical Trials Group Protocol 152 Study Team
    J A Englund
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Infect Dis J 15:1025-36. 1996
    ....
  14. ncbi request reprint Suppurative thrombophlebitis in children: a ten-year experience
    E A Khan
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Pediatr Infect Dis J 16:63-7. 1997
    ..To determine the clinical and diagnostic features, complications, management and prevention of superficial suppurative thrombophlebitis (ST) in children < 18 years of age...
  15. pmc Role of neutrophil receptors in opsonophagocytosis of coagulase-negative staphylococci
    G E Schutze
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030
    Infect Immun 59:2573-8. 1991
    ..The inefficiency of these interactions with neutrophils from premature infants may partially explain the enhanced susceptibility of very-low-birth-weight neonates to disseminated, coagulase-negative staphylococcal infections...
  16. ncbi request reprint Enterococcal sepsis in neonates: features by age at onset and occurrence of focal infection
    S R Dobson
    Myers Black Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030
    Pediatrics 85:165-71. 1990
    ..Enterococcus is a frequent cause of late-onset septicemia in premature neonates, and empiric therapy should include appropriate antimicrobial agents...
  17. ncbi request reprint Systemic candidiasis in extremely low birth weight infants receiving topical petrolatum ointment for skin care: a case-control study
    J R Campbell
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, TX 77030, USA
    Pediatrics 105:1041-5. 2000
    ..We sought to determine whether the use of topical petrolatum ointment (TPO) for skin care of ELBW infants was associated with risk for SC...
  18. ncbi request reprint Predictive value of quantitative plasma HIV RNA and CD4+ lymphocyte count in HIV-infected infants and children
    P E Palumbo
    Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
    JAMA 279:756-61. 1998
    ..Pediatric human immunodeficiency virus (HIV) infection has unique viral pathogenetic features that preclude routine extrapolation from adult studies and require specific analysis...
  19. ncbi request reprint Ophthalmologic, visceral, and cardiac involvement in neonates with candidemia
    D E Noyola
    Section of Infectious Diseases, Department of Pediatrics, Houston, TX 77030, USA
    Clin Infect Dis 32:1018-23. 2001
    ....
  20. ncbi request reprint Virologic and immunologic response to nucleoside reverse-transcriptase inhibitor therapy among human immunodeficiency virus-infected infants and children
    P E Palumbo
    Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    J Infect Dis 179:576-83. 1999
    ..Nevertheless, plasma RNA and CD4 lymphocyte count together possess strong clinical predictive power and are valuable tools for both the clinician and the evaluation of new therapies...
  21. ncbi request reprint Group B streptococcal colonization and serotype-specific immunity in healthy elderly persons
    Morven S Edwards
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Infect Dis 40:352-7. 2005
    ..Rates of colonization and prevalence of antibodies against capsular polysaccharides (CPS) that might confer protection against invasive GBS disease in such persons are not defined...
  22. pmc DNA macrorestriction analysis of nontypeable group B streptococcal isolates: clonal evolution of nontypeable and type V isolates
    Nicole R Amundson
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
    J Clin Microbiol 43:572-6. 2005
    ..PFGE is a valuable approach for comparison of GBS isolate relatedness and for monitoring of NT and typeable GBS isolates for potential clonal divergence...
  23. ncbi request reprint Antibodies to type III group B streptococcal polysaccharide in breast milk
    Morven S Edwards
    Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatr Infect Dis J 23:961-3. 2004
    ....
  24. ncbi request reprint Emergence of new strains of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit
    C Mary Healy
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Infect Dis 39:1460-6. 2004
    ..We determined if MRSA strains causing bacteremia in infants treated from birth in a neonatal intensive care unit (NICU) demonstrated the genetic traits of community-associated MRSA...
  25. ncbi request reprint Features of invasive staphylococcal disease in neonates
    C Mary Healy
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Rm 302A, Houston, TX 77030, USA
    Pediatrics 114:953-61. 2004
    ..We aimed to describe the contemporary incidence, clinical features, and outcome of infants with ISD in a neonatal intensive care unit...
  26. ncbi request reprint Group B streptococcal infections in elderly adults
    Morven S Edwards
    Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 41:839-47. 2005
    ..The safety and immunogenicity of GBS serotype V-tetanus toxoid conjugate vaccine in healthy elderly persons suggest the potential for vaccination as an approach to prevention of invasive GBS infections in elderly persons...
  27. ncbi request reprint Pertussis serostatus among neonates born to Hispanic women
    C Mary Healy
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 42:1439-42. 2006
    ..63 EU/mL; P < or =.001). A lack of maternal immunity is one explanation for pertussis susceptibility in very young Hispanic infants...
  28. ncbi request reprint Group B Streptococcus bacteremia elicits beta C protein-specific IgMand IgG in humans
    Pia S Pannaraj
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX 77030, USA
    J Infect Dis 195:353-6. 2007
    ..Serum from 3 women with beta C GBS bacteremia had significantly higher levels of IgM (6.0) and IgG (52.9) (P=.01 and 0.01, respectively). Invasive disease but not colonization elicits beta C-specific IgM and IgG...
  29. ncbi request reprint Maternal immunization
    C Mary Healy
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
    Pediatr Infect Dis J 26:945-8. 2007
  30. pmc Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease
    Pia S Pannaraj
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX 77030, USA
    Vaccine 26:502-8. 2008
    ..In vitro killing of alpha C-expressing GBS correlated with total alpha C-specific antibody concentration. Invasive disease but not colonization elicits alpha C-specific IgM and IgG in adults...
  31. doi request reprint Fluconazole prophylaxis in extremely low birth weight neonates reduces invasive candidiasis mortality rates without emergence of fluconazole-resistant Candida species
    C Mary Healy
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Room 302A, MS BCM 320, Houston, TX 77030, USA
    Pediatrics 121:703-10. 2008
    ..We evaluated the impact of fluconazole prophylaxis for extremely low birth weight infants on invasive candidiasis incidence, invasive candidiasis-related mortality rates, and fluconazole susceptibility of Candida isolates...
  32. ncbi request reprint Impact of fluconazole prophylaxis on incidence and outcome of invasive candidiasis in a neonatal intensive care unit
    C Mary Healy
    Department of Pediatrics, Baylor College of Medicine and The Woman s Hospital of Texas, Houston, Texas 77030, USA
    J Pediatr 147:166-71. 2005
    ....
  33. ncbi request reprint Prevalence of group B streptococcus colonization and potential for transmission by casual contact in healthy young men and women
    Shannon D Manning
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, USA
    Clin Infect Dis 39:380-8. 2004
    ..Large prospective studies are needed to better understand colonization site-specific factors for GBS and to clarify potential transmission modes...
  34. ncbi request reprint Use of type V group B streptococcal conjugate vaccine in adults 65-85 years old
    Debra L Palazzi
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 190:558-64. 2004
    ..These results suggest the potential for prevention of invasive type V GBS infections in healthy elderly adults through immunization...
  35. ncbi request reprint Quantitative determination of immunoglobulin G specific for group B streptococcal beta C protein in human maternal serum
    Catherine S Lachenauer
    Channing Laboratory and Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Infect Dis 185:368-74. 2002
    ..This difference was not explained by a major difference in epitope specificity...
  36. pmc Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 70:1724-38. 2002
    ..When present, these vaccine-induced cross-reacting antibodies conferred in vitro antibody-mediated opsonophagocytosis and killing of both GBS III and Pn14, two pathogens that cause invasive disease in young infants...
  37. ncbi request reprint Induction of cross-reactive antibodies by immunization of healthy adults with types Ia and Ib group B streptococcal polysaccharide-tetanus toxoid conjugate vaccines
    Anne Karin Brigtsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 185:1277-84. 2002
    ..These results indicate that GBS Ia and Ib PSs should be included in a multivalent conjugate vaccine to prevent GBS disease...
  38. ncbi request reprint Improved methods for typing nontypeable isolates of group B streptococci
    Jeffrey A Benson
    Department of Laboratory Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    Int J Med Microbiol 292:37-42. 2002
    ..8%) had DNA profiles that resembled those of specific types of GBS. These approaches will be useful for classification of NT isolates in continued epidemiological surveillance associated with GBS vaccine trials...
  39. ncbi request reprint Correlates of antibiotic-resistant group B streptococcus isolated from pregnant women
    Shannon D Manning
    Department of Epidemiology and Center for Molecular and Clinical Epidemiology of Infectious Diseases, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 0276, USA
    Obstet Gynecol 101:74-9. 2003
    ..A better understanding of factors associated with antibiotic resistance is needed to minimize group B streptococcus disease risks and to maximize effective chemoprophylaxis...
  40. ncbi request reprint Group B Streptococcus colonization in male and nonpregnant female university students: a cross-sectional prevalence study
    Sandra J Bliss
    Department of Internal Medicine and Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Infect Dis 34:184-90. 2002
    ..However, larger studies are needed to verify these findings...
  41. ncbi request reprint New recommendations for prevention of early-onset group B streptococcal disease in newborns
    William P Kanto
    Department of Pediatrics, Medical College of Georgia, Atlanta, GA, USA
    Pediatr Rev 24:219-21. 2003
  42. ncbi request reprint Healthy elderly people lack neutrophil-mediated functional activity to type V group B Streptococcus
    Rene A Amaya
    Departments of Pediatrics and Molecular Virology and Microbiology, Section of Infectious Disease, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Geriatr Soc 52:46-50. 2004
    ..To determine the function of capsular polysaccharide (CPS)-specific immunoglobulin-G (IgG) and neutrophils from older adults in increasing ingestion and killing of type V group B Streptococcus (GBS)...
  43. ncbi request reprint Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum
    C Mary Healy
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 190:335-40. 2004
    ..Passively acquired maternal antibodies protect infants from many pathogens. With increasing reports of infant pertussis, we evaluated pertussis antibodies in maternal-infant paired sera from 1999-2000...
  44. ncbi request reprint Multilocus sequence typing of serotype III group B streptococcus and correlation with pathogenic potential
    H Dele Davies
    Department of Microbiology, and Child Health Research Unit, Alberta Children s Hospital, University of Calgary, Canada
    J Infect Dis 189:1097-102. 2004
    ..89 microg/mL and 0.39 microg/mL, respectively) for ST-19 and ST-17 (P=.86). The close association of genomic strain 2603V/R (serotype V) with ST-19 suggests that the phenomenon of capsule switching may have occurred...
  45. pmc Comparison of DNA dot blot hybridization and lancefield capillary precipitin methods for group B streptococcal capsular typing
    Stephanie M Borchardt
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Microbiol 42:146-50. 2004
    ..The overall agreement between the methods was 95% (256 of 270 isolates typeable by both methods). We conclude that the DBCT method is a specific and useful alternative to the commonly used LS method...
  46. ncbi request reprint Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection
    Caroline J Chantry
    Department of Pediatrics, University of California Davis Medical Center, Sacramento 95817, USA
    Pediatr Infect Dis J 22:1033-9. 2003
    ..The relationships among weight and height growth, viral load and survival in HIV-infected children remain unclear...
  47. ncbi request reprint Determinants of co-colonization with group B streptococcus among heterosexual college couples
    Shannon D Manning
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Epidemiology 13:533-9. 2002
    ..Group B causes morbidity and mortality among newborns, pregnant women, and nonpregnant adults. Among adults, sexual and fecal-oral routes of transmission are hypothesized; this study addresses whether sexual transmission occurs...
  48. ncbi request reprint Prospects for prevention of childhood infections by maternal immunization
    C Mary Healy
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Infect Dis 19:271-6. 2006
    ..To review the literature on using maternal immunization as a strategy to prevent infections in young infants aged below 6 months..
  49. ncbi request reprint Mutations linked to drug resistance, human immunodeficiency virus type 1 biologic phenotype and their association with disease progression in children receiving nucleoside reverse transcriptase inhibitors
    Janet A Englund
    University of Chicago, Pritzker School of Medicine, Chicago, IL, USA
    Pediatr Infect Dis J 23:15-22. 2004
    ..We evaluated the development of antiretroviral genotypic resistance and clinical outcome in a subgroup of children involved in a prospective antiretroviral therapy trial (Pediatric AIDS Clinical Trials Group Protocol 152)...
  50. ncbi request reprint Another success for hepatitis A vaccine
    Carol J Baker
    N Engl J Med 357:1757-9. 2007
  51. ncbi request reprint The future of meningococcal vaccines
    C Mary Healy
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Pediatr Infect Dis J 24:175-6. 2005
  52. ncbi request reprint Advances in antifungal therapy
    Pia S Pannaraj
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Pediatr Infect Dis J 24:921-2. 2005
  53. ncbi request reprint Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children
    Edmund V Capparelli
    University of California, San Diego, School of Medicine, La Jolla, California, USA
    J Clin Pharmacol 43:133-40. 2003
    ..It was concluded that ZDV oral clearance is reduced in infants compared to older children. This lower clearance leads to higher ZDV exposure in infants and contributes to increased hematologic toxicity...