Shervin Assassi

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Right bundle branch block: a predictor of mortality in early systemic sclerosis
    Hilda T Draeger
    Division of Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 8:e78808. 2013
  2. pmc Genetics of scleroderma: implications for personalized medicine?
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    BMC Med 11:9. 2013
  3. ncbi request reprint Polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in systemic sclerosis
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, TX 77030, USA
    Am J Med 118:907-11. 2005
  4. pmc Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Houston, 6431 Fannin, Houston, TX 77030, USA
    Arthritis Res Ther 12:R166. 2010
  5. pmc Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5
    Shervin Assassi
    Department of Medicine, Division of Rheumatology, University of Texas Health Science Center, Houston, TX 77030, USA
    J Rheumatol 38:87-98. 2011
  6. pmc Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
    Shervin Assassi
    Department of Medicine, Division of Rheumatology, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e26061. 2011
  7. pmc Clinical and genetic factors predictive of mortality in early systemic sclerosis
    Shervin Assassi
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Rheum 61:1403-11. 2009
  8. pmc Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients
    Shervin Assassi
    The University of Texas Health Science Center at Houston, 6431 Fannin, MSB 5 232, Houston, TX 77030, USA
    J Rheumatol 36:2250-6. 2009
  9. ncbi request reprint Clinical, immunologic, and genetic features of familial systemic sclerosis
    Shervin Assassi
    University of Texas Health Science Center, Houston, TX 77030, USA
    Arthritis Rheum 56:2031-7. 2007
  10. ncbi request reprint Genetics of scleroderma: update on single nucleotide polymorphism analysis and microarrays
    Shervin Assassi
    Division of Rheumatology, Department of Internal Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Curr Opin Rheumatol 17:761-7. 2005

Detail Information

Publications36

  1. pmc Right bundle branch block: a predictor of mortality in early systemic sclerosis
    Hilda T Draeger
    Division of Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 8:e78808. 2013
    ....
  2. pmc Genetics of scleroderma: implications for personalized medicine?
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    BMC Med 11:9. 2013
    ..Future genetic studies in well-characterized systemic sclerosis cohorts paired with advanced analytic approaches can lead to development of genetic biomarkers for targeted diagnostic and therapeutic interventions in systemic sclerosis...
  3. ncbi request reprint Polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in systemic sclerosis
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, TX 77030, USA
    Am J Med 118:907-11. 2005
  4. pmc Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Houston, 6431 Fannin, Houston, TX 77030, USA
    Arthritis Res Ther 12:R166. 2010
    ....
  5. pmc Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5
    Shervin Assassi
    Department of Medicine, Division of Rheumatology, University of Texas Health Science Center, Houston, TX 77030, USA
    J Rheumatol 38:87-98. 2011
    ..to identify differentially expressed genes in peripheral blood cells (PBC) of patients with ankylosing spondylitis (AS) relative to healthy controls and controls with systemic inflammation...
  6. pmc Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
    Shervin Assassi
    Department of Medicine, Division of Rheumatology, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e26061. 2011
    ..We also examined baseline predictors of change in fatigue severity over time...
  7. pmc Clinical and genetic factors predictive of mortality in early systemic sclerosis
    Shervin Assassi
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Rheum 61:1403-11. 2009
    ..To investigate the clinical and genetic variables at initial presentation that predict survival in the Genetics versus Environment in Scleroderma Outcome Study (GENISOS) cohort...
  8. pmc Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients
    Shervin Assassi
    The University of Texas Health Science Center at Houston, 6431 Fannin, MSB 5 232, Houston, TX 77030, USA
    J Rheumatol 36:2250-6. 2009
    ..Further, to assess the association of SSc-related antibodies with hepatic parameter abnormalities...
  9. ncbi request reprint Clinical, immunologic, and genetic features of familial systemic sclerosis
    Shervin Assassi
    University of Texas Health Science Center, Houston, TX 77030, USA
    Arthritis Rheum 56:2031-7. 2007
    ....
  10. ncbi request reprint Genetics of scleroderma: update on single nucleotide polymorphism analysis and microarrays
    Shervin Assassi
    Division of Rheumatology, Department of Internal Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Curr Opin Rheumatol 17:761-7. 2005
    ..The purpose of this review is to summarize the results of genetic association and gene expression profiling studies from January 2004 to May 2005...
  11. pmc Systemic sclerosis and lupus: points in an interferon-mediated continuum
    Shervin Assassi
    University of Texas Health Science Center, Houston, TX, USA
    Arthritis Rheum 62:589-98. 2010
    ..To investigate peripheral blood (PB) cell transcript profiles of systemic sclerosis (SSc) and its subtypes in direct comparison with systemic lupus erythematosus (SLE)...
  12. pmc Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis
    Sandeep K Agarwal
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Texas 77030, USA
    J Rheumatol 36:2715-23. 2009
    ..We investigated the possible association of IL23R with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis...
  13. pmc Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis
    Maureen D Mayes
    The University of Texas Health Science Center at Houston, Houston, TX 77030, USA Electronic address
    Am J Hum Genet 94:47-61. 2014
    ....
  14. pmc Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston UTHSC H, Houston, TX 77030, USA
    J Autoimmun 34:155-62. 2010
    ..The current report sought to determine if polymorphisms in the C8orf13-BLK region (chromosome 8p23.1-B lymphoid tyrosine kinase), which is associated with SLE, are associated also with SSc...
  15. pmc Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, MSB 5 278, Houston, Texas 77030, USA
    Ann Rheum Dis 69:550-5. 2010
    ..Accordingly, the aim of the current study was to investigate the possible association of the TNFSF4 gene region with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis...
  16. pmc Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines
    Pravitt Gourh
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Rheum 60:3794-806. 2009
    ....
  17. ncbi request reprint Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis
    Pravitt Gourh
    University of Texas Health Science Center at Houston, TX 77030, USA
    Arthritis Rheum 54:3945-53. 2006
    ....
  18. pmc Psychological correlates of self-reported disease activity in ankylosing spondylitis
    Tamar F Brionez
    Department of Medicine, Division of Rheumatology, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Rheumatol 37:829-34. 2010
    ..To investigate the role of psychological variables in self-reported disease activity in patients with ankylosing spondylitis (AS), while controlling for demographic and medical variables...
  19. pmc IRF5 polymorphism predicts prognosis in patients with systemic sclerosis
    Roozbeh Sharif
    Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Ann Rheum Dis 71:1197-202. 2012
    ..The goal of this study was to investigate the impact of these gene variants on survival and severity of interstitial lung disease (ILD) in SSc...
  20. pmc Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin M S B 5 278, Houston, TX 77030, USA
    Arthritis Res Ther 11:R147. 2009
    ..The current report sought to determine whether plasma cytokine profiles differ in SSc patients grouped according to these SSc-associated autoantibody subsets...
  21. pmc Correlation of interferon-inducible chemokine plasma levels with disease severity in systemic sclerosis
    Xiaochun Liu
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Rheum 65:226-35. 2013
    ..To measure interferon (IFN)-inducible chemokines in the plasma of patients with systemic sclerosis (SSc) and investigate whether the chemokine levels are correlated with disease severity...
  22. pmc Does C-reactive protein predict the long-term progression of interstitial lung disease and survival in patients with early systemic sclerosis?
    Xiaochun Liu
    University of Texas Health Science Center, Houston, TX 77030, USA
    Arthritis Care Res (Hoboken) 65:1375-80. 2013
    ..Elevated C-reactive protein (CRP) levels have been reported in SSc patients. We examined the predictive significance of CRP level for long-term ILD progression in a large early SSc cohort...
  23. pmc Determinants of work disability in patients with systemic sclerosis: a longitudinal study of the GENISOS cohort
    Roozbeh Sharif
    Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Semin Arthritis Rheum 41:38-47. 2011
    ..We hypothesized that WD in systemic sclerosis (SSc) is a function of demographic, clinical, and psychosocial factors...
  24. pmc Separate influences of birth order and gravidity/parity on the development of systemic sclerosis
    Tonya Cockrill
    University of Texas Health Science Center at Houston, TX 77030, USA
    Arthritis Care Res (Hoboken) 62:418-24. 2010
    ..In order to better evaluate these influences, we studied the association of birth order and gravidity/parity as risk factors for systemic sclerosis (SSc; scleroderma)...
  25. pmc Cigarette smoking is not a risk factor for systemic sclerosis
    Prateek Chaudhary
    University of Texas Health Science Center at Houston, Houston, TX, USA
    Arthritis Rheum 63:3098-102. 2011
    ..To investigate the association of cigarette smoking with susceptibility to systemic sclerosis (SSc) in a large, well-defined patient population...
  26. pmc Anti-fibrillarin antibody in African American patients with systemic sclerosis: immunogenetics, clinical features, and survival analysis
    Roozbeh Sharif
    Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Rheumatol 38:1622-30. 2011
    ..We examined the immunogenetic, clinical, and survival correlates of AFA in a large group of AA patients with SSc...
  27. pmc Autoimmune diseases and autoantibodies in the first degree relatives of patients with systemic sclerosis
    Rajpreet K Arora-Singh
    Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX, USA
    J Autoimmun 35:52-7. 2010
    ....
  28. pmc The contribution of disease activity on functional limitations over time through psychological mediators: a 12-month longitudinal study in patients with ankylosing spondylitis
    Jennifer H Jang
    Department of Medicine, Division of Rheumatology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Becker B 131, Los Angeles, CA 90048, USA
    Rheumatology (Oxford) 50:2087-92. 2011
    ..To explore whether helplessness, internality and depression would mediate the relationship between disease activity and functional limitations in patients with AS in a 12-month longitudinal study...
  29. pmc Can serum surfactant protein D or CC-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis?
    Mona Elhaj
    University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Rheumatol 40:1114-20. 2013
    ..To examine the predictive significance of 2 pneumoproteins, surfactant protein D (SP-D) and CC-chemokine ligand 18 (CCL18), for the course of systemic sclerosis (SSc)-related interstitial lung disease...
  30. pmc Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
    Olga Gorlova
    Department of Epidemiology, M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 7:e1002178. 2011
    ..Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc...
  31. doi request reprint What does global gene expression profiling tell us about the pathogenesis of systemic sclerosis?
    Shervin Assassi
    University of Texas Health Science Center at Houston, Houston, Texas, USA
    Curr Opin Rheumatol 25:686-91. 2013
    ..The purpose of this study is to review recent hypothesis-driven studies that utilize global gene expression data for elucidating the molecular basis of systemic sclerosis (SSc) and its various clinical manifestations...
  32. doi request reprint Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis
    Shervin Assassi
    University of Texas Health Science Center at, Houston
    Arthritis Rheum 65:2917-27. 2013
    ..We undertook this hypothesis-generating study to identify skin transcripts correlating with severity of interstitial lung disease (ILD) in systemic sclerosis (SSc)...
  33. pmc Osteopontin in systemic sclerosis and its role in dermal fibrosis
    Minghua Wu
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Invest Dermatol 132:1605-14. 2012
    ..Finally, TGF-β production by OPN-deficient macrophages was reduced compared with WT. These data demonstrate an important role for OPN in the development of dermal fibrosis and suggest that it may be a new therapeutic target in SSc...
  34. pmc Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial
    Emily W Hung
    Rheumatology Associates of Houston, Division of Northwest Diagnostic Clinic, Houston, Texas, USA
    J Rheumatol 40:455-60. 2013
    ..To describe the prevalence and clinical correlates of endoscopic gastric antral vascular ectasia (GAVE; "watermelon stomach") in early diffuse systemic sclerosis (SSc)...
  35. pmc Psychological correlates of self-reported functional limitation in patients with ankylosing spondylitis
    Tamar F Brionez
    Department of Medicine, Division of Rheumatology, University of Texas Houston, 6431 Fannin, Houston, Texas 77030, USA
    Arthritis Res Ther 11:R182. 2009
    ..The purpose of this study was to investigate the role of psychological variables in self-reported functional limitation in patients with AS, while controlling for demographic and medical variables...
  36. pmc Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts
    Xiaodong Zhou
    Division of Rheumatology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Res Ther 13:R128. 2011
    ..The aims of this study were to examine the catalytic function and sumoylation of topo I in the nuclei of SSc fibroblasts, a major cell type involved in the fibrotic process...