Saima Aslam

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Cerebellar involvement in legionellosis
    Samuel A Shelburne
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, St Luke s Episcopal Hospital, Houston, TX 77030, USA
    South Med J 97:61-4. 2004
  2. ncbi request reprint The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy
    Samuel A Shelburne
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA
    Clin Infect Dis 40:1049-52. 2005
  3. pmc Sequential outbreaks of infections by distinct Acinetobacter baumannii strains in a public teaching hospital in Houston, Texas
    Samuel A Shelburne
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Room 535E, 1 Baylor Plaza, Houston, TX 77030, USA
    J Clin Microbiol 46:198-205. 2008
  4. ncbi request reprint Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci
    Samuel A Shelburne
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, N 1319, BCM 286, 1 Baylor Plaza, Houston, TX 77030, USA
    J Infect 54:e99-101. 2007
  5. doi request reprint Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia
    Saima Aslam
    Sections of Infectious Disease, Department of Medicine, Baylor College of Medicine, the Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 29:894-7. 2008
  6. pmc Risk factors and outcomes of fungal ventricular-assist device infections
    Saima Aslam
    Baylor College of Medicine, Houston, Texas, USA
    Clin Infect Dis 50:664-71. 2010
  7. ncbi request reprint Prolonged bacterial exposure to minocycline/rifampicin-impregnated vascular catheters does not affect antimicrobial activity of catheters
    Saima Aslam
    Section of Infectious Diseases, Department of Medicine and Center for Prosthesis Infection, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Antimicrob Chemother 60:148-51. 2007
  8. ncbi request reprint Treatment of Clostridium difficile-associated disease: old therapies and new strategies
    Saima Aslam
    Medical Service Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Lancet Infect Dis 5:549-57. 2005
  9. ncbi request reprint Effect of antibacterials on biofilms
    Saima Aslam
    Section of Infectious Diseases, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    Am J Infect Control 36:S175.e9-11. 2008
  10. pmc N-acetylcysteine lock solution prevents catheter-associated bacteremia in rabbits
    Saima Aslam
    Division of Infectious Diseases, Department of Medicine, University of California, San Diego, California, USA
    Int J Artif Organs 35:893-7. 2012

Research Grants

  1. Analysis Of Group A Streptococcus-Saliva Interaction
    SAMUEL SHELBURNE; Fiscal Year: 2007

Detail Information

Publications22

  1. ncbi request reprint Cerebellar involvement in legionellosis
    Samuel A Shelburne
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, St Luke s Episcopal Hospital, Houston, TX 77030, USA
    South Med J 97:61-4. 2004
    ..Finally, possible methods of pathogenicity are discussed including data regarding direct bacterial invasion, toxin production, and immune-mediated mechanisms...
  2. ncbi request reprint The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy
    Samuel A Shelburne
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA
    Clin Infect Dis 40:1049-52. 2005
    ..Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis...
  3. pmc Sequential outbreaks of infections by distinct Acinetobacter baumannii strains in a public teaching hospital in Houston, Texas
    Samuel A Shelburne
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Room 535E, 1 Baylor Plaza, Houston, TX 77030, USA
    J Clin Microbiol 46:198-205. 2008
    ..Taken together, we conclude that the outbreak of the A. calcoaceticus-A. baumannii complex in our institution was due to two distinct A. baumannii clones that were associated with significantly different patient outcomes...
  4. ncbi request reprint Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci
    Samuel A Shelburne
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, N 1319, BCM 286, 1 Baylor Plaza, Houston, TX 77030, USA
    J Infect 54:e99-101. 2007
    ..The lack of evidence supporting the recommendations for treatment of endocarditis due to penicillin non-susceptible viridans streptococci is discussed...
  5. doi request reprint Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia
    Saima Aslam
    Sections of Infectious Disease, Department of Medicine, Baylor College of Medicine, the Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 29:894-7. 2008
    ..Treatment was successful for 15 (83%) of the 18 case patients within 90 days of follow-up, with a median catheter retention interval of 64.5 days...
  6. pmc Risk factors and outcomes of fungal ventricular-assist device infections
    Saima Aslam
    Baylor College of Medicine, Houston, Texas, USA
    Clin Infect Dis 50:664-71. 2010
    ..The objectives of this study were to investigate the frequency of fungal VAD infections and assess various risk factors and their effects on mortality as compared with bacterial VAD infections...
  7. ncbi request reprint Prolonged bacterial exposure to minocycline/rifampicin-impregnated vascular catheters does not affect antimicrobial activity of catheters
    Saima Aslam
    Section of Infectious Diseases, Department of Medicine and Center for Prosthesis Infection, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Antimicrob Chemother 60:148-51. 2007
    ..We assessed the in vitro effect of exposing various bacteria to minocycline/rifampicin-impregnated vascular catheters on the antimicrobial activity of the catheters and the antimicrobial susceptibility of tested organisms...
  8. ncbi request reprint Treatment of Clostridium difficile-associated disease: old therapies and new strategies
    Saima Aslam
    Medical Service Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Lancet Infect Dis 5:549-57. 2005
    ..Hospital infection control and pertinent use of antibiotics can limit the spread of CDAD. A vaccine directed against C difficile toxin may eventually offer a solution to the CDAD problem...
  9. ncbi request reprint Effect of antibacterials on biofilms
    Saima Aslam
    Section of Infectious Diseases, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    Am J Infect Control 36:S175.e9-11. 2008
    ..Some antibacterials are better than others in treating biofilm-associated bacteria, such as rifampin (in combination with other antibiotics), tigecycline, daptomycin, N-acetylysteine (in combination with tigecycline), and ethanol...
  10. pmc N-acetylcysteine lock solution prevents catheter-associated bacteremia in rabbits
    Saima Aslam
    Division of Infectious Diseases, Department of Medicine, University of California, San Diego, California, USA
    Int J Artif Organs 35:893-7. 2012
    ..The primary purpose of this study was to determine the efficacy of N-acetylcysteine (NAC) lock solution in preventing peripheral bacteremia using an in vivo model of catheter-associated infection...
  11. doi request reprint Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices
    Maria D Hernandez
    Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Infect Control Hosp Epidemiol 30:190-2. 2009
    ..Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model...
  12. doi request reprint Treatment of clostridium difficile colitis in the critical care setting
    Daniel M Musher
    Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Crit Care Clin 24:279-91, viii. 2008
    ..This article emphasizes treatment of Clostridium difficile colitis, considers diagnostic techniques, and describes means for preventing the spread of this infection in the intensive care setting...
  13. doi request reprint Characteristics of biofilm on tunneled cuffed hemodialysis catheters in the presence and absence of clinical infection
    Venkataraman Ramanathan
    Renal Section, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Kidney Dis 60:976-82. 2012
    ..We studied biofilm formation on catheters from patients with and without bacteremia to identify the location of bacterial growth and measure biofilm thickness...
  14. pmc Mechanical integrity of hemodialysis catheters after exposure to a novel catheter lock solution
    Saima Aslam
    Section of Infectious Diseases and Center for Prostheses Infection, Baylor College of Medicine and The Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Infect Control Hosp Epidemiol 31:1124-9. 2010
    ..To examine the mechanical integrity of hemodialysis catheters after exposure to the combination of N-acetylcysteine, tigecycline, and heparin, compared with that of catheters exposed to heparin alone...
  15. ncbi request reprint An update on diagnosis, treatment, and prevention of Clostridium difficile-associated disease
    Saima Aslam
    Medical Service Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center, Room 4B 370, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Gastroenterol Clin North Am 35:315-35. 2006
    ..Biotherapy and vaccination are currently being explored as treatment options for patients who have recurrent disease. Greater attention should be paid to hospital infection control policies and restriction of broad-spectrum antibiotics...
  16. doi request reprint Risk factors for subsequent diagnosis of prosthetic joint infection
    Saima Aslam
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Infect Control Hosp Epidemiol 31:298-301. 2010
    ..25 [95% confidence interval {CI}, 1.3-3.8]), nonsurgical trauma to the prosthetic joint (OR, 21.5 [95% CI, 2.6-175.2]), and surgical site infection (OR, 5.25 [95% CI, 1.7-16.7])...
  17. pmc Bacterial translocation across ePTFE vascular graft surfaces
    Supriya Narasimhan
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Infect 60:486-90. 2010
    ..We assessed whether methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli could translocate through pores of ePTFE grafts...
  18. ncbi request reprint Nitazoxanide: clinical studies of a broad-spectrum anti-infective agent
    Saima Aslam
    Michael E DeBakey VA Medical Center, Section of Infectious Diseases, Room 4B 370, 2002 Holcombe Blvd, Houston, TX 77030, USA
    Future Microbiol 2:583-90. 2007
    ..Further investigations regarding its use in patients with AIDS is needed. Nitazoxanide represents a significant advance in the treatment of intestinal parasitic infections worldwide...
  19. pmc Prosthetic joint infections
    Saima Aslam
    Division of Infectious Diseases, Department of Medicine, University of California, San Diego, 200 W Arbor Drive, NARF 307, MC 8415, San Diego, CA, 92103, USA
    Curr Infect Dis Rep 14:551-7. 2012
    ....
  20. doi request reprint Epstein-Barr virus-related lymphoproliferative disorder induced by equine anti-thymocyte globulin therapy
    George M Viola
    Department of Medicine, Section of Infectious Diseases, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1460, Houston, TX 77030, USA
    Med Oncol 28:1604-8. 2011
    ..We review current concepts of EBV-PTLD, including risk factors, the potential for preemptive therapy and various management strategies...
  21. pmc Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters
    Saima Aslam
    Infectious Disease Section, Department of Medicine, Baylor College of Medicine, and Room 4B 370, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Antimicrob Agents Chemother 51:1556-8. 2007
    ..N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis...
  22. ncbi request reprint Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole
    Daniel M Musher
    Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Clin Infect Dis 40:1586-90. 2005
    ..In recent years, the rate of response to treatment with this drug has appeared to be much lower...

Research Grants2

  1. Analysis Of Group A Streptococcus-Saliva Interaction
    SAMUEL SHELBURNE; Fiscal Year: 2007
    ..GAS pharyngitis costs an estimated $15 billion/year in the US alone, and as the instigator of rheumatic fever, GAS remains, worldwide, the leading cause of preventable pediatric heart disease. ..