Joe A Arosh

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis
    Joe A Arosh
    Department of Integrative Biosciences, Texas A and M University, College Station, TX 77843
    Proc Natl Acad Sci U S A 112:9716-21. 2015
  2. doi request reprint PPARγ activation inhibits growth and survival of human endometriotic cells by suppressing estrogen biosynthesis and PGE2 signaling
    Dan I Lebovic
    PhD, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Mail Stop TAMU 4458, Texas A and M University, College Station, Texas 77843
    Endocrinology 154:4803-13. 2013
  3. pmc Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors
    Jone A Stanley
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Reprod Toxicol 32:112-23. 2011
  4. doi request reprint Early pregnancy induced expression of prostaglandin E2 receptors EP2 and EP4 in the ovine endometrium and regulated by interferon tau through multiple cell signaling pathways
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Mol Cell Endocrinol 348:211-23. 2012
  5. doi request reprint Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, United States
    Mol Cell Endocrinol 332:306-13. 2011
  6. doi request reprint Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, USA
    Biol Reprod 87:97. 2012
  7. ncbi request reprint Intrauterine inhibition of prostaglandin transporter protein blocks release of luteolytic PGF2alpha pulses without suppressing endometrial expression of estradiol or oxytocin receptor in ruminants
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 89:27. 2013
  8. pmc Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 88:77. 2013
  9. doi request reprint Transport of prostaglandin F(2alpha) pulses from the uterus to the ovary at the time of luteolysis in ruminants is regulated by prostaglandin transporter-mediated mechanisms
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Endocrinology 151:3326-35. 2010
  10. doi request reprint Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans
    Sakhila K Banu
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Fertil Steril 91:2199-209. 2009

Collaborators

Detail Information

Publications21

  1. pmc Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis
    Joe A Arosh
    Department of Integrative Biosciences, Texas A and M University, College Station, TX 77843
    Proc Natl Acad Sci U S A 112:9716-21. 2015
    ..Our novel findings provide a molecular and preclinical basis to formulate long-term nonestrogen or nonsteroidal therapy for endometriosis. ..
  2. doi request reprint PPARγ activation inhibits growth and survival of human endometriotic cells by suppressing estrogen biosynthesis and PGE2 signaling
    Dan I Lebovic
    PhD, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Mail Stop TAMU 4458, Texas A and M University, College Station, Texas 77843
    Endocrinology 154:4803-13. 2013
    ..Activation of PPARγ combined with inhibition of EP2 and EP4 may emerge as novel nonsteroidal therapeutic targets for endometriosis-associated pain and infertility, if clinically proven safe and efficacious. ..
  3. pmc Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors
    Jone A Stanley
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Reprod Toxicol 32:112-23. 2011
    ..Vitamin C mitigated the effects of CrVI. This study shows that CrVI causes cell cycle arrest in granulosa cells by altering cell cycle regulatory proteins with potential intervention by vitamin C...
  4. doi request reprint Early pregnancy induced expression of prostaglandin E2 receptors EP2 and EP4 in the ovine endometrium and regulated by interferon tau through multiple cell signaling pathways
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Mol Cell Endocrinol 348:211-23. 2012
    ..Our results indicate a role for EP2 and EP4-mediated PGE(2) signaling in endometrial functions and establishment of pregnancy in ruminants...
  5. doi request reprint Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, United States
    Mol Cell Endocrinol 332:306-13. 2011
    ..These novel findings provide an important molecular and cellular framework for further evaluation of selective inhibition of EP2 and EP4 as potential nonsteroidal therapy for endometriosis in childbearing-age women...
  6. doi request reprint Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, USA
    Biol Reprod 87:97. 2012
    ....
  7. ncbi request reprint Intrauterine inhibition of prostaglandin transporter protein blocks release of luteolytic PGF2alpha pulses without suppressing endometrial expression of estradiol or oxytocin receptor in ruminants
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 89:27. 2013
    ..PGT emerges as an important final component in the luteolytic machinery that controls the release of luteolytic pulses of PGF2(alpha) from the endometrium in sheep...
  8. pmc Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 88:77. 2013
    ....
  9. doi request reprint Transport of prostaglandin F(2alpha) pulses from the uterus to the ovary at the time of luteolysis in ruminants is regulated by prostaglandin transporter-mediated mechanisms
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Endocrinology 151:3326-35. 2010
    ..These findings also suggest that impaired PGT-mediated transport of PGF(2alpha) from the utero-ovarian vein into the ovarian artery could adversely influence luteolysis and thus affect fertility in ruminants...
  10. doi request reprint Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans
    Sakhila K Banu
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Fertil Steril 91:2199-209. 2009
    ..To determine whether a mixed population of immortalized human endometriosis epithelial and stromal cells is able to induce peritoneal endometriosis in nude mice...
  11. pmc Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53
    Sakhila K Banu
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Toxicol Appl Pharmacol 251:253-66. 2011
    ..Our study, for the first time provides a clear insight into the effect of CrVI on multiple pathways that lead to apoptosis of granulosa cells which could be mitigated by vitamin C...
  12. pmc Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring
    Kirthiram K Sivakumar
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, TAMU 4458, Texas A and M University, College Station, TX 77843, USA
    Dev Biol 388:22-34. 2014
    ..As a result of the above events, CrVI induced early reproductive senescence and decrease in litter size in F1 female progeny...
  13. doi request reprint Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Fertil Steril 93:2498-506. 2010
    ..To determine interactions between prostaglandin (PG) E(2) signaling and proliferation of endometriotic cells to increase our knowledge about PGE(2) signaling in the pathogenesis of endometriosis in humans...
  14. pmc Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes
    Jone A Stanley
    Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Free Radic Biol Med 61:179-96. 2013
    ..Vitamin C is able to protect the ovary from CrIII-induced oxidative stress and follicle atresia through protective effects on GCs rather than TCs. ..
  15. doi request reprint Interferon tau regulates PGF2alpha release from the ovine endometrial epithelial cells via activation of novel JAK/EGFR/ERK/EGR-1 pathways
    Sakhila K Banu
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Mol Endocrinol 24:2315-30. 2010
    ....
  16. pmc Edaravone mitigates hexavalent chromium-induced oxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the rat ovary in F1 offspring
    Jone A Stanley
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas
    Biol Reprod 91:12. 2014
    ..E₂ restored CrVI-induced depletion of glutathione peroxidase 1, catalase, thioredoxin 2, and peroxiredoxin 3 in the ovary. This is the first study to demonstrate the protective effects of EDA against any toxicant in the ovary...
  17. doi request reprint Intrauterine coadministration of ERK1/2 inhibitor U0126 inhibits interferon TAU action in the endometrium and restores luteolytic PGF2alpha pulses in sheep
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas
    Biol Reprod 91:46. 2014
    ..This novel IFNT-ERK1/2 signaling module needs to be explored in future studies to understand molecular and cellular mechanisms of IFNT action in endometrial LE in ruminants. ..
  18. pmc Identifying a Novel Role for X-prolyl Aminopeptidase (Xpnpep) 2 in CrVI-Induced Adverse Effects on Germ Cell Nest Breakdown and Follicle Development in Rats
    Sakhila K Banu
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas
    Biol Reprod 92:67. 2015
    ..We also found that Xpnpep2 inversely regulated the expression of Col1, Col3, and Col4 in all the developmental stages studied. Thus, CrVI advanced GCN breakdown and increased follicle atresia in F1 female progeny by targeting Xpnpep2. ..
  19. ncbi request reprint Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells
    Sakhila K Banu
    Department of Integrative Biosciences, Reproductive Endocrinology and Cell Signaling Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Fertil Steril 90:972-87. 2008
    ..To determine whether immortalized endometriotic cells can be used as potential models to unravel pathophysiology/pathogenesis of endometriosis in humans...
  20. doi request reprint Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms
    Sakhila K Banu
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Mol Endocrinol 23:1291-305. 2009
    ....
  21. doi request reprint Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats
    Sakhila K Banu
    Reproductive Endocrinology and Cell Signaling Laboratory, Texas A and M University, TAMU 4458, College Station, Texas 77843, USA
    Toxicol Appl Pharmacol 232:180-9. 2008
    ..Therefore, Cr(VI) toxicity could be a potential risk to the reproductive system in developing females, and vitamin C plays a protective role against Cr(VI)-induced ovotoxicity...