Frank C Arnett

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Attenuation of fibrosis in vitro and in vivo with SPARC siRNA
    Jiu Cun Wang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Arthritis Res Ther 12:R60. 2010
  2. ncbi request reprint The genetics of systemic sclerosis
    Randall W Johnson
    University of Texas Health Science Center, Department of Internal Medicine, 6431 Fannin MSB 5 260, Houston, TX 77030, USA
    Curr Rheumatol Rep 4:99-107. 2002
  3. pmc Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls
    Frank C Arnett
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston UTHSC H, 6431 Fannin Street, MSB 5 270, Houston, TX 77030, USA
    Ann Rheum Dis 69:822-7. 2010
  4. pmc Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston UTHSC H, Houston, TX 77030, USA
    J Autoimmun 34:155-62. 2010
  5. pmc Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis
    Maureen D Mayes
    The University of Texas Health Science Center at Houston, Houston, TX 77030, USA Electronic address
    Am J Hum Genet 94:47-61. 2014
  6. pmc Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis
    Sandeep K Agarwal
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Texas 77030, USA
    J Rheumatol 36:2715-23. 2009
  7. pmc Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines
    Pravitt Gourh
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Rheum 60:3794-806. 2009
  8. ncbi request reprint Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic, and behavioral factors
    Terry A McNearney
    Division of Rheumatology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1165, USA
    Arthritis Rheum 57:318-26. 2007
  9. pmc Systemic sclerosis and lupus: points in an interferon-mediated continuum
    Shervin Assassi
    University of Texas Health Science Center, Houston, TX, USA
    Arthritis Rheum 62:589-98. 2010
  10. ncbi request reprint Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis
    Pravitt Gourh
    University of Texas Health Science Center at Houston, TX 77030, USA
    Arthritis Rheum 54:3945-53. 2006

Research Grants

  1. Center for Clinical and Translational Sciences
    Frank Arnett; Fiscal Year: 2007
  2. Center for Clinical and Translational Sciences
    Frank Arnett; Fiscal Year: 2007
  3. Center for Clinical and Translational Sciences
    Frank Arnett; Fiscal Year: 2007
  4. ADMINISTRATIVE CORE
    Frank Arnett; Fiscal Year: 2007

Detail Information

Publications68

  1. pmc Attenuation of fibrosis in vitro and in vivo with SPARC siRNA
    Jiu Cun Wang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Arthritis Res Ther 12:R60. 2010
    ..The purpose of this study was to examine whether inhibition of SPARC can regulate collagen expression in vitro and in vivo, and subsequently attenuate fibrotic stimulation by bleomycin in mouse skin and lungs...
  2. ncbi request reprint The genetics of systemic sclerosis
    Randall W Johnson
    University of Texas Health Science Center, Department of Internal Medicine, 6431 Fannin MSB 5 260, Houston, TX 77030, USA
    Curr Rheumatol Rep 4:99-107. 2002
    ..Recent studies investigating polymorphisms in genes coding for extracellular matrix proteins and cell-signaling molecules implicate non-MHC areas in SSc pathogenesis. The data reviewed suggest that SSc is a multigenic complex disorder...
  3. pmc Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls
    Frank C Arnett
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston UTHSC H, 6431 Fannin Street, MSB 5 270, Houston, TX 77030, USA
    Ann Rheum Dis 69:822-7. 2010
    ....
  4. pmc Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston UTHSC H, Houston, TX 77030, USA
    J Autoimmun 34:155-62. 2010
    ..The current report sought to determine if polymorphisms in the C8orf13-BLK region (chromosome 8p23.1-B lymphoid tyrosine kinase), which is associated with SLE, are associated also with SSc...
  5. pmc Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis
    Maureen D Mayes
    The University of Texas Health Science Center at Houston, Houston, TX 77030, USA Electronic address
    Am J Hum Genet 94:47-61. 2014
    ....
  6. pmc Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis
    Sandeep K Agarwal
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Texas 77030, USA
    J Rheumatol 36:2715-23. 2009
    ..We investigated the possible association of IL23R with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis...
  7. pmc Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines
    Pravitt Gourh
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Rheum 60:3794-806. 2009
    ....
  8. ncbi request reprint Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic, and behavioral factors
    Terry A McNearney
    Division of Rheumatology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1165, USA
    Arthritis Rheum 57:318-26. 2007
    ..To determine the relative contributions of genetic, clinical, serologic, sociodemographic, and behavioral/psychological variables to early pulmonary involvement in the Genetics versus Environment in Scleroderma Outcome Study cohort...
  9. pmc Systemic sclerosis and lupus: points in an interferon-mediated continuum
    Shervin Assassi
    University of Texas Health Science Center, Houston, TX, USA
    Arthritis Rheum 62:589-98. 2010
    ..To investigate peripheral blood (PB) cell transcript profiles of systemic sclerosis (SSc) and its subtypes in direct comparison with systemic lupus erythematosus (SLE)...
  10. ncbi request reprint Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis
    Pravitt Gourh
    University of Texas Health Science Center at Houston, TX 77030, USA
    Arthritis Rheum 54:3945-53. 2006
    ....
  11. pmc Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, MSB 5 278, Houston, Texas 77030, USA
    Ann Rheum Dis 69:550-5. 2010
    ..Accordingly, the aim of the current study was to investigate the possible association of the TNFSF4 gene region with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis...
  12. pmc HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans
    Xiaodong Zhou
    University of Texas Health Science Center at Houston, Houston, TX, USA
    Arthritis Rheum 60:3807-14. 2009
    ..To identify systemic sclerosis (SSc) susceptibility loci via a genome-wide association study...
  13. ncbi request reprint Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts from the skin of patients with scleroderma
    Xiaodong Zhou
    University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Arthritis Rheum 54:2626-31. 2006
    ..The purpose of this study was to examine whether inhibition of SPARC with small interfering RNA (siRNA) can be used to ameliorate the overproduction of major extracellular matrix components in SSc fibroblasts...
  14. pmc IRF5 polymorphism predicts prognosis in patients with systemic sclerosis
    Roozbeh Sharif
    Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Ann Rheum Dis 71:1197-202. 2012
    ..The goal of this study was to investigate the impact of these gene variants on survival and severity of interstitial lung disease (ILD) in SSc...
  15. pmc Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
    Olga Gorlova
    Department of Epidemiology, M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 7:e1002178. 2011
    ..Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc...
  16. pmc Anti-fibrillarin antibody in African American patients with systemic sclerosis: immunogenetics, clinical features, and survival analysis
    Roozbeh Sharif
    Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Rheumatol 38:1622-30. 2011
    ..We examined the immunogenetic, clinical, and survival correlates of AFA in a large group of AA patients with SSc...
  17. pmc Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin M S B 5 278, Houston, TX 77030, USA
    Arthritis Res Ther 11:R147. 2009
    ..The current report sought to determine whether plasma cytokine profiles differ in SSc patients grouped according to these SSc-associated autoantibody subsets...
  18. ncbi request reprint Polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in systemic sclerosis
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, TX 77030, USA
    Am J Med 118:907-11. 2005
  19. pmc Clinical and genetic factors predictive of mortality in early systemic sclerosis
    Shervin Assassi
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Rheum 61:1403-11. 2009
    ..To investigate the clinical and genetic variables at initial presentation that predict survival in the Genetics versus Environment in Scleroderma Outcome Study (GENISOS) cohort...
  20. pmc Autoimmune diseases and autoantibodies in the first degree relatives of patients with systemic sclerosis
    Rajpreet K Arora-Singh
    Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX, USA
    J Autoimmun 35:52-7. 2010
    ....
  21. pmc Separate influences of birth order and gravidity/parity on the development of systemic sclerosis
    Tonya Cockrill
    University of Texas Health Science Center at Houston, TX 77030, USA
    Arthritis Care Res (Hoboken) 62:418-24. 2010
    ..In order to better evaluate these influences, we studied the association of birth order and gravidity/parity as risk factors for systemic sclerosis (SSc; scleroderma)...
  22. pmc Cigarette smoking is not a risk factor for systemic sclerosis
    Prateek Chaudhary
    University of Texas Health Science Center at Houston, Houston, TX, USA
    Arthritis Rheum 63:3098-102. 2011
    ..To investigate the association of cigarette smoking with susceptibility to systemic sclerosis (SSc) in a large, well-defined patient population...
  23. pmc Osteopontin in systemic sclerosis and its role in dermal fibrosis
    Minghua Wu
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Invest Dermatol 132:1605-14. 2012
    ..Finally, TGF-β production by OPN-deficient macrophages was reduced compared with WT. These data demonstrate an important role for OPN in the development of dermal fibrosis and suggest that it may be a new therapeutic target in SSc...
  24. pmc Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts
    Xiaodong Zhou
    Division of Rheumatology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Res Ther 13:R128. 2011
    ..The aims of this study were to examine the catalytic function and sumoylation of topo I in the nuclei of SSc fibroblasts, a major cell type involved in the fibrotic process...
  25. ncbi request reprint Clinical, immunologic, and genetic features of familial systemic sclerosis
    Shervin Assassi
    University of Texas Health Science Center, Houston, TX 77030, USA
    Arthritis Rheum 56:2031-7. 2007
    ....
  26. ncbi request reprint Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-beta pathway to recapitulate the "scleroderma phenotype"
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center, Houston 77030, USA
    J Immunol 175:4555-60. 2005
    ....
  27. pmc Determinants of work disability in patients with systemic sclerosis: a longitudinal study of the GENISOS cohort
    Roozbeh Sharif
    Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Semin Arthritis Rheum 41:38-47. 2011
    ..We hypothesized that WD in systemic sclerosis (SSc) is a function of demographic, clinical, and psychosocial factors...
  28. pmc Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Houston, 6431 Fannin, Houston, TX 77030, USA
    Arthritis Res Ther 12:R166. 2010
    ....
  29. pmc Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients
    Shervin Assassi
    The University of Texas Health Science Center at Houston, 6431 Fannin, MSB 5 232, Houston, TX 77030, USA
    J Rheumatol 36:2250-6. 2009
    ..Further, to assess the association of SSc-related antibodies with hepatic parameter abnormalities...
  30. doi request reprint Genetics and genomic studies in scleroderma (systemic sclerosis)
    Sandeep K Agarwal
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 6431 Fannin, MSB 5 270, Houston, TX 77030, USA
    Rheum Dis Clin North Am 34:17-40; v. 2008
    ..These studies implicate potential pathogenetic mechanisms involved in scleroderma, which, it is hoped, may translate into clinical utility, including determination of disease risk, diagnosis, prognosis, and novel therapeutics...
  31. pmc Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5
    Shervin Assassi
    Department of Medicine, Division of Rheumatology, University of Texas Health Science Center, Houston, TX 77030, USA
    J Rheumatol 38:87-98. 2011
    ..to identify differentially expressed genes in peripheral blood cells (PBC) of patients with ankylosing spondylitis (AS) relative to healthy controls and controls with systemic inflammation...
  32. pmc Differential dynamic properties of scleroderma fibroblasts in response to perturbation of environmental stimuli
    Momiao Xiong
    Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston UTHSC H, Houston, Texas, USA
    PLoS ONE 3:e1693. 2008
    ..Our findings may open a new avenue in exploring the functions of cells and mechanism operative in disease development...
  33. ncbi request reprint Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor beta1 in cultured normal human fibroblasts
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Arthritis Rheum 52:257-61. 2005
    ..The purpose of this study was to examine whether specific inhibition of SPARC can influence the expression of type I collagen and ameliorate the profibrotic activity of TGFbeta1 on normal human fibroblasts...
  34. pmc Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts
    Sandeep K Agarwal
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 6431 Fannin Avenue, Houston, TX 77030, USA
    Arthritis Res Ther 13:R3. 2011
    ..Therefore, we investigated the regulation of TLR expression on dermal fibroblasts by IFN...
  35. ncbi request reprint Classification analysis of the transcriptosome of nonlesional cultured dermal fibroblasts from systemic sclerosis patients with early disease
    Filemon K Tan
    Department of Internal Medicine, University of Texas at Houston Medical School, 77030, USA
    Arthritis Rheum 52:865-76. 2005
    ....
  36. pmc Can serum surfactant protein D or CC-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis?
    Mona Elhaj
    University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Rheumatol 40:1114-20. 2013
    ..To examine the predictive significance of 2 pneumoproteins, surfactant protein D (SP-D) and CC-chemokine ligand 18 (CCL18), for the course of systemic sclerosis (SSc)-related interstitial lung disease...
  37. ncbi request reprint cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Med Sci Monit 10:BR191-7. 2004
    ..This study was to use gene microarray analysis of muscle biopsies from PM and DM patients to obtain a comprehensive view of molecules participating in disease pathogenesis...
  38. pmc Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus
    Hui Wu
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:3961-6. 2007
    ..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus...
  39. pmc Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis
    David R Karp
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Hum Mol Genet 19:707-19. 2010
    ....
  40. pmc Characterization of the inflammatory cells in ascending thoracic aortic aneurysms in patients with Marfan syndrome, familial thoracic aortic aneurysms, and sporadic aneurysms
    Rumin He
    Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Thorac Cardiovasc Surg 136:922-9, 929.e1. 2008
    ..This study sought to characterize the inflammatory infiltrate in ascending thoracic aortic aneurysm in patients with Marfan syndrome, familial thoracic aortic aneurysm, or nonfamilial thoracic aortic aneurysm...
  41. ncbi request reprint Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Houston Medical School, 6431 Fannin, MSB 5 270, Houston, TX 77030, USA
    Arthritis Rheum 46:2990-9. 2002
    ..SPARC (secreted protein, acidic and rich in cysteine) regulates the deposition or assembly of ECM components. The aim of this study was to investigate the role of SPARC in SSc susceptibility by functional and genetic association studies...
  42. ncbi request reprint Familiality and co-occurrence of clinical features of systemic lupus erythematosus
    Betty P Tsao
    Division of Rheumatology, Department of Medicine, Rehabilitation Center, Room 32 59, University of California Los Angeles School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 46:2678-85. 2002
    ..To evaluate familiality of 15 clinical and laboratory features in systemic lupus erythematosus (SLE)-affected sibpairs, and to estimate correlations with the age at SLE diagnosis in affected sibpairs and parent-offspring pairs...
  43. ncbi request reprint A systems biology approach to genetic studies of complex diseases
    Momiao Xiong
    Human Genetics Center, University of Texas School of Public Health, Houston, 77030, USA
    FEBS Lett 579:5325-32. 2005
    ..To prove the concept in principle, the proposed approach is applied to genetic studies of the autoimmune disease scleroderma or systemic sclerosis...
  44. ncbi request reprint Polymorphisms beta2-glycoprotein I: phospholipid binding and multimeric structure
    Francisca C Gushiken
    Division of Thrombosis Research, Department of Medicine, University of Texas Health Science Center, Houston, USA
    Thromb Res 108:175-80. 2002
    ..In conclusion, the normal cardiolipin binding in heterozygous state for mutations at phospholipid-binding domain may be due to the multimeric structure of beta2-glycoprotein I...
  45. ncbi request reprint Autoantibodies to the epidermal growth factor receptor in systemic sclerosis, lupus, and autoimmune mice
    Stephanie Planque
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Internal Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    FASEB J 17:136-43. 2003
    ..Short-lived but strong inhibition of cellular DNA synthesis was observed in the presence of the autoantibodies. We concluded that autoantibody responses to EGFR hold the potential of fulfilling a pathogenic role in autoimmune disease...
  46. ncbi request reprint Spondyloarthritis: update on pathogenesis and management
    John D Reveille
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Houston Health Science Center, USA
    Am J Med 118:592-603. 2005
    ..Their high cost and considerable side effect profile, however, have necessitated the establishment of guidelines for their use in these diseases in order to target the patient in whom they are likely to have the most benefit...
  47. ncbi request reprint A mariner with crippling arthritis and bleeding eyes
    Frank C Arnett
    Department of Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
    Am J Med Sci 332:123-30. 2006
    ..quot; He died shortly before his 55 birthday "quite paralyzed and bedridden." Who was he, and what was the likely etiology of his disorder?..
  48. ncbi request reprint Association of 5'-untranslated region of the Fibrillin-1 gene with Japanese scleroderma
    Takao Kodera
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gene 297:61-7. 2002
    ..Sequence analysis revealed eight coding and 14 non-coding SNPs and other polymorphisms. Among them, a CT insertion in the 5'-untranslated region of exon A had a significant negative association with disease...
  49. ncbi request reprint Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groups
    Kakali Sarkar
    National Institute of Environmental Health Sciences, NIH, DHHS, Bethesda, MD 20892, USA
    Arthritis Rheum 52:2433-8. 2005
    ..To assess possible seasonal patterns in the onset of polymyositis (PM) and dermatomyositis (DM)...
  50. ncbi request reprint The complex genetics of scleroderma
    S Sohail Ahmed
    Am J Med 112:584-6. 2002
  51. ncbi request reprint Genetic signatures of pre-expansion bottleneck in the Choctaw population of Oklahoma
    Ning Wang
    Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Phys Anthropol 124:373-9. 2004
    ..Taken together, these observations are consistent with a signature of the recent population size expansion of the Choctaws, preceded by bottleneck event(s)...
  52. ncbi request reprint Genotypic analysis of the TGF beta-509 allele in patients with systemic lupus erythematosus and Sjogren's syndrome
    Tina M Caserta
    Department of Anatomy and Physiology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, 042 Biological Sciences Building, Dayton, OH 45435, USA
    Ann Genet 47:359-63. 2004
    ..Genomic PCR and RFLP analysis of a 441 bp sequence encompassing the -509 polymorphism of the TGFbeta gene indicated that there were no statistically significant clinical correlations...
  53. ncbi request reprint Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles
    Xiaodong Zhou
    University of Texas Medical School at Houston, USA
    Arthritis Rheum 52:3305-14. 2005
    ..To discover genetic versus nongenetic molecular pathways important to the pathogenesis of SSc, we compared global gene expression patterns in twins discordant for SSc...
  54. ncbi request reprint Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Rockville, MD 20892 0958, USA
    Medicine (Baltimore) 84:338-49. 2005
    ..These variations in associated HLA polymorphisms may reflect responses to unique environmental triggers resulting in the tissue pathospecificity and distinct clinicopathologic syndromes of the IIM...
  55. ncbi request reprint Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:111-27. 2006
    ....
  56. ncbi request reprint Fibrillin 1 abnormalities in dermal fibroblast cultures from first-degree relatives of patients with systemic sclerosis (scleroderma)
    Debra D Wallis
    University of Texas Houston Medical School
    Arthritis Rheum 50:329-32. 2004
  57. ncbi request reprint Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies
    S Sohail Ahmed
    Boston University School of Medicine, Arthritis Center E 5, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 54:2250-62. 2006
    ....
  58. ncbi request reprint Is scleroderma an autoantibody mediated disease?
    Frank C Arnett
    Curr Opin Rheumatol 18:579-81. 2006
    ..Such reports provide novel avenues to pursue in understanding this enigmatic disease...
  59. ncbi request reprint Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma
    Sou Pan Wu
    Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    Arthritis Rheum 54:3661-9. 2006
    ..To investigate the potential association between functional polymorphisms in the gene for the innate mediator, macrophage migration inhibitory factor (MIF), and the clinical expression of systemic sclerosis (SSc)...
  60. ncbi request reprint HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Bethesda, Maryland 20892, USA
    Arthritis Rheum 54:3670-81. 2006
    ..To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM...
  61. ncbi request reprint Examination of the possible role of biologically relevant genes around FBN1 in systemic sclerosis in the Choctaw population
    Filemon K Tan
    Arthritis Rheum 48:3295-6. 2003
  62. ncbi request reprint CTGF polymorphism associated with systemic sclerosis
    Pravitt Gourh
    N Engl J Med 358:308-9; author reply 309. 2008
  63. doi request reprint Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis
    Daniel Kim
    University of Washington, Seattle, WA 98195, USA
    Arthritis Rheum 58:2163-73. 2008
    ..The aim of this study was to determine whether SSc patient sera could induce IFNalpha and whether IFNalpha induction was associated with specific autoantibodies and/or clinical features of the disease...
  64. ncbi request reprint Alu insertion polymorphisms in Native Americans and related Asian populations
    Jaqueline Battilana
    Centro de Biologia Genômica e Molecular, Pontificia Universidade Catolica do Rio Grande do Sul, Faculdade de Biociencias, Porto Alegre, RS, Brazil
    Ann Hum Biol 33:142-60. 2006
    ..Alu insertions provide useful markers for the study of inter-population affinities and historical processes, but data on these systems are not numerous in Native Americans and related populations...
  65. ncbi request reprint Genome-wide association study for regions of systemic sclerosis susceptibility in a Choctaw Indian population with high disease prevalence
    Xiaodong Zhou
    University of Texas Houston Medical School
    Arthritis Rheum 48:2585-92. 2003
    ..The aim of this study was to localize chromosome regions associated with susceptibility to SSc in a relatively isolated and homogeneous population of Choctaw Indians with a high prevalence of SSc...
  66. ncbi request reprint Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome
    Sanil J Manavalan
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:187-98. 2004
    ..g., due to genomic deletion) has functional significance. We examined this question in relation to a known 21.6-kb insertion/deletion-related polymorphism (IDRP) in the human BV locus...
  67. ncbi request reprint The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes
    Kristi L Rupert
    Children s Research Institute, Department of Pediatrics and Ohio State Biochemistry Program, Ohio State University, Columbus, OH 43205, USA
    J Immunol 169:1570-8. 2002
    ..Hence, complete C4 deficiency is one of the most penetrant genetic risk factors for human systemic lupus erythematosus...
  68. ncbi request reprint Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus
    Betty P Tsao
    Department of Medicine, Rehabilitation Center, Room 32 59, 1000 Veteran Avenue, UCLA School of Medicine, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 46:2928-36. 2002
    ....

Research Grants7

  1. Center for Clinical and Translational Sciences
    Frank Arnett; Fiscal Year: 2007
    ..abstract_text> ..
  2. Center for Clinical and Translational Sciences
    Frank Arnett; Fiscal Year: 2007
    ..abstract_text> ..
  3. Center for Clinical and Translational Sciences
    Frank Arnett; Fiscal Year: 2007
    ..abstract_text> ..
  4. ADMINISTRATIVE CORE
    Frank Arnett; Fiscal Year: 2007
    ..Mayes who also is Associate Director of the CORT), as well as with other investigators and research projects ongoing at this and other institutions. A Data Sharing Plan is proposed as well as a modest Enrichment Program. ..