Cesar A Arias

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc The rise of the Enterococcus: beyond vancomycin resistance
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Re Emerging Pathogens, Houston, Texas 77030, USA
    Nat Rev Microbiol 10:266-78. 2012
  2. pmc Genetic basis for in vivo daptomycin resistance in enterococci
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
    N Engl J Med 365:892-900. 2011
  3. doi request reprint Emergence and management of drug-resistant enterococcal infections
    Cesar A Arias
    Center for the Study of Emerging and Re Emerging Pathogens, Division of Infectious Diseases, and Department of Internal Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Expert Rev Anti Infect Ther 6:637-55. 2008
  4. pmc A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant Enterococcus faecalis
    José M Munita
    Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, Texas, USA
    Antimicrob Agents Chemother 57:2831-3. 2013
  5. pmc Correlation between mutations in liaFSR of Enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints
    José M Munita
    Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, Texas, USA
    Antimicrob Agents Chemother 56:4354-9. 2012
  6. ncbi request reprint Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster
    Cesar A Arias
    Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, The University of Texas Medical School, Houston, TX 77030, USA
    Clin Infect Dis 45:1343-6. 2007
  7. pmc Analysis of clonality and antibiotic resistance among early clinical isolates of Enterococcus faecium in the United States
    Jessica R Galloway-Peña
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    J Infect Dis 200:1566-73. 2009
  8. pmc The hylEfm gene in pHylEfm of Enterococcus faecium is not required in pathogenesis of murine peritonitis
    Diana Panesso
    Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Reemerging Pathogens, Houston, TX, USA
    BMC Microbiol 11:20. 2011
  9. pmc Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Antimicrob Agents Chemother 53:4240-6. 2009
  10. ncbi request reprint Evaluation of ceftobiprole medocaril against Enterococcus faecalis in a mouse peritonitis model
    Cesar A Arias
    Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 2 112, Houston, TX 77030, USA
    J Antimicrob Chemother 60:594-8. 2007

Collaborators

Detail Information

Publications22

  1. pmc The rise of the Enterococcus: beyond vancomycin resistance
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Re Emerging Pathogens, Houston, Texas 77030, USA
    Nat Rev Microbiol 10:266-78. 2012
    ..Finally, we review the most important mechanisms of resistance to the antibiotics that are used to treat vancomycin-resistant enterococci...
  2. pmc Genetic basis for in vivo daptomycin resistance in enterococci
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
    N Engl J Med 365:892-900. 2011
    ..However, the emergence of resistance to daptomycin during therapy threatens its usefulness...
  3. doi request reprint Emergence and management of drug-resistant enterococcal infections
    Cesar A Arias
    Center for the Study of Emerging and Re Emerging Pathogens, Division of Infectious Diseases, and Department of Internal Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Expert Rev Anti Infect Ther 6:637-55. 2008
    ....
  4. pmc A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant Enterococcus faecalis
    José M Munita
    Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, Texas, USA
    Antimicrob Agents Chemother 57:2831-3. 2013
    ....
  5. pmc Correlation between mutations in liaFSR of Enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints
    José M Munita
    Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, Texas, USA
    Antimicrob Agents Chemother 56:4354-9. 2012
    ..Concomitant susceptibility testing on BHIA may be useful for identifying these E. faecium first-step mutants. Our results also suggest that the current DAP breakpoint for E. faecium may need to be reevaluated...
  6. ncbi request reprint Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster
    Cesar A Arias
    Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, The University of Texas Medical School, Houston, TX 77030, USA
    Clin Infect Dis 45:1343-6. 2007
    ..The infecting organism exhibited in vivo emergence of a vancomycin-susceptible subpopulation lacking vanA. Treatment with a combination of high-dose daptomycin, gentamicin, and high-dose ampicillin cleared the infection...
  7. pmc Analysis of clonality and antibiotic resistance among early clinical isolates of Enterococcus faecium in the United States
    Jessica R Galloway-Peña
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    J Infect Dis 200:1566-73. 2009
    ..The Enterococcus faecium genogroup, referred to as clonal complex 17 (CC17), seems to possess multiple determinants that increase its ability to survive and cause disease in nosocomial environments...
  8. pmc The hylEfm gene in pHylEfm of Enterococcus faecium is not required in pathogenesis of murine peritonitis
    Diana Panesso
    Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Reemerging Pathogens, Houston, TX, USA
    BMC Microbiol 11:20. 2011
    ..faecium, although its direct contribution to virulence has not been investigated. Here, we constructed mutants of the hylEfm-region and we evaluated their effect on virulence using a murine peritonitis model...
  9. pmc Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Antimicrob Agents Chemother 53:4240-6. 2009
    ..Our findings indicate that the acquisition of the hyl(Efm) plasmids may explain, at least in part, the recent successful emergence of some E. faecium strains as nosocomial pathogens...
  10. ncbi request reprint Evaluation of ceftobiprole medocaril against Enterococcus faecalis in a mouse peritonitis model
    Cesar A Arias
    Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 2 112, Houston, TX 77030, USA
    J Antimicrob Chemother 60:594-8. 2007
    ..The objective of this study was to assess the in vivo activity of ceftobiprole against four strains of E. faecalis, including beta-lactamase- producing (Bla+) and vancomycin-resistant strains...
  11. pmc Whole-genome analysis of a daptomycin-susceptible enterococcus faecium strain and its daptomycin-resistant variant arising during therapy
    Truc T Tran
    Department of Internal Medicine, Division of Infectious Diseases, University of Houston College of Pharmacy, Houston, Texas, USA
    Antimicrob Agents Chemother 57:261-8. 2013
    ..Our results suggest that, apart from the LiaFSR system, the essential YycFG system is likely to be an important mediator of DAP resistance in some E. faecium strains...
  12. pmc Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis, including beta-lactamase-producing and vancomycin-resistant isolates
    Cesar A Arias
    University of Texas Medical School, Houston, TX 77030, USA
    Antimicrob Agents Chemother 51:2043-7. 2007
    ..In conclusion, ceftobiprole exhibited good in vitro activity against E. faecalis, including Bla(+) and vancomycin-resistant strains, and exhibited synergism with aminoglycosides against selected isolates...
  13. pmc Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?
    Truc T Tran
    University of Houston College of Pharmacy, Department of Internal Medicine, Division of Infectious Diseases, Houston, Texas, USA
    Antimicrob Agents Chemother 56:3461-4. 2012
    ..The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin...
  14. pmc A trilocus sequence typing scheme for hospital epidemiology and subspecies differentiation of an important nosocomial pathogen, Enterococcus faecalis
    Shahreen A Chowdhury
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    J Clin Microbiol 47:2713-9. 2009
    ..In conclusion, the TLST scheme described here was shown to be successful for investigating short-term epidemiology in a hospital setting and may provide an alternative to MLST for discriminating isolates...
  15. pmc Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci
    Milya Davlieva
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, USA
    Antimicrob Agents Chemother 57:289-96. 2013
    ..As mutations to Cls are part of a larger genomic adaptation process, increased Cls activity is likely to be highly epistatic with other changes to facilitate DAP resistance...
  16. pmc Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis
    Lorena Diaz
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
    Antimicrob Agents Chemother 56:3917-22. 2012
    ..The cfr gene was flanked by IS256-like sequences both upstream and downstream. This is the first characterization of the potential horizontal transferability of the cfr gene from a human linezolid-resistant isolate of E. faecalis...
  17. pmc Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
    Agathe Bourgogne
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Genome Biol 9:R110. 2008
    ..Enterococcus faecalis has emerged as a major hospital pathogen. To explore its diversity, we sequenced E. faecalis strain OG1RF, which is commonly used for molecular manipulation and virulence studies...
  18. doi request reprint Unmet needs and prospects for oritavancin in the management of vancomycin-resistant enterococcal infections
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School, 6431 Fannin St, Houston, TX 77030, USA
    Clin Infect Dis 54:S233-8. 2012
    ....
  19. doi request reprint The Majority of a Collection of U.S. Endocarditis Enterococcus faecalis Isolates Obtained from 1974 to 2004 Lack Capsular Genes and Belong to Diverse, Non-Hospital-Associated Lineages
    Shahreen A Chowdhury
    Center for the Study of Emerging and Re Emerging Pathogens, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, Texas, USA
    J Clin Microbiol 52:549-56. 2014
    ..faecalis endocarditis, these results indicate that nonencapsulated strains belonging to non-hospital-associated lineages were predominant among endocarditis E. faecalis isolates recovered during this time period. ..
  20. pmc Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance
    Corwin Miller
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, USA
    Antimicrob Agents Chemother 57:5373-83. 2013
    ....
  21. ncbi request reprint Enterococcal endocarditis: can we win the war?
    José M Munita
    Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, TX, USA
    Curr Infect Dis Rep 14:339-49. 2012
    ..Although it appears that we are winning the war against E. faecalis, the battle rages on against isolates of multidrug-resistant E. faecium...
  22. pmc Rapid identification of Enterococcus hirae and Enterococcus durans by PCR and detection of a homologue of the E. hirae mur-2 Gene in E. durans
    Cesar A Arias
    Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, TX 77030, USA
    J Clin Microbiol 44:1567-70. 2006
    ..A combination of murG and mur-2(ed) primers in a multiplex PCR assay differentiated E. hirae from E. durans in all cases. PCR using these primers appears to be a rapid alternative for identification of E. hirae and E. durans isolates...