Haruhiko Akiyama

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Interactions between Sox9 and beta-catenin control chondrocyte differentiation
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:1072-87. 2004
  2. pmc Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:14665-70. 2005
  3. pmc Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6502-7. 2004
  4. ncbi request reprint The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Matrix Biol 23:499-505. 2005
  5. pmc Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
    Yuko Mori-Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9360-5. 2003
  6. pmc Sertoli cell behaviors in developing testis cords and postnatal seminiferous tubules of the mouse
    Liesl Nel-Themaat
    Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, 77005, USA
    Biol Reprod 84:342-50. 2011
  7. pmc The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 16:2813-28. 2002
  8. pmc Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 23:1900-13. 2009
  9. doi request reprint Illuminating testis morphogenesis in the mouse
    Liesl Nel-Themaat
    Department of Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Androl 31:5-10. 2010
  10. pmc Lung epithelial branching program antagonizes alveolar differentiation
    Daniel R Chang
    Department of Pulmonary Medicine and Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030
    Proc Natl Acad Sci U S A 110:18042-51. 2013

Collaborators

Detail Information

Publications23

  1. pmc Interactions between Sox9 and beta-catenin control chondrocyte differentiation
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:1072-87. 2004
    ..Our results strongly suggest that chondrogenesis is controlled by interactions between Sox9 and the Wnt/beta-catenin signaling pathway...
  2. pmc Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:14665-70. 2005
    ..Thus, our results strongly suggest that all osteo-chondroprogenitor cells, as well as progenitors in a variety of tissues, are derived from Sox9-expressing precursors during mouse embryogenesis...
  3. pmc Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6502-7. 2004
    ..We propose that loss of Sox9 inhibits epithelial-mesenchymal transformation after delamination and initial migration, but before definitive mesenchymal transformation...
  4. ncbi request reprint The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Matrix Biol 23:499-505. 2005
    ..Our in vitro studies indicate that the ubiquitin-proteasome proteolytic system degrades Sox9 and regulates its transcriptional activity...
  5. pmc Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
    Yuko Mori-Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9360-5. 2003
    ..We hypothesize that these cells change their cell fate and acquire the ability to differentiate into osteoblasts. We conclude that Sox9 is required for the determination of the chondrogenic lineage in CNC cells...
  6. pmc Sertoli cell behaviors in developing testis cords and postnatal seminiferous tubules of the mouse
    Liesl Nel-Themaat
    Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, 77005, USA
    Biol Reprod 84:342-50. 2011
    ..This revealed the physical relationship between Sertoli and germ cells in developing testis cords and provided a novel perspective on Sertoli cell development...
  7. pmc The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 16:2813-28. 2002
    ..We conclude that Sox9 is required during sequential steps of the chondrocyte differentiation pathway...
  8. pmc Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 23:1900-13. 2009
    ..Our results demonstrate that RB is essential for proper terminal differentiation of Sertoli cells...
  9. doi request reprint Illuminating testis morphogenesis in the mouse
    Liesl Nel-Themaat
    Department of Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Androl 31:5-10. 2010
    ..Transgenic mice that express fluorescent protein reporters offer new opportunities for time-lapse imaging to visualize live cells and their behaviors during testis differentiation and morphogenesis...
  10. pmc Lung epithelial branching program antagonizes alveolar differentiation
    Daniel R Chang
    Department of Pulmonary Medicine and Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030
    Proc Natl Acad Sci U S A 110:18042-51. 2013
    ..The resulting temporal delay of differentiation by the branching program may provide new insights to lung immaturity in preterm neonates and the increase in organ complexity during evolution. ..
  11. pmc Morphometric analysis of testis cord formation in Sox9-EGFP mice
    Liesl Nel-Themaat
    Department of Genetics, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Dyn 238:1100-10. 2009
    ..These results suggest that cord formation is a highly dynamic process that subsequently becomes refined to establish the final number of seminiferous tubule precursors...
  12. doi request reprint Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice
    Patrick P Lin
    Department of Orthopaedic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Carcinogenesis 30:1789-95. 2009
    ..Deletion of Rb does not initiate sarcoma formation in mice, but it accelerates formation of both soft tissue sarcomas and OS...
  13. ncbi request reprint Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, Kyoto 606 8507, Japan
    Matrix Biol 26:224-33. 2007
    ..These results provide evidence that Sox9 induces ectopic chondrogenesis in mesenchymal cells and strongly suggest that its expression may be regulated by Hox genes during limb bud development...
  14. doi request reprint Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud
    Jianjian Zhu
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Dev Cell 14:624-32. 2008
    ..The progressive loss of digits upon successively earlier Shh removal mirrors this alternating sequence and highlights Shh's role in cell expansion to produce the normal digit complement...
  15. pmc SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells
    Eriko Sumi
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Am J Pathol 170:1854-64. 2007
    ..These results indicate that SOX9 is essential for Col4a2 expression in mesangial cells and might be involved in the accumulation of alpha2(IV) collagen in experimental nephritis...
  16. ncbi request reprint Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass
    Rika Nakanishi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Bone Miner Res 23:271-7. 2008
    ..Transgenic mice overexpressing Sfrp4 in osteoblasts were established. These mice exhibited low bone mass caused by a decrease in bone formation...
  17. pmc Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation
    Hiroaki Kimura
    Department of Orthopaedics, Kyoto University, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 356:935-41. 2007
    ..Our results indicate that TN-W is a novel marker of preosteoblasts in early stage of osteogenesis, and that TN-W inhibits cell proliferation and differentiation of preosteoblasts mediated by canonical Wnt signaling...
  18. ncbi request reprint Expression analysis of actin-related genes as an underlying mechanism for mood disorders
    Noriaki Nakatani
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Biochem Biophys Res Commun 352:780-6. 2007
    ..These data suggest that the balance of actin dynamics might be altered towards actin depolymerization in mood disorders...
  19. ncbi request reprint Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein
    Kiyoko S Murayama
    Department of Demyelinating Disease and Ageing, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Eur J Neurosci 24:1237-44. 2006
    ..Because RTN3 and RTN4-B/C are substantially expressed in neural tissues, our findings suggest that they play important roles in the regulation of BACE1 function and Abeta production in the brain...
  20. ncbi request reprint [Sox family regulate chondrogenesis]
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University
    Clin Calcium 16:368- 72. 2006
    ..Indeed, mouse genetics approaches clearly indicate that these Sox family transcription factors are essential for chondrogenesis...
  21. ncbi request reprint Transforming growth factor-beta1 mediates the effects of low-intensity pulsed ultrasound in chondrocytes
    Shogo Mukai
    Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan
    Ultrasound Med Biol 31:1713-21. 2005
    ..These results indicate that LIPUS promotes the proliferation and retains the differentiation state of chondrocytes in the aggregate culture and that TGF-beta1 plays an important role in mediating the LIPUS effects in chondrocytes...
  22. ncbi request reprint Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, 156 8585 Tokyo, Japan
    Acta Neuropathol 105:489-98. 2003
    ..Advanced modification may expose the MBD in brain tissues of AD and PiD. It is suggested that the processing of abnormally accumulated tau characterizes the pathophysiology of each tauopathy...
  23. ncbi request reprint Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases
    Takashi Togo
    Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    J Neuroimmunol 124:83-92. 2002
    ..Antigen-triggered clonal expansion is not likely to take place. Local inflammatory conditions might cause accumulation and activation of T cells in the AD brain...