B B Aggarwal

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis
    S K Manna
    Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 164:5156-66. 2000
  2. pmc Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB
    B B Aggarwal
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, PO Box 143, Houston, Texas 77030, USA
    Ann Rheum Dis 59:i6-16. 2000
  3. ncbi request reprint Apoptosis and nuclear factor-kappa B: a tale of association and dissociation
    B B Aggarwal
    Department of Bioimmunotherapy, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Biochem Pharmacol 60:1033-9. 2000
  4. ncbi request reprint Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation
    M M Chaturvedi
    Cytokine Research Section, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 272:30129-34. 1997
  5. ncbi request reprint Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:7724-31. 1999
  6. ncbi request reprint Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation
    S Majumdar
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 167:2911-20. 2001
  7. ncbi request reprint Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines
    A Mukhopadhyay
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 20:7597-609. 2001
  8. ncbi request reprint Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis
    S K Manna
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 165:5962-9. 2000
  9. ncbi request reprint Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase
    A Mukhopadhyay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:15978-81. 1999
  10. ncbi request reprint VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth
    V Haridas
    Department of Molecular Oncology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Oncogene 18:6496-504. 1999

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis
    S K Manna
    Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 164:5156-66. 2000
    ..Overall, our results demonstrate that p56lck plays a critical role in the activation of NF-kappa B, AP-1, JNK, and apoptosis by HIV-tat protein but has minimal or no role in activation of these responses by TNF...
  2. pmc Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB
    B B Aggarwal
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, PO Box 143, Houston, Texas 77030, USA
    Ann Rheum Dis 59:i6-16. 2000
    ..Inhibitors of TNF signalling have therapeutic value as indicated by the approval of the soluble TNF receptors and anti-TNF antibodies for rheumatoid arthritis and for inflammatory bowl disease...
  3. ncbi request reprint Apoptosis and nuclear factor-kappa B: a tale of association and dissociation
    B B Aggarwal
    Department of Bioimmunotherapy, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Biochem Pharmacol 60:1033-9. 2000
    ..Thus, inhibitors of NF-kappa B activation have a potential in overcoming resistance to apoptosis induced by various agents. The evidence for and against such a notion is discussed...
  4. ncbi request reprint Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation
    M M Chaturvedi
    Cytokine Research Section, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 272:30129-34. 1997
    ..Overall, our results demonstrate that sanguinarine is a potent suppressor of NF-kappaB activation and it acts at a step prior to IkappaBalpha phosphorylation...
  5. ncbi request reprint Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:7724-31. 1999
    ....
  6. ncbi request reprint Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation
    S Majumdar
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 167:2911-20. 2001
    ..Overall, our results clearly demonstrate that MTX suppresses NF-kappaB activation through the release of adenosine, which may contribute to the role of MTX in anti-inflammatory, immunomodulatory, and antiproliferative effects...
  7. ncbi request reprint Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines
    A Mukhopadhyay
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 20:7597-609. 2001
    ..Overall, our results suggest that NF-kappaB and AP-1 may play a role in the survival of prostate cancer cells, and curcumin abrogates their survival mechanisms...
  8. ncbi request reprint Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis
    S K Manna
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 165:5962-9. 2000
    ..Overall, our results suggest that suppression of TNF signaling is one of the possible mechanisms for inhibitory activity of leflunomide against rheumatoid arthritis...
  9. ncbi request reprint Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase
    A Mukhopadhyay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:15978-81. 1999
    ..Thus our results indicate that THANK is a novel cytokine that belongs to the TNF family and activates apoptosis, NF-kappaB, and JNK through a distinct receptor...
  10. ncbi request reprint VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth
    V Haridas
    Department of Molecular Oncology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Oncogene 18:6496-504. 1999
    ..These results suggest that VEGI, a new member of the TNF family, has a signaling pathway similar to TNF and is most likely a multifunctional cytokine...
  11. ncbi request reprint Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB
    A Kumar
    Cytokine Research Section, Department of Molecular Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe St Box 143, Houston, TX 77030, USA
    FEBS Lett 462:140-4. 1999
    ..These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB...
  12. ncbi request reprint IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis
    S K Manna
    Cytokine Research Laboratory, Department of Bioimmunotherapy, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    J Immunol 165:4927-34. 2000
    ..Overall our results suggest that IFN-alpha potentiates the apoptotic effects of TNF possibly by suppressing NF-kappaB and AP-1 activation...
  13. ncbi request reprint Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1
    S K Manna
    Department of Molecular Oncology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Oncogene 18:4371-82. 1999
    ..Overall, our results indicate that most of the pleiotropic actions of TNF are regulated by the glutathione-controlled redox status of the cell...
  14. ncbi request reprint Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma
    D G Jackson-Bernitsas
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 26:1385-97. 2007
    ..Our results clearly demonstrate that constitutive activation of NF-kappaB is mediated through the TRADD-TRAF2-RIP-TAK1-IKK pathway, making TNF a novel target in the treatment of head and neck cancer...
  15. ncbi request reprint Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspases in the rat brain
    G T Ramesh
    Center for Toxicological Research, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
    Toxicol Lett 123:195-207. 2001
    ..Overall our results indicate that lead exposure induces the activation of NF-kappaB, AP-1, JNK, MAPKK, and caspases in the brain, which may contribute to its neurotoxic effects...
  16. ncbi request reprint Genetic deletion of the tumor necrosis factor receptor p60 or p80 abrogates ligand-mediated activation of nuclear factor-kappa B and of mitogen-activated protein kinases in macrophages
    A Mukhopadhyay
    Cytokine Research Section, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:31906-12. 2001
    ..Overall, our studies suggest that both types of TNF receptors are needed in macrophages for optimum TNF cell signaling...
  17. ncbi request reprint Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha
    G Sethi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 26:7324-32. 2007
    ..Overall, our results indicate that tyrosine phosphorylation of IkappaBalpha at residue 42 is critical for EGF-induced NF-kappaB activation pathway...
  18. ncbi request reprint Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:20551-5. 1998
    ....
  19. pmc Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells
    M Amit-Vazina
    Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Br J Cancer 93:70-80. 2005
    ..These data suggest that Atiprimod has a role in future therapies for MM...
  20. ncbi request reprint Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression
    S Shishodia
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 25:1463-73. 2006
    ....
  21. ncbi request reprint Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines
    P Fiumara
    Department of Lymphoma and Myeloma, Head and Neck Surgery, and Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 98:2784-90. 2001
    ..The coexpression of RANK and RANKL in H/RS cells suggests that they may regulate cytokine and chemokine secretion in H/RS cells by an autocrine mechanism...
  22. ncbi request reprint Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines
    K Mehta
    Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Anticancer Drugs 8:470-81. 1997
    ..Overall our results suggest that curcumin is a potent antiproliferative agent for breast tumor cells and may have potential as an anticancer agent...
  23. ncbi request reprint Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation
    Y Takada
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 26:1201-12. 2007
    ..Overall, our results indicate that PKR differentially regulates TNF signaling; IKK, Akt and JNK were positively regulated, whereas p44/p42 MAPK and p38 MAPK were negatively regulated...
  24. ncbi request reprint HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1
    A Kumar
    Department of Molecular Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Immunol 161:776-81. 1998
    ..Overall our results demonstrate that HIV-tat activates JNK and AP-1, which may contribute to the pathogenesis of AIDS...
  25. ncbi request reprint Nuclear transcription factor-kappaB as a target for cancer drug development
    A Garg
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 16:1053-68. 2002
    ..Here, we review our current knowledge of NF-kappaB, the possible mechanisms of its activation, its potential role in cancer, and various strategies being employed to target the NF-kappaB signaling pathway for cancer drug development...
  26. ncbi request reprint Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation
    S Singh
    Cytokine Research Laboratory, Department of Molecular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 271:31049-54. 1996
    ..Our results demonstrate that inducible phosphorylation and degradation of IkappaBalpha are negatively regulated by phosphorylation at Tyr-42, thus preventing NF-kappaB activation...
  27. ncbi request reprint Autocrine lymphotoxin production in Epstein-Barr virus-immortalized B cells: induction via NF-kappaB activation mediated by EBV-derived latent membrane protein 1
    M P Thompson
    Department of Bioimmunotherapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 17:2196-201. 2003
    ..Therefore, in our model system, autocrine lymphotoxin production is largely driven by NF-kappaB activation, which is in turn mediated by EBV-derived LMP1 signaling...
  28. ncbi request reprint The p80 TNF receptor-associated kinase (p80TRAK) associates with residues 354-397 of the p80 cytoplasmic domain: similarity to casein kinase
    B G Darnay
    Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    FEBS Lett 406:101-5. 1997
    ..Thus, our results indicate that p80TRAK associates with a short stretch of approximately 44 residues located in the cytoplasmic domain of the p80 TNF receptor and that this kinase is similar to CK1...
  29. ncbi request reprint Antiproliferative effects of IFN-alpha correlate with the downregulation of nuclear factor-kappa B in human Burkitt lymphoma Daudi cells
    P C Rath
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    J Interferon Cytokine Res 21:523-8. 2001
    ..Overall, our results suggest that IFN-alpha is a potent suppressor of constitutive NF-kappaB, which may contribute to the inhibition of cell proliferation...
  30. pmc Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function
    M Higuchi
    Department of Internal Medicine, The University of Texas Houston Health Science Center, 77030, USA
    J Clin Invest 99:1751-8. 1997
    ..Thus, the apoptosis signaling block in respiration-deficient clones is located at a step before CPP32-like protease activation, which can be bypassed by staurosporine...
  31. ncbi request reprint All pathways to cancer apoptosis meeting in Thiruvananthapuram (India)
    K Mehta
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Death Differ 13:2163-4. 2006
  32. ncbi request reprint pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor
    B B Aggarwal
    Department of Clinical Immunology and Biological Therapy, University of Texas, M D Anderson Cancer Center, Houston 77030
    FEBS Lett 345:219-24. 1994
    ..The pp60v-src-induced cellular resistance to TNF could be abrogated by interferon-gamma. Thus, these results indicate that the resistance of certain tumors to TNF may also be due in part to the overexpression of pp60v-src oncogene...
  33. pmc NF-κB addiction and its role in cancer: 'one size does not fit all'
    M M Chaturvedi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 30:1615-30. 2011
    ..This review discusses multiple mechanisms of NF-κB activation and their regulation by multitargeted agents in contrast to monotargeted agents, thus 'one size does not fit all' cancers...