Garry L Adams

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Role of SPI-1 secreted effectors in acute bovine response to Salmonella enterica Serovar Typhimurium: a systems biology analysis approach
    Sara D Lawhon
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 6:e26869. 2011
  2. pmc Spatial segregation of virulence gene expression during acute enteric infection with Salmonella enterica serovar Typhimurium
    Richard C Laughlin
    MBio 5:e00946-13. 2014
  3. pmc Systems biology analysis of Brucella infected Peyer's patch reveals rapid invasion with modest transient perturbations of the host transcriptome
    Carlos A Rossetti
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 8:e81719. 2013
  4. pmc Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e42127. 2012
  5. pmc Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses
    Nabil Hanna
    Universite Montpellier 1, Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, Montpellier, France
    BMC Genomics 14:459. 2013
  6. pmc Vaccination with attenuated Salmonella enterica Dublin expressing E coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 USA
    BMC Vet Res 6:35. 2010
  7. pmc Diagnosis of foot-and mouth disease by real time reverse transcription polymerase chain reaction under field conditions in Brazil
    Tatiane A Paixao
    Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinária da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    BMC Vet Res 4:53. 2008
  8. pmc A species independent universal bio-detection microarray for pathogen forensics and phylogenetic classification of unknown microorganisms
    Shamira J Shallom
    Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA
    BMC Microbiol 11:132. 2011
  9. pmc Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with potential insights for understanding Brucella:host initial interactions
    Carlos A Rossetti
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77483 4467, USA
    BMC Microbiol 9:81. 2009
  10. ncbi request reprint The pathology of brucellosis reflects the outcome of the battle between the host genome and the Brucella genome
    L Garry Adams
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Microbiol 90:553-61. 2002

Research Grants

  1. Veterinary Medical Student Research Training
    LESLIE ADAMS; Fiscal Year: 2004
  2. Veterinary Medical Student Research Training
    LESLIE ADAMS; Fiscal Year: 2005
  3. Veterinary Medical Student Research Training
    LESLIE GARRY ADAMS; Fiscal Year: 2010
  4. Veterinary Medical Student Research Training
    LESLIE ADAMS; Fiscal Year: 2006
  5. Veterinary Medical Student Research Training
    LESLIE ADAMS; Fiscal Year: 2007

Collaborators

Detail Information

Publications30

  1. pmc Role of SPI-1 secreted effectors in acute bovine response to Salmonella enterica Serovar Typhimurium: a systems biology analysis approach
    Sara D Lawhon
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 6:e26869. 2011
    ....
  2. pmc Spatial segregation of virulence gene expression during acute enteric infection with Salmonella enterica serovar Typhimurium
    Richard C Laughlin
    MBio 5:e00946-13. 2014
    ..Typhimurium in extruding epithelium as a mechanism for reseeding the lumen...
  3. pmc Systems biology analysis of Brucella infected Peyer's patch reveals rapid invasion with modest transient perturbations of the host transcriptome
    Carlos A Rossetti
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 8:e81719. 2013
    ..Cumulatively, our results indicate that the in vivo pathogenesis of the early infectious process of Brucella is primarily accomplished by compromising the mucosal immune barrier and subverting critical immune response mechanisms. ..
  4. pmc Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e42127. 2012
    ..Our study provides evidence that MAP infection resulted in differentially regulated genes, perturbed pathways and specifically modified mechanistic genes contributing to the colonization of Peyer's patch...
  5. pmc Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses
    Nabil Hanna
    Universite Montpellier 1, Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, Montpellier, France
    BMC Genomics 14:459. 2013
    ..A single, bi-functional enzyme Rsh catalyzes synthesis and hydrolysis of the alarmone (p)ppGpp, responsible for differential gene expression under stringent conditions...
  6. pmc Vaccination with attenuated Salmonella enterica Dublin expressing E coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 USA
    BMC Vet Res 6:35. 2010
    ..The present study was undertaken to test the hypothesis that an adaptive mucosal immune response directed against intimin will reduce or prevent enteric colonization and fecal shedding of E. coli O157:H7 in cattle...
  7. pmc Diagnosis of foot-and mouth disease by real time reverse transcription polymerase chain reaction under field conditions in Brazil
    Tatiane A Paixao
    Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinária da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    BMC Vet Res 4:53. 2008
    ..Virus isolation and enzyme-linked immunosorbent assay (ELISA) are the gold standard tests for diagnosis of FMD. As these methods are time consuming, assays based on viral nucleic acid amplification have been developed...
  8. pmc A species independent universal bio-detection microarray for pathogen forensics and phylogenetic classification of unknown microorganisms
    Shamira J Shallom
    Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA
    BMC Microbiol 11:132. 2011
    ..Given the enormous spectrum of genetic possibilities, a field deployable, robust technology, such as a universal (any species) microarray has near-term potential to address these needs...
  9. pmc Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with potential insights for understanding Brucella:host initial interactions
    Carlos A Rossetti
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77483 4467, USA
    BMC Microbiol 9:81. 2009
    ..melitensis cultures to HeLa cells, as a preliminary approach for identifying candidate pathogen genes involved in invasion of epithelial cells...
  10. ncbi request reprint The pathology of brucellosis reflects the outcome of the battle between the host genome and the Brucella genome
    L Garry Adams
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Microbiol 90:553-61. 2002
    ..These discoveries will be expected to provide a frameshift in rationales for interrupting and/or controlling brucellosis at host and/or pathogen levels...
  11. pmc Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: linking systems biology with vaccine development
    L Garry Adams
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Vaccine 29:7197-206. 2011
    ..Thus, we propose that such an approach has immediate application to the rational design of brucellosis and salmonellosis vaccines...
  12. pmc Selective amplification of Brucella melitensis mRNA from a mixed host-pathogen total RNA
    Carlos A Rossetti
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    BMC Res Notes 3:244. 2010
    ..The characterization of brucelae transcriptome's during host-pathogen interaction has been limited due to the difficulty of obtaining an adequate quantity of good quality eukaryotic RNA-free pathogen RNA for downstream applications...
  13. pmc Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis
    L Garry Adams
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    BMC Proc 5:S6. 2011
    ....
  14. doi request reprint Geostatistical analysis of biomarkers of genotoxicity in cattle, Bos taurus and Bos taurus x Bos indicus, sentinels near industrial facilities
    Wesley Bissett
    Department of Large Animal Clinical Sciences, Texas A and M University, 4475 TAMU, Mail Stop 4476, College Station, TX 77843 4475, USA
    Ecotoxicology 18:87-93. 2009
    ..Results indicated that proximity to and location down-prevailing winds from industrial facilities increased the locational risk of genotoxicity in this sentinel species...
  15. ncbi request reprint Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis
    Melissa M Kahl-McDonagh
    Department of Veterinary Pathobiology, Texas A and M University and Texas Agricultural Experiment Station, College Station, TX 77843 4467, United States
    Vaccine 24:5169-77. 2006
    ..Both strains were protective against abortion and against infection in the majority of pregnant goats, although BMDeltaasp24 was more efficacious than BMDeltavirB2 against challenge infection...
  16. pmc Brucella melitensis VjbR and C12-HSL regulons: contributions of the N-dodecanoyl homoserine lactone signaling molecule and LuxR homologue VjbR to gene expression
    Jenni N Weeks
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    BMC Microbiol 10:167. 2010
    ..In an effort to further delineate the role of VjbR to virulence and survival, gene expression under the control of VjbR and AI was characterized using microarray analysis...
  17. ncbi request reprint Salmonella serotype Typhimurium infection of bovine Peyer's patches down-regulates plasma membrane calcium-transporting ATPase expression
    Renato L Santos
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University System Health Science Center, College Station 77843 4467, USA
    J Infect Dis 186:372-8. 2002
    ....
  18. ncbi request reprint Hematologic and serum biochemical changes in Salmonella ser Typhimurium-infected calves
    Renato L Santos
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4467, USA
    Am J Vet Res 63:1145-50. 2002
    ..To evaluate hematologic and serum biochemical changes in Salmonella ser Typhimurium-infected calves...
  19. pmc Molecular pathogenesis of Salmonella enterica serotype typhimurium-induced diarrhea
    Shuping Zhang
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Infect Immun 71:1-12. 2003
  20. pmc The Salmonella enterica serotype Typhi Vi capsular antigen is expressed after the bacterium enters the ileal mucosa
    Quynh T Tran
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Infect Immun 78:527-35. 2010
    ..Together, these results support the concept that expression of the Vi capsular antigen is induced when S. Typhi transits from the intestinal lumen into the ileal mucosa...
  21. pmc Secreted effector proteins of Salmonella enterica serotype typhimurium elicit host-specific chemokine profiles in animal models of typhoid fever and enterocolitis
    Shuping Zhang
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    Infect Immun 71:4795-803. 2003
    ..Thus, different disease outcomes between mice (i.e., no diarrhea) and calves (i.e., diarrhea) may be due to differences in sipA sopABDE2-dependent CXC chemokine gene expression in epithelial cells...
  22. pmc Rapid and sensitive detection of Mycobacterium avium subsp. paratuberculosis in bovine milk and feces by a combination of immunomagnetic bead separation-conventional PCR and real-time PCR
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    J Clin Microbiol 42:1075-81. 2004
    ....
  23. pmc Host restriction of Salmonella enterica serotype Typhimurium pigeon isolates does not correlate with loss of discrete genes
    Helene L Andrews-Polymenis
    Department of Medical Microbiology and Immunology, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843, USA
    J Bacteriol 186:2619-28. 2004
    ..We conclude that serotype Typhimurium phage types with broad host range do not possess genetic islands influencing host restriction, which are absent from the host-restricted pigeon isolates...
  24. ncbi request reprint Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves
    Shuping Zhang
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    FEMS Microbiol Lett 217:243-7. 2002
    ..Typhimurium in the bovine ligated ileal loop model. These data support the hypothesis that phage mediated horizontal transfer of the sopE1 gene contributes to the emergence of epidemic cattle-associated S. Typhimurium clones...
  25. pmc Salmonella enterica serovar Typhimurium-induced internalization and IL-8 expression in HeLa cells does not have a direct relationship with intracellular Ca(2+) levels
    Josely F Figueiredo
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Microbes Infect 11:850-8. 2009
    ....
  26. pmc SipA, SopA, SopB, SopD, and SopE2 contribute to Salmonella enterica serotype typhimurium invasion of epithelial cells
    Manuela Raffatellu
    Department of Medical Microbiology and Immunology, College of Medicine, Texas A and M University System Health Science Center, 407 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Infect Immun 73:146-54. 2005
    ..We conclude that SipA, SopA, SopB, SopD, and SopE2 contribute to S. enterica serotype Typhimurium invasion of epithelial cells in vitro...
  27. doi request reprint Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways
    Josely F Figueiredo
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Microbes Infect 11:302-10. 2009
    ..These data indicate that S. typhimurium SipA induces expression of CXC chemokines through phosphorylation of IL-8-transcription regulatory proteins, JUN and p38MAK...
  28. pmc virB-Mediated survival of Brucella abortus in mice and macrophages is independent of a functional inducible nitric oxide synthase or NADPH oxidase in macrophages
    Yao Hui Sun
    Department of Medical Microbiology and Immunology, Texas A and M University System Health Science Center, College Station, USA
    Infect Immun 70:4826-32. 2002
    ..A virB mutant did not exhibit increased survival in either of the knockout mouse strains, indicating that this locus does not contribute to evasion of nitrosative or oxidative killing mechanisms in vivo...
  29. pmc The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves
    Shuping Zhang
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    Infect Immun 70:3843-55. 2002
    ..These data demonstrate that SipA, SopA, SopB, SopD, and SopE2 are major virulence factors responsible for diarrhea during Salmonella serotype Typhimurium infection of calves...
  30. pmc Upregulation of thymosin beta-10 by Mycobacterium bovis infection of bovine macrophages is associated with apoptosis
    José A Gutiérrez-Pabello
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Infect Immun 70:2121-7. 2002
    ..01) and parental cells (P < 0.001). Our evidence suggests that upregulation of thymosin beta-10 in M. bovis-infected macrophages is linked with increased cell death due to apoptosis...

Research Grants6

  1. Veterinary Medical Student Research Training
    LESLIE ADAMS; Fiscal Year: 2004
    ..Our VMSRTP is squarely aimed at developing pre-doctoral veterinary into R01 level scientists for the future. ..
  2. Veterinary Medical Student Research Training
    LESLIE ADAMS; Fiscal Year: 2005
    ..Our VMSRTP is squarely aimed at developing pre-doctoral veterinary into R01 level scientists for the future. ..
  3. Veterinary Medical Student Research Training
    LESLIE GARRY ADAMS; Fiscal Year: 2010
    ..The Veterinary Medical Student Research Training Program encourages veterinary students to enter research careers by immersing them in a focused 12-week program comprised of major aspects of a research career. ..
  4. Veterinary Medical Student Research Training
    LESLIE ADAMS; Fiscal Year: 2006
    ..Our VMSRTP is squarely aimed at developing pre-doctoral veterinary into R01 level scientists for the future. ..
  5. Veterinary Medical Student Research Training
    LESLIE ADAMS; Fiscal Year: 2007
    ..Our VMSRTP is squarely aimed at developing pre-doctoral veterinary into R01 level scientists for the future. ..