Kjersti M Aagaard

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Maternal high-fat diet modulates the fetal thyroid axis and thyroid gene expression in a nonhuman primate model
    Melissa A Suter
    Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Endocrinol 26:2071-80. 2012
  2. pmc A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
    Melissa A Suter
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 26:5106-14. 2012
  3. pmc Obesity and the risk and detection of fetal malformations
    Diana Racusin
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Perinatol 36:213-21. 2012
  4. doi request reprint Influence of maternal BMI on genetic sonography in the FaSTER trial
    Kjersti M Aagaard-Tillery
    University of Utah, Salt Lake City, UT, USA
    Prenat Diagn 30:14-22. 2010
  5. pmc Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes
    Kjersti Aagaard-Tillery
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Obstet Gynecol 115:568-77. 2010
  6. pmc In utero tobacco exposure epigenetically modifies placental CYP1A1 expression
    Melissa Suter
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Metabolism 59:1481-90. 2010
  7. pmc Obstructive sleep apnea screening in pregnancy, perinatal outcomes, and impact of maternal obesity
    Sofia A Olivarez
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Houston, Texas, USA
    Am J Perinatol 28:651-8. 2011
  8. ncbi request reprint Sample bias among women with retained DNA samples for future genetic studies
    Kjersti Aagaard-Tillery
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 108:1115-20. 2006
  9. pmc Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates
    Melissa Suter
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 25:714-26. 2011
  10. ncbi request reprint Prospective trial on obstructive sleep apnea in pregnancy and fetal heart rate monitoring
    Sofia A Olivarez
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Ben Taub General Hospital, Houston, TX, USA
    Am J Obstet Gynecol 202:552.e1-7. 2010

Collaborators

Detail Information

Publications22

  1. pmc Maternal high-fat diet modulates the fetal thyroid axis and thyroid gene expression in a nonhuman primate model
    Melissa A Suter
    Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Endocrinol 26:2071-80. 2012
    ..We speculate that maternal HFD exposure in utero may set the stage for later in life obesity through epigenomic modifications to the histone code, which modulates the fetal thyroid axis...
  2. pmc A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
    Melissa A Suter
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 26:5106-14. 2012
    ..Our data implicate SIRT1 as a likely molecular mediator of the fetal epigenome and metabolome under MHFD conditions...
  3. pmc Obesity and the risk and detection of fetal malformations
    Diana Racusin
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Perinatol 36:213-21. 2012
    ....
  4. doi request reprint Influence of maternal BMI on genetic sonography in the FaSTER trial
    Kjersti M Aagaard-Tillery
    University of Utah, Salt Lake City, UT, USA
    Prenat Diagn 30:14-22. 2010
    ..We sought to evaluate the influence of maternal body mass index (BMI) on sonographic detection employing data from the FaSTER trial...
  5. pmc Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes
    Kjersti Aagaard-Tillery
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Obstet Gynecol 115:568-77. 2010
    ..To assess whether functional maternal or fetal genotypes along well-characterized metabolic pathways (ie, CYP1A1, GSTT1, and CYP2A6) may account for varying associations with adverse outcomes among pregnant women who smoke...
  6. pmc In utero tobacco exposure epigenetically modifies placental CYP1A1 expression
    Melissa Suter
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Metabolism 59:1481-90. 2010
    ..737, P = .007). Thus, in utero tobacco exposure significantly increases placental CYP1A1 expression in association with differential methylation at a critical xenobiotic response element...
  7. pmc Obstructive sleep apnea screening in pregnancy, perinatal outcomes, and impact of maternal obesity
    Sofia A Olivarez
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Houston, Texas, USA
    Am J Perinatol 28:651-8. 2011
    ..Nevertheless, OSA status continues to exert an independent influence, as obese and nonobese gravidae are at increased risk for a limited number of adverse perinatal outcomes in multivariate models...
  8. ncbi request reprint Sample bias among women with retained DNA samples for future genetic studies
    Kjersti Aagaard-Tillery
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 108:1115-20. 2006
    ..To evaluate whether women who agree to future use of their biologic specimens for genetic studies reflect the larger study population from which they are derived...
  9. pmc Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates
    Melissa Suter
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 25:714-26. 2011
    ..In summary, the data suggest that peripheral Npas2 expression is uniquely vulnerable to diet exposure...
  10. ncbi request reprint Prospective trial on obstructive sleep apnea in pregnancy and fetal heart rate monitoring
    Sofia A Olivarez
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Ben Taub General Hospital, Houston, TX, USA
    Am J Obstet Gynecol 202:552.e1-7. 2010
    ..Incorporating simultaneous fetal heart rate monitoring (FHM), we examined the association of maternal apnea with FHM abnormalities...
  11. ncbi request reprint In utero exposure to a maternal high-fat dietĀ alters the epigenetic histone code in a murine model
    Melissa A Suter
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX
    Am J Obstet Gynecol 210:463.e1-463.e11. 2014
    ....
  12. pmc High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model
    Jun Ma
    1 Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine at Baylor College of Medicine and Texas Children s Hospital, Houston, Texas 77030, USA 2 Department of Molecular and Human Genetics, Bioinformatics Research Lab at Baylor College of Medicine, Houston, Texas 77030, USA 3
    Nat Commun 5:3889. 2014
    ..Our data challenge the concept of an obesity-causing gut microbiome and rather provide evidence for a contribution of the maternal diet in establishing the microbiota, which in turn affects intestinal maintenance of metabolic health. ..
  13. pmc Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model
    Derek O'Neil
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 110:378-87. 2013
    ..7 fold) and adult (1.8 fold) Npas2-/- animals. These findings are consistent with an essential role for Npas2 in programming the peripheral circadian response and hepatic metabolism, which has not been previously described...
  14. ncbi request reprint Genetic and epigenetic influences associated with intrauterine growth restriction due to in utero tobacco exposure
    Melissa Suter
    Baylor College of Medicine, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatr Endocrinol Rev 8:94-102. 2010
    ..The complex interplay of genomic and epigenomic factors may contribute to specific phenotypic outcomes and can help begin to elucidate the differential susceptibilities to tobacco smoke in utero...
  15. pmc Evolutionary genetics and implications of small size and twinning in callitrichine primates
    R Alan Harris
    Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine and Molecular and Human Genetics, Human Genome Sequencing Center, and Department of Molecular and Cell Biology and the Reproductive Medicine Center, Baylor College of Medicine, Houston, TX 77030
    Proc Natl Acad Sci U S A 111:1467-72. 2014
    ..We postulate that positive selection affected NWM growth patterns, with callitrichine miniaturization coevolving with a series of reproductive adaptations. ..
  16. pmc Early origins of adult disease: approaches for investigating the programmable epigenome in humans, nonhuman primates, and rodents
    Radhika S Ganu
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    ILAR J 53:306-21. 2012
    ..This review summarizes recent epigenetic advances using rodent and primate (both human and nonhuman) models during in utero development and contributing to adult diseases later in life...
  17. doi request reprint The role of microbial communities in parturition: is there evidence of association with preterm birth and perinatal morbidity and mortality?
    Radhika S Ganu
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Perinatol 30:613-24. 2013
    ....
  18. doi request reprint Use of whole genome shotgun metagenomics: a practical guide for the microbiome-minded physician scientist
    Jun Ma
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine
    Semin Reprod Med 32:5-13. 2014
    ..Several applications that are uniquely applicable to microbiome studies in reproductive and perinatal medicine are also discussed. ..
  19. doi request reprint The Microbiome and Development: A Mother's Perspective
    Amanda L Prince
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine
    Semin Reprod Med 32:14-22. 2014
    ....
  20. pmc Postweaning exposure to a high-fat diet is associated with alterations to the hepatic histone code in Japanese macaques
    Melissa A Suter
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
    Pediatr Res 74:252-8. 2013
    ..Expression of circadian gene, Npas2, is altered in fetal life with maternal high-fat (HF) diet exposure by virtue of alterations in the fetal histone code. We postulated that these disruptions would persist postnatally...
  21. pmc Maternal smoking as a model for environmental epigenetic changes affecting birthweight and fetal programming
    Melissa A Suter
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, 1 Baylor Plaza, Jones 314, Houston, TX 77030, USA
    Mol Hum Reprod 19:1-6. 2013
    ..First, does exposure to maternal tobacco smoke in utero alter the fetal epigenome? Secondly, could these alterations be associated with the reduced fetal growth observed with MTSE?..
  22. doi request reprint Management of ornithine transcarbamylase deficiency in pregnancy
    Hector Mendez-Figueroa
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Perinatol 27:775-84. 2010
    ..A comprehensive plan for patients who develop hyperammonemia is recommended...