Genomes and Genes
Texas A and M University
Organization: Texas A and M University
- Humane design for hospital landscapes: a case study in landscape architecture of a healing garden for nursesJody Rosenblatt Naderi
Texas A and M University, College Station, TX 77845, USA
HERD 2:82-119. 2008..A site-specific design concept and user-specific survey instrument were developed to gather data directly from the nursing staff on campus...
- DNA vaccine construct incorporating intercellular trafficking and intracellular targeting motifs effectively primes and induces memory B- and T-cell responses in outbred animalsWaithaka Mwangi
Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
Clin Vaccine Immunol 14:304-11. 2007..These results demonstrate that DNA vaccines targeting key intercellular and intracellular events significantly enhance priming and expansion and support the feasibility of single-dose DNA immunization in outbred populations...
- Age-related changes in neuroprotection: is estrogen pro-inflammatory for the reproductive senescent brain?Farida Sohrabji
Neuroscience and Experimental Therapeutics, Department of Human Anatomy and Medical Neurobiology, TAMHSC College of Medicine, College Station, TX 77843 1114, USA
Endocrine 29:191-7. 2006....
- One-to-one and polyrhythmic temporal coordination in bimanual circle tracingJohn J Buchanan
Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
J Mot Behav 38:163-84. 2006..Tactile feedback played a minimal role in stabilizing bimanual coordination in the current tasks...
- Patterning of geographic variation in Middle Pleistocene Homo frontal bone morphologySheela Athreya
Department of Anthropology, Texas A and M University, 4352 TAMU, College Station, TX 77843, USA
J Hum Evol 50:627-43. 2006....
- The role of vision in the control of continuous multijoint movementsCaroline J Ketcham
Motor Control Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
J Mot Behav 38:29-44. 2006....
- Measuring microlymphatic flow using fast video microscopyJ Brandon Dixon
Texas A and M University, Department of Biomedical Engineering, Mail Stop 3120, College Station, Texas 77843, USA
J Biomed Opt 10:064016. 2005..Lymph velocity fluctuates cyclically with the vessel wall contractions, ranging from -1 to 7 mmsec. These rates are higher than would be possible with standard video microscopy (3.75 mmsec maximum)...
- Current status and future directions in couple therapyDouglas K Snyder
Department of Psychology, Texas A and M University, College Station, Texas 77843 4235, USA
Annu Rev Psychol 57:317-44. 2006..The chapter concludes with 12 recommendations regarding future directions in couple therapy research and clinical training...
- Warren K. Sinclair Keynote Address: Current challenges in countering radiological terrorismJohn W Poston
Department of Nuclear Engineering, Texas A and M University, 3133 TAMU, College Station, TX 77843 3133, USA
Health Phys 89:450-6. 2005..More detailed discussions will be provided by the presentations at this NCRP Annual Meeting...
- Law and Psychiatry: mental illness and reasonable accommodations at work: definition of a mental disability under the ADARamona L Paetzold
Department of Management at Texas A and M University, College Station, Texas 77843-4221, USA
Psychiatr Serv 56:1188-90. 2005
- An autocorrelation-based time domain analysis technique for monitoring perfusion and oxygenation in transplanted organsHariharan Subramanian
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, USA
IEEE Trans Biomed Eng 52:1355-8. 2005..It was shown that the autocorrelation-based method was able to perform comparably with FFT (limited to a sampling frequency of 300 Hz) and maintain accuracy down to acquisition times as low as 4 s in length...
- Rural cases of equine West Nile virus encephalomyelitis and the normalized difference vegetation indexMichael P Ward
Department of Veterinary Pathobiology, Purdue University School of Veterinary Medicine, West Lafayette, Indiana, USA
Vector Borne Zoonotic Dis 5:181-8. 2005..3% and 5.1%, respectively) at 1 and 5 weeks preceding occurrence of the cluster. The NDVI may be useful for identifying foci of WNV transmission...
- Labeling bias and categorical induction: generative aspects of category informationTakashi Yamauchi
Department of Psychology, Texas A and M University, College Station, TX 77843, USA
J Exp Psychol Learn Mem Cogn 31:538-53. 2005....
- Play-Doh and water-soaked gauze sponges as alternative bolus material for cobalt-60 teletherapyMichael Walker
Department of Veterinary Large Animal Clinical Sciences, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
Vet Radiol Ultrasound 46:179-81. 2005..The results of this study suggest that either Play-Doh or water-soaked cotton gauze sponges can suffice as material for carefully made bolus for cobalt-60 teletherapy...
- A cluster-adjusted sample size algorithm for proportions was developed using a beta-binomial modelG T Fosgate
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
J Clin Epidemiol 60:250-5. 2007....
- Use of guar by-products in high-production laying hen dietsO Gutierrez
Department of Poultry Science, Texas A and M University, College Station 77843, USA
Poult Sci 86:1115-20. 2007..The results showed that both guar germ and guar meal can be fed to high-production laying hens at up to 5% without adverse effects on laying hen performance...
- Commentary: Linking particulate matter and sulphur concentrations to air pollution annoyance: problems of measurement, scale and controlSamuel D Brody
Environmental Planning and Sustainability Research Unit, Hazard Reduction and Recovery Center, Department of Landscape Architecture and Urban Planning, Texas A and M University, TAMU 3137, College Station, TX 77843-3137, USA
Int J Epidemiol 36:820-3. 2007
- Complementary and alternative medicine use among Asian Indians in the United States: a national studyRanjita Misra
Center for the Study of Health Disparities, Department of Health and Kinesiology, Intercollegiate Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
J Altern Complement Med 16:843-52. 2010..Asian Americans use complementary and alternative medicine (CAM) at a higher rate than Americans...
- "Megatrends" driving healthcare facility design: a look at the major trends that will shape medical facility designGeorge J Mann
College of Architecture, Texas A and M University, USA
World Hosp Health Serv 46:13-7. 2010..Knowing the "Megatrends" defining and driving the future of healthcare delivery and healthcare facility design will help decision makers anticipate the future...
- Quantification of quercetin glycosides in 6 onion cultivars and comparisons of hydrolysis-HPLC and spectrophotometric methods in measuring total quercetin concentrationsKil Sun Yoo
Vegetable and Fruit Improvement Center, Dept of Horticultural Science, Texas A and M Univ, College Station, TX 77843, USA
J Food Sci 75:C160-5. 2010..TQ ranged from 83 to 330 microg/g F.W. in 6 selected cultivars of long-day or short-day onions. Q3,4'G and Q4'G were the 2 major compounds and comprised approximately between 94% and 97% of TQ in onions...
- A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 testsLianfu Chen
Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843, USA
BMC Proc 3:S6. 2009..In addition, SNPs with the largest TH score on each chromosome were identified. These SNPs may be located in the regions of genes that have modest effects on rheumatoid arthritis. These regions deserve further investigation...
- A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cellsGonzalo M Rivera
Raymond and Beverly Sacker Laboratory of Genetics and Molecular Medicine, Department of Genetics and Developmental Biology and Richard D Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT 06030, USA
Mol Cell 36:525-35. 2009..This study uncovers a strong reciprocal interdependence between Nck and PI(4,5)P(2) in promoting localized N-WASp-mediated actin polymerization in cells...
- Oral vaccination with microencapsuled strain 19 vaccine confers enhanced protection against Brucella abortus strain 2308 challenge in red deer (Cervus elaphus elaphus)Angela M Arenas-Gamboa
Department of Veterinary Pathobiology, Texas A and M University and Texas Agricultural Experiment Station, College Station, Texas 77845 1114, USA
J Wildl Dis 45:1021-9. 2009..This system is a potential improvement for efficacious Brucella-vaccine delivery to wildlife in the GYA...
- The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencingJan S Suchodolski
Gastrointestinal Laboratory, Texas A and M University, College Station, TX, USA
BMC Microbiol 9:210. 2009..Jejunal brush samples were collected through the fistula on days 0, 14, and 28 (14 days after withdrawal of tylosin). Bacterial diversity was characterized using massive parallel 16S rRNA gene pyrosequencing...
- On interpreting the relationship between remember-know judgments and confidence: the role of instructionsLisa Geraci
Department of Psychology, Texas A and M University, College Station, 4235 TAMU, TX 77845 4235, USA
Conscious Cogn 18:701-9. 2009....
- Septicemia in a neonatal calf associated with Chromobacterium violaceumD K Ajithdoss
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
Vet Pathol 46:71-4. 2009..C. violaceum was isolated in high numbers from the lungs, liver, spleen, carpus, and in pure culture from the cerebrospinal fluid. To our knowledge, this is the first case report of chromobacteriosis in a calf...
- Pathogen prevalence and influence of composted dairy manure application on antimicrobial resistance profiles of commensal soil bacteriaTom S Edrington
Southern Plains Agricultural Research Center, U S Department of Agriculture, College Station, Texas 77845, USA
Foodborne Pathog Dis 6:217-24. 2009..No treatment differences were observed in antimicrobial resistance patterns in any of the soil isolates examined. Results reported herein support the use of composted dairy manure as an environmentally friendly soil amendment...
- Information theory provides a comprehensive framework for the evaluation of protein structure predictionsRosemarie Swanson
Department of Biochemistry and Biophysics, Texas A and M University, 2128 TAMU, College Station, Texas 77843, USA
Proteins 74:701-11. 2009..Mutual information provides both a theoretical basis for evaluating structure similarity and an explanatory surround for existing similarity measures...
- Cell death in normal and abnormal developmentPhilip E Mirkes
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843, USA
Congenit Anom (Kyoto) 48:7-17. 2008..Therefore, the purpose of this review is to highlight what is known about PCD and teratogen-induced cell death and their relationships to the mechanisms of apoptosis and abnormal development...
- PCR amplification of microsatellites from single cells of Karenia brevis preserved in Lugol's iodine solutionD W Henrichs
Department of Biology, Texas A and M University, College Station, Texas 77843 3578, USA
Mar Biotechnol (NY) 10:122-7. 2008..Destaining of Lugol's-preserved cells with sodium thiosulfate allowed successful amplification of single-copy, nuclear-encoded microsatellites in single cells of K. brevis that have been preserved for up to 6 years...
- Atmospheric imaging results from the Mars exploration rovers: Spirit and OpportunityM T Lemmon
Texas A and M University, College Station, TX 77843, USA
Science 306:1753-6. 2004..52 +/- 0.18 mm at Meridiani. Comparison of visible optical depths with 9-mm optical depths shows a visible-to-infrared optical depth ratio of 2.0 +/- 0.2 for comparison with previous monitoring of infrared optical depths...
- Uterine and placental factors regulating conceptus growth in domestic animalsT E Spencer
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station 77843 2471, USA
J Anim Sci 82:E4-13. 2004..Knowledge of the basic mechanisms regulating uterine development is expected to suggest means to increase uterine capacity, litter size, and neonatal survival, as well as ameliorate certain types of infertility...
- Effects of temperature and relative humidity on sporulation of Metarhizium anisopliae var. acridum in mycosed cadavers of Schistocerca gregariaS Arthurs
Leverhulme Unit for Population Biology and Biological Control, NERC Centre for Population Biology and CABI Bioscience, Imperial College, Silwood Park, Ascot, Berkshire, SL5 7PY, United Kingdom
J Invertebr Pathol 78:59-65. 2001..The duration of daily exposure to high humidity appears to be a crucial constraint to the recycling ability of M. anisopliae var. acridum...
- Physical and mechanical characteristics of tibias from transgenic mice expressing mutant bovine growth hormone genesN D Turner
Texas A and M University, Department of Animal Science and Faculty of Nutrition, College Station 77843 2471, USA
Exp Biol Med (Maywood) 226:133-9. 2001....
- Sequence-specific detection of individual DNA strands using engineered nanoporesS Howorka
Department of Medical Biochemistry and Genetics, The Texas A and M University System Health Science Center, 440 Reynolds Medical Building, College Station, TX 77843 1114, USA
Nat Biotechnol 19:636-9. 2001..This was exemplified by the detection of a drug resistance-conferring mutation in the reverse transcriptase gene of HIV. In addition, the approach was used to sequence a complete codon in an individual DNA strand tethered to a nanopore...
- Molecular biology of the Ah receptor and its role in carcinogenesisS Safe
Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843 4466, USA
Toxicol Lett 120:1-7. 2001..Both TCDD and phytochemicals inhibit estrogen-induced breast and endometrial cancer, and the molecular mechanisms of this common response will be described...
- Bayesian survival analysis using a MARS modelB K Mallick
Department of Statistics, Texas A and M University, College Station 77843 3143, USA
Biometrics 55:1071-7. 1999..A reversible jump Markov chain Monte Carlo algorithm is described to obtain the estimate of the hazard function as well as the survival curve...
- Effect of sodium chlorate on Salmonella typhimurium concentrations in the weaned pig gutR C Anderson
US Department of Agriculture, Agricultural Research Service, Southern Plains Agricultural Research Center, Food and Feed Safety Research Unit, College Station, Texas 77845, USA
J Food Prot 64:255-8. 2001..An observed treatment by time after treatment interaction suggests the chlorate effect was concentration dependent. Chlorate treatment may provide a means to reduce foodborne pathogens immediately before harvest...
- Third trimester binge ethanol exposure results in fetal hypercapnea and acidemia but not hypoxemia in pregnant sheepT A Cudd
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
Alcohol Clin Exp Res 25:269-76. 2001....
- The inbred mouse in pigmentation research: significance of a congenic developmental systemM L Lamoreux
Department of Veterinary Pathobiology, Texas A and M University College Station 77843, USA
Pigment Cell Res 13:421-30. 2000....
- Occupation and adult gliomasS E Carozza
Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A and M University System Health Science Center, College Station 77843 1266, USA
Am J Epidemiol 152:838-46. 2000....
- Isotope effects and the mechanism of allylic hydroxylation of alkenes with selenium dioxideD A Singleton
Department of Chemistry, Texas A and M University, College Station, Texas 77843, USA
J Org Chem 65:7554-60. 2000..A concerted ene reaction with SeO(2) as the active oxidant appears to be the major mechanistic pathway operative in these reactions...
- Dehydration, stress, and water consumption of horses during long-distance commercial transportT H Friend
Department of Animal Science, Texas A and M University, College Station 77843 2471, USA
J Anim Sci 78:2568-80. 2000..Transporting healthy horses for more than 24 h during hot weather and without water will cause severe dehydration; transport for more than 28 h even with periodic access to water will likely be harmful due to increasing fatigue...
- A comparison of the influence of conflictual and supportive social interactions on psychological distressJ F Finch
Department of Psychology, Texas A and M University, College Station 77843 4235, USA
J Pers 67:581-621. 1999....
- Stabilization of intramolecular triple/single-strand structure by cationic peptidesV N Potaman
Institute of Biosciences and Technology, Texas A and M University, Houston 77030 3303, USA
Biochemistry 37:12952-61. 1998..It is possible that Arg-rich peptides interact with the unpaired single strand in H-DNA and stabilize its unpaired conformation...
- Fetal and maternal thyroid hormone responses to ethanol exposure during the third trimester equivalent of gestation in sheepTimothy A Cudd
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4466, USA
Alcohol Clin Exp Res 26:53-8. 2002..We investigated whether a binge pattern of maternal ethanol consumption over the last trimester equivalent of gestation in sheep results in an alteration in fetal or maternal thyroid function...
- First-pass nuclear angiocardiography in the evaluation of patent ductus arteriosus in dogsAnne Bahr
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A and M University, College Station 77843 4475, USA
J Vet Intern Med 16:74-9. 2002....
- Temperature effects and genotype-temperature interactions on sex determination in the European sea bass (Dicentrarchus labrax L.)Eric Saillant
Laboratoire de Recherche en Pisciculture Marine, IFREMER, Chemin de Maguelonne, 34250 Palavas les Flots, France
J Exp Zool 292:494-505. 2002..Genotype temperature interactions were also detected and their existence suggests the interesting possibility of selecting nonsensitive genotypes in breeding programs...
- Molecular parentage analysis in experimental newt populations: the response of mating system measures to variation in the operational sex ratioAdam G Jones
Department of Biology, Texas A and M University, College Station, Texas 77843, USA
Am Nat 164:444-56. 2004..Overall, our results show that Bateman's principles provide the best available method for the statistical characterization of mating systems in nature...
- Conservation genetics and demographic history of the endangered Cape Fear shiner (Notropis mekistocholas)E Saillant
Center for Biosystematics and Biodiversity, Texas A and M University, College Station, Texas 77843 2258, USA
Mol Ecol 13:2947-58. 2004..These results suggest that rapidly evolving markers such as microsatellites may constitute a suitable tool when inferring recent demographic dynamics of populations...
- Mental health and substance abuse services among rural minoritiesLarry D Gamm
School of Rural Public Health, Texas A and M University System Health Science Center, Bryan, TX 77802, USA
J Rural Health 20:206-9. 2004....
- Dynamic response of Permian brachiopod communities to long-term environmental changeThomas D Olszewski
Department of Geology and Geophysics, 3115 TAMU, Texas A and M University, College Station, Texas 77843, USA
Nature 428:738-41. 2004..Neither these long-term environmental changes nor higher-frequency sea level fluctuations resulted in wholesale extinction or major innovation within evolutionary lineages...
- Information technology in veterinary pharmacology instructionDeborah T Kochevar
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
J Vet Med Educ 30:331-7. 2003..Creation of high-quality IT resources that promote this goal has the potential to improve veterinary pharmacology instruction within and across institutions...
- Early developmental lead exposure increases sensitivity to cocaine in a self-administration paradigmJack R Nation
Department of Psychology, Texas A and M University, College Station, TX 77843, USA
Pharmacol Biochem Behav 77:127-35. 2004..Collectively, these data suggest that early developmental lead exposure may increase sensitivity to cocaine later in the life cycle...
- Fundamental predictability in multispecies competition: the influence of large disturbanceDaniel Roelke
Wildlife and Fisheries Sciences, Texas A and M University, College Station, Texas 77843 2258, USA
Am Nat 162:615-23. 2003..Our numerical findings also revealed that large hydraulic disturbances could introduce to the system another aspect of complex behavior, aperiodic succession...
- Predation experiments on infant spectral tarsiers (Tarsius spectrum)Sharon Gursky
Department of Anthropology, Texas A and M University, College Station, Tex 77843 4352, USA
Folia Primatol (Basel) 74:272-84. 2003..Infants and mothers both produced a twittering alarm call in response to the bird of prey models, whereas they both produced a harsh loud call 3 times in rapid succession in response to the presence of the rubber snakes...
- Fisher Lecture: the 2002 R. A. Fisher lecture: dedicated to the memory of Shanti S. Gupta. Variances are not always nuisance parametersRaymond J Carroll
Department of Statistics, Texas A and M University, College Station, Texas 77843 3143, USA
Biometrics 59:211-20. 2003..In these and other problems, treating variance structure as a nuisance instead of a central part of the modeling effort not only leads to inefficient estimation of means, but also to misleading conclusions...
- A social network analysis of communication about hereditary nonpolyposis colorectal cancer genetic testing and family functioningLaura M Koehly
Department of Psychology, Texas A and M University, College Station, Texas 77843 4235, USA
Cancer Epidemiol Biomarkers Prev 12:304-13. 2003..Results of this study suggest encouraging family members who act in the mother role to take a "team approach" with the family proband when discussing HNPCC risks and management with family members...
- An evolutionary perspective of sex-typed toy preferences: pink, blue, and the brainGerianne M Alexander
Yale Child Study Center, New Haven, Connecticut, USA
Arch Sex Behav 32:7-14. 2003....
- Forewarned and forearmed? Two meta-analytic syntheses of forewarnings of influence appealsWendy Wood
Department of Psychology, Texas A and M University, College Station 77843, USA
Psychol Bull 129:119-38. 2003....
- Learning nonlinearly separable categories by inference and classificationTakashi Yamauchi
Department of Psychology, Texas A and M University, College Station 77843, USA
J Exp Psychol Learn Mem Cogn 28:585-93. 2002..The results from this study suggest that having a cohesive category structure is more important for inference than it is for classification...
- The record of horizontal gene transfer in SalmonellaA J Bäumler
Dept of Medical Microbiology and Immunology, Texas A and M University, College Station 77843 1114, USA
Trends Microbiol 5:318-22. 1997..Tracing the record of horizontal gene transfer can provide clues to the virulence factors that contribute to the formation of new pathovars...
- NUR77 Agonists: New Targets for Pancreatic Cancer ChemotherapyStephen H Safe; Fiscal Year: 2010..These studies will serve to highlight the potential role of selective Nur77 modulators as a new class of chemotherapeutic drugs for treatment of pancreatic cancer. ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2007..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2006..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- Inhibition of Pancreatic Cancer by New PPARgamma Agonis*Stephen Safe; Fiscal Year: 2007..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
- NUR77 Agonists: New Targets for Pancreatic Cancer ChemotherapyStephen Safe; Fiscal Year: 2007..These studies will serve to highlight the potential role of selective Nur77 modulators as a new class of chemotherapeutic drugs for treatment of pancreatic cancer. ..
- MicroRNAs as Targets for Colon Cancer ChemotherapyStephen H Safe; Fiscal Year: 2010....
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2009..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- Molecular Mechanisms and Application of Ah Receptor-MicroRNA InteractionsStephen H Safe; Fiscal Year: 2010..The proposed research will investigate the AhR-dependent induction of the antimetastatic microRNA-335 and microRNA-205 and delineate their role in the anticarcinogenic activity of SAhRMs. ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITEStephen Safe; Fiscal Year: 2007..To support the research projects, the Program also includes three Research Support Cores (Image Analysis, Analytical Services & Biostatistics, and Field Services) and Administrative, Outreach, and Training Cores. ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- MECHANISMS OF GROWTH FACTOR/ESTROGEN RECEPTOR CROSSTALKStephen Safe; Fiscal Year: 2001..The effects of AhR agonists will determine impacts of important dietary/environmental endocrine disruptors on these coupled endocrine pathways, which play important roles in development of hormone-dependent cancers. ..
- 2, 3, 7, 8--TCDD EFFECTS ON ESTROGENIC RESPONSESStephen Safe; Fiscal Year: 2001..iDREs are important new 5'-promoter sequences which affect hormone-induced transactivation, and functional iDREs in critical E2-regulated genes could serve as important genomic target sequences for antiestrogen chemotherapy. ..
- Arginine and Ovine Model for Fetal Growth RestrictionGuoyao Wu; Fiscal Year: 2007..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. ..
- Heavy Metal and Drug Self-Administration: MechanismsPAUL JEFFERSON WELLMAN; Fiscal Year: 2010..e., lead contamination and cocaine use. Based on the available literature, there is reason to believe that environmental pollutants may increase vulnerability to drug addiction. ..
- Heavy Metal and Drug Self-Administration: MechanismsPaul Wellman; Fiscal Year: 2009..e., lead contamination and cocaine use. Based on the available literature, there is reason to believe that environmental pollutants may increase vulnerability to drug addiction. ..
- Psychostimulants and Alpha-1 Adrenoceptor SubtypesPaul Wellman; Fiscal Year: 2006..These studies will advance our understanding of the behavioral functions of brain a l-AR subtypes and may lead to the identification of new drugs that inhibit eating without activating brain reinforcement systems. ..