Diana S Woodruff-Pak

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi request reprint Animal models of Alzheimer's disease: therapeutic implications
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    J Alzheimers Dis 15:507-21. 2008
  2. pmc Young and older good learners have higher levels of brain nicotinic receptor binding
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Aging 31:1032-43. 2010
  3. ncbi request reprint The long-term effects of nefiracetam on learning in older rabbits
    Diana S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
    Behav Brain Res 136:299-308. 2002
  4. ncbi request reprint A rabbit model of Alzheimer's disease: valid at neuropathological, cognitive, and therapeutic levels
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    J Alzheimers Dis 11:371-83. 2007
  5. pmc A comparison of low- and high-impact forced exercise: effects of training paradigm on learning and memory
    John A Kennard
    Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
    Physiol Behav 106:423-7. 2012
  6. ncbi request reprint The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure
    Diana S Woodruff-Pak
    Cognitive Neuroscience Laboratory, Albert Einstein Healthcare Network, Philadelphia, PA, USA
    Integr Physiol Behav Sci 37:103-13. 2002
  7. ncbi request reprint Nicotinic cholinergic modulation: galantamine as a prototype
    Diana S Woodruff-Pak
    Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
    CNS Drug Rev 8:405-26. 2002
  8. ncbi request reprint Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
    Neurobiol Aging 25:807-16. 2004
  9. pmc Differential effects and rates of normal aging in cerebellum and hippocampus
    Diana S Woodruff-Pak
    Neuroscience Program and Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Proc Natl Acad Sci U S A 107:1624-9. 2010
  10. pmc Unimpaired trace classical eyeblink conditioning in Purkinje cell degeneration (pcd) mutant mice
    Kevin L Brown
    Temple University, 1701 North 13th Street Weiss Hall, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 93:303-11. 2010

Detail Information

Publications21

  1. ncbi request reprint Animal models of Alzheimer's disease: therapeutic implications
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    J Alzheimers Dis 15:507-21. 2008
    ..Each animal model has limitations and strengths, but used together in complementary fashion, animal models for research on AD are essential for rapid progress toward a cure...
  2. pmc Young and older good learners have higher levels of brain nicotinic receptor binding
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Aging 31:1032-43. 2010
    ..However, individual differences in alphabeta heteromeric nAChRs also exist early in life, as better learning in 4-month rabbits was associated with significantly higher binding...
  3. ncbi request reprint The long-term effects of nefiracetam on learning in older rabbits
    Diana S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
    Behav Brain Res 136:299-308. 2002
    ..In this experiment, nefiracetam had a significant effect long after drug administration had ceased. Prolonged administration of nefiracetam may have ameliorating effects greater than those observed in only 15 days of drug administration...
  4. ncbi request reprint A rabbit model of Alzheimer's disease: valid at neuropathological, cognitive, and therapeutic levels
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    J Alzheimers Dis 11:371-83. 2007
    ..Galantamine ameliorated impaired eyeblink conditioning, extending the validity of the AD rabbit model to treatment modalities...
  5. pmc A comparison of low- and high-impact forced exercise: effects of training paradigm on learning and memory
    John A Kennard
    Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
    Physiol Behav 106:423-7. 2012
    ..Comparison of these two paradigms begins to address the window between the beneficial and detrimental effects of forced exercise, and have suggested a boundary of exercise intensity that leads to impairment in learning...
  6. ncbi request reprint The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure
    Diana S Woodruff-Pak
    Cognitive Neuroscience Laboratory, Albert Einstein Healthcare Network, Philadelphia, PA, USA
    Integr Physiol Behav Sci 37:103-13. 2002
    ..25 mg/kg scopolamine. Results exhibit parallels in performance on delay eyeblink classical conditioning between scopolamine-treated older rabbits and human patients diagnosed with AD...
  7. ncbi request reprint Nicotinic cholinergic modulation: galantamine as a prototype
    Diana S Woodruff-Pak
    Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
    CNS Drug Rev 8:405-26. 2002
    ....
  8. ncbi request reprint Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
    Neurobiol Aging 25:807-16. 2004
    ....
  9. pmc Differential effects and rates of normal aging in cerebellum and hippocampus
    Diana S Woodruff-Pak
    Neuroscience Program and Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Proc Natl Acad Sci U S A 107:1624-9. 2010
    ..Our results demonstrate that processes of aging impact brain structures and associated behaviors differentially, with cerebellum showing earlier senescence than hippocampus...
  10. pmc Unimpaired trace classical eyeblink conditioning in Purkinje cell degeneration (pcd) mutant mice
    Kevin L Brown
    Temple University, 1701 North 13th Street Weiss Hall, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 93:303-11. 2010
    ..Results indicate that the essential neural circuitry for trace eyeblink conditioning involves connectivity that bypasses cerebellar cortex...
  11. ncbi request reprint Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning
    Diana S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
    Behav Brain Res 143:159-67. 2003
    ..Reversal of mecamylamine-induced learning deficits by nicotine and GTS-21 suggests that nAChR agonists may have efficacy in ameliorating deficits caused by the loss of some types of nAChRs in diseases such as AD...
  12. ncbi request reprint Preclinical investigation of the functional effects of memantine and memantine combined with galantamine or donepezil
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neuropsychopharmacology 32:1284-94. 2007
    ..In the absence of AD neuropathology in older rabbits, memantine had no efficacy alone or in combination with the other drugs...
  13. pmc The context preexposure facilitation effect in mice: a dose-response analysis of pretraining scopolamine administration
    Kevin L Brown
    Department of Psychology, Temple University, 1701 North 13th Street Weiss Hall, Philadelphia, PA 19122, United States
    Behav Brain Res 225:290-6. 2011
    ..These findings support use of the Rudy CPFE task as a behavioral assay for hippocampal function in mice...
  14. ncbi request reprint Inactivation of sodium channel Scn8A (Na-sub(v)1.6) in Purkinje neurons impairs learning in Morris water maze and delay but not trace eyeblink classical conditioning
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Behav Neurosci 120:229-40. 2006
    ....
  15. doi request reprint Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits
    Jian Guo Li
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Neuropsychopharmacology 33:2820-30. 2008
    ..Results provide evidence for cortical as well as hippocampal nAChR modulation of delay eyeblink conditioning and demonstrate that more sensitive binding assays are required to assess nAChR effects in cerebellum...
  16. pmc Effects of paradigm and inter-stimulus interval on age differences in eyeblink classical conditioning in rabbits
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Learn Mem 14:287-94. 2007
    ..Results demonstrate that the magnitude of age differences in eyeblink conditioning can be enlarged or eliminated by ISI and paradigm...
  17. doi request reprint Where is the trace in trace conditioning?
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122 6011, USA
    Trends Neurosci 31:105-12. 2008
    ..This temporal gap appears to impose forebrain dependencies and differentially engage different cerebellar circuitry during acquisition of conditioned responses...
  18. ncbi request reprint Immunotherapy for Alzheimer's disease: harnessing our knowledge of T cell biology using a cholesterol-fed rabbit model
    Richard Coico
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Alzheimers Dis 15:657-71. 2008
    ....
  19. pmc Eyeblink conditioning in the developing rabbit
    Kevin L Brown
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Dev Psychobiol 54:423-32. 2012
    ..With further characterization of optimal conditioning parameters, this preparation may have applications to neurodevelopmental disease models as well as research exploring the ontogeny of memory...
  20. pmc Delay eyeblink classical conditioning is impaired in Fragile X syndrome
    Michael J Tobia
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Behav Neurosci 123:665-76. 2009
    ..Fragile X impairs the acquisition and timing of conditioned eyeblink responses, but with repeated training adults with Fragile X syndrome show significant plasticity...
  21. ncbi request reprint Associative and motor learning in 12-month-old transgenic APP+PS1 mice
    Michael Ewers
    Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
    Neurobiol Aging 27:1118-28. 2006
    ....