Research Topics
| Diana S Woodruff-PakSummaryAffiliation: Temple University Country: USA Publications
| Collaborators |
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Publications
Animal models of Alzheimer's disease: therapeutic implicationsDiana S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
J Alzheimers Dis 15:507-21. 2008..Each animal model has limitations and strengths, but used together in complementary fashion, animal models for research on AD are essential for rapid progress toward a cure...
Young and older good learners have higher levels of brain nicotinic receptor bindingDiana S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Neurobiol Aging 31:1032-43. 2010..However, individual differences in alphabeta heteromeric nAChRs also exist early in life, as better learning in 4-month rabbits was associated with significantly higher binding...- The long-term effects of nefiracetam on learning in older rabbitsDiana S Woodruff-Pak
Research and Technology Development, Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
Behav Brain Res 136:299-308. 2002..In this experiment, nefiracetam had a significant effect long after drug administration had ceased. Prolonged administration of nefiracetam may have ameliorating effects greater than those observed in only 15 days of drug administration... - A rabbit model of Alzheimer's disease: valid at neuropathological, cognitive, and therapeutic levelsDiana S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
J Alzheimers Dis 11:371-83. 2007..Galantamine ameliorated impaired eyeblink conditioning, extending the validity of the AD rabbit model to treatment modalities... - A comparison of low- and high-impact forced exercise: effects of training paradigm on learning and memoryJohn A Kennard
Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
Physiol Behav 106:423-7. 2012..Comparison of these two paradigms begins to address the window between the beneficial and detrimental effects of forced exercise, and have suggested a boundary of exercise intensity that leads to impairment in learning... - The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedureDiana S Woodruff-Pak
Cognitive Neuroscience Laboratory, Albert Einstein Healthcare Network, Philadelphia, PA, USA
Integr Physiol Behav Sci 37:103-13. 2002..25 mg/kg scopolamine. Results exhibit parallels in performance on delay eyeblink classical conditioning between scopolamine-treated older rabbits and human patients diagnosed with AD... - Nicotinic cholinergic modulation: galantamine as a prototypeDiana S Woodruff-Pak
Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
CNS Drug Rev 8:405-26. 2002.... - Nefiracetam and physostigmine: separate and combined effects on learning in older rabbitsDiana S Woodruff-Pak
Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
Neurobiol Aging 25:807-16. 2004.... - Differential effects and rates of normal aging in cerebellum and hippocampusDiana S Woodruff-Pak
Neuroscience Program and Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Proc Natl Acad Sci U S A 107:1624-9. 2010..Our results demonstrate that processes of aging impact brain structures and associated behaviors differentially, with cerebellum showing earlier senescence than hippocampus... - Unimpaired trace classical eyeblink conditioning in Purkinje cell degeneration (pcd) mutant miceKevin L Brown
Temple University, 1701 North 13th Street Weiss Hall, Philadelphia, PA 19122, USA
Neurobiol Learn Mem 93:303-11. 2010..Results indicate that the essential neural circuitry for trace eyeblink conditioning involves connectivity that bypasses cerebellar cortex... - Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioningDiana S Woodruff-Pak
Research and Technology Development, Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
Behav Brain Res 143:159-67. 2003..Reversal of mecamylamine-induced learning deficits by nicotine and GTS-21 suggests that nAChR agonists may have efficacy in ameliorating deficits caused by the loss of some types of nAChRs in diseases such as AD... - Preclinical investigation of the functional effects of memantine and memantine combined with galantamine or donepezilDiana S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Neuropsychopharmacology 32:1284-94. 2007..In the absence of AD neuropathology in older rabbits, memantine had no efficacy alone or in combination with the other drugs... - The context preexposure facilitation effect in mice: a dose-response analysis of pretraining scopolamine administrationKevin L Brown
Department of Psychology, Temple University, 1701 North 13th Street Weiss Hall, Philadelphia, PA 19122, United States
Behav Brain Res 225:290-6. 2011..These findings support use of the Rudy CPFE task as a behavioral assay for hippocampal function in mice... - Inactivation of sodium channel Scn8A (Na-sub(v)1.6) in Purkinje neurons impairs learning in Morris water maze and delay but not trace eyeblink classical conditioningDiana S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Behav Neurosci 120:229-40. 2006.... 
Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbitsJian Guo Li
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19122, USA
Neuropsychopharmacology 33:2820-30. 2008..Results provide evidence for cortical as well as hippocampal nAChR modulation of delay eyeblink conditioning and demonstrate that more sensitive binding assays are required to assess nAChR effects in cerebellum...- Effects of paradigm and inter-stimulus interval on age differences in eyeblink classical conditioning in rabbitsDiana S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
Learn Mem 14:287-94. 2007..Results demonstrate that the magnitude of age differences in eyeblink conditioning can be enlarged or eliminated by ISI and paradigm... - Where is the trace in trace conditioning?Diana S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122 6011, USA
Trends Neurosci 31:105-12. 2008..This temporal gap appears to impose forebrain dependencies and differentially engage different cerebellar circuitry during acquisition of conditioned responses... - Immunotherapy for Alzheimer's disease: harnessing our knowledge of T cell biology using a cholesterol-fed rabbit modelRichard Coico
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Alzheimers Dis 15:657-71. 2008.... - Eyeblink conditioning in the developing rabbitKevin L Brown
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Dev Psychobiol 54:423-32. 2012..With further characterization of optimal conditioning parameters, this preparation may have applications to neurodevelopmental disease models as well as research exploring the ontogeny of memory... - Delay eyeblink classical conditioning is impaired in Fragile X syndromeMichael J Tobia
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Behav Neurosci 123:665-76. 2009..Fragile X impairs the acquisition and timing of conditioned eyeblink responses, but with repeated training adults with Fragile X syndrome show significant plasticity... - Associative and motor learning in 12-month-old transgenic APP+PS1 miceMichael Ewers
Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
Neurobiol Aging 27:1118-28. 2006....