ELLEN ANN WALKER

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi request reprint Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Neuropharmacology 49:1210-9. 2005
  2. pmc Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Psychopharmacology (Berl) 217:539-48. 2011
  3. doi request reprint Acquisition session length modulates consolidation effects produced by 5-HT2C ligands in a mouse autoshaping-operant procedure
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Behav Pharmacol 21:83-9. 2010
  4. ncbi request reprint In vivo Schild regression analyses using nonselective 5-HT2C receptor antagonists in a rat operant behavioral assay
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Psychopharmacology (Berl) 193:187-97. 2007
  5. ncbi request reprint Effects of opioids in morphine-treated pigeons trained to discriminate among morphine, the low-efficacy agonist nalbuphine, and saline
    Ellen A Walker
    Department of Psychology, University of North Carolina at Chapel Hill, USA
    J Pharmacol Exp Ther 310:150-8. 2004
  6. pmc Opioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependence
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Br J Pharmacol 145:975-83. 2005
  7. pmc In vivo pharmacological resultant analysis reveals noncompetitive interactions between opioid antagonists in the rat tail-withdrawal assay
    E A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Br J Pharmacol 149:1071-82. 2006
  8. pmc Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice
    Sara Jane Ward
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA
    Anesth Analg 113:947-50. 2011
  9. ncbi request reprint Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids
    L Zhang
    Department of Psychology, Wayne State University, 71 West Warren Avenue, Detroit, MI 48202, USA
    Psychopharmacology (Berl) 148:136-45. 2000
  10. ncbi request reprint Three-choice discrimination in pigeons is based on relative efficacy differences among opioids
    E A Walker
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Psychopharmacology (Berl) 155:389-96. 2001

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Neuropharmacology 49:1210-9. 2005
    ..Taken together, these data indicate that the serotonin agonists MK212 and mCPP produce conditioned taste aversion and that these effects are mediated predominantly through 5-HT(2C) receptors...
  2. pmc Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Psychopharmacology (Berl) 217:539-48. 2011
    ..A number of cancer chemotherapeutic agents have been associated with a loss of memory in breast cancer patients although little is known of the causality of this effect...
  3. doi request reprint Acquisition session length modulates consolidation effects produced by 5-HT2C ligands in a mouse autoshaping-operant procedure
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Behav Pharmacol 21:83-9. 2010
    ..Furthermore, decreasing the length of the acquisition session to 1h significantly increased the difficulty of the autoshaping task further modulating the consolidation effects produced by the 5-HT2C ligands tested...
  4. ncbi request reprint In vivo Schild regression analyses using nonselective 5-HT2C receptor antagonists in a rat operant behavioral assay
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Psychopharmacology (Berl) 193:187-97. 2007
    ....
  5. ncbi request reprint Effects of opioids in morphine-treated pigeons trained to discriminate among morphine, the low-efficacy agonist nalbuphine, and saline
    Ellen A Walker
    Department of Psychology, University of North Carolina at Chapel Hill, USA
    J Pharmacol Exp Ther 310:150-8. 2004
    ....
  6. pmc Opioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependence
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Br J Pharmacol 145:975-83. 2005
    ..Furthermore, the observation that nalorphine and naloxonazine blocked the naloxone-induced withdrawal jumping provides additional evidence that nalorphine and naloxonazine are weaker inverse agonists than naloxone...
  7. pmc In vivo pharmacological resultant analysis reveals noncompetitive interactions between opioid antagonists in the rat tail-withdrawal assay
    E A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Br J Pharmacol 149:1071-82. 2006
    ..The utility of pharmacological resultant analysis as a potential tool for the investigation of antagonist interactions in vivo was examined in the present study using two opioid antagonists, naltrexone and CTAP...
  8. pmc Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice
    Sara Jane Ward
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA
    Anesth Analg 113:947-50. 2011
    ..Our preliminary findings therefore indicate that cannabidiol may prevent the development of paclitaxel-induced allodynia in mice and therefore be effective at preventing dose-limiting paclitaxel-induced peripheral neuropathy in humans...
  9. ncbi request reprint Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids
    L Zhang
    Department of Psychology, Wayne State University, 71 West Warren Avenue, Detroit, MI 48202, USA
    Psychopharmacology (Berl) 148:136-45. 2000
    ..Discriminative stimulus effects of mu opioids vary systematically as a function of training dose. Differences among training doses may arise from multiple mechanisms...
  10. ncbi request reprint Three-choice discrimination in pigeons is based on relative efficacy differences among opioids
    E A Walker
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Psychopharmacology (Berl) 155:389-96. 2001
    ..Drug discrimination assays can provide important information on receptor selectivity and relative efficacy to guide the classification and characterization of opioid agonists...
  11. ncbi request reprint Differential tolerance to antinociceptive effects of mu opioids during repeated treatment with etonitazene, morphine, or buprenorphine in rats
    E A Walker
    Research and Technology Development Psychology, Albert Einstein Healthcare Network La Salle University, Philadelphia, PA 19141, USA
    Psychopharmacology (Berl) 154:131-42. 2001
    ..Repeated treatment experiments with high and low efficacy agonists provide critical insight into possible mechanisms underlying development of opioid tolerance...
  12. ncbi request reprint Naltrexone and beta-funaltrexamine antagonism of the antinociceptive and response rate-decreasing effects of morphine, dezocine, and d-propoxyphene
    E A Walker
    Department of Psychology, University of North Carolina at Chapel Hill, 27599 3270, USA
    Psychopharmacology (Berl) 144:45-53. 1999
    ..Patterns of competitive and insurmountable antagonism provide important data to guide the classification and characterization of different types of opioid agonists as well as infer the mechanism of action for agonists...

Research Grants9

  1. Society for the Stimulus Properties of Drugs Satellite
    Ellen Walker; Fiscal Year: 2005
    ..The SSPD Satellite to the EBPS 2005 Conference promises to coordinate, exchange, and disseminate information to further our understanding of drug abuse. ..
  2. Behavioral Pharmacology of Serotonin Inverse Agoinsts
    Ellen Walker; Fiscal Year: 2006
    ..Taken together, these experiments will provide a novel pharmacological and/or behavioral profile for 5-HT2C inverse agonists and neutral antagonists while testing hypotheses generated from in vitro data. ..
  3. Effects of chemotherapeutic agents on learning and memory in mice
    Ellen Walker; Fiscal Year: 2009
    ..If certain drugs/combinations produce more adverse effects than others do, clinicians can make informed choices about their patients' therapy and improve the quality of life for cancer survivors and their families. ..
  4. Effects of chemotherapeutic agents on learning and memory in mice
    ELLEN ANN WALKER; Fiscal Year: 2010
    ..If certain drugs/combinations produce more adverse effects than others do, clinicians can make informed choices about their patients'therapy and improve the quality of life for cancer survivors and their families. ..