E M Unterwald

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi Dopamine-opioid interactions in the rat striatum: a modulatory role for dopamine D1 receptors in delta opioid receptor-mediated signal transduction
    E M Unterwald
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuropharmacology 39:372-81. 2000
  2. ncbi The frequency of cocaine administration impacts cocaine-induced receptor alterations
    E M Unterwald
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Brain Res 900:103-9. 2001
  3. ncbi Regulation of opioid receptors by cocaine
    E M Unterwald
    Department of Pharmacology, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, USA
    Ann N Y Acad Sci 937:74-92. 2001
  4. ncbi An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice
    M Hummel
    Department of Pharmacology and the Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuroscience 142:481-91. 2006
  5. ncbi Modulation of cocaine-induced activity by intracerebral administration of CXCL12
    J Trecki
    Department of Pharmacology, and Center for Substance Abuse Research, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Neuroscience 161:13-22. 2009
  6. ncbi Cocaine reward and hyperactivity in the rat: sites of mu opioid receptor modulation
    A R Soderman
    Department of Pharmacology and the Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuroscience 154:1506-16. 2008
  7. ncbi Dopamine-D1 and delta-opioid receptors co-exist in rat striatal neurons
    L M Ambrose
    Farber Institute for Neurosciences, Department of Neurosurgery, Thomas Jefferson University, 900 Walnut Street, Suite 417, Philadelphia, PA 19107, USA
    Neurosci Lett 399:191-6. 2006
  8. ncbi Ultrastructural evidence for co-localization of dopamine D2 and micro-opioid receptors in the rat dorsolateral striatum
    L M Ambrose
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Anat Rec A Discov Mol Cell Evol Biol 279:583-91. 2004
  9. ncbi Distribution and ultrastructural localization of GEC1 in the rat CNS
    Y Wang
    Department of Pharmacology, School of Medicine, Temple University, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Neuroscience 140:1265-76. 2006
  10. ncbi Genetic and pharmacological manipulation of mu opioid receptors in mice reveals a differential effect on behavioral sensitization to cocaine
    M Hummel
    Department of Pharmacology and the Center for Substance Abuse Research, Temple University School of Medicine, 3420 North Broad Street, MRB 324, Philadelphia, PA 19140, USA
    Neuroscience 125:211-20. 2004

Collaborators

Detail Information

Publications10

  1. ncbi Dopamine-opioid interactions in the rat striatum: a modulatory role for dopamine D1 receptors in delta opioid receptor-mediated signal transduction
    E M Unterwald
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuropharmacology 39:372-81. 2000
    ..These results suggest that repeated activation of D1 receptors attenuates the functional coupling of delta opioid receptors with adenylyl cyclase due to decreased coupling between delta receptors and G proteins...
  2. ncbi The frequency of cocaine administration impacts cocaine-induced receptor alterations
    E M Unterwald
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Brain Res 900:103-9. 2001
    ..This suggests that the interval between cocaine injections is an important variable when studying the effects of cocaine on neurochemistry...
  3. ncbi Regulation of opioid receptors by cocaine
    E M Unterwald
    Department of Pharmacology, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, USA
    Ann N Y Acad Sci 937:74-92. 2001
    ..This chapter reviews studies on the regulation of opioid receptors as the result of exposure to cocaine...
  4. ncbi An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice
    M Hummel
    Department of Pharmacology and the Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuroscience 142:481-91. 2006
    ..MOR AS ODN also reduced [3H]DAMGO binding. Collectively, these findings implicate the MOR as playing an important neuromodulatory role in the behavioral effects of cocaine in mice...
  5. ncbi Modulation of cocaine-induced activity by intracerebral administration of CXCL12
    J Trecki
    Department of Pharmacology, and Center for Substance Abuse Research, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Neuroscience 161:13-22. 2009
    ..These results demonstrate that CXCL12 can modulate the behavioral effects produced by cocaine in a brain region-specific manner...
  6. ncbi Cocaine reward and hyperactivity in the rat: sites of mu opioid receptor modulation
    A R Soderman
    Department of Pharmacology and the Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuroscience 154:1506-16. 2008
    ....
  7. ncbi Dopamine-D1 and delta-opioid receptors co-exist in rat striatal neurons
    L M Ambrose
    Farber Institute for Neurosciences, Department of Neurosurgery, Thomas Jefferson University, 900 Walnut Street, Suite 417, Philadelphia, PA 19107, USA
    Neurosci Lett 399:191-6. 2006
    ..The present data provide ultrastructural evidence for co-existence between DOR and D1R in striatal neurons, suggesting a possible mechanism whereby D1R modulation may alter DOR function...
  8. ncbi Ultrastructural evidence for co-localization of dopamine D2 and micro-opioid receptors in the rat dorsolateral striatum
    L M Ambrose
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Anat Rec A Discov Mol Cell Evol Biol 279:583-91. 2004
    ..These data also suggest that the molecular mechanism responsible for the up-regulation of microOrs in the caudate and putamen following cocaine exposure may depend, in part, on the co-existence of D2rs and micro-Ors in these cells...
  9. ncbi Distribution and ultrastructural localization of GEC1 in the rat CNS
    Y Wang
    Department of Pharmacology, School of Medicine, Temple University, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Neuroscience 140:1265-76. 2006
    ..The widespread distribution of GEC1 suggests that GEC1 may be associated with many proteins, in addition to the kappa opioid receptor...
  10. ncbi Genetic and pharmacological manipulation of mu opioid receptors in mice reveals a differential effect on behavioral sensitization to cocaine
    M Hummel
    Department of Pharmacology and the Center for Substance Abuse Research, Temple University School of Medicine, 3420 North Broad Street, MRB 324, Philadelphia, PA 19140, USA
    Neuroscience 125:211-20. 2004
    ..Moreover, MORs appear to differentially modulate a sensitized response to cocaine in different strains of mice as delineated by MOR-1 gene deletion and pharmacological antagonism...