George Tuszynski

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin alpha6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion
    Anitha S John
    Division of Pediatric Cardiology, Children s National Medical Center, George Washington University, Washington, DC 20052, USA
    J Oncol 2010:645376. 2010
  2. pmc Endothelial apoptotic activity of angiocidin is dependent on its polyubiquitin binding activity
    S Dimitrov
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 354 Biology Life Sciences Building 015 96, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Br J Cancer 93:662-9. 2005
  3. doi request reprint Angiocidin induces differentiation of acute myeloid leukemia cells
    George P Tuszynski
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, United States Electronic address
    Exp Mol Pathol 95:249-54. 2013
  4. doi request reprint G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer
    George P Tuszynski
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Exp Mol Pathol 91:608-13. 2011
  5. doi request reprint Angiocidin promotes pro-inflammatory cytokine production and antigen presentation in multiple sclerosis
    Sergey G Kremlev
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA 19122, United States
    J Neuroimmunol 194:132-42. 2008
  6. ncbi request reprint Reduction of angiocidin expression in human umbilical vein endothelial cells via siRNA silencing inhibits angiogenesis
    Xiao Yang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Exp Mol Pathol 81:108-14. 2006
  7. ncbi request reprint Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo
    Cezary Marcinkiewicz
    Temple University, School of Medicine, Thrombosis Research Center, Philadelphia, Pennsylvania 19140, USA
    Cancer Res 63:2020-3. 2003
  8. pmc Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in experimental melanoma growth
    MEGHAN C BROWN
    Department of Neuroscience, Center for Neurovirology and Cancer Biology, Temple University, School of Medicine, Philadelphia, PA, USA
    Int J Cancer 123:2195-203. 2008
  9. ncbi request reprint Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis
    Izabela Staniszewska
    Department of Neuroscience, Center for Neurovirology, Temple University, School of Medicine, Philadelphia, PA 19122, USA
    Circ Res 100:1308-16. 2007
  10. ncbi request reprint Integrin alpha2beta1 mediates the anti-angiogenic and anti-tumor activities of angiocidin, a novel tumor-associated protein
    Yamini Sabherwal
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Exp Cell Res 312:2443-53. 2006

Research Grants

  1. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2001
  2. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2003
  3. Angiociden, A New Angiogenesis Inhibitor
    George Tuszynski; Fiscal Year: 2003
  4. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2001
  5. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2004

Collaborators

  • Xiao Yang
  • Sergey G Kremlev
  • Cezary Marcinkiewicz
  • J J Calvete
  • S A Mousa
  • Izabela Staniszewska
  • Vicki L Rothman
  • Daniel Albo
  • Meena R Sharma
  • MEGHAN C BROWN
  • Svetoslav Dimitrov
  • Anitha S John
  • Thomas N Wang
  • Anita Gaurnier-Hausser
  • Luis Del Valle
  • Yamini Sabherwal
  • S Dimitrov
  • Mahesh Sharma
  • Mahesh C Sharma
  • Jing Zhou
  • Mahmut Safak
  • Shimon Lecht
  • Erin M Walsh
  • Philip Lazarovici
  • Ilker K Sariyer
  • Isabela Oliva
  • Sidney E Croul
  • Shachi Zaveri
  • Deane F Mosher
  • David D Roberts
  • Darryl Z L'Heureux
  • Vicki Rothman
  • Q Lu
  • Y Sabherwal
  • D Z L'Heureux
  • D D Raymond
  • Cuie Qiu
  • Elana Smith
  • Joel Sheffield
  • Irene Sargiannidou
  • Tetsuo Shinohara

Detail Information

Publications19

  1. pmc Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin alpha6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion
    Anitha S John
    Division of Pediatric Cardiology, Children s National Medical Center, George Washington University, Washington, DC 20052, USA
    J Oncol 2010:645376. 2010
    ..These data suggest that TSP-1 plays an integral role in the attachment of cells to the ECM facilitating cell motility and angiogenesis...
  2. pmc Endothelial apoptotic activity of angiocidin is dependent on its polyubiquitin binding activity
    S Dimitrov
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 354 Biology Life Sciences Building 015 96, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Br J Cancer 93:662-9. 2005
    ..The in vitro apoptotic activity of these mutants correlated with their polyubiquitin binding activity. These data strongly argue that the apoptotic activity of angiocidin is dependent on its polyubiquitin binding activity...
  3. doi request reprint Angiocidin induces differentiation of acute myeloid leukemia cells
    George P Tuszynski
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, United States Electronic address
    Exp Mol Pathol 95:249-54. 2013
    ..These observations support the continued evaluation and development of angiocidin as a potential novel, non-toxic therapy for AML...
  4. doi request reprint G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer
    George P Tuszynski
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Exp Mol Pathol 91:608-13. 2011
    ..These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer and suggest that GASP-1 may be a novel target for the development of breast cancer therapeutics...
  5. doi request reprint Angiocidin promotes pro-inflammatory cytokine production and antigen presentation in multiple sclerosis
    Sergey G Kremlev
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA 19122, United States
    J Neuroimmunol 194:132-42. 2008
    ..Angiocidin, therefore appears to play a previously unappreciated and potentially important role in the regulation of immune response during the clinical course of MS...
  6. ncbi request reprint Reduction of angiocidin expression in human umbilical vein endothelial cells via siRNA silencing inhibits angiogenesis
    Xiao Yang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Exp Mol Pathol 81:108-14. 2006
    ..These results suggest that endogenous angiocidin and its homologues promote endothelial cell invasion, adhesion, and angiogenesis through mechanisms involving polyubiquitin-dependent protein degradation and MMP-2 expression...
  7. ncbi request reprint Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo
    Cezary Marcinkiewicz
    Temple University, School of Medicine, Thrombosis Research Center, Philadelphia, Pennsylvania 19140, USA
    Cancer Res 63:2020-3. 2003
    ....
  8. pmc Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in experimental melanoma growth
    MEGHAN C BROWN
    Department of Neuroscience, Center for Neurovirology and Cancer Biology, Temple University, School of Medicine, Philadelphia, PA, USA
    Int J Cancer 123:2195-203. 2008
    ..Summarizing, we present studies of low molecular weight disintegrin, obtustatin as a potential therapeutic compound for treatment of melanoma that contain a high level of vascularization...
  9. ncbi request reprint Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis
    Izabela Staniszewska
    Department of Neuroscience, Center for Neurovirology, Temple University, School of Medicine, Philadelphia, PA 19122, USA
    Circ Res 100:1308-16. 2007
    ..In summary, our results revealed that alpha9beta1 integrin expressed on microvascular endothelial cells interacts with thrombospondin-1, and this interaction is involved in modulation of angiogenesis...
  10. ncbi request reprint Integrin alpha2beta1 mediates the anti-angiogenic and anti-tumor activities of angiocidin, a novel tumor-associated protein
    Yamini Sabherwal
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Exp Cell Res 312:2443-53. 2006
    ..Our results provide support for the concept that targeting matrix-cell interactions is a viable strategy for the development of anti-cancer therapeutics...
  11. ncbi request reprint Antibody-directed targeting of angiostatin's receptor annexin II inhibits Lewis Lung Carcinoma tumor growth via blocking of plasminogen activation: possible biochemical mechanism of angiostatin's action
    Meena R Sharma
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:136-45. 2006
    ..Plasmin is known to influence angiogenic, invasive and metastatic capability of tumors...
  12. ncbi request reprint Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1
    Jing Zhou
    Temple University, Center for Neurovirology and Cancer Biology, 354 Biology Life Sciences Building 015 96, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 92:125-46. 2004
    ..Such proteins may function as tumor-suppressor proteins, which limit the growth of tumors by inhibiting angiogenesis and cell matrix interaction...
  13. ncbi request reprint Antiangiogenic therapy
    Daniel Albo
    Department of Surgery, Section of Surgical Oncology, Medical College of Georgia, Augusta, GA 30912, USA
    Curr Pharm Des 10:27-37. 2004
    ..In this article, we review the different classes of antiangiogenic agents available, ongoing clinical trials, as well as potential pitfalls and future directions in this exciting field...
  14. pmc Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins
    Izabela Staniszewska
    Department of Neuroscience, Center for Neurovirology and Cancer Biology, Temple University, School of Medicine, Philadelphia, PA 19122, USA
    J Cell Sci 121:504-13. 2008
    ..Moreover, alpha9beta1 integrin is a signaling receptor for NGF, which activates the MAPK (Erk1/2) pathway. The alpha9beta1-dependent chemotactic ability of NGF appears to result from the activation of paxillin...
  15. pmc The novel angiogenic inhibitor, angiocidin, induces differentiation of monocytes to macrophages
    Anita Gaurnier-Hausser
    Department of Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Cancer Res 68:5905-14. 2008
    ..These data suggest that angiocidin activates monocytes to secrete cytokines and differentiates them to a macrophage-like phenotype through at least two pathways mediated by MAPK and NF-kappaB, as well as PI3K...
  16. ncbi request reprint Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5
    Meena R Sharma
    Laboratory of Biochemistry, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Cell Biochem 91:398-409. 2004
    ..These data suggest for the first time that neuron specific protein cdk5 may have significant role in the regulation of ECs proliferation, apoptosis, and angiogenesis and extends beyond its role in neurogenesis...
  17. ncbi request reprint Angiostatin binds to tyrosine kinase substrate annexin II through the lysine-binding domain in endothelial cells
    George P Tuszynski
    Department of Surgery, MCP Hahnemann University, MS 413, 245 North 15th Street, Philadelphia, PA 19102, USA
    Microvasc Res 64:448-62. 2002
    ..Identification of annexin II as a receptor for angiostatin provides further evidence that clotting and fibrinolytic pathways are directly involved in the angiogenic process...
  18. ncbi request reprint Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer
    Daniel Albo
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Surg Res 108:51-60. 2002
    ..We previously demonstrated that thrombospondin 1 (TSP-1) up-regulates MMP-9 expression by endothelial cells and promotes tumor cell invasion. We hypothesized that TSP-1 plays a role in the up-regulation of MMP-9 in gastric cancer...
  19. ncbi request reprint Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production
    Thomas N Wang
    Department of Surgery, The Medical College of Georgia, Augusta 30912, USA
    Surgery 132:220-5. 2002
    ..Stromal TSP-1 may play a role in regulating tumor cell invasion. We hypothesize that fibroblasts promote breast cancer cell invasion by upregulating the production of MMP-9 through TSP-1...

Research Grants5

  1. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2001
    ..Finally, these experiments should provide the basis for the development of angiocidin as an anti-cancer therapeutic. ..
  2. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2003
    ..Finally, these experiments should provide the basis for the development of angiocidin as an anti-cancer therapeutic. ..
  3. Angiociden, A New Angiogenesis Inhibitor
    George Tuszynski; Fiscal Year: 2003
    ..These experiments will develop the necessary protocols needed for commercial production of protein under GMP (good manufacturing practices) conditions suitable for use in clinical trials ..
  4. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2001
    ..Finally, these experiments should provide the basis for the development of angiocidin as an anti-cancer therapeutic. ..
  5. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2004
    ..Finally, these experiments should provide the basis for the development of angiocidin as an anti-cancer therapeutic. ..