Italo Tempera


Affiliation: Temple University
Country: USA


  1. Lupey Green L, Caruso L, Madzo J, Martin K, Tan Y, Hulse M, et al. PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type. J Virol. 2018;92: pubmed publisher
    ..Understanding how viral latency type is regulated at the chromatin level may reveal potential targets for EBV-specific pharmacological intervention in EBV-associated cancers. ..
  2. Martin K, Cesaroni M, Denny M, Lupey L, Tempera I. Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Mol Cell Biol. 2015;35:3934-44 pubmed publisher
    ..Together, these data show that PARP plays an important role in global gene regulation and identifies for the first time a direct role of PARP1 in regulating the expression and function of EZH2. ..
  3. Martin K, Lupey L, Tempera I. Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. J Virol. 2016;90:8520-30 pubmed publisher
    ..PARP1 inhibition or depletion led to a decrease in LMP1-induced cellular transformation. Therefore, targeting PARP1 activity may be an effective treatment for EBV-associated malignancies. ..
  4. Lupey Green L, Moquin S, Martin K, McDevitt S, Hulse M, Caruso L, et al. PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. Virology. 2017;507:220-230 pubmed publisher
    ..Moreover, EBV reactivation attenuates PARP activity, and Zta expression alone is sufficient to decrease PARP activity. Here we demonstrate a restrictive function of PARP1 in EBV lytic reactivation. ..