Affiliation: Temple University
- A homozygous frameshift mutation in the ESCO2 gene: evidence of intertissue and interindividual variation in Nmd efficiencyNicoletta Resta
Dipartimento di Biomedicina dell Eta Evolutiva, Sezione di Genetica Medica, Universita di Bari, Italy
J Cell Physiol 209:67-73. 2006....
- SWI/SNF: the crossroads where extracellular signaling pathways meet chromatinCristiano Simone
Department of Biomedicine in Childhood, Division of Medical Genetics, University of Bari, Bari, Italy
J Cell Physiol 207:309-14. 2006..The SWI/SNF chromatin remodeling complex offers the ideal surface for integrating these signals in the execution of diverse or even opposite biological programs...
- Signal-dependent control of autophagy and cell death in colorectal cancer cell: the role of the p38 pathwayCristiano Simone
Division of Medical Genetics, Department of Biomedicine in Childhood, University of Bari, Bari, Italy
Autophagy 3:468-71. 2007....
- Identification of murine cdk10: association with Ets2 transcription factor and effects on the cell cycleLuigi Bagella
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Biochem 99:978-85. 2006..Murine cdk10 binds Ets2 transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed...
- p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific lociCristiano Simone
Laboratory of Gene Expression, Dulbecco Telethon Institute at Fondazione A Cesalpino, Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park of Rome, Rome 00128, Italy
Nat Genet 36:738-43. 2004..These results identify an unexpected function of differentiation-activated p38 in converting external cues into chromatin modifications at discrete loci, by selectively targeting SWI-SNF to muscle-regulatory elements...
- Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiationCarlo Serra
The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037 1062, USA
Mol Cell 28:200-13. 2007....
- MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regionsCristina Giacinti
Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 206:807-13. 2006....
- Activation of MyoD-dependent transcription by cdk9/cyclin T2Cristiano Simone
Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania, PA 19122, USA
Oncogene 21:4137-48. 2002..Finally, cdk9 can phosphorylate MyoD in vitro, suggesting the possibility that cdk9/cycT2a regulation of muscle differentiation includes the direct enzymatic activity of the kinase on MyoD...
- Signal-dependent regulation of gene expression as a target for cancer treatment: inhibiting p38alpha in colorectal tumorsFulvio Chiacchiera
Laboratory of Signal dependent Transcription, Department of Translational Pharmacology DTP, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro Chieti, Italy
Cancer Lett 265:16-26. 2008..In this review we will focus on the possibility to inhibit p38alpha in colorectal cancer to arrest tumor progression and induce autophagic cell death...
- Porous silicon surfaces: a candidate substrate for reverse protein arrays in cancer biomarker detectionAnton Ressine
Department of Electrical Measurement, Lund University, Lund, Sweden
Electrophoresis 28:4407-15. 2007..The data demonstrate the potential use of macroporous silicon as a substrate for quantitative determination of a cancer biomarker cyclin E in tissue lysates...
- Tumor-specific hyperactive low-molecular-weight cyclin E isoforms detection and characterization in non-metastatic colorectal tumorsIrina Corin
Department of Oncology, Sahlgrenska Hospital, Gothenburg University, Gothenburg, Sweden
Cancer Biol Ther 5:198-203. 2006..We investigated the status of cyclin E and p53 in cell lines and tissue samples of colorectal cancer, one of the leading causes of death from a tumor in the Western world...
- Differentiation-induced radioresistance in muscle cellsLucia Latella
Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
Mol Cell Biol 24:6350-61. 2004....
- Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatinSimona Iezzi
Muscle Gene Expression Group, Laboratory of Muscle Biology, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 6:673-84. 2004....
- Physical interaction between pRb and cdk9/cyclinT2 complexCristiano Simone
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA
Oncogene 21:4158-65. 2002....
- Cdk9-55: a new player in muscle regenerationCristina Giacinti
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, USA
J Cell Physiol 216:576-82. 2008..This alternative form is specifically induced in injured myofibers and its activity is strictly required for the completion of muscle regeneration process...