MICHAEL RAYMOND contact RUGGIERI

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Gastric body cholinergic contractile signal transduction in M2 and M3 receptor knockout mice
    Michael R Ruggieri
    Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Recept Signal Transduct Res 33:249-54. 2013
  2. pmc Functional reinnervation of the canine bladder after spinal root transection and genitofemoral nerve transfer at one and three months after denervation
    Michael R Ruggieri
    Department of Urology, Temple University, Philadelphia, Pennsylvania, USA
    J Neurotrauma 25:401-9. 2008
  3. pmc Functional reinnervation of the canine bladder after spinal root transection and immediate end-on-end repair
    Michael R Ruggieri
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Neurotrauma 23:1125-36. 2006
  4. pmc Functional reinnervation of the canine bladder after spinal root transection and immediate somatic nerve transfer
    Michael R Ruggieri
    Department of Urology, Temple University, Philadelphia, Pennsylvania 19140 5104, USA
    J Neurotrauma 25:214-24. 2008
  5. pmc Reinnervation of urethral and anal sphincters with femoral motor nerve to pudendal nerve transfer
    Michael R Ruggieri
    Department of Urology, Temple University, Pennsylvania, USA
    Neurourol Urodyn 30:1695-704. 2011
  6. doi request reprint Central nervous system findings on functional magnetic resonance imaging in patients before and after treatment with anticholinergic medication
    Michel A Pontari
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Urol 183:1899-905. 2010
  7. pmc Mechanisms in prostatitis/chronic pelvic pain syndrome
    Michel A Pontari
    Department of Urology, Temple University School of Medicine, 3401 N Broad Street, Philadelphia, PA 19140, USA
    J Urol 172:839-45. 2004
  8. ncbi request reprint Mechanisms of disease: role of purinergic signaling in the pathophysiology of bladder dysfunction
    Michael R Ruggieri
    Department of Urology, Temple University, Philadelphia, PA 19140, USA
    Nat Clin Pract Urol 3:206-15. 2006
  9. pmc The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction
    Michel A Pontari
    Temple University School of Medicine, 3400 N Broad St, 715 OMS, Philadelphia, PA 19140 5104, USA
    Am J Physiol Regul Integr Comp Physiol 286:R874-80. 2004
  10. pmc Quantitation of the contractile response mediated by two receptors: M2 and M3 muscarinic receptor-mediated contractions of human gastroesophageal smooth muscle
    Alan S Braverman
    Department of Urology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Pharmacol Exp Ther 329:218-24. 2009

Research Grants

  1. Gastroesophageal Antireflux Mechanisms
    MICHAEL RAYMOND contact RUGGIERI; Fiscal Year: 2010
  2. URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPES
    MICHAEL RUGGIERI; Fiscal Year: 1993
  3. Bladder, Urethra and Anal Sphincter Reinnervation
    MICHAEL RAYMOND contact RUGGIERI; Fiscal Year: 2010
  4. URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPES
    MICHAEL RUGGIERI; Fiscal Year: 2003

Collaborators

Detail Information

Publications21

  1. pmc Gastric body cholinergic contractile signal transduction in M2 and M3 receptor knockout mice
    Michael R Ruggieri
    Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Recept Signal Transduct Res 33:249-54. 2013
    ..These studies suggest that multiple parallel pathways mediate cholinergic contractions in stomach body smooth muscle...
  2. pmc Functional reinnervation of the canine bladder after spinal root transection and genitofemoral nerve transfer at one and three months after denervation
    Michael R Ruggieri
    Department of Urology, Temple University, Philadelphia, Pennsylvania, USA
    J Neurotrauma 25:401-9. 2008
    ..This study presents initial proof of concept that GF NT is a potentially viable clinical approach to reinnervation of the lower motor neuron-lesioned urinary bladder...
  3. pmc Functional reinnervation of the canine bladder after spinal root transection and immediate end-on-end repair
    Michael R Ruggieri
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Neurotrauma 23:1125-36. 2006
    ..This feasibility study paves the way for future studies utilizing other more proximal motor nerves to bypass the transection site for bladder reinnervation...
  4. pmc Functional reinnervation of the canine bladder after spinal root transection and immediate somatic nerve transfer
    Michael R Ruggieri
    Department of Urology, Temple University, Philadelphia, Pennsylvania 19140 5104, USA
    J Neurotrauma 25:214-24. 2008
    ....
  5. pmc Reinnervation of urethral and anal sphincters with femoral motor nerve to pudendal nerve transfer
    Michael R Ruggieri
    Department of Urology, Temple University, Pennsylvania, USA
    Neurourol Urodyn 30:1695-704. 2011
    ....
  6. doi request reprint Central nervous system findings on functional magnetic resonance imaging in patients before and after treatment with anticholinergic medication
    Michel A Pontari
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Urol 183:1899-905. 2010
    ..Muscarinic receptors are located in areas beyond the detrusor muscle. In this study we measured changes in central nervous system activity in patients with lower urinary tract symptoms treated with tolterodine or a placebo...
  7. pmc Mechanisms in prostatitis/chronic pelvic pain syndrome
    Michel A Pontari
    Department of Urology, Temple University School of Medicine, 3401 N Broad Street, Philadelphia, PA 19140, USA
    J Urol 172:839-45. 2004
    ..We reviewed the current literature on mechanisms involved in the pathogenesis of prostatitis/chronic pelvic pain syndrome (CPPS)...
  8. ncbi request reprint Mechanisms of disease: role of purinergic signaling in the pathophysiology of bladder dysfunction
    Michael R Ruggieri
    Department of Urology, Temple University, Philadelphia, PA 19140, USA
    Nat Clin Pract Urol 3:206-15. 2006
    ..Antagonists with selectivity for P2X(3) receptors on bladder sensory nerves might be clinically beneficial for treatment of urinary urgency, and perhaps chronic pelvic pain...
  9. pmc The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction
    Michel A Pontari
    Temple University School of Medicine, 3400 N Broad St, 715 OMS, Philadelphia, PA 19140 5104, USA
    Am J Physiol Regul Integr Comp Physiol 286:R874-80. 2004
    ....
  10. pmc Quantitation of the contractile response mediated by two receptors: M2 and M3 muscarinic receptor-mediated contractions of human gastroesophageal smooth muscle
    Alan S Braverman
    Department of Urology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Pharmacol Exp Ther 329:218-24. 2009
    ....
  11. pmc Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptors
    Anil K Vegesna
    Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Physiol Gastrointest Liver Physiol 298:G530-4. 2010
    ..Taken together, the data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp and sling fibers similar to human clasp and sling fibers...
  12. pmc Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction
    Alan S Braverman
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Physiol Regul Integr Comp Physiol 283:R663-8. 2002
    ..Thus in normal bladders both M(2) and M(3) receptors can induce contraction. In the denervated bladder, the M(2) and the M(3) receptors interact in a facilitatory manner to mediate contraction...
  13. pmc M2 mediated contractions of human bladder from organ donors is associated with an increase in urothelial muscarinic receptors
    Alan S Braverman
    Department of Urology, School of Medicine, Temple University, Philadelphia, Pennsylvania, USA
    Neurourol Urodyn 26:63-70. 2007
    ..The aim of the current study is to determine whether human bladders with an M2 contractile phenotype also have a greater density of bladder M2 receptors...
  14. pmc M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder
    Alan S Braverman
    Department of Urology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Pharmacol Exp Ther 316:875-80. 2006
    ..In the denervated bladder, the rho kinase pathway is more dominant than in normal bladders. PKA seems to mediate a contractile response in normal bladders, whereas it seems to inhibit contraction in denervated bladders...
  15. pmc The use of occupation isoboles for analysis of a response mediated by two receptors: M2 and M3 muscarinic receptor subtype-induced mouse stomach contractions
    Alan S Braverman
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Pharmacol Exp Ther 325:954-60. 2008
    ..The new method of analysis also expands the traditional Schild theory that was based on a single receptor type to which the agonist and antagonist bind...
  16. pmc Combined use of alpha-adrenergic and muscarinic antagonists for the treatment of voiding dysfunction
    Michael R Ruggieri
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 5104, USA
    J Urol 174:1743-8. 2005
    ..We provide an overview of the medical literature supporting the combined use of muscarinic and alpha-adrenergic antagonist therapy for the treatment of voiding dysfunction...
  17. pmc M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder
    Alan S Braverman
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 316:869-74. 2006
    ....
  18. pmc Refinement in the management of the denervated canine urinary bladder using an abdominal vesicostomy
    Alexis Agelan
    Central Animal Facility, Temple University in Philadelphia, Pennsylvania, USA
    ILAR J 49:E8-14. 2008
    ..The procedure avoids the distress as well as potential bladder hypertrophy induced by multiple daily interventions to empty the bladder by either catheterization or manual compression...
  19. pmc Pharmacologic specificity of nicotinic receptor-mediated relaxation of muscarinic receptor precontracted human gastric clasp and sling muscle fibers within the gastroesophageal junction
    Alan S Braverman
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Pharmacol Exp Ther 338:37-46. 2011
    ..Agents that selectively prevent these relaxations may be useful in the treatment of GERD...
  20. pmc Hypertrophy changes the muscarinic receptor subtype mediating bladder contraction from M3 toward M2
    Alan S Braverman
    Temple Univ School of Medicine, 3400 N Broad St, 715 OMS, Philadelphia, PA 19140, USA
    Am J Physiol Regul Integr Comp Physiol 285:R701-8. 2003
    ..Thus bladder hypertrophy, independent from bladder denervation, causes a shift in the muscarinic receptor subtype mediating bladder contraction from M3 toward M2...
  21. pmc Does phospholipase C mediate muscarinic receptor-induced rat urinary bladder contraction?
    Elfaridah P Frazier
    Department of Pharmacology and Pharmacotherapy, University of Amsterdam, The Netherlands
    J Pharmacol Exp Ther 322:998-1002. 2007
    ..We conclude that previously reported differences relate to the use of inhibitors rather than experimental protocols and that the overall data do not support a role for PLC in M(3) muscarinic receptor-mediated rat bladder contraction...

Research Grants13

  1. Gastroesophageal Antireflux Mechanisms
    MICHAEL RAYMOND contact RUGGIERI; Fiscal Year: 2010
    ..The goal of this proposal is to define the role of the various components of the gastroesophageal high-pressure zone, in particular the gastric sling-clasp fiber complex, in the pathogenesis of GERD. ..
  2. URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPES
    MICHAEL RUGGIERI; Fiscal Year: 1993
    ..In addition these studies will determine the dynamics of muscarinic receptor subtype regulation in animal models and should provide correlates of chronic clinical use of muscarinic agonists and antagonists and bladder hyper reflexia...
  3. Bladder, Urethra and Anal Sphincter Reinnervation
    MICHAEL RAYMOND contact RUGGIERI; Fiscal Year: 2010
    ..These studies are intended to provide the final burden of proof for human trials of somatic nerve transfer to reinnervate the urinary bladder. ..
  4. URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPES
    MICHAEL RUGGIERI; Fiscal Year: 2003
    ..3. To characterize the changes in M2 M3 receptor phosphorylation that may accompany receptor desensitization and receptor up and down regulation. ..