Slava Rom

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania Electronic address
    Am J Pathol 183:1548-58. 2013
  2. pmc Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, 3401 N Broad St, Philadelphia, PA 19140, USA
    J Neuroimmune Pharmacol 8:608-20. 2013
  3. pmc Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e55972. 2013
  4. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
  5. pmc HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
    Slava Rom
    Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Biochim Biophys Acta 1813:1836-44. 2011
  6. pmc Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 181:1414-25. 2012
  7. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010

Collaborators

Detail Information

Publications7

  1. pmc Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania Electronic address
    Am J Pathol 183:1548-58. 2013
    ..These results indicate that selective CB2 activation in leukocytes decreases key steps in monocyte-BBB engagement, thus suppressing inflammatory leukocyte responses and preventing neuroinflammation...
  2. pmc Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, 3401 N Broad St, Philadelphia, PA 19140, USA
    J Neuroimmune Pharmacol 8:608-20. 2013
    ..This review attempts to summarize recent advances in studies of CB(2) activation in the setting of neuroinflammation, immunomodulation and HIV-1 infection...
  3. pmc Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e55972. 2013
    ..Collectively, our findings suggest the possibility of using GSK3β inhibitors as a means to extend the half-life of key tight junction proteins to promote re-sealing of the BBB during neuroinflammation...
  4. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
    ..Together, these results indicate that CB₂ may offer a means to limit HIV-1 infection in macrophages...
  5. pmc HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
    Slava Rom
    Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Biochim Biophys Acta 1813:1836-44. 2011
    ..The Tat/Grb2 interaction affects also viral function by inhibiting the Tat-mediated transactivation of HIV-1 LTR and viral replication in infected primary microglia...
  6. pmc Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 181:1414-25. 2012
    ..These results indicate that GSK3β inhibition in monocytes affects active integrin expression, cytoskeleton rearrangement, and adhesion via suppression of Rac1-diminishing inflammatory leukocyte responses...
  7. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010
    ....