Slava Rom

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania Electronic address
    Am J Pathol 183:1548-58. 2013
  2. pmc Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, 3401 N Broad St, Philadelphia, PA 19140, USA
    J Neuroimmune Pharmacol 8:608-20. 2013
  3. pmc Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 181:1414-25. 2012
  4. pmc Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e55972. 2013
  5. pmc HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
    Slava Rom
    Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Biochim Biophys Acta 1813:1836-44. 2011
  6. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
  7. pmc Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 35:28-36. 2015
  8. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010
  9. pmc Emerging roles of pericytes in the regulation of the neurovascular unit in health and disease
    Jeremy Hill
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    J Neuroimmune Pharmacol 9:591-605. 2014
  10. pmc HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity
    Giovanni Passiatore
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
    Biochim Biophys Acta 1793:378-87. 2009

Collaborators

Detail Information

Publications10

  1. pmc Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania Electronic address
    Am J Pathol 183:1548-58. 2013
    ..These results indicate that selective CB2 activation in leukocytes decreases key steps in monocyte-BBB engagement, thus suppressing inflammatory leukocyte responses and preventing neuroinflammation...
  2. pmc Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, 3401 N Broad St, Philadelphia, PA 19140, USA
    J Neuroimmune Pharmacol 8:608-20. 2013
    ..This review attempts to summarize recent advances in studies of CB(2) activation in the setting of neuroinflammation, immunomodulation and HIV-1 infection...
  3. pmc Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 181:1414-25. 2012
    ..These results indicate that GSK3β inhibition in monocytes affects active integrin expression, cytoskeleton rearrangement, and adhesion via suppression of Rac1-diminishing inflammatory leukocyte responses...
  4. pmc Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e55972. 2013
    ..Collectively, our findings suggest the possibility of using GSK3β inhibitors as a means to extend the half-life of key tight junction proteins to promote re-sealing of the BBB during neuroinflammation...
  5. pmc HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
    Slava Rom
    Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Biochim Biophys Acta 1813:1836-44. 2011
    ..The Tat/Grb2 interaction affects also viral function by inhibiting the Tat-mediated transactivation of HIV-1 LTR and viral replication in infected primary microglia...
  6. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
    ..Together, these results indicate that CB₂ may offer a means to limit HIV-1 infection in macrophages...
  7. pmc Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 35:28-36. 2015
    ..These results point to PARP suppression as a novel approach to BBB protection in the setting of endothelial dysfunction caused by inflammation. ..
  8. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010
    ....
  9. pmc Emerging roles of pericytes in the regulation of the neurovascular unit in health and disease
    Jeremy Hill
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    J Neuroimmune Pharmacol 9:591-605. 2014
    ..The uncovering of the regulatory role of pericytes on the BBB will provide key insight into how barrier integrity can be re-established during neuroinflammation. ..
  10. pmc HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity
    Giovanni Passiatore
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
    Biochim Biophys Acta 1793:378-87. 2009
    ..Moreover, cleavage of Tat101 by calpain 1 increased neurotoxic effect of this viral protein and presence of the calpain inhibitor protected neuronal cells from Tat-mediated toxicity...