Krzysztof Reiss

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi request reprint Insulin-like growth factor-I produced by seminal vesicles: relationship to intraepithelial basal cell hyperplasia in the prostate
    Fernando U Garcia
    Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Clin Cancer Res 13:3140-6. 2007
  2. ncbi request reprint JC virus large T-antigen and IGF-I signaling system merge to affect DNA repair and genomic integrity
    Krzysztof Reiss
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Biology Life Science Building, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 206:295-300. 2006
  3. ncbi request reprint IRS-1-Rad51 nuclear interaction sensitizes JCV T-antigen positive medulloblastoma cells to genotoxic treatment
    Joanna Trojanek
    Center for Neurovirology, Department of Neuroscience, Temple University, Philadelphia, PA 19122, USA
    Int J Cancer 119:539-48. 2006
  4. pmc Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma
    Katarzyna Urbanska
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 219:392-401. 2009
  5. pmc Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processes
    Jin Ying Wang
    Center for Neurovirology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurosci Res 85:2360-73. 2007
  6. ncbi request reprint T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51
    Joanna Trojanek
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Biology Life Science Building, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 206:35-46. 2006
  7. ncbi request reprint Dysregulation of NGF-signaling and Egr-1 expression by Tat in neuronal cell culture
    Nune Darbinian-Sarkissian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 208:506-15. 2006
  8. pmc Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 110:182-90. 2010
  9. pmc Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells
    Lori Rink
    Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140, USA
    Blood 110:651-60. 2007
  10. pmc Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines
    Katarzyna Urbanska
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    Int J Cancer 123:1015-24. 2008

Research Grants

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Insulin-like growth factor-I produced by seminal vesicles: relationship to intraepithelial basal cell hyperplasia in the prostate
    Fernando U Garcia
    Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Clin Cancer Res 13:3140-6. 2007
    ..This study examined the seminal vesicle fluid (SVF) as a potential local source of insulin-like growth factor-I (IGF-I) in the peripheral zone of the prostate...
  2. ncbi request reprint JC virus large T-antigen and IGF-I signaling system merge to affect DNA repair and genomic integrity
    Krzysztof Reiss
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Biology Life Science Building, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 206:295-300. 2006
    ....
  3. ncbi request reprint IRS-1-Rad51 nuclear interaction sensitizes JCV T-antigen positive medulloblastoma cells to genotoxic treatment
    Joanna Trojanek
    Center for Neurovirology, Department of Neuroscience, Temple University, Philadelphia, PA 19122, USA
    Int J Cancer 119:539-48. 2006
    ..JCV T-antigen did not affect HRR directly. In the presence of JCV T-antigen, insulin receptor substrate 1 (IRS-1) translocated to the nucleus where it co-localized with Rad51, possibly attenuating HRR...
  4. pmc Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma
    Katarzyna Urbanska
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 219:392-401. 2009
    ....
  5. pmc Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processes
    Jin Ying Wang
    Center for Neurovirology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurosci Res 85:2360-73. 2007
    ..IGF-I counteracts TNFalpha-mediated accumulation of pS-IRS-1-beta1-integrin complexes supporting the stability of neuronal processes...
  6. ncbi request reprint T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51
    Joanna Trojanek
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Biology Life Science Building, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 206:35-46. 2006
    ..Our observations define a new mechanism by which viral protein utilizes cytosolic molecule to inhibit faithful DNA repair, and suggest how polyomaviruses could compromise stability of the genome. (c) 2005 Wiley-Liss, Inc...
  7. ncbi request reprint Dysregulation of NGF-signaling and Egr-1 expression by Tat in neuronal cell culture
    Nune Darbinian-Sarkissian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 208:506-15. 2006
    ..All of these observations support a model where the interplay between Tat and Puralpha dysregulates the NGF pathway including the MAPK/Erk network, resulting in reduced expression and activity of Egr-1 in neuronal cells...
  8. pmc Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 110:182-90. 2010
    ..In turn, this "perturbation" may trigger a network of signals strictly connected with survival and apoptosis...
  9. pmc Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells
    Lori Rink
    Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140, USA
    Blood 110:651-60. 2007
    ..Interestingly, inhibition of Nbs1 phosphorylation by S343A mutant enhanced the antileukemia effect of the combination of imatinib and genotoxic agent...
  10. pmc Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines
    Katarzyna Urbanska
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    Int J Cancer 123:1015-24. 2008
    ..These results indicate a strong supportive role of fenofibrate in chemoprevention against IGF-I-induced growth responses in medulloblastoma...
  11. ncbi request reprint Involvement of alpha1beta1 integrin in insulin-like growth factor-1-mediated protection of PC12 neuronal processes from tumor necrosis factor-alpha-induced injury
    Jin Ying Wang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Neurosci Res 83:7-18. 2006
    ....
  12. ncbi request reprint HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression
    Galina Chipitsyna
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Philadelphia, PA 19122, USA
    Oncogene 23:2664-71. 2004
    ..These observations ascribe a new role for Tat in host genomic integrity, perhaps by affecting the expression of genes involved in DNA repair...
  13. pmc Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination
    Joanna Trojanek
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Mol Cell Biol 23:7510-24. 2003
    ..These results point to a direct role of IRS-1 in HRR and suggest a novel role for the IGF-IR/IRS-1 axis in supporting the stability of the genome...
  14. pmc p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28
    Shohreh Amini
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Mol Cell Biol 25:8126-38. 2005
    ..Furthermore, p73 prevented the interaction of Tat with cyclin T1 in vitro but not in vivo. These findings suggest possible new therapeutic approaches, using p73, for Tat-mediated AIDS pathogenesis...
  15. ncbi request reprint HIV-Tat promotes cellular proliferation and inhibits NGF-induced differentiation through mechanisms involving Id1 regulation
    Valeria Bergonzini
    Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
    Oncogene 23:7701-11. 2004
    ..Taken together, these studies suggest additional targets for Tat action in neuronal cells and provide new insights into the mechanisms involved in the dysregulation of neuronal functions...
  16. ncbi request reprint T-antigen of human polyomavirus JC cooperates withIGF-IR signaling system in cerebellar tumors of the childhood-medulloblastomas
    Kamel Khalili
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Anticancer Res 23:2035-41. 2003
    ....
  17. ncbi request reprint Human polyomaviruses and brain tumors
    Martyn K White
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Room 203, Philadelphia, PA 19122, USA
    Brain Res Brain Res Rev 50:69-85. 2005
    ....
  18. pmc IGF-IR in neuroprotection and brain tumors
    Elisa Gualco
    Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Front Biosci 14:352-75. 2009
    ..Therefore, better understanding of the beneficial and potentially harmful aspects of the IGF-IR can be critical for the development of new clinical regimens against neurodegenerative disorders and brain tumors...
  19. ncbi request reprint Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: implication for HIV-associated dementia
    Francesca Peruzzi
    Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
    Brain Res Brain Res Rev 50:114-25. 2005
    ....
  20. pmc Effects of JC virus infection on anti-apoptotic protein survivin in progressive multifocal leukoencephalopathy
    Sergio Piña-Oviedo
    Department of Neuroscience, Neuropathology Core, Temple University School of Medicine, 1900 North 12th St, Suite 240, Philadelphia, PA 19122, USA
    Am J Pathol 170:1291-304. 2007
    ..These observations provide new insights into the anti-apoptotic mechanisms used by JCV to complete its lytic cycle and may suggest new therapeutic targets for PML...
  21. ncbi request reprint Evidence for the involvement of Puralpha in response to DNA replication stress
    Huichen Wang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    Cancer Biol Ther 6:596-602. 2007
    ..These results suggest a role for Puralpha as a caretaker protein that is involved in the repair of DSBs induced by stalled replication forks...
  22. ncbi request reprint Impaired homologous recombination DNA repair and enhanced sensitivity to DNA damage in prostate cancer cells exposed to anchorage-independence
    Jin Ying Wang
    1Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, Biology Life Science Building, Philadelphia, PA 19122, USA
    Oncogene 24:3748-58. 2005
    ..This temporal attenuation of HRR may contribute to the accumulation mutations after DNA damage, and possibly the selection of new adaptations in cells, which survived genotoxic treatment...
  23. ncbi request reprint Insulin-like growth factor I receptor signaling system in JC virus T antigen-induced primitive neuroectodermal tumors--medulloblastomas
    Luis Del Valle
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurovirol 8:138-47. 2002
    ....
  24. ncbi request reprint Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAg
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 212:96-104. 2007
    ..Moreover, Small interference RNA experiments directed toward silencing the Rb2/p130 gene demonstrated that pRb2/p130 does not play a predominant role in the nuclear transportation of E2F4 and E2F5...
  25. pmc Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation
    Paul Fiorilli
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
    Lab Invest 88:1143-56. 2008
    ..These data suggest that adhesion of medulloblastoma to the meninges is necessary for the survival and proliferation of these tumor cells at the secondary site...
  26. ncbi request reprint Neuroprotective effects of IGF-I against TNFalpha-induced neuronal damage in HIV-associated dementia
    Jin Ying Wang
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Virology 305:66-76. 2003
    ..All together these results suggest that the balance between TNFalpha and IGF-IR signaling pathways may control the extent of neuronal injury in this HIV-related experimental setting...
  27. ncbi request reprint Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt
    Maja Grabacka
    Center for Neurovirology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    Clin Cancer Res 12:3028-36. 2006
    ..We previously reported the antimetastatic activity of the PPARalpha ligand, fenofibrate, against melanoma tumors in vivo. Here we investigated possible molecular mechanisms of fenofibrate anti metastatic action...
  28. ncbi request reprint Viruses and cancer: lessons from the human polyomavirus, JCV
    Krzysztof Reiss
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 22:6517-23. 2003
    ..Here, we will focus our attention on JCV and describe several pathways employed by the virus to contribute to and/or accelerate cancer development...
  29. pmc Medulloblastoma: from molecular pathology to therapy
    Alessandra Rossi
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    Clin Cancer Res 14:971-6. 2008
    ....
  30. ncbi request reprint Insulin-like growth factor I receptor activity in human medulloblastomas
    Luis Del Valle
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Clin Cancer Res 8:1822-30. 2002
    ..These observations direct our attention to the IGF-IR system as a potential therapeutic target in medulloblastomas and suggest a possibility of using the anti-pY1316 antibody as a potential prognostic marker for medulloblastomas...
  31. ncbi request reprint Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype
    Janaki Chintapalli
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania, USA
    Am J Physiol Renal Physiol 292:F523-30. 2007
    ..We conclude that knockdown of WTp66ShcA redox function prevents HG-dependent FOXO3a regulation and promotes the survival phenotype...
  32. pmc HIV-1 Tat inhibits NGF-induced Egr-1 transcriptional activity and consequent p35 expression in neural cells
    Nune Darbinian
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Cell Physiol 216:128-34. 2008
    ..These observations ascribe a role for Tat in altering p35 expression and its activity that affects phosphorylation of proteins involved in neuronal cell survival...
  33. ncbi request reprint Insulin-like growth factor-I receptor - a potential therapeutic target in medulloblastomas
    Krzysztof Reiss
    Expert Opin Ther Targets 6:539-44. 2002
    ....
  34. ncbi request reprint Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombination
    Shuo Yang
    Dept of Medicine, Division of Nephrology and Hypertension, University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07103, USA
    Am J Physiol Renal Physiol 289:F1144-52. 2005
    ..We conclude that the activated IGF-1R rescues mesangial cells from hyperglycemia-induced danger signals that target genomic DNA by suppressing ROS and enhancing DNA repair by HRR...
  35. ncbi request reprint Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes
    Judith Miklossy
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Neurobiol Aging 27:228-36. 2006
    ..These observations indicate that, by exposure to bacteria or to their toxic products, host responses similar in nature to those observed in AD may be induced...

Research Grants8

  1. Nuclear IRS-1-DNA repair and mutagenesis in medulloblastoma
    Krzysztof Reiss; Fiscal Year: 2010
    ..The proposed studies of DNA repair mechanisms in association with cell signaling pathways are critically important for the development of new therapeutic strategies against malignant dissemination of these cerebellar tumors in CNS. ..
  2. IRS-1 - JC T-antigen Interaction in Cerebellar Tumors
    Krzysztof Reiss; Fiscal Year: 2006
    ..abstract_text> ..