Research Topics
Genomes and Genes
| Krzysztof ReissSummaryAffiliation: Temple University Country: USA Publications
Research Grants
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Detail Information
Publications
Insulin-like growth factor-I produced by seminal vesicles: relationship to intraepithelial basal cell hyperplasia in the prostateFernando U Garcia
Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Clin Cancer Res 13:3140-6. 2007..This study examined the seminal vesicle fluid (SVF) as a potential local source of insulin-like growth factor-I (IGF-I) in the peripheral zone of the prostate...- JC virus large T-antigen and IGF-I signaling system merge to affect DNA repair and genomic integrityKrzysztof Reiss
Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Biology Life Science Building, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 206:295-300. 2006.... - IRS-1-Rad51 nuclear interaction sensitizes JCV T-antigen positive medulloblastoma cells to genotoxic treatmentJoanna Trojanek
Center for Neurovirology, Department of Neuroscience, Temple University, Philadelphia, PA 19122, USA
Int J Cancer 119:539-48. 2006..JCV T-antigen did not affect HRR directly. In the presence of JCV T-antigen, insulin receptor substrate 1 (IRS-1) translocated to the nucleus where it co-localized with Rad51, possibly attenuating HRR... 
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastomaKatarzyna Urbanska
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 219:392-401. 2009....- Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processesJin Ying Wang
Center for Neurovirology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
J Neurosci Res 85:2360-73. 2007..IGF-I counteracts TNFalpha-mediated accumulation of pS-IRS-1-beta1-integrin complexes supporting the stability of neuronal processes... - T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51Joanna Trojanek
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Biology Life Science Building, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 206:35-46. 2006..Our observations define a new mechanism by which viral protein utilizes cytosolic molecule to inhibit faithful DNA repair, and suggest how polyomaviruses could compromise stability of the genome. (c) 2005 Wiley-Liss, Inc... - Dysregulation of NGF-signaling and Egr-1 expression by Tat in neuronal cell cultureNune Darbinian-Sarkissian
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 208:506-15. 2006..All of these observations support a model where the interplay between Tat and Puralpha dysregulates the NGF pathway including the MAPK/Erk network, resulting in reduced expression and activity of Egr-1 in neuronal cells... - Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastomaValentina Caracciolo
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Biochem 110:182-90. 2010..In turn, this "perturbation" may trigger a network of signals strictly connected with survival and apoptosis... - Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cellsLori Rink
Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140, USA
Blood 110:651-60. 2007..Interestingly, inhibition of Nbs1 phosphorylation by S343A mutant enhanced the antileukemia effect of the combination of imatinib and genotoxic agent... - Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell linesKatarzyna Urbanska
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
Int J Cancer 123:1015-24. 2008..These results indicate a strong supportive role of fenofibrate in chemoprevention against IGF-I-induced growth responses in medulloblastoma... - Involvement of alpha1beta1 integrin in insulin-like growth factor-1-mediated protection of PC12 neuronal processes from tumor necrosis factor-alpha-induced injuryJin Ying Wang
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
J Neurosci Res 83:7-18. 2006.... - HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expressionGalina Chipitsyna
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Philadelphia, PA 19122, USA
Oncogene 23:2664-71. 2004..These observations ascribe a new role for Tat in host genomic integrity, perhaps by affecting the expression of genes involved in DNA repair... - Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombinationJoanna Trojanek
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Mol Cell Biol 23:7510-24. 2003..These results point to a direct role of IRS-1 in HRR and suggest a novel role for the IGF-IR/IRS-1 axis in supporting the stability of the genome... - p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28Shohreh Amini
Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
Mol Cell Biol 25:8126-38. 2005..Furthermore, p73 prevented the interaction of Tat with cyclin T1 in vitro but not in vivo. These findings suggest possible new therapeutic approaches, using p73, for Tat-mediated AIDS pathogenesis... - HIV-Tat promotes cellular proliferation and inhibits NGF-induced differentiation through mechanisms involving Id1 regulationValeria Bergonzini
Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
Oncogene 23:7701-11. 2004..Taken together, these studies suggest additional targets for Tat action in neuronal cells and provide new insights into the mechanisms involved in the dysregulation of neuronal functions... - T-antigen of human polyomavirus JC cooperates withIGF-IR signaling system in cerebellar tumors of the childhood-medulloblastomasKamel Khalili
Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
Anticancer Res 23:2035-41. 2003.... - Human polyomaviruses and brain tumorsMartyn K White
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015-96, Room 203, Philadelphia, PA 19122, USA
Brain Res Brain Res Rev 50:69-85. 2005.... - IGF-IR in neuroprotection and brain tumorsElisa Gualco
Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19122, USA
Front Biosci 14:352-75. 2009..Therefore, better understanding of the beneficial and potentially harmful aspects of the IGF-IR can be critical for the development of new clinical regimens against neurodegenerative disorders and brain tumors... - Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: implication for HIV-associated dementiaFrancesca Peruzzi
Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
Brain Res Brain Res Rev 50:114-25. 2005.... - Effects of JC virus infection on anti-apoptotic protein survivin in progressive multifocal leukoencephalopathySergio Piña-Oviedo
Department of Neuroscience, Neuropathology Core, Temple University School of Medicine, 1900 North 12th St, Suite 240, Philadelphia, PA 19122, USA
Am J Pathol 170:1291-304. 2007..These observations provide new insights into the anti-apoptotic mechanisms used by JCV to complete its lytic cycle and may suggest new therapeutic targets for PML... - Evidence for the involvement of Puralpha in response to DNA replication stressHuichen Wang
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
Cancer Biol Ther 6:596-602. 2007..These results suggest a role for Puralpha as a caretaker protein that is involved in the repair of DSBs induced by stalled replication forks... - Impaired homologous recombination DNA repair and enhanced sensitivity to DNA damage in prostate cancer cells exposed to anchorage-independenceJin Ying Wang
1Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, Biology Life Science Building, Philadelphia, PA 19122, USA
Oncogene 24:3748-58. 2005..This temporal attenuation of HRR may contribute to the accumulation mutations after DNA damage, and possibly the selection of new adaptations in cells, which survived genotoxic treatment... - Insulin-like growth factor I receptor signaling system in JC virus T antigen-induced primitive neuroectodermal tumors--medulloblastomasLuis Del Valle
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Neurovirol 8:138-47. 2002.... - Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAgValentina Caracciolo
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 212:96-104. 2007..Moreover, Small interference RNA experiments directed toward silencing the Rb2/p130 gene demonstrated that pRb2/p130 does not play a predominant role in the nuclear transportation of E2F4 and E2F5... - Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferationPaul Fiorilli
Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
Lab Invest 88:1143-56. 2008..These data suggest that adhesion of medulloblastoma to the meninges is necessary for the survival and proliferation of these tumor cells at the secondary site... - Neuroprotective effects of IGF-I against TNFalpha-induced neuronal damage in HIV-associated dementiaJin Ying Wang
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Virology 305:66-76. 2003..All together these results suggest that the balance between TNFalpha and IGF-IR signaling pathways may control the extent of neuronal injury in this HIV-related experimental setting... - Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of AktMaja Grabacka
Center for Neurovirology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
Clin Cancer Res 12:3028-36. 2006.... - Viruses and cancer: lessons from the human polyomavirus, JCVKrzysztof Reiss
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, PA 19122, USA
Oncogene 22:6517-23. 2003..Here, we will focus our attention on JCV and describe several pathways employed by the virus to contribute to and/or accelerate cancer development... - Medulloblastoma: from molecular pathology to therapyAlessandra Rossi
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
Clin Cancer Res 14:971-6. 2008.... - Insulin-like growth factor I receptor activity in human medulloblastomasLuis Del Valle
Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
Clin Cancer Res 8:1822-30. 2002..These observations direct our attention to the IGF-IR system as a potential therapeutic target in medulloblastomas and suggest a possibility of using the anti-pY1316 antibody as a potential prognostic marker for medulloblastomas... - Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotypeJanaki Chintapalli
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania, USA
Am J Physiol Renal Physiol 292:F523-30. 2007..We conclude that knockdown of WTp66ShcA redox function prevents HG-dependent FOXO3a regulation and promotes the survival phenotype... - HIV-1 Tat inhibits NGF-induced Egr-1 transcriptional activity and consequent p35 expression in neural cellsNune Darbinian
Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania
J Cell Physiol 216:128-34. 2008..These observations ascribe a role for Tat in altering p35 expression and its activity that affects phosphorylation of proteins involved in neuronal cell survival... - Insulin-like growth factor-I receptor - a potential therapeutic target in medulloblastomasKrzysztof Reiss
Expert Opin Ther Targets 6:539-44. 2002.... - Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombinationShuo Yang
Dept of Medicine, Division of Nephrology and Hypertension, University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07103, USA
Am J Physiol Renal Physiol 289:F1144-52. 2005..We conclude that the activated IGF-1R rescues mesangial cells from hyperglycemia-induced danger signals that target genomic DNA by suppressing ROS and enhancing DNA repair by HRR... - Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetesJudith Miklossy
Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
Neurobiol Aging 27:228-36. 2006..These observations indicate that, by exposure to bacteria or to their toxic products, host responses similar in nature to those observed in AD may be induced...
Research Grants
- Nuclear IRS-1-DNA repair and mutagenesis in medulloblastomaKrzysztof Reiss; Fiscal Year: 2010..The proposed studies of DNA repair mechanisms in association with cell signaling pathways are critically important for the development of new therapeutic strategies against malignant dissemination of these cerebellar tumors in CNS. ..
- IRS-1 - JC T-antigen Interaction in Cerebellar TumorsKrzysztof Reiss; Fiscal Year: 2006..abstract_text> ..