Robert Raffa

Summary

Affiliation: Temple University
Country: USA

Publications

  1. doi request reprint Sequestered naltrexone in sustained release morphine or oxycodone - a way to inhibit illicit use?
    Robert B Raffa
    Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Philadelphia, PA, USA
    Expert Opin Drug Saf 13:181-90. 2014
  2. ncbi request reprint Opioid receptor types involved in the development of nicotine physical dependence in an invertebrate (Planaria) model
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA Electronic address
    Pharmacol Biochem Behav 112:9-14. 2013
  3. pmc Cancer 'survivor-care': II. Disruption of prefrontal brain activation top-down control of working memory capacity as possible mechanism for chemo-fog/brain (chemotherapy-associated cognitive impairment)
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 38:265-8. 2013
  4. doi request reprint Opioid-induced hyperalgesia: is it clinically relevant for the treatment of pain patients?
    Robert B Raffa
    Temple University School of Pharmacy, Philadelphia, PA 19401, USA
    Pain Manag Nurs 14:e67-83. 2013
  5. ncbi request reprint Orally active opioid compounds from a non-poppy source
    Robert B Raffa
    Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, USA
    J Med Chem 56:4840-8. 2013
  6. pmc Intracerebroventricular opioids for intractable pain
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Br J Clin Pharmacol 74:34-41. 2012
  7. doi request reprint CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant)
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 37:260-5. 2012
  8. doi request reprint QTc interval prolongation by d-propoxyphene: what about other analgesics?
    Robert B Raffa
    Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Expert Opin Pharmacother 13:1397-409. 2012
  9. doi request reprint Fixed-dose combinations for emerging treatment of pain
    Robert B Raffa
    Temple University School of Pharmacy, Department of Pharmaceutical Sciences, 3307 N Broad Street, PA 19140, USA
    Expert Opin Pharmacother 13:1261-70. 2012
  10. doi request reprint Multi-mechanistic analgesia for opioid-induced hyperalgesia
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 37:125-7. 2012

Research Grants

  1. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2004
  2. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2005
  3. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2006

Collaborators

Detail Information

Publications77

  1. doi request reprint Sequestered naltrexone in sustained release morphine or oxycodone - a way to inhibit illicit use?
    Robert B Raffa
    Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Philadelphia, PA, USA
    Expert Opin Drug Saf 13:181-90. 2014
    ..Many abusers tamper with formulations in an effort to convert the active ingredient into a form suitable for alternative and more abuse-desirable routes of administration, such as snorting, inhaling or injecting...
  2. ncbi request reprint Opioid receptor types involved in the development of nicotine physical dependence in an invertebrate (Planaria) model
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA Electronic address
    Pharmacol Biochem Behav 112:9-14. 2013
    ..An involvement of MOR and DOR, but not KOR, in the development of nicotine physical dependence or in abstinence-induced withdrawal was thus demonstrated in a sensitive and facile invertebrate model. ..
  3. pmc Cancer 'survivor-care': II. Disruption of prefrontal brain activation top-down control of working memory capacity as possible mechanism for chemo-fog/brain (chemotherapy-associated cognitive impairment)
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 38:265-8. 2013
    ..Two recent studies, one postulating a mechanism for 'top-down control' of working memory capacity and another visualizing chemotherapy-induced alterations in brain activation during working memory processing, are reviewed and integrated...
  4. doi request reprint Opioid-induced hyperalgesia: is it clinically relevant for the treatment of pain patients?
    Robert B Raffa
    Temple University School of Pharmacy, Philadelphia, PA 19401, USA
    Pain Manag Nurs 14:e67-83. 2013
    ..We conclude that given the clinical ramifications, opioid-induced hyperalgesia is one of the most understudied important aspects of opioid research. ..
  5. ncbi request reprint Orally active opioid compounds from a non-poppy source
    Robert B Raffa
    Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, USA
    J Med Chem 56:4840-8. 2013
    ..However, other characteristics of the compounds suggest novelty, particularly chemical structure and possible greater separation from side effects. We review the chemical and pharmacological properties of these compounds. ..
  6. pmc Intracerebroventricular opioids for intractable pain
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Br J Clin Pharmacol 74:34-41. 2012
    ..Intracerebroventricular infusion of opioid analgesics thus appears to be a safe and effective therapy for the palliative treatment of refractory pain...
  7. doi request reprint CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant)
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 37:260-5. 2012
    ..It is generally assumed that these compounds are CB₁ 'selective' and produce their effects exclusively via CB₁ receptors...
  8. doi request reprint QTc interval prolongation by d-propoxyphene: what about other analgesics?
    Robert B Raffa
    Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Expert Opin Pharmacother 13:1397-409. 2012
    ..The drug had previously been withdrawn from European markets. These recent actions prompt the question: what is known about QT prolongation and analgesic drugs?..
  9. doi request reprint Fixed-dose combinations for emerging treatment of pain
    Robert B Raffa
    Temple University School of Pharmacy, Department of Pharmaceutical Sciences, 3307 N Broad Street, PA 19140, USA
    Expert Opin Pharmacother 13:1261-70. 2012
    ..Better outcomes might be achieved using a combination of analgesics. The ratio of the combinations matters and should therefore be evaluated using rigorous quantitative and well-documented analysis...
  10. doi request reprint Multi-mechanistic analgesia for opioid-induced hyperalgesia
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 37:125-7. 2012
    ..Our objective is to briefly summarize the basic science and clinical evidence about OIH as background to consider the possible benefit of using a multi-mechanistic analgesic approach...
  11. ncbi request reprint The evolving understanding of the analgesic mechanism of action of flupirtine
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 37:4-6. 2012
    ..Our objective was to trace the evolution of the understanding of flupirtine's mechanism of analgesic action to its current status...
  12. pmc The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Brain Res 1193:51-6. 2008
    ..These results provide evidence that the withdrawal from cocaine and amphetamine, but not cannabinoids, in planarians is mediated through a common nor-BNI-sensitive (kappa-opioid receptor-like) pathway...
  13. doi request reprint Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 325:500-6. 2008
    ..No synergistic effect on seizure induction was observed between concomitant tramadol and codeine or morphine...
  14. ncbi request reprint Basic pharmacology relevant to drug abuse assessment: tramadol as example
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19104, USA
    J Clin Pharm Ther 33:101-8. 2008
    ..There is nothing unique about tramadol in this regard, but its multimodal mechanism of action, pharmacologically active enantiomers, and active metabolite make it a particularly instructive and relevant example...
  15. pmc Flumazenil-sensitive dose-related physical dependence in planarians produced by two benzodiazepine and one non-benzodiazepine benzodiazepine-receptor agonists
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Eur J Pharmacol 564:88-93. 2007
    ....
  16. doi request reprint Is a picture worth a thousand (forgotten) words?: neuroimaging evidence for the cognitive deficits in 'chemo-fog'/'chemo-brain'
    R B Raffa
    Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 35:1-9. 2010
    ..The relatively few such studies, and fewer electrophysiological studies, offer an alternative way to evaluate changes that might be related to cognitive deficits in patients treated with cancer chemotherapeutic regimens...
  17. pmc Oxycodone combinations for pain relief
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA
    Drugs Today (Barc) 46:379-98. 2010
    ..As with all combinations, the profile of adverse effects must also be determined in order to provide the clinician with the overall benefit/risk assessment...
  18. pmc Topiramate-antagonism of L-glutamate-induced paroxysms in planarians
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Eur J Pharmacol 649:150-3. 2010
    ..3-3 mM) inhibited L-glutamate-induced paroxysms. These results provide further evidence of a topiramate-sensitive glutamate receptor-mediated activity in this model...
  19. pmc Effects on the visual system might contribute to some of the cognitive deficits of cancer chemotherapy-induced 'chemo-fog'
    R B Raffa
    Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 35:249-55. 2010
    ....
  20. doi request reprint Diselenium, instead of disulfide, bonded analogs of conotoxins: novel synthesis and pharmacotherapeutic potential
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Life Sci 87:451-6. 2010
    ..The technique results in analogs that retain the folding of the native peptides, are more potent, and have the same or greater biological activity...
  21. pmc The determination and application of fixed-dose analgesic combinations for treating multimodal pain
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    J Pain 11:701-9. 2010
    ..We discuss the quantitative analysis of multimodal action using the treatment of pain as a practical example and give examples of its application to some widely used analgesic drugs...
  22. doi request reprint Opioid formulations designed to resist/deter abuse
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Drugs 70:1657-75. 2010
    ..Nevertheless, these formulations are important innovations and warrant further study to assess their appropriate role as analgesics...
  23. doi request reprint The M5 muscarinic receptor as possible target for treatment of drug abuse
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 34:623-9. 2009
    ....
  24. ncbi request reprint Short introduction and history
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Adv Exp Med Biol 678:1-10. 2010
    ..This chapter introduces the reader to the fascinating and complex challenges-to patients, healthcare providers, basic scientists, employers, insurers and others-inherent in this topic and the current state of knowledge about it...
  25. ncbi request reprint Patient's perspective
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Adv Exp Med Biol 678:11-2. 2010
    ..The deficits are reported to persist. The magnitude of the negative impact on quality of life depends, as does the condition itself, on multiple and varied factors. This chapter relates the experience of one patient...
  26. ncbi request reprint Imaging as a means of studying chemotherapy-related cognitive impairment
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Adv Exp Med Biol 678:70-6. 2010
    ..Neuroimaging techniques might offer additional insight. This chapter is a succinct summary of a more expanded review of the relatively few such studies...
  27. ncbi request reprint Future directions
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Adv Exp Med Biol 678:165-7. 2010
    ..The chapters of this book summarize much of what has been done and reported regarding cancer chemotherapy-related cognitive impairment. In this chapter, we point out some future directions for investigation...
  28. pmc Nonlinear isobologram and superadditive withdrawal from cocaine: cannabinoid combinations in planarians
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Eur J Pharmacol 556:89-90. 2007
    ..01) of certain ratios of this combination was possible. This synergy, here analyzed with the latest (nonlinear) isobolographic methodology, is now quantitatively established for the first time...
  29. pmc Modified 'Joyce model' of opioid dependence/withdrawal
    Robert B Raffa
    Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Philadelphia PA 19140, USA
    Eur J Pharmacol 551:54-7. 2006
    ..We report excellent fit of the data (R(2)=0.96) by adding: (1) a transient early phase, and (2) a delay in the buildup of protein...
  30. ncbi request reprint kappa-Opioid withdrawal in Planaria
    Robert B Raffa
    Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Neurosci Lett 349:139-42. 2003
    ..These data provide pharmacologic evidence of a kappa-opioid receptor-mediated withdrawal phenomenon and neuroadaptation to a pharmacologic stimulus (adaptations in transduction mechanisms) in this model...
  31. ncbi request reprint Combination strategies for pain management
    Robert B Raffa
    Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Expert Opin Pharmacother 4:1697-708. 2003
    ..This review examines the multiple basic science, clinical and pharmacoeconomic issues relating to analgesic combinations and the methodologies available for assessing these issues...
  32. ncbi request reprint Chemotherapy-related visual system toxicity
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Adv Exp Med Biol 678:113-8. 2010
    ..This chapter is a succint summary of a more expanded review...
  33. ncbi request reprint Mechanism of action of analgesics used to treat osteoarthritis pain
    Robert B Raffa
    Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Rheum Dis Clin North Am 29:733-45. 2003
    ..e., it often originates from multiple causes and is transmitted by multiple mediators). Therefore, the choice of the analgesics for the patient who has OA should be based upon the most appropriate mechanisms of action...
  34. ncbi request reprint Protonation effect on drug affinity
    Robert B Raffa
    Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA
    Eur J Pharmacol 483:323-4. 2004
    ..The results demonstrate the importance of protonation in measures of affinity...
  35. ncbi request reprint Opioid receptors and acetaminophen (paracetamol)
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Eur J Pharmacol 503:209-10. 2004
    ..These findings further implicate endogenous opioids (viz., endorphins, enkephalins, and dynorphins) and their pathways as contributors to the central antinociceptive action of acetaminophen...
  36. ncbi request reprint Disruption of a drug-induced choice behavior by UV light
    R B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Behav Pharmacol 14:569-71. 2003
    ..05) by UV light (366 nm and 254 nm). The results demonstrate alteration of a relatively complex choice behavior by UV light...
  37. ncbi request reprint Bacterial communication ("quorum sensing") via ligands and receptors: a novel pharmacologic target for the design of antibiotic drugs
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140 5101, USA
    J Pharmacol Exp Ther 312:417-23. 2005
    ..Such drugs would have novel mechanisms of action and might therefore be more effective against antibiotic-resistant strains of bacteria...
  38. ncbi request reprint Amphetamine-induced increase in planarian locomotor activity and block by UV light
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Brain Res 1031:138-40. 2005
    ..These findings strengthen the hypothesis that the effects of dopaminergic ligands and UV light on pLMV relate to interaction with neurotransmitter transduction process(es)...
  39. pmc Cancer 'survivor-care': I. the α7 nAChR as potential target for chemotherapy-related cognitive impairment
    R B Raffa
    Temple University School of Pharmacy RBR, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 36:437-45. 2011
    ..Our objective is to review and to comment on the basic science and clinical evidence of potential pharmacologic targets for managing this emerging concern...
  40. ncbi request reprint Subadditive withdrawal from cocaine/kappa-opioid agonist combinations in Planaria
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Brain Res 1114:31-5. 2006
    ..The concept that certain combinations of drugs leads to attenuated withdrawal might generalize to humans...
  41. pmc A proposed mechanism for chemotherapy-related cognitive impairment ('chemo-fog')
    R B Raffa
    Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 36:257-9. 2011
    ..Our objective is to comment on a proposed mechanism for 'chemo-fog'...
  42. ncbi request reprint Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Eur J Pharmacol 540:200-1. 2006
    ..The results provide further evidence of a kappa-opioid-like receptor in planarians...
  43. ncbi request reprint Is 'chemo-fog'/'chemo-brain' caused by cancer chemotherapy?
    R B Raffa
    Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 31:129-38. 2006
  44. doi request reprint Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example
    R B Raffa
    Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 36:283-98. 2011
    ..Therefore, the elucidation of the mechanism(s) of action of natural products is important, but presents significant challenges. This article examines this issue using peroxide oil (essential oxygen oil) as an illustrative example...
  45. pmc Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine
    Zhe Ding
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Br J Pharmacol 157:831-43. 2009
    ..Buprenorphine displays attributes of opioids, but also some features distinct from them. We examined spinal and supraspinal signal transduction of buprenorphine-induced anti-nociception in mice compared with morphine and fentanyl...
  46. doi request reprint The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians
    Scott M Rawls
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Eur J Pharmacol 584:278-84. 2008
    ....
  47. ncbi request reprint Pharmacological aspects of successful long-term analgesia
    Robert Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Suite 540, Philadelphia, PA 19140 5101, USA
    Clin Rheumatol 25:S9-15. 2006
    ..Laboratory studies have demonstrated that these agents interact to produce synergistic analgesia with a desirable safety/efficacy profile...
  48. doi request reprint Withdrawal-like behavior in planarians is dependent on drug exposure duration
    Steve Sacavage
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA
    Neurosci Lett 439:84-8. 2008
    ..The present results suggest that the magnitude of withdrawal-like behavior in planarians is dependent on both the duration and type of drug exposure, and that planarians do not display withdrawal to caffeine...
  49. ncbi request reprint Cocaine and kappa-opioid withdrawal in Planaria blocked by D-, but not L-, glucose
    Sumiyo Umeda
    Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Brain Res 1018:181-5. 2004
    ....
  50. ncbi request reprint Toward the design of ribonuclease (RNase) inhibitors: ion effects on the thermodynamics of binding of 2'-CMP to RNase A
    Shawn D Spencer
    Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N Broad Street, Philadelphia, PA 19140, USA
    J Pharmacol Exp Ther 301:925-9. 2002
    ..These data should be useful for molecular modeling and suggest that inhibitor activity will be a function of cellular conditions (normal or pathological)...
  51. ncbi request reprint Isothermal titration calorimetric study of RNase-A kinetics (cCMP --> 3'-CMP) involving end-product inhibition
    Shawn D Spencer
    Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, Pennsylvania 19140, USA
    Pharm Res 21:1642-7. 2004
    ..Isothermal titration calorimetry (ITC) and progress curve analysis was used to measure the enzyme kinetic parameters (KM and kcat) of the hydrolysis of cCMP by RNase-A, a reaction that includes end-product competitive inhibition by 3'-CMP...
  52. pmc 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians
    Scott M Rawls
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA
    Neurosci Lett 484:113-7. 2010
    ....
  53. ncbi request reprint A nitric oxide synthase inhibitor (L-NAME) attenuates abstinence-induced withdrawal from both cocaine and a cannabinoid agonist (WIN 55212-2) in Planaria
    Scott M Rawls
    Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Brain Res 1099:82-7. 2006
    ..These results suggest a common NO-dependent pathway of withdrawal from cocaine and WIN 55212-2 in Planaria...
  54. ncbi request reprint Differential behavioral effect of the TRPM8/TRPA1 channel agonist icilin (AG-3-5)
    Scott M Rawls
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    Eur J Pharmacol 575:103-4. 2007
    ..This is the first demonstration of a TRPM8/TRPA1 channel subtype agonist-induced differential pharmacological effect in invertebrates and provides a novel sensitive, quantifiable end-point for studying TRP channel pharmacology...
  55. ncbi request reprint Description and quantification of cocaine withdrawal signs in Planaria
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Brain Res 1032:200-2. 2005
    ..Compared to the cocaine/cocaine group, the cocaine/water group displayed a significant number of atypical behaviors, providing direct evidence of a 'withdrawal phenomenon' in planarians...
  56. ncbi request reprint Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice
    Ronald J Tallarida
    Department of Pharmacology, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140 5104, USA
    J Pharmacol Exp Ther 307:699-704. 2003
    ....
  57. ncbi request reprint An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2)
    Scott M Rawls
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Pharmacol Biochem Behav 86:499-504. 2007
    ..The present results reveal that NMDA receptor activation mediates the development of cannabinoid physical dependence and the expression of cannabinoid withdrawal in planarians...
  58. doi request reprint Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians
    Scott M Rawls
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy and Center for Substance Abuse Research, Philadelphia, PA 19140, USA
    Neuropeptides 42:229-37. 2008
    ....
  59. ncbi request reprint Harmonic mean relationship between affinity for wild-type receptors and alanine-scan mutants
    Robert B Raffa
    Temple University School of Pharmacy and School of Medicine, 3307 N Broad St 602 00, Philadelphia, PA 19140 5193, USA
    J Theor Biol 218:207-14. 2002
    ..The harmonic mean was found to be a good estimator when applied to the published data from 14 alanine-scan studies. This result is consonant with the present understanding of ligand-receptor interactions...
  60. doi request reprint Agmatine: identification and inhibition of methamphetamine, kappa opioid, and cannabinoid withdrawal in planarians
    Scott M Rawls
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Synapse 62:927-34. 2008
    ..This suggests that a change in agmatine signaling is a common mechanism in the withdrawal caused by these drugs, at least in planarians...
  61. ncbi request reprint Topiramate antagonizes NMDA- and AMPA-induced seizure-like activity in planarians
    Scott M Rawls
    Department of Pharmaceutical Sciences and Pharmacology, Temple University School of Pharmacy and Medicine, Philadelphia, PA 19140, United States
    Pharmacol Biochem Behav 93:363-7. 2009
    ..The present results provide pharmacologic evidence of a functional inhibitory action of topiramate on glutamate receptor activity in invertebrates and provide a sensitive, quantifiable end-point for studying anti-seizure pharmacology...
  62. pmc On deriving the dose-effect relation of an unknown second component: an example using buprenorphine preclinical data
    Ronald J Tallarida
    Department of Pharmacology, Temple University School of Medicine and Center for Substance Abuse Research, 3420 N Broad Street, Philadelphia, PA 19140, United States
    Drug Alcohol Depend 109:126-9. 2010
    ..This novel technique offers possible insight into the dual low-dose (analgesic), high-dose (addiction medication) uses of buprenorphine...
  63. ncbi request reprint Toward RNase inhibitors: thermodynamics of 2'-CMP/RNase-A binding in multi-ion buffer
    Robert B Raffa
    Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Biochem Pharmacol 63:1937-9. 2002
    ..90 kcal/mol; DeltaH degrees =-15.7 kcal/mol; and DeltaS degrees =-0.028 kcal/mol-K ('enthalpy-driven' interaction). These data should assist drug design of small-molecule inhibitors of homologous RNase catalytic domains...
  64. pmc First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians
    Scott M Rawls
    Department of Pharmaceutical Sciences, Center for Substance Abuse Research, Temple University Health Sciences Center, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Behav Pharmacol 21:301-13. 2010
    ....
  65. ncbi request reprint Measurement of glutamate and aspartate in Planaria
    Scott M Rawls
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    J Pharmacol Toxicol Methods 53:291-5. 2006
    ....
  66. pmc Levamisole and cocaine synergism: a prevalent adulterant enhances cocaine's action in vivo
    Christopher S Tallarida
    Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA
    Neuropharmacology 79:590-5. 2014
    ..Most important is the identification of synergism for the levamisole/cocaine interaction, which now requires further study in mammals. ..
  67. doi request reprint Behavioral characterization of serotonergic activation in the flatworm Planaria
    Martilias S Farrell
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, USA
    Behav Pharmacol 19:177-82. 2008
    ....
  68. ncbi request reprint Looking beyond the administered drug: metabolites of opioid analgesics
    Swati Nagar
    Temple University School of Pharmacy, Philadelphia, PA, USA
    J Fam Pract 57:S25-32. 2008
  69. pmc Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory
    John J Foley
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Psychopharmacology (Berl) 199:527-38. 2008
    ..The concern that adjuvant cancer chemotherapy agents cause cognitive impairment in a significant number of patients has been expressed by patients and healthcare providers, but clinical studies have yielded conflicting results to date...
  70. ncbi request reprint A reverse-phase HPLC and fluorescence detection method for measurement of 5-hydroxytryptamine (serotonin) in Planaria
    Sumiyo Umeda
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA
    J Pharmacol Toxicol Methods 51:73-6. 2005
    ..To correlate behavior (specifically, drug withdrawal) with neurotransmitter levels, we developed a method to quantify 5-hydroxytryptamine (5-HT; serotonin) in planarians...
  71. ncbi request reprint Liquid chromatography-mass spectrometric analysis of buprenorphine and its N-dealkylated metabolite norbuprenorphine in rat brain tissue and plasma
    Hongfei Yue
    Department of Chemistry, Temple University, Philadelphia, PA 19140, USA
    J Pharmacol Toxicol Methods 52:314-22. 2005
    ....
  72. pmc The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations
    Ronald J Tallarida
    Department of Pharmacology, School of Medicine, Center for Substance Abuse Research RJT, Temple University, Philadelphia, PA 19140, USA
    Pharmacol Ther 127:165-74. 2010
    ..New formulas derived to assess the statistical variance for additive combinations are included, and the more detailed mathematical topics are included in the Appendix...
  73. ncbi request reprint Role of pharmacogenetics in variable response to drugs: focus on opioids
    Esin Kadiev
    Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia PA 19140, USA
    Expert Opin Drug Metab Toxicol 4:77-91. 2008
    ..The role of genetic variability in clinical opioid therapy is examined, and relevant clinical trials cited. The present status of opioid pharmacogenetics, promises and challenges and future directions are discussed...
  74. ncbi request reprint Changes in aorta alpha1-adrenoceptor number and affinity during one year of streptozotocin-induced diabetes in rats
    Robert J Schulingkamp
    Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA, USA
    Pharmacology 74:23-30. 2005
    ..These results suggest compensatory mechanisms in receptor number and abnormalities in 2nd messenger transduction and can help direct efforts for improving antihypertensive or other pharmacological therapy for diabetic patients...
  75. ncbi request reprint Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: III. Retinoids
    Anne Schock Citver
    Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 27:161-8. 2002
    ....
  76. ncbi request reprint Acetaminophen and metabolite: lack of effect on nitric oxide synthase (constitutive or inducible)
    Robert B Raffa
    Headache 42:237-8. 2002
  77. ncbi request reprint LiCl attenuates M(1)AChR-mediated intrathecal pilocarpine-induced reciprocal hindlimb scratching in mice
    Rebecca P Martinez
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Spring House, PA 19140, USA
    Pharmacology 65:210-4. 2002
    ..These findings provide in vivo evidence for a possible link between RHS and a LiCl-sensitive, possibly phosphoinositide-related, effector pathway...

Research Grants3

  1. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2004
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
  2. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2005
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
  3. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2006
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..