Francesca Peruzzi

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi The multiple functions of HIV-1 Tat: proliferation versus apoptosis
    Francesca Peruzzi
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Front Biosci 11:708-17. 2006
  2. ncbi Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: implication for HIV-associated dementia
    Francesca Peruzzi
    Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
    Brain Res Brain Res Rev 50:114-25. 2005
  3. pmc Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processes
    Jin Ying Wang
    Center for Neurovirology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurosci Res 85:2360-73. 2007
  4. ncbi Dysregulation of NGF-signaling and Egr-1 expression by Tat in neuronal cell culture
    Nune Darbinian-Sarkissian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 208:506-15. 2006
  5. ncbi HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression
    Galina Chipitsyna
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Philadelphia, PA 19122, USA
    Oncogene 23:2664-71. 2004
  6. ncbi HIV-Tat promotes cellular proliferation and inhibits NGF-induced differentiation through mechanisms involving Id1 regulation
    Valeria Bergonzini
    Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
    Oncogene 23:7701-11. 2004
  7. pmc Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination
    Joanna Trojanek
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Mol Cell Biol 23:7510-24. 2003
  8. pmc HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
    Slava Rom
    Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Biochim Biophys Acta 1813:1836-44. 2011
  9. ncbi Involvement of alpha1beta1 integrin in insulin-like growth factor-1-mediated protection of PC12 neuronal processes from tumor necrosis factor-alpha-induced injury
    Jin Ying Wang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Neurosci Res 83:7-18. 2006
  10. ncbi Neuroprotective effects of IGF-I against TNFalpha-induced neuronal damage in HIV-associated dementia
    Jin Ying Wang
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Virology 305:66-76. 2003

Research Grants

  1. Mechanisms involved in HIV-1 Tat mediated neuronal damage
    Francesca Peruzzi; Fiscal Year: 2010
  2. Mechanisms involved in HIV-1 Tat mediated neuronal damage
    Francesca Peruzzi; Fiscal Year: 2007
  3. Molecular basis of neuronal dysfunction in AIDS
    Francesca Peruzzi; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. ncbi The multiple functions of HIV-1 Tat: proliferation versus apoptosis
    Francesca Peruzzi
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Front Biosci 11:708-17. 2006
    ..Here, we discuss intracellular activities of Tat in HIV-infected cells, as well as in cells exposed to Tat, and focus on two contradictory aspects of Tat-mediated effects: cell proliferation and cell death...
  2. ncbi Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: implication for HIV-associated dementia
    Francesca Peruzzi
    Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
    Brain Res Brain Res Rev 50:114-25. 2005
    ....
  3. pmc Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processes
    Jin Ying Wang
    Center for Neurovirology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurosci Res 85:2360-73. 2007
    ..IGF-I counteracts TNFalpha-mediated accumulation of pS-IRS-1-beta1-integrin complexes supporting the stability of neuronal processes...
  4. ncbi Dysregulation of NGF-signaling and Egr-1 expression by Tat in neuronal cell culture
    Nune Darbinian-Sarkissian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 208:506-15. 2006
    ..All of these observations support a model where the interplay between Tat and Puralpha dysregulates the NGF pathway including the MAPK/Erk network, resulting in reduced expression and activity of Egr-1 in neuronal cells...
  5. ncbi HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression
    Galina Chipitsyna
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Philadelphia, PA 19122, USA
    Oncogene 23:2664-71. 2004
    ..These observations ascribe a new role for Tat in host genomic integrity, perhaps by affecting the expression of genes involved in DNA repair...
  6. ncbi HIV-Tat promotes cellular proliferation and inhibits NGF-induced differentiation through mechanisms involving Id1 regulation
    Valeria Bergonzini
    Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
    Oncogene 23:7701-11. 2004
    ..Taken together, these studies suggest additional targets for Tat action in neuronal cells and provide new insights into the mechanisms involved in the dysregulation of neuronal functions...
  7. pmc Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination
    Joanna Trojanek
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Mol Cell Biol 23:7510-24. 2003
    ..These results point to a direct role of IRS-1 in HRR and suggest a novel role for the IGF-IR/IRS-1 axis in supporting the stability of the genome...
  8. pmc HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
    Slava Rom
    Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Biochim Biophys Acta 1813:1836-44. 2011
    ..The Tat/Grb2 interaction affects also viral function by inhibiting the Tat-mediated transactivation of HIV-1 LTR and viral replication in infected primary microglia...
  9. ncbi Involvement of alpha1beta1 integrin in insulin-like growth factor-1-mediated protection of PC12 neuronal processes from tumor necrosis factor-alpha-induced injury
    Jin Ying Wang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Neurosci Res 83:7-18. 2006
    ....
  10. ncbi Neuroprotective effects of IGF-I against TNFalpha-induced neuronal damage in HIV-associated dementia
    Jin Ying Wang
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Virology 305:66-76. 2003
    ..All together these results suggest that the balance between TNFalpha and IGF-IR signaling pathways may control the extent of neuronal injury in this HIV-related experimental setting...
  11. ncbi Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal-dependent degradation of microtubule-associated protein 2 and neuronal damage
    Susanna Aprea
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Neurosci 26:4054-62. 2006
    ..It involves proteasome-mediated MAP2 degradation and may account for the loss of MAP2 and neuronal damage observed in the brain of AIDS patients with neurological dysfunctions...
  12. pmc HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity
    Giovanni Passiatore
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
    Biochim Biophys Acta 1793:378-87. 2009
    ..Moreover, cleavage of Tat101 by calpain 1 increased neurotoxic effect of this viral protein and presence of the calpain inhibitor protected neuronal cells from Tat-mediated toxicity...
  13. pmc Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewal
    Raphael Rubin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Physiol 213:445-53. 2007
    ..Conversely, over expression of IRS-1 inhibits mES cell differentiation. Taken together, these results suggest that expression and activity of IRS-1 are critical to the maintenance of the self-renewal program in mES cells...
  14. pmc IGF-IR in neuroprotection and brain tumors
    Elisa Gualco
    Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Front Biosci 14:352-75. 2009
    ..Therefore, better understanding of the beneficial and potentially harmful aspects of the IGF-IR can be critical for the development of new clinical regimens against neurodegenerative disorders and brain tumors...
  15. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010
    ....
  16. ncbi Insulin-like growth factor I receptor signaling system in JC virus T antigen-induced primitive neuroectodermal tumors--medulloblastomas
    Luis Del Valle
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurovirol 8:138-47. 2002
    ....
  17. pmc Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a
    Davide Eletto
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19112, USA
    J Cell Physiol 216:764-70. 2008
    ..Altogether, our data provide a novel mechanism by which HIV-Tat perturbs neuronal activity...
  18. ncbi Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway
    Francesca Peruzzi
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurovirol 8:91-6. 2002
    ..These data demonstrate the cooperativity between HIV-1 Tat and the Puralpha in deregulation of the NGF signal transduction pathway in neuronal cells...
  19. ncbi Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes
    Marlene R D Quadros
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 64:3934-9. 2004
    ..They also highlight complex regulation of STAT3 phosphorylation through EGFR activation including negative regulation via the MAPK kinase/MAPK signaling pathway...
  20. ncbi The IGF-1 receptor in cancer biology
    Renato Baserga
    Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, 624 BLSB, Philadelphia, PA 19107, USA
    Int J Cancer 107:873-7. 2003
    ..Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy...
  21. ncbi Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen
    Adam Lassak
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Biol Chem 277:17231-8. 2002
    ..It may involve uncoupling of IRS-1 from its surface receptor and translocation of its function to the nucleus...
  22. pmc HIV-1 Tat inhibits NGF-induced Egr-1 transcriptional activity and consequent p35 expression in neural cells
    Nune Darbinian
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Cell Physiol 216:128-34. 2008
    ..These observations ascribe a role for Tat in altering p35 expression and its activity that affects phosphorylation of proteins involved in neuronal cell survival...

Research Grants10

  1. Mechanisms involved in HIV-1 Tat mediated neuronal damage
    Francesca Peruzzi; Fiscal Year: 2010
    ..We expect that results from this study will critically redefine our knowledge of Tat-mediated neurotoxicity, and can provide potential targets for more effective therapeutic intervention. ..
  2. Mechanisms involved in HIV-1 Tat mediated neuronal damage
    Francesca Peruzzi; Fiscal Year: 2007
    ..We expect that results from this study will critically redefine our knowledge of Tat-mediated neurotoxicity, and can provide potential targets for more effective therapeutic intervention. ..
  3. Molecular basis of neuronal dysfunction in AIDS
    Francesca Peruzzi; Fiscal Year: 2007
    ..The outcome of these studies will provide a new information on the pathways which are affected by HIV-1 Tat, and will assist to improve our effort for developing strategies against HIV-1 induced neuronal cell injury. ..