Research Topics
Genomes and Genes
| Francesca PeruzziSummaryAffiliation: Temple University Country: USA Publications
Research Grants
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Detail Information
Publications
The multiple functions of HIV-1 Tat: proliferation versus apoptosisFrancesca Peruzzi
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
Front Biosci 11:708-17. 2006..Here, we discuss intracellular activities of Tat in HIV-infected cells, as well as in cells exposed to Tat, and focus on two contradictory aspects of Tat-mediated effects: cell proliferation and cell death...- Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: implication for HIV-associated dementiaFrancesca Peruzzi
Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
Brain Res Brain Res Rev 50:114-25. 2005.... 
Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processesJin Ying Wang
Center for Neurovirology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
J Neurosci Res 85:2360-73. 2007..IGF-I counteracts TNFalpha-mediated accumulation of pS-IRS-1-beta1-integrin complexes supporting the stability of neuronal processes...- Dysregulation of NGF-signaling and Egr-1 expression by Tat in neuronal cell cultureNune Darbinian-Sarkissian
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 208:506-15. 2006..All of these observations support a model where the interplay between Tat and Puralpha dysregulates the NGF pathway including the MAPK/Erk network, resulting in reduced expression and activity of Egr-1 in neuronal cells... - HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expressionGalina Chipitsyna
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Philadelphia, PA 19122, USA
Oncogene 23:2664-71. 2004..These observations ascribe a new role for Tat in host genomic integrity, perhaps by affecting the expression of genes involved in DNA repair... - HIV-Tat promotes cellular proliferation and inhibits NGF-induced differentiation through mechanisms involving Id1 regulationValeria Bergonzini
Center for Neurovirology and Cancer Biology, Temple University, 1900 12th North Street, Philadelphia, PA 19122, USA
Oncogene 23:7701-11. 2004..Taken together, these studies suggest additional targets for Tat action in neuronal cells and provide new insights into the mechanisms involved in the dysregulation of neuronal functions... - Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombinationJoanna Trojanek
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Mol Cell Biol 23:7510-24. 2003..These results point to a direct role of IRS-1 in HRR and suggest a novel role for the IGF-IR/IRS-1 axis in supporting the stability of the genome... - HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interactionSlava Rom
Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
Biochim Biophys Acta 1813:1836-44. 2011..The Tat/Grb2 interaction affects also viral function by inhibiting the Tat-mediated transactivation of HIV-1 LTR and viral replication in infected primary microglia... - Involvement of alpha1beta1 integrin in insulin-like growth factor-1-mediated protection of PC12 neuronal processes from tumor necrosis factor-alpha-induced injuryJin Ying Wang
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
J Neurosci Res 83:7-18. 2006.... - Neuroprotective effects of IGF-I against TNFalpha-induced neuronal damage in HIV-associated dementiaJin Ying Wang
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Virology 305:66-76. 2003..All together these results suggest that the balance between TNFalpha and IGF-IR signaling pathways may control the extent of neuronal injury in this HIV-related experimental setting... - Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal-dependent degradation of microtubule-associated protein 2 and neuronal damageSusanna Aprea
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
J Neurosci 26:4054-62. 2006..It involves proteasome-mediated MAP2 degradation and may account for the loss of MAP2 and neuronal damage observed in the brain of AIDS patients with neurological dysfunctions... - HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicityGiovanni Passiatore
Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
Biochim Biophys Acta 1793:378-87. 2009..Moreover, cleavage of Tat101 by calpain 1 increased neurotoxic effect of this viral protein and presence of the calpain inhibitor protected neuronal cells from Tat-mediated toxicity... - Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewalRaphael Rubin
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Cell Physiol 213:445-53. 2007..Conversely, over expression of IRS-1 inhibits mES cell differentiation. Taken together, these results suggest that expression and activity of IRS-1 are critical to the maintenance of the self-renewal program in mES cells... - IGF-IR in neuroprotection and brain tumorsElisa Gualco
Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19122, USA
Front Biosci 14:352-75. 2009..Therefore, better understanding of the beneficial and potentially harmful aspects of the IGF-IR can be critical for the development of new clinical regimens against neurodegenerative disorders and brain tumors... - CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cellsSlava Rom
Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
FASEB J 24:2292-300. 2010.... - Insulin-like growth factor I receptor signaling system in JC virus T antigen-induced primitive neuroectodermal tumors--medulloblastomasLuis Del Valle
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Neurovirol 8:138-47. 2002.... - Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128aDavide Eletto
Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19112, USA
J Cell Physiol 216:764-70. 2008..Altogether, our data provide a novel mechanism by which HIV-Tat perturbs neuronal activity... - Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathwayFrancesca Peruzzi
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Neurovirol 8:91-6. 2002..These data demonstrate the cooperativity between HIV-1 Tat and the Puralpha in deregulation of the NGF signal transduction pathway in neuronal cells... - Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytesMarlene R D Quadros
Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 64:3934-9. 2004..They also highlight complex regulation of STAT3 phosphorylation through EGFR activation including negative regulation via the MAPK kinase/MAPK signaling pathway... - The IGF-1 receptor in cancer biologyRenato Baserga
Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, 624 BLSB, Philadelphia, PA 19107, USA
Int J Cancer 107:873-7. 2003..Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy... - Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigenAdam Lassak
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Biol Chem 277:17231-8. 2002..It may involve uncoupling of IRS-1 from its surface receptor and translocation of its function to the nucleus... - HIV-1 Tat inhibits NGF-induced Egr-1 transcriptional activity and consequent p35 expression in neural cellsNune Darbinian
Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania
J Cell Physiol 216:128-34. 2008..These observations ascribe a role for Tat in altering p35 expression and its activity that affects phosphorylation of proteins involved in neuronal cell survival...
Research Grants
- Mechanisms involved in HIV-1 Tat mediated neuronal damageFrancesca Peruzzi; Fiscal Year: 2010..We expect that results from this study will critically redefine our knowledge of Tat-mediated neurotoxicity, and can provide potential targets for more effective therapeutic intervention. ..
- Mechanisms involved in HIV-1 Tat mediated neuronal damageFrancesca Peruzzi; Fiscal Year: 2007..We expect that results from this study will critically redefine our knowledge of Tat-mediated neurotoxicity, and can provide potential targets for more effective therapeutic intervention. ..
- Molecular basis of neuronal dysfunction in AIDSFrancesca Peruzzi; Fiscal Year: 2007..The outcome of these studies will provide a new information on the pathways which are affected by HIV-1 Tat, and will assist to improve our effort for developing strategies against HIV-1 induced neuronal cell injury. ..