YURI contact PERSIDSKY

Summary

Affiliation: Temple University
Country: USA

Publications

  1. doi request reprint Dysfunction of brain pericytes in chronic neuroinflammation
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA
    J Cereb Blood Flow Metab 36:794-807. 2016
  2. doi request reprint Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, 19140, USA
    J Neuroimmune Pharmacol 10:302-8. 2015
  3. doi request reprint Insights into end-organ injury in HIV infection: dynamics of monocyte trafficking to the brain in SIV encephalitis
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania Electronic address
    Am J Pathol 185:1548-51. 2015
  4. pmc SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans
    Yu Zhou
    The Center for Animal Experiment ABSL III Laboratory, State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan, Hubei 430071, P, R, China
    Retrovirology 10:89. 2013
  5. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
  6. pmc Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages
    Jieliang Li
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuroinflammation 8:15. 2011
  7. pmc HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Brain Behav Immun 25:S61-70. 2011

Research Grants

Collaborators

  • Slava Rom
  • Wen Zhe Ho
  • Yu Zhou
  • Servio H Ramirez
  • Xu Wang
  • Jieliang Li
  • Steven F Merkel
  • Shongshan Fan
  • Nancy L Haigwood
  • Nancy L Reichenbach
  • Rong Bao
  • Denise R Cook
  • Li Ye
  • Dennis L Kolson
  • Jinping Liu

Detail Information

Publications7

  1. doi request reprint Dysfunction of brain pericytes in chronic neuroinflammation
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA
    J Cereb Blood Flow Metab 36:794-807. 2016
    ..These data suggest an important role of pericytes in BBB regulation in neuroinflammation. ..
  2. doi request reprint Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, 19140, USA
    J Neuroimmune Pharmacol 10:302-8. 2015
    ..Such changes in gene expression paralleled diminished secretion of proinflammatory factors. These results indicate the potential utility of CB2 agonists for the treatment of neuroinflammation...
  3. doi request reprint Insights into end-organ injury in HIV infection: dynamics of monocyte trafficking to the brain in SIV encephalitis
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania Electronic address
    Am J Pathol 185:1548-51. 2015
    ..This commentary highlights the article by Nowlin et al, which explores the dynamic roles of macrophages in early and late central nervous system lentiviral disease. ..
  4. pmc SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans
    Yu Zhou
    The Center for Animal Experiment ABSL III Laboratory, State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan, Hubei 430071, P, R, China
    Retrovirology 10:89. 2013
    ..Therefore, to examine and compare results obtained from RM models of Indian and Chinese origins should lead to further validation and improvement of these animal models for HIV/AIDS research. ..
  5. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
    ..Together, these results indicate that CB₂ may offer a means to limit HIV-1 infection in macrophages...
  6. pmc Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages
    Jieliang Li
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuroinflammation 8:15. 2011
    ..In this study, we examined whether BBI has the ability to inhibit LPS-mediated macrophage activation, reducing the release of pro-inflammatory cytokines and subsequent neurotoxicity in primary cortical neural cultures...
  7. pmc HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Brain Behav Immun 25:S61-70. 2011
    ..Agonists of cannabinoid receptor 2 (CB₂) possess potent anti-inflammatory and neuroprotective properties. We address multifaceted beneficial effects of CB₂ activation in the setting of HIV-1 brain infection and alcohol abuse...

Research Grants1

  1. PPAR-gamma-mediated neuroprotection against HIV-1 and alcohol CNS injury
    Yuri Persidsky; Fiscal Year: 2009
    ..The availability of PPARgamma agonists approved for clinical use will permit rapid translation of experimental findings into therapeutic applications. ..