Henry P Parkman

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Cholecystectomy and clinical presentations of gastroparesis
    Henry P Parkman
    Gastroenterology Section, Parkinson Pavilion, School of Medicine, Temple University, 8th Floor 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 58:1062-73. 2013
  2. ncbi request reprint Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters
    Henry P Parkman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    J Clin Gastroenterol 46:494-503. 2012
  3. doi request reprint Gastric emptying scintigraphy: is four hours necessary?
    Murali Pathikonda
    Department of Medicine, Gastroenterology Section, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Clin Gastroenterol 46:209-15. 2012
  4. pmc Similarities and differences between diabetic and idiopathic gastroparesis
    Henry P Parkman
    Temple University, School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Clin Gastroenterol Hepatol 9:1056-64; quiz e133-4. 2011
  5. doi request reprint Scintigraphy for evaluation of patients for GI motility disorders--the referring physician's perspective
    Henry P Parkman
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia PA 19140, USA
    Semin Nucl Med 42:76-8. 2012
  6. ncbi request reprint Assessment of gastric emptying and small-bowel motility: scintigraphy, breath tests, manometry, and SmartPill
    Henry P Parkman
    Temple University School of Medicine, Gastroenterology Section, Parkinson Pavilion, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Gastrointest Endosc Clin N Am 19:49-55, vi. 2009
  7. doi request reprint Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects
    Henry P Parkman
    Gastroenterology Section, School of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 56:115-24. 2011
  8. pmc Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity
    Henry P Parkman
    Gastroenterology Section, Temple University, Philadelphia, Pennsylvania 19140, USA
    Gastroenterology 140:101-15. 2011
  9. ncbi request reprint Advances in the management of gastroparesis
    Frank K Friedenberg
    Henry P Parkman, MD Gastroenterology Section, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Curr Treat Options Gastroenterol 10:283-93. 2007
  10. pmc Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
    H P Parkman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 22:113-33. 2010

Collaborators

Detail Information

Publications72

  1. pmc Cholecystectomy and clinical presentations of gastroparesis
    Henry P Parkman
    Gastroenterology Section, Parkinson Pavilion, School of Medicine, Temple University, 8th Floor 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 58:1062-73. 2013
    ..Many patients with gastroparesis have had their gallbladders removed...
  2. ncbi request reprint Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters
    Henry P Parkman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    J Clin Gastroenterol 46:494-503. 2012
    ..Metoclopramide is associated with variable efficacy and side effects when used in the treatment of gastroparesis...
  3. doi request reprint Gastric emptying scintigraphy: is four hours necessary?
    Murali Pathikonda
    Department of Medicine, Gastroenterology Section, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Clin Gastroenterol 46:209-15. 2012
    ..Recommendations for gastric emptying scintigraphy (GES) suggest imaging over 4 hours to better define gastroparesis...
  4. pmc Similarities and differences between diabetic and idiopathic gastroparesis
    Henry P Parkman
    Temple University, School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Clin Gastroenterol Hepatol 9:1056-64; quiz e133-4. 2011
    ..We compared clinical characteristics, symptoms, and gastric emptying in patients with type 1 or type 2 diabetic (DG) or idiopathic (IG) gastroparesis...
  5. doi request reprint Scintigraphy for evaluation of patients for GI motility disorders--the referring physician's perspective
    Henry P Parkman
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia PA 19140, USA
    Semin Nucl Med 42:76-8. 2012
    ..This article discusses a physician's perspective on evaluating GI transit in patients with suspected GI disorders, particularly those involving the stomach for gastroparesis and the colon in patients with constipation...
  6. ncbi request reprint Assessment of gastric emptying and small-bowel motility: scintigraphy, breath tests, manometry, and SmartPill
    Henry P Parkman
    Temple University School of Medicine, Gastroenterology Section, Parkinson Pavilion, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Gastrointest Endosc Clin N Am 19:49-55, vi. 2009
    ..This article covers several tests that are used to evaluate gastric and small-bowel motility in patients, either in clinical evaluation or in clinical research...
  7. doi request reprint Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects
    Henry P Parkman
    Gastroenterology Section, School of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 56:115-24. 2011
    ..Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets...
  8. pmc Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity
    Henry P Parkman
    Gastroenterology Section, Temple University, Philadelphia, Pennsylvania 19140, USA
    Gastroenterology 140:101-15. 2011
    ..We studied characteristics of patients with IG enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium Registry...
  9. ncbi request reprint Advances in the management of gastroparesis
    Frank K Friedenberg
    Henry P Parkman, MD Gastroenterology Section, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Curr Treat Options Gastroenterol 10:283-93. 2007
    ..However, which patients are likely to respond, the optimal electrode position, and the optimal stimulation parameters remain areas that need to be addressed...
  10. pmc Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
    H P Parkman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 22:113-33. 2010
    ..Similarly, the diagnostic and treatment options for these two disorders are relatively limited despite recent advances in our understanding of both disorders...
  11. ncbi request reprint The gastrointestinal motility laboratory
    Henry P Parkman
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Gastroenterol Clin North Am 36:515-29, vii-viii. 2007
    ..This article addresses important concepts in setting up and running an efficient and practical GI motility laboratory...
  12. doi request reprint Tests of gastric neuromuscular function
    Henry P Parkman
    Gastroenterology Section, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Gastroenterology 136:1526-43. 2009
    ..This article reviews tests of gastric function and provides a basic description of the tests, the methodologies behind them, descriptions of the physiology that they assess, and their clinical utility...
  13. ncbi request reprint The gastrointestinal motility laboratory
    Henry P Parkman
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Gastrointest Endosc Clin N Am 19:171-84, viii. 2009
    ..This article addresses important concepts in setting up and running an efficient and practical GI motility laboratory...
  14. pmc Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis
    Henry P Parkman
    Gastroenterology Section, Department of Medicine, Temple University, Philadelphia, Pennsylvania 19140, USA
    Gastroenterology 141:486-98, 498.e1-7. 2011
    ..Gastroparesis can lead to food aversion, poor oral intake, and subsequent malnutrition. We characterized dietary intake and nutritional deficiencies in patients with diabetic and idiopathic gastroparesis...
  15. doi request reprint Gastric emptying of solids and liquids for evaluation for gastroparesis
    Priyanka Sachdeva
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Dig Dis Sci 56:1138-46. 2011
    ..Gastric emptying scintigraphy (GES) of solids is typically used to evaluate for gastroparesis...
  16. ncbi request reprint Endoscopic pyloric injection of botulinum toxin A for the treatment of refractory gastroparesis
    Matthew Q Bromer
    Section of Gastroenterology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Gastrointest Endosc 61:833-9. 2005
    ..Botulinum toxin A injected into the pyloric sphincter has been reported in small case series to treat gastroparesis. This study reviews the use of this treatment in a large number of patients with gastroparesis...
  17. ncbi request reprint Use of a high caloric liquid meal as an alternative to a solid meal for gastric emptying scintigraphy
    Priyanka Sachdeva
    Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 58:2001-6. 2013
    ..Gastric emptying scintigraphy (GES) using a solid meal is often recommended for the evaluation of gastroparesis. However, some patients cannot tolerate the standardized egg-white sandwich (EWS) solid meal and an alternative meal is needed...
  18. pmc Predictive factors for clinical improvement with Enterra gastric electric stimulation treatment for refractory gastroparesis
    Jennifer L Maranki
    Department of Medicine, Gastroenterology Section, Temple University School of Medicine, Parkinson Pavilion, Philadelphia, PA 19140, USA
    Dig Dis Sci 53:2072-8. 2008
    ..The objectives of this study were to determine the clinical response to Enterra gastric electric stimulation (GES) in patients with refractory gastroparesis and to determine factors associated with a favorable response...
  19. doi request reprint Fatigue: a prevalent symptom in gastroparesis
    Dinu Cherian
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    Dig Dis Sci 57:2088-95. 2012
    ..Fatigue is seen in many medical conditions. Patients with gastroparesis may complain of fatigue...
  20. ncbi request reprint Multichannel electrogastrography (EGG) in normal subjects: a multicenter study
    Hrair P Simonian
    Temple University School of Medicine, Philadelphia, Pennsylvania, PA 19140, USA
    Dig Dis Sci 49:594-601. 2004
    ..This multicenter study of normal subjects shows similar multichannel EGG values among different genders and ages. Body mass and ethnicity may impact on some of the EGG values...
  21. doi request reprint Characteristics of nausea and its effects on quality of life in diabetic and idiopathic gastroparesis
    Jane K Jaffe
    Department of Medicine, Gastrointestinal Section, Temple University School of Medicine, Philadelphia, PA, USA
    J Clin Gastroenterol 45:317-21. 2011
    ..Nausea is a common symptom of gastroparesis (GP). The study is to determine the manifestations and impact of nausea in GP and to determine if there are any differences in diabetic (DG) and idiopathic gastroparesis (IG)...
  22. doi request reprint Chronic idiopathic constipation: more than a simple colonic transit disorder
    Shabana Shahid
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Clin Gastroenterol 46:150-4. 2012
    ..The purposes of this study were to determine the percentage of constipated patients with the different pathophysiologic subtypes and and to evaluate what percentage of constipated patients has a diffuse GI tract transit disorder...
  23. ncbi request reprint Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial
    Henry P Parkman
    Temple University, Philadelphia, Pennsylvania
    JAMA 310:2640-9. 2013
    ..Tricyclic antidepressants are often used to treat refractory symptoms of nausea, vomiting, and abdominal pain. Evidence from well-designed studies for this use is lacking...
  24. ncbi request reprint Botulinum toxin A for the treatment of delayed gastric emptying
    Frank K Friedenberg
    Section of Gastroenterology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Gastroenterol 103:416-23. 2008
    ..Our purpose was to determine whether botulinum toxin improves symptoms to a significantly greater extent than placebo. An additional objective was to determine whether there is an acceleration of gastric emptying after injection...
  25. ncbi request reprint Wireless capsule motility: comparison of the SmartPill GI monitoring system with scintigraphy for measuring whole gut transit
    Sabba Maqbool
    Gastroenterology Section, Department of Medicine, 8th Floor Parkinson Pavilion, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Dig Dis Sci 54:2167-74. 2009
    ..The objective of this study was to compare the SmartPill with whole gut transit scintigraphy to determine whether the SmartPill system could serve as a test for measurement of whole gut motility and transit...
  26. ncbi request reprint Treatment of idiopathic gastroparesis with injection of botulinum toxin into the pyloric sphincter muscle
    Larry S Miller
    Section of Gastroenterology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Gastroenterol 97:1653-60. 2002
    ..We aimed to determine if botulinum toxin injection into the pyloric sphincter improves gastric emptying and reduces symptoms in patients with idiopathic gastroparesis...
  27. ncbi request reprint Simultaneous assessment of gastric accommodation and emptying: studies with liquid and solid meals
    Hrair P Simonian
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Nucl Med 45:1155-60. 2004
    ..The aim of this study was to develop a scintigraphic test to measure gastric emptying and accommodation simultaneously...
  28. ncbi request reprint Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis
    Kishore V Gaddipati
    Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Dig Dis Sci 51:1339-46. 2006
    ..Vagal function and regulation of ghrelin levels are impaired in diabetic gastroparesis...
  29. ncbi request reprint American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis
    Henry P Parkman
    Temple University School of Medicine, Philadelphia, PA, USA
    Gastroenterology 127:1592-622. 2004
    ..The paper was approved by the Committee on May 16, 2004, and by the AGA Governing Board on September 23, 2004...
  30. doi request reprint Tonic and phasic pyloric activity in response to CCK-octapeptide
    Frank K Friedenberg
    Department of Medicine, Section of Gastroenterology, Temple University Hospital, Temple University School of Medicine, 3401 N Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 53:905-11. 2008
    ..The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide...
  31. ncbi request reprint Regional gastric contractility alterations in a diabetic gastroparesis mouse model: effects of cholinergic and serotoninergic stimulation
    Arlene N James
    Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Physiol Gastrointest Liver Physiol 287:G612-9. 2004
    ..This study suggests that fundic hypomotility and pyloric hypercontractility, rather than antral hypomotility, play important roles for the gastric dysmotility that occurs in diabetes...
  32. ncbi request reprint Esophageal bacteria and Barrett's esophagus: a preliminary report
    Glenn L Osias
    Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Dig Dis Sci 49:228-36. 2004
    ..Increasing bacterial stain scores were associated with metaplasia and increasing dysplasia. Esophageal bacteria, possibly related to stasis or gastric acid suppression therapy, may play a role in the pathogenesis of BE and dysplasia...
  33. ncbi request reprint Regional postprandial differences in pH within the stomach and gastroesophageal junction
    Hrair P Simonian
    The Gastroenterology Section, Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    Dig Dis Sci 50:2276-85. 2005
    ..Despite the intragastric buffering effect of meals, focal areas of acidity were observed in the region of the cardia-gastroesophageal junction during the postprandial period...
  34. pmc Effect of atilmotin, a motilin receptor agonist, on esophageal, lower esophageal sphincter, and gastric pressures
    Annapurna Korimilli
    Division of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    Dig Dis Sci 55:300-6. 2010
    ..Prior studies at higher doses of 100-450 microg IV demonstrated that some subjects developed noncardiac chest pain...
  35. doi request reprint Abdominal pain is a frequent symptom of gastroparesis
    Dinu Cherian
    Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Clin Gastroenterol Hepatol 8:676-81. 2010
    ..We aimed to define the prevalence, severity, and quality of abdominal pain in GP and to correlate abdominal pain with gastric emptying (GE) and quality of life...
  36. ncbi request reprint The influence of race on symptom severity and quality of life in gastroparesis
    Frank K Friedenberg
    Department of Medicine, Gastroenterology Section, Temple University School of Medicine, Philadelphia, PA
    J Clin Gastroenterol 47:757-61. 2013
    ..Our aim was to compare the etiology, clinical characteristics, healthcare utilization, symptom profile, and quality of life (QOL) in white and nonwhite patients with gastroparesis...
  37. doi request reprint Small intestinal bacterial overgrowth in gastroparesis
    Nina S George
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    Dig Dis Sci 59:645-52. 2014
    ..To determine symptoms of small intestinal bacterial overgrowth (SIBO) in gastroparesis patients...
  38. ncbi request reprint Egg labeling methods for gastric emptying scintigraphy are not equivalent in producing a stable solid meal
    Linda C Knight
    Division of Nuclear Medicine, Department of Radiology, Temple University School of Medicine and Hospital, Philadelphia, PA 19140, USA
    J Nucl Med 48:1897-900. 2007
    ..The purpose of this study was to test whether (99m)Tc-sulfur colloid-labeled liquid egg white is as stable as 2 fresh whole eggs labeled with (99m)Tc-sulfur colloid and whether the cooking method is important...
  39. ncbi request reprint Symptoms of gastroparesis: use of the gastroparesis cardinal symptom index in symptomatic patients referred for gastric emptying scintigraphy
    Daniel W Cassilly
    Gastrointestinal Section, Department of Medicine, Temple University, Philadelphia, PA 19140, USA
    Digestion 78:144-51. 2008
    ..The aim of this study was to correlate symptoms using the GCSI with delayed gastric emptying (DGE) in symptomatic patients referred for gastric emptying scintigraphy (GES)...
  40. doi request reprint Wireless capsules for esophageal pH monitoring: are we placing them correctly?
    Siva Doma
    Gastroenterology Section, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Digestion 82:54-9. 2010
    ..Recommended Bravo capsule placement is 6 cm proximal to the squamocolumnar junction. This is because the junction resides 1 cm distal to the lower esophageal sphincter...
  41. ncbi request reprint Update on gastrointestinal scintigraphy
    Alan H Maurer
    Nuclear Medicine, Temple University Hospital and School of Medicine, Philadelphia, PA 19140, USA
    Semin Nucl Med 36:110-8. 2006
    ..This review summarizes the state-of-the-art of prior established and newer scintigraphic studies with an emphasis on their clinical applications...
  42. ncbi request reprint Transsphincteric pH profile at the gastroesophageal junction
    Jyothi Mekapati
    Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Clin Gastroenterol Hepatol 6:630-4. 2008
    ..Esophageal acid exposure conventionally is measured 5 cm above the lower esophageal sphincter (LES). The aim of this study was to compare pH profiles at sites within the LES, the distal esophagus, and the proximal stomach...
  43. ncbi request reprint Simultaneous measurement of gastric emptying with a simple muffin meal using [13C]octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms
    Matthew Q Bromer
    Department of Internal Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Dig Dis Sci 47:1657-63. 2002
    ..In conclusion, the OBT for GE, using an easily prepared muffin meal, significantly correlates with GES for solids. This muffin-based OBT is a sensitive and specific method to detect delayed GE in dyspeptic patients...
  44. doi request reprint Surgical outcomes after gastric electric stimulator placement for refractory gastroparesis
    Deborah S Keller
    Department of Surgery, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Gastrointest Surg 17:620-6. 2013
    ..Although symptomatic improvement has been reported with GES, few studies describe the need for additional surgery after placement. Our goal was to evaluate the outcomes of a large series of GES at a single institution...
  45. ncbi request reprint American Gastroenterological Association medical position statement: diagnosis and treatment of gastroparesis
    Henry P Parkman
    Temple University School of Medicine, Philadelphia, PA, USA
    Gastroenterology 127:1589-91. 2004
    ..It was approved by the Clinical Practice Committee on May 16, 2004, and by the AGA Governing Board on September 23, 2004...
  46. doi request reprint Continuous glucose monitoring in gastroparesis
    Zeeshan Ramzan
    Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 56:2646-55. 2011
    ..Continuous glucose monitoring (CGM) may be useful to assess the relationship between gastric emptying and blood glucose levels...
  47. ncbi request reprint Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients
    Sutep Gonlachanvit
    Gastroenterology Section, Department of Internal Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Dig Dis Sci 48:488-97. 2003
    ..These results suggest that administration of opiate analgesics or prokinetic agents to diabetic patients may alter glucose control. Modifying gastric emptying may be helpful in achieving glucose control in T II DM...
  48. ncbi request reprint Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation
    Satish S C Rao
    Department of Medicine, University of Iowa, Iowa City, Iowa 52242 1009, USA
    Clin Gastroenterol Hepatol 7:537-44. 2009
    ..We assessed regional and CTT with the SmartPill (SmartPill Corporation, Buffalo, NY), a new wireless pH and pressure recording capsule, in constipated and healthy subjects and compared this with ROM...
  49. ncbi request reprint The use of botulinum toxin for the treatment of gastrointestinal motility disorders
    Frank Friedenberg
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Dig Dis Sci 49:165-75. 2004
    ..Despite uncontrolled data, botulinum toxin is now used for a variety of spastic disorders of GI smooth muscle. In some instances this therapy may preclude the need for more invasive treatments. Controlled trials are needed...
  50. ncbi request reprint Granisetron transdermal system improves refractory nausea and vomiting in gastroparesis
    Kellie Simmons
    GI Section, Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Temple University Hospital, 3401 N Broad Street, Philadelphia, PA, 19140, USA
    Dig Dis Sci 59:1231-4. 2014
    ..Symptoms of gastroparesis include nausea and vomiting, which can markedly diminish quality of life. Nausea and vomiting can also make treatment with oral antiemetics problematic...
  51. ncbi request reprint Gastroparesis after combined heart and lung transplantation
    Sudeep S Sodhi
    Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Clin Gastroenterol 34:34-9. 2002
    ..To determine the prevalence, severity, and outcome of gastroparesis after heart and lung transplantation (HLT)...
  52. ncbi request reprint Neurotrophin-3 improves functional constipation
    Henry P Parkman
    Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    Am J Gastroenterol 98:1338-47. 2003
    ..Our aim was to assess 1) the dose-related effects of NT-3 on bowel function, colon transit, and symptoms of chronic constipation, and 2) its safety...
  53. doi request reprint DNA microarray SNP associations with clinical efficacy and side effects of domperidone treatment for gastroparesis
    Dairong Wang
    Data Analytics and Biomedical Informatics Center, Temple University, Philadelphia, PA, USA
    J Biomed Inform 45:316-22. 2012
    ..DNA microarray single nucleotide polymorphism (SNP) analysis may help to elucidate the role of genetic variability on the therapeutic effectiveness and toxicity of domperidone...
  54. ncbi request reprint Gastric neuromuscular pathology in gastroparesis: analysis of full-thickness antral biopsies
    Justin Harberson
    Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Dig Dis Sci 55:359-70. 2010
    ..Pathologic assessment of gastric tissue in patients with gastroparesis is limited. Aims To evaluate gastric histopathology in patients with gastroparesis...
  55. ncbi request reprint Factors contributing to hospitalization for gastroparesis exacerbations
    Sesha S Uppalapati
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, Philadelphia, PA 19140, USA
    Dig Dis Sci 54:2404-9. 2009
    ..The clinical course of patients with gastroparesis is characterized by symptomatic exacerbations often necessitating hospitalization...
  56. ncbi request reprint Identification of domperidone metabolites in plasma and urine of gastroparesis patients with LC-ESI-MS/MS
    Amir S Youssef
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA
    Xenobiotica 43:1073-83. 2013
    ..In total, 12 domperidone metabolites including 7 new metabolites were identified in the present study. These results allow a better understanding of domperidone disposition in humans...
  57. ncbi request reprint Comparison of a salivary/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung
    Sunitha Potluri
    Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    Dig Dis Sci 48:1813-7. 2003
    ..In conclusion, detection of pepsin in the saliva and/or sputum may provide a noninvasive method to test for the proximal reflux of gastric contents...
  58. ncbi request reprint Training in gastrointestinal motility
    Henry P Parkman
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Dig Dis 24:221-7. 2006
    ....
  59. ncbi request reprint Achalasia presenting after operative and nonoperative trauma
    Rupa N Shah
    Division of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    Dig Dis Sci 49:1818-21. 2004
    ..Patients with posttraumatic achalasia may have symptoms which differ from those of other achalasia patients...
  60. ncbi request reprint Detection of JC virus DNA sequences and expression of viral T antigen and agnoprotein in esophageal carcinoma
    Luis Del Valle
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
    Cancer 103:516-27. 2005
    ..The objective of this study was to examine the presence of JCV DNA sequences and JCV protein expression in normal and malignant human esophageal tissues...
  61. ncbi request reprint Increased Barrett's esophagus for the decade between 1991 and 2000 at a single university medical center
    Shayan Irani
    Gastroenterology Section and Department of Pathology, Temple University School of Medicine, 3401 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Dig Dis Sci 50:2141-6. 2005
    ..The endoscopic impression of Barrett's esophagus was about four times higher than the confirmed diagnosis of Barrett's esophagus (intestinal metaplasia) on histology...
  62. doi request reprint Migraine and gastroparesis from a gastroenterologist's perspective
    Henry P Parkman
    Gastroenterology Section, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Headache 53:4-10. 2013
    ..Several non-oral formulations that do not rely on gastrointestinal absorption are available or in development for the treatment of migraine and symptoms of gastroparesis...
  63. ncbi request reprint Barrett's esophagus and achalasia
    Jin Ping Guo
    Division of Gastroenterology, Samaritan Program, Temple University Health System, Temple University Hospital, Philadelphia, Pennsylvania, USA
    J Clin Gastroenterol 34:439-43. 2002
    ..No other patients have been reported to develop Barrett's esophagus after pneumatic dilation alone. Patients with achalasia and Barrett's esophagus may be at a particularly high risk for developing dysplasia and adenocarcinoma...
  64. ncbi request reprint New advances in the diagnosis and management of nausea and vomiting
    Henry P Parkman
    GI Motility Laboratory, Temple University Hospital, Philadelphia, PA, USA
    Case Manager 13:83-6; quiz 87. 2002
    ..Finally, specific emphasis is placed on chronic drug refractory nausea and vomiting (gastroparesis) and the clinical cost and quality of life data associated with gastric electric stimulation...
  65. ncbi request reprint Treatment of chest pain in patients with noncardiac, nonreflux, nonachalasia spastic esophageal motor disorders using botulinum toxin injection into the gastroesophageal junction
    Larry S Miller
    Department of Gastroenterology, Temple University Hospital, Philadelphia, Pennsylvania 19401, USA
    Am J Gastroenterol 97:1640-6. 2002
    ..The aim of this study was to determine if botulinum toxin injection in the gastroesophageal junction improves symptoms in patients with noncardiac chest pain with a spastic esophageal motility disorder...
  66. ncbi request reprint Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995-2004
    Yize R Wang
    Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Gastroenterol 103:313-22. 2008
    ..Gastroparesis is an increasingly recognized disorder. Its prevalence in the United States is unknown. We examined the trends, characteristics, and outcomes of gastroparesis-related hospitalizations during 1995-2004...
  67. ncbi request reprint Inhibitory effects of botulinum toxin on pyloric and antral smooth muscle
    Arlene N James
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Physiol Gastrointest Liver Physiol 285:G291-7. 2003
    ..At higher concentrations, botulinum toxin directly inhibits smooth muscle contractility as evidenced by the decreased contractile response to ACh...
  68. ncbi request reprint Multichannel electrogastrography (EGG) in symptomatic patients: a single center study
    Hrair P Simonian
    Temple University Hospital, Philadelphia, PA, USA
    Am J Gastroenterol 99:478-85. 2004
    ..To determine the value of multichannel versus conventional single-channel electrogastrography (EGG) and of an additional postprandial hour recording in symptomatic patients...
  69. ncbi request reprint Gastric electric stimulation for the treatment of gastroparesis
    Jennifer Maranki
    Gastroenterology Section, Temple University School of Medicine, Gastroenterology Section, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Curr Gastroenterol Rep 9:286-94. 2007
    ..As treatment with gastric electric stimulation evolves, further delineation of its overall effectiveness, the type of patient that will likely respond, optimal electrode placement(s), and stimulus parameters should be explored...
  70. ncbi request reprint Management of delayed gastric emptying
    Frank K Friedenberg
    Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    Clin Gastroenterol Hepatol 3:642-6. 2005
  71. ncbi request reprint Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine
    Thomas L Abell
    Gastroenterology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Gastroenterol 103:753-63. 2008
    ..Adoption of this standardized protocol will resolve the lack of uniformity of testing, add reliability and credibility to the results, and improve the clinical utility of the GE test...
  72. ncbi request reprint Differences in intragastric pH in diabetic vs. idiopathic gastroparesis: relation to degree of gastric retention
    William L Hasler
    Division of Gastroenterology, Univ of Michigan Health System, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1384-91. 2008
    ..those with mild delays. Thus both etiology and degree of gastric stasis determine gastric acidity in gastroparesis...