Affiliation: Temple University
- Application of a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to the pharmacokinetics of ON01910 in brain tumor-bearing miceSilpa Nuthalapati
Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N Broad Street, Philadelphia, PA 19140, USA
J Pharm Biomed Anal 56:1117-20. 2011..ON01910 exhibited a clearance of 3.61±0.85 l/h/kg and a half life of 8.66±3.30 h at 50 mg/kg dose given I.V...
- Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapySilpa Nuthalapati
Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, Pennsylvania 19140, USA
Pharm Res 29:2499-511. 2012..Na, as a potential chemotherapeutic agent for brain tumors using a series of PK/PD studies, which led to the evaluation of its structural analog, ON013105, a prodrug of the more lipophilic product, ON013100...
- Preclinical pharmacokinetic and pharmacodynamic evaluation of metronomic and conventional temozolomide dosing regimensQingyu Zhou
Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N Broad St, Philadelphia, PA 19140, USA
J Pharmacol Exp Ther 321:265-75. 2007..In conclusion, several PK/PD factors contributing to the antitumor activity of the MD TMZ therapy have been identified and form a foundation for further investigations of low-dose TMZ regimens...