Muniswamy Madesh

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak
    Muniswamy Madesh
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Mol Cell Biol 29:3099-112. 2009
  2. pmc MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
    Karthik Mallilankaraman
    Department of Biochemistry, Temple University, Philadelphia, Pennsylvania 19140, USA
    Nat Cell Biol 14:1336-43. 2012
  3. pmc Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress
    Tatyana Milovanova
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, One John Morgan Building, Philadelphia, PA 19104 6068, USA
    Biochim Biophys Acta 1783:1866-75. 2008
  4. pmc Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation
    Rajesh Kumar Gandhirajan
    Department of Biochemistry, Temple University, Philadelphia, Pennsylvania, USA
    J Clin Invest 123:887-902. 2013
  5. pmc G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence
    Brian J Hawkins
    Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6068, USA
    Mol Cell Biol 27:7582-93. 2007
  6. pmc Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle
    Salvatore Mancarella
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    FASEB J 27:893-906. 2013
  7. pmc Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis
    Muniswamy Madesh
    Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 170:1079-90. 2005
  8. pmc Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis
    Krishna M Irrinki
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Mol Cell Biol 31:3745-58. 2011
  9. pmc MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival
    Karthik Mallilankaraman
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Cell 151:630-44. 2012
  10. pmc STIM proteins: dynamic calcium signal transducers
    Jonathan Soboloff
    Department of Biochemistry, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Nat Rev Mol Cell Biol 13:549-65. 2012

Collaborators

Detail Information

Publications49

  1. pmc Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak
    Muniswamy Madesh
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Mol Cell Biol 29:3099-112. 2009
    ....
  2. pmc MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
    Karthik Mallilankaraman
    Department of Biochemistry, Temple University, Philadelphia, Pennsylvania 19140, USA
    Nat Cell Biol 14:1336-43. 2012
    ..Thus, MCUR1 is a critical component of a mitochondrial uniporter channel complex required for mitochondrial Ca(2+) uptake and maintenance of normal cellular bioenergetics...
  3. pmc Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress
    Tatyana Milovanova
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, One John Morgan Building, Philadelphia, PA 19104 6068, USA
    Biochim Biophys Acta 1783:1866-75. 2008
    ..These studies indicate that caveolin-1 functions as a shear sensor in flow-adapted EC resulting in ROS-mediated cell signaling and endothelial cell proliferation following the abrupt reduction in flow...
  4. pmc Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation
    Rajesh Kumar Gandhirajan
    Department of Biochemistry, Temple University, Philadelphia, Pennsylvania, USA
    J Clin Invest 123:887-902. 2013
    ..These results indicate that ROS-driven Ca2+ signaling promotes vascular barrier dysfunction and that the SOCe machinery may provide crucial therapeutic targets to limit sepsis-induced ALI...
  5. pmc G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence
    Brian J Hawkins
    Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6068, USA
    Mol Cell Biol 27:7582-93. 2007
    ..These results demonstrate that mROS is the downstream effector molecule that translates receptor-mediated Ca(2+) signals into proinflammatory signaling and leukocyte/EC firm adhesion...
  6. pmc Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle
    Salvatore Mancarella
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    FASEB J 27:893-906. 2013
    ..Potireddy, S., Wang, Y., Gao, H., Gandhirajan, K., Autieri, M., Scalia, R., Cheng, Z., Wang, H., Madesh, M., Houser, S. R., Gill, D. L. Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle...
  7. pmc Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis
    Muniswamy Madesh
    Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 170:1079-90. 2005
    ..This study provides evidence that O2*- facilitates an InsP3R-linked apoptotic cascade and may serve a critical function in I/R injury and inflammation...
  8. pmc Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis
    Krishna M Irrinki
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Mol Cell Biol 31:3745-58. 2011
    ..Finally, elimination of BAX and BAK or overexpression of Bcl-x(L) protects cells from necroptosis at a later step. These findings provide evidence that mitochondria play an amplifying role in inflammation-induced necroptosis...
  9. pmc MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival
    Karthik Mallilankaraman
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Cell 151:630-44. 2012
    ..Thus, MICU1 is a gatekeeper of MCU-mediated Ca(2+)(m) uptake that is essential to prevent [Ca(2+)](m) overload and associated stress...
  10. pmc STIM proteins: dynamic calcium signal transducers
    Jonathan Soboloff
    Department of Biochemistry, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Nat Rev Mol Cell Biol 13:549-65. 2012
    ..Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM...
  11. pmc The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis
    Russell G Jones
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 27:268-80. 2007
    ..Together, the data establish that Bax and Bak play an essential role in the control of T cell proliferation by modulating ER Ca(2+) release...
  12. pmc Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death
    Soumya Sinha Roy
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 33:377-88. 2009
    ..Thus, phospho-regulatory mechanisms converge on Bad to switch between the survival and apoptotic functions of mitochondrial calcium signaling by activating a mechanism whereby a BH3-only protein bypasses Bax/Bak and engages the PTP...
  13. pmc Intracellular endothelin type B receptor-driven Ca2+ signal elicits nitric oxide production in endothelial cells
    Elena Deliu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 287:41023-31. 2012
    ..Endothelin-1 acts in an intracrine fashion on endolysosomal ET(B) to induce nitric oxide formation, thus modulating endothelial function...
  14. pmc Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling
    Brian J Hawkins
    Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6068, USA
    Mol Biol Cell 18:2002-12. 2007
    ..This study demonstrates that O(2)(.-) flux across the endothelial cell plasma membrane occurs through ClC-3 channels and induces intracellular Ca(2+) release, which activates mitochondrial O(2)(.-) generation...
  15. ncbi request reprint Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells
    Kumar Sharma
    Dorrance Hamilton Research Laboratories, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Suite 353, Jeff Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA
    Am J Physiol Renal Physiol 285:F1258-70. 2003
    ..We conclude that TGF-beta plays an important role in the vascular dysfunction of early diabetes by inhibiting calcium transients in vascular smooth muscle cells...
  16. pmc Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis
    Christiana W Davis
    Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Free Radic Biol Med 48:306-17. 2010
    ....
  17. pmc Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential loss
    Brian J Hawkins
    Department of Biochemistry, Temple University, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 285:26494-505. 2010
    ..This finding is important as it sets the stage for complex II functional preservation as an attractive therapy to maintain mitochondrial function during hypoxia...
  18. pmc NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis
    Roshan J Thapa
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 31:2934-46. 2011
    ..Together, these studies demonstrate that NF-κB protects cells from IFN-γ-mediated necroptosis by transcriptionally activating a survival response that quenches ROS to preserve mitochondrial integrity...
  19. pmc PECAM-targeted delivery of SOD inhibits endothelial inflammatory response
    Vladimir V Shuvaev
    Institute for Environmental Medicine, Department of Pharmacology, University of Pennsylvania School of Medicine, 1 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104 6068, USA
    FASEB J 25:348-57. 2011
    ....
  20. pmc S-glutathionylation activates STIM1 and alters mitochondrial homeostasis
    Brian J Hawkins
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    J Cell Biol 190:391-405. 2010
    ..These experiments reveal that cysteine 56 is a sensor for oxidant-dependent activation of STIM1 and demonstrate a molecular link between oxidant stress and Ca(2+) signaling via the CRAC channel...
  21. pmc The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nat Cell Biol 8:170-9. 2006
    ..These data provide important insights into Vpr biology and its role in HIV pathogenesis...
  22. pmc The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury
    Barbara A Miller
    Center of Translational Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    Am J Physiol Heart Circ Physiol 304:H1010-22. 2013
    ..We conclude that TRPM2 channels protected hearts from I/R injury by decreasing generation and enhancing scavenging of ROS, thereby reducing I/R-induced oxidative stress...
  23. pmc Sensing cellular stress through STIM proteins
    Jonathan Soboloff
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Chem Biol 7:488-92. 2011
    ..In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis...
  24. ncbi request reprint ABCA3 is critical for lamellar body biogenesis in vivo
    NaEun Cheong
    Department of Physiology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:23811-7. 2007
    ..Collectively, these findings strongly suggest that ABCA3 is necessary for lamellar body biogenesis, surfactant protein-B processing, and lung development late in gestation...
  25. pmc Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex
    Salvatore Mancarella
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 286:44788-98. 2011
    ....
  26. pmc Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein
    Venkatadri Kolla
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1019-30. 2009
    ..Because CEACAM6 acts as an antiapoptotic factor and stabilizes surfactant function, in addition to a putative role in innate defense against bacteria, we propose that it is a multifunctional alveolar protein...
  27. pmc tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    EMBO J 21:2198-206. 2002
    ..Facilitation of Ca(2+) delivery to the mitochondria by tcBid may also support recruitment of mitochondria to the cell death machinery...
  28. pmc The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R
    Carl White
    Department of Physiology, Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
    Nat Cell Biol 7:1021-8. 2005
    ..As a consequence, cells are protected against apoptosis by a more sensitive and dynamic coupling of ER to mitochondria through Ca(2+)-dependent signal transduction that enhances cellular bioenergetics and preserves survival...
  29. pmc Inflammasomes: sensors of metabolic stresses for vascular inflammation
    Ying Yin
    Department of Pharmacology and Cardiovascular Research Center, Temple University School of Medicine, 3500 North Broad Street, MERB 1059, Philadelphia, PA 19140, USA
    Front Biosci (Landmark Ed) 18:638-49. 2013
    ....
  30. pmc Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury
    Z Maggie Huang
    1Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Sci Signal 6:ra95. 2013
    ..Our findings suggest new insights into the mechanism of action of classic drugs used to treat heart failure and new therapeutic approaches to ischemic heart disease. ..
  31. pmc Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms
    Jason M Duran
    Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Circ Res 113:539-52. 2013
    ..Finding the optimal stem cell type best suited for cardiac regeneration is the key toward improving clinical outcomes...
  32. pmc MICU1 motifs define mitochondrial calcium uniporter binding and activity
    Nicholas E Hoffman
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA
    Cell Rep 5:1576-88. 2013
    ..These studies establish a molecular mechanism for MICU1 control of MCU-mediated mitochondrial Ca(2+) accumulation, and dysregulation of this mechanism probably enhances vascular dysfunction...
  33. ncbi request reprint Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins
    Shiva Kazerounian
    Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 314:1013-22. 2005
    ..They suggest that combining guanylyl cyclase C agonists and SOC inhibitors offers a novel paradigm for cGMP-directed therapy and prevention for colorectal tumors...
  34. ncbi request reprint Calcium signaling and apoptosis
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 304:445-54. 2003
    ..In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca(2+) and the interactions of Bcl-2 family proteins with the Ca(2+) storage organelles are discussed...
  35. pmc Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88
    Kosuke Kato
    Department of Physiology, Center for Inflammation, Translational and Clinical Lung Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 188:2014-22. 2012
    ..This unique ability of MUC1 to control TLR5 signaling suggests its potential role in the pathogenesis of chronic inflammatory lung diseases...
  36. ncbi request reprint Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome
    NaEun Cheong
    Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6068, USA
    J Biol Chem 281:9791-800. 2006
    ..We conclude that ABCA3 is required for lysosomal loading of phosphatidylcholine and conversion of lysosomes to lamellar body-like structures...
  37. pmc SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death
    Nicholas E Hoffman
    Department of Biochemistry, Temple University, Philadelphia, PA 19140 Center for Translational Medicine, Temple University, Philadelphia, PA 19140
    Mol Biol Cell 25:936-47. 2014
    ..Further, reconstitution with short hairpin RNA-insensitive SLC25A23 cDNA restores mitochondrial Ca(2+) uptake and superoxide production. These findings indicate that SLC25A23 plays an important role in mitochondrial matrix Ca(2+) influx...
  38. pmc Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55
    Justine Yu
    Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 288:22481-92. 2013
    ..This work may serve as a platform for future studies exploring the potential of GPR55 as a therapeutic target in cardiac disorders. ..
  39. pmc Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, 1 John Morgan Building, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6068, USA
    Biomaterials 29:215-27. 2008
    ..Vascular targeting of PNC-loaded detoxifying enzymes may find wide medical applications including management of oxidative stress and other toxicities...
  40. pmc Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure
    G Cristina Brailoiu
    Departments of Pharmacology, University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 285:37133-7. 2010
    ..Our data extend the actions of NAADP to the endothelium both in vitro and in vivo, pointing to a previously unrecognized role for this messenger in controlling blood pressure...
  41. pmc Modulation of pyridinium cationic lipid-DNA complex properties by pyridinium gemini surfactants and its impact on lipoplex transfection properties
    Vishnu Dutt Sharma
    Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, United States
    Mol Pharm 11:545-59. 2014
    ....
  42. pmc Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice
    Zhongjian Cheng
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 118:1998-2006. 2011
    ..Our results suggest that HHcy impairs EDHF relaxation in SMAs by inhibiting SK/IK activities via oxidation- and tyrosine nitration-related mechanisms...
  43. ncbi request reprint The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein
    Ramesh Hegde
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:38699-706. 2003
    ....
  44. ncbi request reprint Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species
    Tatyana Milovanova
    Institute for Environmental Medicine, Univ of Pennsylvania Medical Center, One John Morgan Bldg, Philadelphia, PA 19104 6068, USA
    Am J Physiol Cell Physiol 290:C66-76. 2006
    ..Thus loss of shear stress in flow-adapted mPMVECs results in cell division associated with ROS generated by NADPH oxidase. This effect requires a functioning cell membrane KATP channel...
  45. pmc Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers
    Mark D Levin
    Penn Cardiovascular Institute and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:3420-36. 2009
    ..These data suggest that dysfunction of melanocyte-like cells in the atrium and pulmonary veins may contribute to atrial arrhythmias...
  46. ncbi request reprint TGF-beta-induced Ca(2+) influx involves the type III IP(3) receptor and regulates actin cytoskeleton
    Tracy A McGowan
    Dorrance Hamilton Laboratory, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Renal Physiol 282:F910-20. 2002
    ..The alterations in the actin cytoskeleton by TGF-beta are dependent on TGF-beta-induced Ca(2+) influx. These studies identify a novel pathway by which TGF-beta regulates Ca(2+) influx and induces cytoskeletal alterations...
  47. doi request reprint Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart
    Ronald J Vagnozzi
    Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Sci Transl Med 5:207ra141. 2013
    ..Pharmacologic TNNI3K inhibition would be cardiac-selective, preventing potential adverse effects of systemic kinase inhibition. ..
  48. doi request reprint The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors
    Huafeng Wei
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 108:251-60. 2008
    ..The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis...
  49. ncbi request reprint Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization
    Muniswamy Madesh
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:5651-9. 2002
    ..The tBid-induced loss of DeltaPsi(m) occurs after cytochrome c release and reflects impairment of oxidative metabolism...

Research Grants4