Dan Liebermann

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi request reprint Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence
    Jennifer S Tront
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Cancer Res 66:8448-54. 2006
  2. pmc Gadd45a levels in human breast cancer are hormone receptor dependent
    Jennifer S Tront
    Fels Institute for Cancer Research and Molecular Biology, Philadelphia, USA
    J Transl Med 11:131. 2013
  3. pmc Gadd45 stress sensors in malignancy and leukemia
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania 19140, USA
    Crit Rev Oncog 16:129-40. 2011
  4. pmc Gadd45 in the response of hematopoietic cells to genotoxic stress
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology, and Department of Biochemistry, Temple University School of Medicine, 3307 N Broad St Philadelphia, PA 19140, USA
    Blood Cells Mol Dis 39:329-35. 2007
  5. ncbi request reprint Myeloid differentiation (MyD) primary response genes in hematopoiesis
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood Cells Mol Dis 31:213-28. 2003
  6. pmc Gadd45 in stress signaling
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology, and Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Mol Signal 3:15. 2008
  7. ncbi request reprint p53 induced growth arrest versus apoptosis and its modulation by survival cytokines
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Cell Cycle 6:166-70. 2007
  8. ncbi request reprint Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition
    Mamta Gupta
    Fels Institute of Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 N Broad Street, Philadelphia, PA 19140, USA
    J Biol Chem 281:17552-8. 2006
  9. ncbi request reprint Terminal myeloid differentiation is uncoupled from cell cycle arrest
    John D Gibbs
    Department of Biochemistry, Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania 19140, USA
    Cell Cycle 6:1205-9. 2007
  10. ncbi request reprint Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis
    Mamta Gupta
    Fels Institute of Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Oncogene 24:7170-9. 2005

Research Grants

  1. MyD118, CR6 and GADD45 in Genotoxic Stress
    Dan Liebermann; Fiscal Year: 2001
  2. Gadd 45 in the Response of Hematopoietic Cells to Stress
    Dan A Liebermann; Fiscal Year: 2010
  3. Gadd 45 genes sensors of stress and tumor modulators
    Dan A Liebermann; Fiscal Year: 2010
  4. Gadd 45 in the Response of Hematopoietic Cells to Stress
    Dan Liebermann; Fiscal Year: 2009
  5. Gadd 45 genes sensors of stress and tumor modulators
    Dan Liebermann; Fiscal Year: 2009
  6. Gadd 45 in the Response of Hematopoietic Cells to Stress
    Dan Liebermann; Fiscal Year: 2007
  7. Gadd 45 genes sensors of stress and tumor modulators
    Dan Liebermann; Fiscal Year: 2007
  8. MyD118/CR6/GADD45 in Hematopoietic Homeostasis
    Dan Liebermann; Fiscal Year: 2005
  9. MyD118/CR6/GADD45 in Hematopoietic Homeostasis
    Dan Liebermann; Fiscal Year: 2004
  10. MyD118, CR6 and GADD45 in Genotoxic Stress
    Dan Liebermann; Fiscal Year: 2003

Collaborators

  • Barbara Hoffman
  • Jennifer S Tront
  • Keith E Latham
  • Nora Engel
  • Mariappan Vairapandi
  • Xavier Grana
  • Arshad Amanullah
  • Mamta Gupta
  • Marianna Shafarenko
  • Arthur G Balliet
  • Albert J Fornace
  • Steven D Zumbrun
  • Yali Xiong
  • Santo D'Angelo
  • John D Gibbs
  • Jiyun Yoo
  • Sushil G Rane
  • Robert M Tjin Tham Sjin
  • Eliezer J Holtzman
  • Ossie Geifman-Holtzman
  • Yajue Huang
  • Shiv Kumar Gupta
  • Shiv K Gupta
  • Mary Christine Hollander
  • Bernard Gregory
  • Mayshan Ghiassi
  • Arthur Balliet
  • Albert Fornace
  • M Christine Hollander
  • Naiyer Azam
  • Anita B Roberts
  • Christine Hollander
  • Ludmila Jirmanova
  • Erwin P Bottinger
  • Kandasamy Krishnaraju
  • Renu K Vora
  • James K Mangan
  • Brian C Wong
  • E Premkumar Reddy

Detail Information

Publications29

  1. ncbi request reprint Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence
    Jennifer S Tront
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Cancer Res 66:8448-54. 2006
    ....
  2. pmc Gadd45a levels in human breast cancer are hormone receptor dependent
    Jennifer S Tront
    Fels Institute for Cancer Research and Molecular Biology, Philadelphia, USA
    J Transl Med 11:131. 2013
    ..The present study was aimed at clarifying the expression of Gadd45a in human breast cancer and its correlation with clinicopathologic features...
  3. pmc Gadd45 stress sensors in malignancy and leukemia
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania 19140, USA
    Crit Rev Oncog 16:129-40. 2011
    ....
  4. pmc Gadd45 in the response of hematopoietic cells to genotoxic stress
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology, and Department of Biochemistry, Temple University School of Medicine, 3307 N Broad St Philadelphia, PA 19140, USA
    Blood Cells Mol Dis 39:329-35. 2007
    ..These observations set the stage to evaluate, in clinically relevant settings, the impact that the status of gadd45a and gadd45b might have on the efficacy of DNR or VP-16 in killing leukemic cells...
  5. ncbi request reprint Myeloid differentiation (MyD) primary response genes in hematopoiesis
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood Cells Mol Dis 31:213-28. 2003
    ....
  6. pmc Gadd45 in stress signaling
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology, and Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Mol Signal 3:15. 2008
    ..An attractive working model to consider is that the extent of cellular/DNA damage, in a given cell type, dictates the association of different Gadd45 proteins with particular partner proteins, which determines the outcome...
  7. ncbi request reprint p53 induced growth arrest versus apoptosis and its modulation by survival cytokines
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Cell Cycle 6:166-70. 2007
    ....
  8. ncbi request reprint Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition
    Mamta Gupta
    Fels Institute of Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 N Broad Street, Philadelphia, PA 19140, USA
    J Biol Chem 281:17552-8. 2006
    ....
  9. ncbi request reprint Terminal myeloid differentiation is uncoupled from cell cycle arrest
    John D Gibbs
    Department of Biochemistry, Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania 19140, USA
    Cell Cycle 6:1205-9. 2007
    ....
  10. ncbi request reprint Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis
    Mamta Gupta
    Fels Institute of Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Oncogene 24:7170-9. 2005
    ..Taken together, these findings identify gadd45a and gadd45b as anti-apoptotic genes that increase the survival of hematopoietic cells following exposure to UV radiation and certain anticancer drugs...
  11. pmc Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation
    Marianna Shafarenko
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 N Broad St, Philadelphia, PA 19140, USA
    Blood 106:871-8. 2005
    ..These findings indicate that Egr-1 can act as a tumor suppressor gene and suggest that Egr-1 or Egr-1 targets may provide important tools for differentiation therapy in certain leukemic phenotypes...
  12. doi request reprint The c-myc apoptotic response is not intrinsic to blocking terminal myeloid differentiation
    Santo D'Angelo
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Cell Physiol 216:120-7. 2008
    ..This knowledge can be exploited to manipulate the downstream effectors, such as RIP1, to promote apoptosis and drive the death of cancer cells...
  13. pmc Role of gadd45 in myeloid cells in response to hematopoietic stress
    Barbara Hoffman
    Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, 3307 N Broad Street, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood Cells Mol Dis 39:344-7. 2007
    ..This topic is discussed within the context of what is known about Gadd45 proteins in stress signaling, hematopoietic development and the innate immune response...
  14. ncbi request reprint The proto-oncogene c-myc in hematopoietic development and leukemogenesis
    Barbara Hoffman
    Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, Pennsylvania, PA 19140, USA
    Oncogene 21:3414-21. 2002
    ..Understanding how c-Myc controls cellular phenotypes, including the leukemic phenotype, should provide novel tools for designing drugs to promote differentiation and/or apoptosis of leukemic cells...
  15. ncbi request reprint Myeloid differentiation (MyD) primary response genes in hematopoiesis
    Dan A Liebermann
    Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, PA 19140, USA
    Oncogene 21:3391-402. 2002
    ....
  16. doi request reprint Gadd45 modulation of intrinsic and extrinsic stress responses in myeloid cells
    Barbara Hoffman
    Department of Biochemistry, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Cell Physiol 218:26-31. 2009
    ....
  17. ncbi request reprint GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
    Mariappan Vairapandi
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Physiol 192:327-38. 2002
    ....
  18. ncbi request reprint Conserved DNA methylation in Gadd45a(-/-) mice
    Nora Engel
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Epigenetics 4:98-9. 2009
    ..Based on these exciting results, Gadd45a(-/-) mice might be predicted to have a hypermethylation phenotype. We report here that neither global nor locus-specific methylation is increased in Gadd45a(-/-) mice...
  19. ncbi request reprint Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation
    Arshad Amanullah
    Fels Institute for Cancer Research, Temple University School of Medicine, 3307 N Broad Street, Philadelphia, Pennsylvania, PA 19140, USA
    Oncogene 21:1600-10. 2002
    ..Our findings offer important new insights into understanding how deregulated c-myc alters normal blood cell homeostasis, and how additional mutations might promote leukemogenesis...
  20. ncbi request reprint Transcriptional regulation of myeloid differentiation primary response (MyD) genes during myeloid differentiation is mediated by nuclear factor Y
    Robert M Tjin Tham Sjin
    Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 100:80-8. 2002
    ..It can be concluded that NF-Y plays a role in the transcriptional regulation of MyD genes and is required for optimum myeloid differentiation...
  21. ncbi request reprint Fos modulates myeloid cell survival and differentiation and partially abrogates the c-Myc block in terminal myeloid differentiation
    Marianna Shafarenko
    Fels Institute for Cancer Research and Molecular Biology, and Department of Biochemistry, Temple University School of Medicine, 3307 N Broad St, Philadelphia, PA 19140, USA
    Blood 103:4259-67. 2004
    ....
  22. ncbi request reprint Cell signalling: cell survival and a Gadd45-factor deficiency
    Arshad Amanullah
    Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Nature 424:741; discussion 742. 2003
  23. ncbi request reprint Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells
    Sushil G Rane
    Department of Biochemistry and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 100:2753-62. 2002
    ..Taken together, these results indicate that Jak3-mediated signals play an important role in myeloid cell differentiation...
  24. ncbi request reprint Gadd45a stress signaling regulates sFlt-1 expression in preeclampsia
    Yali Xiong
    Department of Obstetrics and Gynecology, and Reproductive Sciences, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Cell Physiol 220:632-9. 2009
    ....
  25. doi request reprint Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli
    Steven D Zumbrun
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Biochem 108:1220-31. 2009
    ....
  26. ncbi request reprint Comparative analysis of the genetic structure and chromosomal mapping of the murine Gadd45g/CR6 gene
    Arthur G Balliet
    Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    DNA Cell Biol 22:457-68. 2003
    ..This suggests that alleles of the Gadd45g gene may function in the regulation of body weight, in addition to its currently recognized roles in differentiation and stress responses...
  27. ncbi request reprint Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation
    Jiyun Yoo
    Laboratory of Cell Regulation and Carcinogenesis, National Instituts of Health, Bethesda, MD 20892 5055, USA
    J Biol Chem 278:43001-7. 2003
    ..All of these findings suggest that GADD45b participates in TGF-beta-induced apoptosis by acting upstream of p38 activation...
  28. ncbi request reprint Myeloid progenitors on demand
    Dan A Liebermann
    Nat Methods 3:248-9. 2006
  29. ncbi request reprint Interferon regulatory factor-1 myelodysplasia and leukemia
    Dan A Liebermann
    Leuk Res 30:1069-71. 2006

Research Grants16

  1. MyD118, CR6 and GADD45 in Genotoxic Stress
    Dan Liebermann; Fiscal Year: 2001
    ....
  2. Gadd 45 in the Response of Hematopoietic Cells to Stress
    Dan A Liebermann; Fiscal Year: 2010
    ....
  3. Gadd 45 genes sensors of stress and tumor modulators
    Dan A Liebermann; Fiscal Year: 2010
    ..Data obtained will be of great importance to better understand the role of stress sensors in tumorigenesis, &how treatment resistance in cancer therapy can arise &be abrogated. ..
  4. Gadd 45 in the Response of Hematopoietic Cells to Stress
    Dan Liebermann; Fiscal Year: 2009
    ....
  5. Gadd 45 genes sensors of stress and tumor modulators
    Dan Liebermann; Fiscal Year: 2009
    ..Data obtained will be of great importance to better understand the role of stress sensors in tumorigenesis, & how treatment resistance in cancer therapy can arise & be abrogated. ..
  6. Gadd 45 in the Response of Hematopoietic Cells to Stress
    Dan Liebermann; Fiscal Year: 2007
    ....
  7. Gadd 45 genes sensors of stress and tumor modulators
    Dan Liebermann; Fiscal Year: 2007
    ..Data obtained will be of great importance to better understand the role of stress sensors in tumorigenesis, & how treatment resistance in cancer therapy can arise & be abrogated. ..
  8. MyD118/CR6/GADD45 in Hematopoietic Homeostasis
    Dan Liebermann; Fiscal Year: 2005
    ....
  9. MyD118/CR6/GADD45 in Hematopoietic Homeostasis
    Dan Liebermann; Fiscal Year: 2004
    ....
  10. MyD118, CR6 and GADD45 in Genotoxic Stress
    Dan Liebermann; Fiscal Year: 2003
    ....
  11. MyD118/CR6/GADD45 in Hematopoietic Homeostasis
    Dan Liebermann; Fiscal Year: 2003
    ....
  12. MyD118, CR6 and GADD45 in Genotoxic Stress
    Dan Liebermann; Fiscal Year: 2002
    ....
  13. MyD118/CR6/GADD45 in Hematopoietic Homeostasis
    Dan Liebermann; Fiscal Year: 2002
    ....
  14. Gadd 45 genes sensors of stress and tumor modulators
    Dan A Liebermann; Fiscal Year: 2010
    ..Data obtained will be of great importance to better understand the role of stress sensors in tumorigenesis, &how treatment resistance in cancer therapy can arise &be abrogated. ..