Keith Latham

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc The epigenetic lorax: gene-environment interactions in human health
    Keith E Latham
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Epigenomics 4:383-402. 2012
  2. ncbi request reprint The Primate Embryo Gene Expression Resource in embryology and stem cell biology
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology, and the Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Reprod Fertil Dev 18:807-10. 2006
  3. ncbi request reprint Somatic cell nuclei in cloning: strangers traveling in a foreign land
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Adv Exp Med Biol 591:14-29. 2007
  4. ncbi request reprint X chromosome imprinting and inactivation in preimplantation mammalian embryos
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology and The Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Trends Genet 21:120-7. 2005
  5. ncbi request reprint Early and delayed aspects of nuclear reprogramming during cloning
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology, and Department of Biochemistry, Temple University School of Medicine, 3307 North Broadway, Philadelphia, PA 19140, USA
    Biol Cell 97:119-32. 2005
  6. ncbi request reprint Cloning: questions answered and unsolved
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Differentiation 72:11-22. 2004
  7. ncbi request reprint Species-dependent expression patterns of DNA methyltransferase genes in mammalian oocytes and preimplantation embryos
    Rita Vassena
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Mol Reprod Dev 72:430-6. 2005
  8. ncbi request reprint Expression of genes encoding chromatin regulatory factors in developing rhesus monkey oocytes and preimplantation stage embryos: possible roles in genome activation
    Ping Zheng
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 70:1419-27. 2004
  9. ncbi request reprint Nuclear-cytoplasmic "tug of war" during cloning: effects of somatic cell nuclei on culture medium preferences of preimplantation cloned mouse embryos
    Young Gie Chung
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Biol Reprod 66:1178-84. 2002
  10. pmc Effects of ooplasm transfer on paternal genome function in mice
    Cheng Guang Liang
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Hum Reprod 24:2718-28. 2009

Collaborators

Detail Information

Publications54

  1. pmc The epigenetic lorax: gene-environment interactions in human health
    Keith E Latham
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Epigenomics 4:383-402. 2012
    ..This general mechanism of gene-environment interaction poses special challenges for individuals, educators, scientists and public policy makers in defining, monitoring and mitigating exposures...
  2. ncbi request reprint The Primate Embryo Gene Expression Resource in embryology and stem cell biology
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology, and the Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Reprod Fertil Dev 18:807-10. 2006
    ..PREGER includes an on-line resource with a database and other useful tools for embryologists. The resource is being expanded to incorporate samples from other species and from embryonic stem cells...
  3. ncbi request reprint Somatic cell nuclei in cloning: strangers traveling in a foreign land
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Adv Exp Med Biol 591:14-29. 2007
    ..This review focuses on recent results revealing these limitations and how they might be overcome...
  4. ncbi request reprint X chromosome imprinting and inactivation in preimplantation mammalian embryos
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology and The Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Trends Genet 21:120-7. 2005
    ..A model accounting for early events related to XCI, including observations in uniparental and aneuploid embryos, is presented...
  5. ncbi request reprint Early and delayed aspects of nuclear reprogramming during cloning
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology, and Department of Biochemistry, Temple University School of Medicine, 3307 North Broadway, Philadelphia, PA 19140, USA
    Biol Cell 97:119-32. 2005
    ..By addressing the unique requirements of cloned embryos, the entire process of reprogramming may be accelerated, thus increasing cloning efficiency...
  6. ncbi request reprint Cloning: questions answered and unsolved
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Differentiation 72:11-22. 2004
    ..They have also raised new questions related to the control of nuclear reprogramming and function. These questions are reviewed here...
  7. ncbi request reprint Species-dependent expression patterns of DNA methyltransferase genes in mammalian oocytes and preimplantation embryos
    Rita Vassena
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Mol Reprod Dev 72:430-6. 2005
    ..We describe species-dependent differences as well as similarities in expression patterns of DNMT genes among mammals...
  8. ncbi request reprint Expression of genes encoding chromatin regulatory factors in developing rhesus monkey oocytes and preimplantation stage embryos: possible roles in genome activation
    Ping Zheng
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 70:1419-27. 2004
    ..Possible roles for these mRNAs in chromatin remodeling, genome activation, DNA replication, cell lineage determination, and nuclear reprogramming are discussed...
  9. ncbi request reprint Nuclear-cytoplasmic "tug of war" during cloning: effects of somatic cell nuclei on culture medium preferences of preimplantation cloned mouse embryos
    Young Gie Chung
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Biol Reprod 66:1178-84. 2002
    ..The relevance of this to understanding the kinetics and mechanisms of nuclear reprogramming and to the eventual improvement of the overall success in cloning is discussed...
  10. pmc Effects of ooplasm transfer on paternal genome function in mice
    Cheng Guang Liang
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Hum Reprod 24:2718-28. 2009
    ..The potential effects of the foreign ooplasm on epigenetic information in the paternal pronucleus are unknown; however, some human progeny from ooplasm donation procedures display abnormalities...
  11. ncbi request reprint X chromosome reactivation and regulation in cloned embryos
    Leisha D Nolen
    Department of Cell and Developmental Biology, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104 6148, USA
    Dev Biol 279:525-40. 2005
    ..We conclude that, although SCNT embryos can reactivate, count, and inactivate X chromosomes, they are not able to regulate XCI consistently. These results illustrate the heterogeneity of epigenetic changes found in cloned embryos...
  12. ncbi request reprint Disruption of imprinted gene methylation and expression in cloned preimplantation stage mouse embryos
    Mellissa R W Mann
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 69:902-14. 2003
    ..Thus, epigenetic errors arise very early in clonal development in the majority of embryos, indicating that reprogramming is inefficient and that some epigenetic information may be lost...
  13. ncbi request reprint The primate embryo gene expression resource: a novel resource to facilitate rapid analysis of gene expression patterns in non-human primate oocytes and preimplantation stage embryos
    Ping Zheng
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 70:1411-8. 2004
    ..These results provide one illustration of how the PREGER can be employed to obtain novel insight into primate embryogenesis...
  14. ncbi request reprint Developmental regulation and in vitro culture effects on expression of DNA repair and cell cycle checkpoint control genes in rhesus monkey oocytes and embryos
    Ping Zheng
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 72:1359-69. 2005
    ..This effect of in vitro culture on nonhuman primate embryos may be relevant to assessing the potential advantages and disadvantages of prolonged in vitro culture of human embryos...
  15. pmc Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development
    Le Ben Wan
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 135:2729-38. 2008
    ..This is the first study detailing a global and essential role for CTCF in mouse oocytes and preimplantation embryos...
  16. ncbi request reprint Deficiency in recapitulation of stage-specific embryonic gene transcription in two-cell stage cloned mouse embryos
    Rita Vassena
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, USA
    Mol Reprod Dev 74:1548-56. 2007
    ..Thus, the oocyte is incapable of efficiently directing the recapitulation of early embryonic stage-specific gene expression...
  17. ncbi request reprint Ubiquitin proteasome pathway gene expression varies in rhesus monkey oocytes and embryos of different developmental potential
    Namdori R Mtango
    The Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania, USA
    Physiol Genomics 31:1-14. 2007
    ..We also report significant differences in UPP gene expression correlating with oocyte and embryo developmental competence and associated with altered regulation of maternally inherited mRNAs encoding these proteins...
  18. ncbi request reprint Comparison of gene expression during preimplantation development between diploid and haploid mouse embryos
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Biol Reprod 67:386-92. 2002
    ..The significance and possible explanations for these differences are discussed...
  19. ncbi request reprint Conserved DNA methylation in Gadd45a(-/-) mice
    Nora Engel
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Epigenetics 4:98-9. 2009
    ..Based on these exciting results, Gadd45a(-/-) mice might be predicted to have a hypermethylation phenotype. We report here that neither global nor locus-specific methylation is increased in Gadd45a(-/-) mice...
  20. pmc Role of glucose in cloned mouse embryo development
    Zhiming Han
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 295:E798-809. 2008
    ..We conclude that cloned embryos may be severely compromised in terms of ATP-dependent processes during the first two cell cycles and that glucose may exert its early beneficial effects via positive effects on the mitochondria...
  21. pmc Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos
    Zhiming Han
    The Fels Institute for Cancer Research and Molecular Biology, Temple Univ School of Medicine, Philadelphia, PA 19140, USA
    Am J Physiol Cell Physiol 298:C1235-44. 2010
    ..These results reveal novel mechanisms by which maternal genotype affects cytofragmentation, including a system of opposing signaling pathways that most likely operate by controlling cytoskeletal function...
  22. ncbi request reprint Cloning of mice by nuclear transfer
    Shaorong Gao
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140
    Cloning Stem Cells 5:287-94. 2003
  23. ncbi request reprint Genetic variation in oocyte phenotype revealed through parthenogenesis and cloning: correlation with differences in pronuclear epigenetic modification
    Shaorong Gao
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 70:1162-70. 2004
    ..These results provide a genetic basis for further studies seeking to identify specific genes that determine oocyte phenotype, as well as genes that determine the success of nuclear reprogramming and clonal development...
  24. pmc Effects of ooplasm manipulation on DNA methylation and growth of progeny in mice
    Yong Cheng
    The Fels Institute for Cancer Research and Molecular Biology, Temple University Medical School, Philadelphia, Pennsylvania, USA
    Biol Reprod 80:464-72. 2009
    ..These results indicate that some ooplasm manipulation procedures may exert subtle effects on growth early in life, while intergenotype GVT can result in significant growth deficiencies after birth...
  25. ncbi request reprint Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in preimplantation stage mouse embryos
    Jean W Williams
    The Fels Institute for Cancer Research and Molecular Biology, Philadelphia, Pennsylvania, USA
    Mol Reprod Dev 61:281-7. 2002
    ....
  26. ncbi request reprint Effects of in vitro oocyte maturation and embryo culture on the expression of glucose transporters, glucose metabolism and insulin signaling genes in rhesus monkey oocytes and preimplantation embryos
    Ping Zheng
    The Fels Institute for Cancer Research and Molecular Biology, Temple University Medical School, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Mol Hum Reprod 13:361-71. 2007
    ....
  27. pmc Effects of in vitro maturation on gene expression in rhesus monkey oocytes
    Young S Lee
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Physiol Genomics 35:145-58. 2008
    ....
  28. pmc Expression of microRNA processing machinery genes in rhesus monkey oocytes and embryos of different developmental potentials
    Namdori R Mtango
    The Fels Institute for Cancer Research and Molecular Biology, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA
    Mol Reprod Dev 76:255-69. 2009
    ..These data extend our understanding of the potential roles of miRNA during primate embryogenesis...
  29. ncbi request reprint Differential expression of cell cycle genes in rhesus monkey oocytes and embryos of different developmental potentials
    Namdori R Mtango
    The Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 78:254-66. 2008
    ....
  30. pmc Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype
    Zhiming Han
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 5101, USA
    Biol Reprod 79:638-48. 2008
    ..These results are relevant to our understanding of the mechanisms of epigenetic effects on development and the possible fertility effects of genetic and epigenetic interactions in reproductive medicine...
  31. ncbi request reprint Maternal factors controlling blastomere fragmentation in early mouse embryos
    Zhiming Han
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Biol Reprod 72:612-8. 2005
    ..The results also indicate that clinical procedures seeking to define or manipulate oocyte quality in humans should take into account early effects of the embryonic genome, particularly the maternal genome...
  32. pmc Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles
    Rita Vassena
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Dev Biol 304:75-89. 2007
    ..e., non-transcribed) mRNA population of SCNT embryos. We conclude that gene expression in early SCNT embryos is grossly abnormal, and that this is at least in part the result of incomplete reprogramming of transcription factor genes...
  33. ncbi request reprint Abnormal regulation of DNA methyltransferase expression in cloned mouse embryos
    Young Gie Chung
    The Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 69:146-53. 2003
    ..Furthermore, aberrant Dnmt1 localization and expression may contribute to the defects in DNA methylation and the developmental abnormalities seen in cloned mammals...
  34. ncbi request reprint Expression and downregulation of WNT signaling pathway genes in rhesus monkey oocytes and embryos
    Ping Zheng
    The Fels Institute for Cancer Research and Molecular Biology, Philadelphia, Pennsylvania, USA
    Mol Reprod Dev 73:667-77. 2006
    ..Additionally, we observed differences between in vitro cultured and in vivo developing blastocysts, indicating possible effects of culture on WNT signaling during the peri-implantation period...
  35. ncbi request reprint Recapitulation of the ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos
    Shaorong Gao
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 72:487-91. 2005
    ..We find that the Om effect is recapitulated but that the parental origin effect at the Om locus is no longer evident in cloned embryos...
  36. ncbi request reprint Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones
    Faical Miyara
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Dev Biol 289:206-17. 2006
    ..These results reveal a striking control of SCC formation by the transplanted nucleus and provide the first identified molecular correlate of donor stage-dependent restriction in nuclear potency...
  37. ncbi request reprint Somatic cell-like features of cloned mouse embryos prepared with cultured myoblast nuclei
    Shaorong Gao
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 69:48-56. 2003
    ....
  38. doi request reprint Oocyte quality and maternal control of development
    Namdori R Mtango
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Int Rev Cell Mol Biol 268:223-90. 2008
    ..Our expanding understanding of the molecular determinants of oocyte quality and how these determinants can be disrupted has revealed exciting new insights into the role of oocyte functions in development and evolution...
  39. ncbi request reprint Stage-dependent effects of oocytes and growth differentiation factor 9 on mouse granulosa cell development: advance programming and subsequent control of the transition from preantral secondary follicles to early antral tertiary follicles
    Keith E Latham
    The Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biol Reprod 70:1253-62. 2004
    ..Thus, at or near the 2 degrees to 3 degrees follicle transition, signals from the growing oocyte contribute to the development of the mural GC phenotype...
  40. ncbi request reprint Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice
    Shaorong Gao
    Department of Biochemistry, The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Dev Biol 266:62-75. 2004
    ..A paucity of all known H1s in two-cell embryos may contribute to precocious gene transcription in fertilized embryos, and the elaboration of somatic cell characteristics in cloned embryos...
  41. pmc The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome
    Lanping Hao
    Fels Institute for Cancer Research and Molecular Biology, Temple University Medical School, Philadelphia, Pennsylvania, USA
    Biol Reprod 80:944-53. 2009
    ..Our results indicate that the unfolded protein response is induced in embryos destined to die of DDK syndrome and that the embryonic death observed is associated with inability to resolve the associated ER stress...
  42. pmc Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic division
    Guangming Wu
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Genetics 170:327-34. 2005
    ..These results demonstrate that meiotic drive occurs at MII and that preferential death of one genotypic class of embryo does not play a large role in the TRD...
  43. pmc Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome
    Young S Lee
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Physiol Endocrinol Metab 301:E196-209. 2011
    ..We identified a panel of 24 marker genes, the expression of which should provide the foundation for understanding how IVM can be improved for monitoring IVM conditions and for diagnosing oocyte quality...
  44. pmc Positive and negative cis-regulatory elements directing postfertilization maternal mRNA translational control in mouse embryos
    Santhi Potireddy
    Fels Institute for Cancer Research and Molecular Biology, Information Science and Technology Center, Temple University, Philadelphia, PA 19140, USA
    Am J Physiol Cell Physiol 299:C818-27. 2010
    ..The combination of bioinformatics analysis and deletion/truncation studies provides the necessary approach for dissecting postfertilization translation regulatory mechanisms...
  45. ncbi request reprint Developmental potential as a criterion for understanding and defining embryos
    Keith E Latham
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA
    Conn Law Rev 36:1171-6. 2004
  46. ncbi request reprint Analysis of polysomal mRNA populations of mouse oocytes and zygotes: dynamic changes in maternal mRNA utilization and function
    Santhi Potireddy
    The Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Dev Biol 298:155-66. 2006
    ..We observe global transitions in the functional classes of translated MmRNAs and apparent changes in the underlying cis-regulatory mechanisms...
  47. doi request reprint Nuclear transfer in mouse oocytes and embryos
    Zhiming Han
    The Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Methods Enzymol 476:171-84. 2010
    ..This chapter reviews methods employed for a range of nuclear transfer techniques including germinal vesicle transfer, spindle transfer, intracytoplasmic sperm injection, pronuclear transfer, and somatic cell nuclear transfer...
  48. ncbi request reprint Alternative splicing and imprinting control of the Meg3/Gtl2-Dlk1 locus in mouse embryos
    Sylvie Croteau
    Department of Obstetrics and Gynecology, Royal Victoria Hospital, Women s Pavilion, F3 32, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    Mamm Genome 14:231-41. 2003
    ..Biallelic expression of Dlk1 and Meg3d did not affect embryo viability and, therefore, cannot be responsible for the lethal phenotypes in UPD12 embryos or for the transmission-ratio distortion...
  49. ncbi request reprint Ooplasmic donation in humans: the potential for epigenic modifications
    Susan M Hawes
    Centre for Early Human Development, Institute of Reproduction and Development, Monash University, Melbourne, Victoria 3168, Australia
    Hum Reprod 17:850-2. 2002
    ..Given the potential for epigenetic modifications to arise following ooplasm donation, the safety and efficacy of this method need to be evaluated in a suitable animal model...
  50. ncbi request reprint Effects of follicle size and oocyte maturation conditions on maternal messenger RNA regulation and gene expression in rhesus monkey oocytes and embryos
    Ping Zheng
    Fels Institute for Cancer Research and Molecular Biology
    Biol Reprod 72:890-7. 2005
    ..These observations are relevant to understanding the role of the in vivo environment on oocyte maturation, and the potential effects of in vitro maturation on human assisted reproduction methods...
  51. pmc The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues
    Anastasia Kuzmin
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ont, Canada
    Gene Expr Patterns 8:107-16. 2008
    ..This possibly identifies a new imprinted domain within the murine genome. We further demonstrate that murine SFMBT2 protein interacts with the transcription factor YY1, similar to the Drosophila PHO-RC...
  52. ncbi request reprint Protease inhibitor MG132 in cloning: no end to the nightmare
    Shaorong Gao
    Trends Biotechnol 23:66-8. 2005
  53. ncbi request reprint Inability of mature oocytes to create functional haploid genomes from somatic cell nuclei
    Hiroyuki Tateno
    Fertil Steril 79:216-8. 2003
  54. ncbi request reprint Optimization of procedures for cloning by somatic cell nuclear transfer in mice
    Young Gie Chung
    Advanced Cell Technology, Worcester, MA, USA
    Methods Mol Biol 348:111-24. 2006
    ..Procedures that minimize damage to the donor genome and that address the unique characteristics of the cloned construct should enhance the efficacy of the method...

Research Grants40

  1. Spindle Formation and Function in Oocytes and Early Embryos
    Keith Latham; Fiscal Year: 2007
    ....
  2. Epigenetic Effect of Ooplasm Manipulation on Development
    Keith Latham; Fiscal Year: 2007
    ..The proposed studies will provide new basic data about ooplasm-nuclear interactions as well as data relevant to the clinical application of microsurgical procedures. ..
  3. The Primate Embryo Gene Expression Resource
    Keith Latham; Fiscal Year: 2007
    ..The proposed activities will at once maintain and expand the resource, produce new and fundamental basic information about primate embryos, and produce novel molecular approaches that may be useful in clinical practice. ..
  4. Nuclear Reprogramming and Phenotype in Cloned Embryos
    Keith Latham; Fiscal Year: 2007
    ....
  5. Nuclear Reprogramming and Phenotype in Cloned Embryos
    Keith Latham; Fiscal Year: 2009
    ....
  6. Nuclear Reprogramming and Phenotype in Cloned Embryos
    Keith E Latham; Fiscal Year: 2010
    ....
  7. Primate Embryo Gene Expression Resource
    Keith E Latham; Fiscal Year: 2011
    ....
  8. Spindle Formation and Function in Oocytes and Early Embryos
    Keith E Latham; Fiscal Year: 2010
    ....
  9. Nuclear Reprogramming and Phenotype in Cloned Embryos
    Keith E Latham; Fiscal Year: 2010
    ....
  10. The Primate Embryo Gene Expression Resource
    Keith E Latham; Fiscal Year: 2010
    ..This will advance the study of human infertility and its treatment. ..
  11. Primate Embryo Gene Expression Resource
    Keith E Latham; Fiscal Year: 2010
    ....
  12. Preimplantation Embryo Blastomere Fragmentation
    Keith Latham; Fiscal Year: 2006
    ..Last, because studies such as those proposed cannot be conducted in the human, the proposed studies will provide unprecedented data regarding the relationship between fragmentation and viability. ..
  13. CREATION OF A NON-HUMAN EMBRYO GENE EXPRESSION RESOURCE
    Keith Latham; Fiscal Year: 2002
    ..The availability of these resources and new data will permit previously unapproachable scientific questions about the primate embryo to be addressed. ..
  14. EFFECT OF CLONING IN EPIGENETIC INHERITANCE IN MICE
    Keith Latham; Fiscal Year: 2004
    ..These studies are relevant to problems of human infertility and a variety of diseases involving inappropriate epigenetic regulation of gene function. ..
  15. Primate Embryo Gene Expression Resource
    Keith E Latham; Fiscal Year: 2010
    ....