Laurie Kilpatrick

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC
    Laurie E Kilpatrick
    Department of Physiology and Lung Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Leukoc Biol 87:153-64. 2010
  2. pmc Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC)
    Laurie E Kilpatrick
    Temple University School of Medicine, 3307 North Broad St, PAH 206, Philadelphia, PA 19140, USA
    J Leukoc Biol 89:3-10. 2011
  3. ncbi request reprint Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of delta-PKC and ERK1/2
    Laurie E Kilpatrick
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Leukoc Biol 80:1512-21. 2006
  4. ncbi request reprint Selective roles for alpha-PKC in positive signaling for O-(2) generation and calcium mobilization but not elastase release in differentiated HL60 cells
    Helen M Korchak
    Department of Pediatrics, University of Pennsylvania School of Medicine, The Joseph Stokes Jr Research Institute of the Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1773:440-9. 2007
  5. ncbi request reprint A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil
    Laurie E Kilpatrick
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Cell Physiol 283:C48-57. 2002
  6. ncbi request reprint Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils
    Laurie E Kilpatrick
    Immunology Section, Rm 1212H Abramson Bldg, Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Am J Physiol Cell Physiol 287:C633-42. 2004
  7. pmc Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R)
    Irene Chernova
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Leukoc Biol 85:154-64. 2009
  8. pmc Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor
    Jian Ping Lai
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:12605-10. 2008
  9. pmc Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism
    John Meshki
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:9280-9. 2009

Research Grants

  1. Apoptosis in Sepsis: Regulation by TNF & delta-PKC
    Laurie Kilpatrick; Fiscal Year: 2006

Collaborators

Detail Information

Publications9

  1. pmc Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC
    Laurie E Kilpatrick
    Department of Physiology and Lung Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Leukoc Biol 87:153-64. 2010
    ..delta-PKC activates p47phox by serine phosphorylation or indirectly through control of ERK recruitment to p47phox...
  2. pmc Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC)
    Laurie E Kilpatrick
    Temple University School of Medicine, 3307 North Broad St, PAH 206, Philadelphia, PA 19140, USA
    J Leukoc Biol 89:3-10. 2011
    ..Thus, δ-PKC is an important regulator of proinflammatory events in the lung. Targeted inhibition of δ-PKC exerted a lung-protective effect 24 h after 2CLP...
  3. ncbi request reprint Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of delta-PKC and ERK1/2
    Laurie E Kilpatrick
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Leukoc Biol 80:1512-21. 2006
    ..Thus, ERK1/2, but not p38 MAPK, is an essential component of TNF-mediated antiapoptotic signaling. In human neutrophils, delta-PKC is a positive regulator of ERK1/2 activation via TNFR-1 but has no role in p38 MAPK activation...
  4. ncbi request reprint Selective roles for alpha-PKC in positive signaling for O-(2) generation and calcium mobilization but not elastase release in differentiated HL60 cells
    Helen M Korchak
    Department of Pediatrics, University of Pennsylvania School of Medicine, The Joseph Stokes Jr Research Institute of the Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1773:440-9. 2007
    ..These results indicate that alpha-PKC and beta-PKC are required for optimal O(-)(2) generation, but play different roles in Ca2+ signaling for phagocytic responses such as O(-)(2) generation...
  5. ncbi request reprint A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil
    Laurie E Kilpatrick
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Cell Physiol 283:C48-57. 2002
    ..Thus both PKC-delta and PI 3-kinase have essential roles in TNF-alpha-mediated antiapoptotic signaling in adherent neutrophils...
  6. ncbi request reprint Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils
    Laurie E Kilpatrick
    Immunology Section, Rm 1212H Abramson Bldg, Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Am J Physiol Cell Physiol 287:C633-42. 2004
    ..These results suggest that delta-PKC and PI 3-kinase regulate TNF antiapoptotic signaling at the level of the TNFR-1 through control of assembly of a TNFR-1-TRADD-RIP-TRAF2 complex...
  7. pmc Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R)
    Irene Chernova
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Leukoc Biol 85:154-64. 2009
    ..Thus, NK1R-T is functional in human monocytes and activates select signaling pathways, and the NK1R-T-mediated enhancement of CCL5 responses does not require the NK1R terminal cytoplasmic domain...
  8. pmc Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor
    Jian Ping Lai
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:12605-10. 2008
    ..These differences may provide important information toward the design of new NK1R receptor antagonists...
  9. pmc Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism
    John Meshki
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:9280-9. 2009
    ..Based on these results, we provide the first evidence that NK1R receptor-ligand interaction can cause apoptosis-independent cellular blebbing and that this process is mediated by the Rho/Rho-associated coiled-coil kinase pathway...

Research Grants6

  1. Apoptosis in Sepsis: Regulation by TNF & delta-PKC
    Laurie Kilpatrick; Fiscal Year: 2006
    ..4: Assess the role of delta-PKC in regulating the assembly of TNFalpha anti-apoptotic signaling complexes and their association with the p60TNFR. ..