Wen Zhe Ho

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Expression and regulation of antiviral protein APOBEC3G in human neuronal cells
    Yan Jian Wang
    Division of Allergy and Immunology, Joseph Stokes, Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neuroimmunol 206:14-21. 2009
  2. pmc IFN-λ3 inhibits HIV infection of macrophages through the JAK-STAT pathway
    Man Qing Liu
    Division of Virology, Wuhan Center for Disease Prevention and Control, Wuhan, Hubei, People s Republic of China
    PLoS ONE 7:e35902. 2012
  3. pmc Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users
    Li Ye
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 5:e9602. 2010
  4. pmc Morphine suppresses IFN signaling pathway and enhances AIDS virus infection
    Yizhong Wang
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e31167. 2012
  5. pmc SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans
    Yu Zhou
    The Center for Animal Experiment ABSL III Laboratory, State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan, Hubei 430071, P, R, China
    Retrovirology 10:89. 2013
  6. pmc RIG-I activation inhibits HIV replication in macrophages
    Yizhong Wang
    Temple University School of Medicine, 843 MERB, 3500 N Broad St, Philadelphia, PA 19140, USA
    J Leukoc Biol 94:337-41. 2013
  7. pmc Modulation of intracellular restriction factors contributes to methamphetamine-mediated enhancement of acquired immune deficiency syndrome virus infection of macrophages
    Xu Wang
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Curr HIV Res 10:407-14. 2012
  8. pmc CD56+ T cells inhibit HIV-1 infection of macrophages
    Wei Hou
    Animal Biosafety Level 3 Laboratory Center for Animal Experiment, Wuhan University, Wuhan, P R China
    J Leukoc Biol 92:343-51. 2012
  9. pmc (-)-Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells
    Jieliang Li
    The Center for Animal Experiment Animal Biosafety Level III Laboratory, Wuhan University Wuhan, Hubei 430071, People s Republic of China
    J Neuroinflammation 9:161. 2012
  10. ncbi request reprint Morphine upregulates functional expression of neurokinin-1 receptor in neurons
    Qi Wan
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, Philadelphia, Pennsylvania
    J Neurosci Res 84:1588-96. 2006

Research Grants

  1. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2009
  2. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2006
  3. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2004
  4. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2009
  5. Drug Abuse, Sustance P and HIV
    Wenzhe Ho; Fiscal Year: 2010
  6. Drug Abuse, Sustance P and HIV
    Wenzhe Ho; Fiscal Year: 2009
  7. Opioids, LPS and HIV
    Wenzhe Ho; Fiscal Year: 2010
  8. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2009
  9. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2010
  10. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2007

Collaborators

Detail Information

Publications50

  1. pmc Expression and regulation of antiviral protein APOBEC3G in human neuronal cells
    Yan Jian Wang
    Division of Allergy and Immunology, Joseph Stokes, Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neuroimmunol 206:14-21. 2009
    ....
  2. pmc IFN-λ3 inhibits HIV infection of macrophages through the JAK-STAT pathway
    Man Qing Liu
    Division of Virology, Wuhan Center for Disease Prevention and Control, Wuhan, Hubei, People s Republic of China
    PLoS ONE 7:e35902. 2012
    ..We thus examined the potential of IFN-λ3 to inhibit HIV replication and the possible mechanisms of the anti-HIV action by IFN-λ3 in human macrophages...
  3. pmc Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users
    Li Ye
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 5:e9602. 2010
    ..We thus investigated the in vivo impact of heroin use or heroin use plus HCV infection on the CD56(+) T cell frequency and function...
  4. pmc Morphine suppresses IFN signaling pathway and enhances AIDS virus infection
    Yizhong Wang
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e31167. 2012
    ..However, the mechanism(s) of their action remains to be determined. We thus investigated the impact of morphine on the intracellular innate antiviral immunity...
  5. pmc SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans
    Yu Zhou
    The Center for Animal Experiment ABSL III Laboratory, State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan, Hubei 430071, P, R, China
    Retrovirology 10:89. 2013
    ..Therefore, to examine and compare results obtained from RM models of Indian and Chinese origins should lead to further validation and improvement of these animal models for HIV/AIDS research. ..
  6. pmc RIG-I activation inhibits HIV replication in macrophages
    Yizhong Wang
    Temple University School of Medicine, 843 MERB, 3500 N Broad St, Philadelphia, PA 19140, USA
    J Leukoc Biol 94:337-41. 2013
    ..These observations highlight the importance of RIG-I signaling in macrophage innate immunity against HIV, which can be beneficial for the treatment of HIV disease, where intracellular immune defense is compromised by the virus. ..
  7. pmc Modulation of intracellular restriction factors contributes to methamphetamine-mediated enhancement of acquired immune deficiency syndrome virus infection of macrophages
    Xu Wang
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Curr HIV Res 10:407-14. 2012
    ..These findings indicate that METH use impairs intracellular innate antiviral mechanism(s) in macrophages, contributing to cell susceptibility to the acquired immune deficiency syndrome (AIDS) virus infection...
  8. pmc CD56+ T cells inhibit HIV-1 infection of macrophages
    Wei Hou
    Animal Biosafety Level 3 Laboratory Center for Animal Experiment, Wuhan University, Wuhan, P R China
    J Leukoc Biol 92:343-51. 2012
    ..These findings provide compelling evidence that CD56+ T cells may have a critical role in innate immunity against HIV-1 infection...
  9. pmc (-)-Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells
    Jieliang Li
    The Center for Animal Experiment Animal Biosafety Level III Laboratory, Wuhan University Wuhan, Hubei 430071, People s Republic of China
    J Neuroinflammation 9:161. 2012
    ..We examined the effect of EGCG on LPS-induced expression of the inflammatory cytokines in human cerebral microvascular endothelial cells (hCMECs) and BBB permeability...
  10. ncbi request reprint Morphine upregulates functional expression of neurokinin-1 receptor in neurons
    Qi Wan
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, Philadelphia, Pennsylvania
    J Neurosci Res 84:1588-96. 2006
    ..These in vitro data provide a plausible cellular mechanism for opioid-mediated neurological disorders...
  11. pmc Morphine withdrawal enhances hepatitis C virus replicon expression
    Chuan qing Wang
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, and the Department of Psychiatry, University of Pennsylvania School of Medicine, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Am J Pathol 167:1333-40. 2005
    ..These in vitro observations support the concept that opioid abuse favors HCV persistence in hepatic cells by suppressing IFN-alpha-mediated intracellular innate immunity and contributes to the development of chronic HCV infection...
  12. ncbi request reprint Alcohol potentiates hepatitis C virus replicon expression
    Ting Zhang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hepatology 38:57-65. 2003
    ..Thus, alcohol may play an important role in vivo as a cofactor in HCV disease progression and compromise IFN-alpha-based therapy against HCV infection...
  13. pmc Interleukin-1beta induces macrophage inflammatory protein-1beta expression in human hepatocytes
    Ting Zhang
    Division of Allergy and Immunology, Joseph Strokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Immunol 226:45-53. 2003
    ..These observations suggest that IL-1beta-mediated up-regulation of MIP-1beta production in the hepatic cells may contribute a critical mechanism for continuous recruitment of inflammatory cell to liver and maintenance of inflammation...
  14. pmc An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P
    Xu Wang
    Department of Pediatrics, Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Pathol 169:1663-70. 2006
    ..These findings provide a cellular mechanism that supports the notion that opioids have a co-factor role in promoting HIV infection of the immune cells...
  15. ncbi request reprint A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes
    Jian Ping Lai
    Division of Immunologic and Infectious Diseases, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    J Neuroimmunol 128:101-8. 2002
    ..Since SP plays an important role in inflammation and viral infections, these studies may have potential applications for therapeutic intervention of inflammation and viral infection of immune cells...
  16. ncbi request reprint Natural killer cells inhibit hepatitis C virus expression
    Yuan Li
    Division of Allergy and Immunology, Joseph Stokes, Jr Research Institute at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    J Leukoc Biol 76:1171-9. 2004
    ..Thus, NK cells hold the potential to play a vital role in controlling HCV replication in hepatic cells using an IFN-gamma-dependent mechanism...
  17. pmc Morphine enhances hepatitis C virus (HCV) replicon expression
    Yuan Li
    Division of Immunologic and Infectious Diseases, Department of Pediatrics, Stokes Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Am J Pathol 163:1167-75. 2003
    ..Our in vitro data indicate that morphine may play an important role as a positive regulator of HCV replication in human hepatic cells and may compromise IFN-alpha therapy...
  18. pmc Interleukin-1beta stimulates macrophage inflammatory protein-1alpha and -1beta expression in human neuronal cells (NT2-N)
    Chang Jiang Guo
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute of The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Neurochem 84:997-1005. 2003
    ..IL-1beta-mediated up-regulation of beta-chemokine expression may have important implications in the immunopathogenesis of inflammatory diseases in the CNS...
  19. pmc Molecular epidemiology of astrovirus infection in infants in Wuhan, China
    Man Qing Liu
    Wuhan Centers for Disease Prevention and Control, 24 Jiang Han Bei Road, Wuhan, Hubei 430022, People s Republic of China
    J Clin Microbiol 45:1308-9. 2007
    ..87%). Genotyping analysis indicated that 23 out of 24 astroviruses identified were classified as belonging to genotype 1, with highest identity (>98%) to a Mongolian strain...
  20. ncbi request reprint Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Leukoc Biol 79:1166-72. 2006
    ..These findings suggest a biological mechanism for the potential therapeutic benefit of naltrexone in treating HIV-infected alcoholics...
  21. pmc Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytes
    Xu Wang
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Pathol 178:41-7. 2011
    ..These in vitro and in vivo findings indicate that opioid use impairs intracellular innate anti-HIV mechanism(s) in monocytes, contributing to cell susceptibility to HIV infection...
  22. ncbi request reprint CD8+ T cell depletion amplifies hepatitis C virus replication in peripheral blood mononuclear cells
    Yuan Li
    Division of Allergy and Immunology, Department of Pediatrics, Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Infect Dis 192:1093-101. 2005
    ..These findings may have important implications for the immunopathogenesis of HCV in both immune and hepatic cells and are relevant to the development of host innate immunity-based anti-HCV interventions...
  23. ncbi request reprint Morphine inhibits CD8+ T cell-mediated, noncytolytic, anti-HIV activity in latently infected immune cells
    Xu Wang
    The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Leukoc Biol 78:772-6. 2005
    ..These data provide additional evidence to support the notion that opioids play a role in impairing the anti-HIV function of the immune system...
  24. pmc Methadone enhances human immunodeficiency virus infection of human immune cells
    Yuan Li
    Division of Immunologic and Infectious Diseases, Joseph Stokes Jr Research Institute of The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Infect Dis 185:118-22. 2002
    ..Although the in vivo relevance of these findings remains to be determined, the data underscore the necessity of further studies to define the role of opioids, including methadone, in the immunopathogenesis of HIV infection and AIDS...
  25. ncbi request reprint Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines
    Ting Zhang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hepatology 42:819-27. 2005
    ..In conclusion, we provide direct evidence that HCV undermines the intracellular innate immunity of the target cells, which may account for HCV persistence in hepatic cells...
  26. pmc Interleukin-1beta upregulates functional expression of neurokinin-1 receptor (NK-1R) via NF-kappaB in astrocytes
    Chang Jiang Guo
    Division of Allergy and Immunology, Department of Pediatrics, Joseph Stokes Jr Research Institute of Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Glia 48:259-66. 2004
    ..These findings provide additional evidence that there is a biological interaction between IL-1beta and the neuropeptide SP in the CNS, which may have important implications in the inflammatory diseases in the CNS...
  27. pmc Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages
    Wei Hou
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Virol 83:3834-42. 2009
    ..These findings indicate that IFN-lambda may have therapeutic value in the treatment of HIV-1 infection...
  28. pmc Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 113:671-4. 2009
    ..These findings provide compelling and direct evidence at the molecular level to support the notion that intracellular anti-HIV-1 miRNA-mediated innate immunity may have a key role in protecting monocytes/macrophages from HIV-1 infection...
  29. pmc Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes
    Wen Zhe Ho
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Pharmacol Exp Ther 307:1158-62. 2003
    ..The ability of MNTX to block opioid-induced CCR5 expression and HIV replication at clinically relevant doses may have additional benefit for opioid abusers with HIV infection, or patients with AIDS pain receiving opioids...
  30. pmc Methamphetamine enhances HIV infection of macrophages
    Hao Liang
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Pathol 172:1617-24. 2008
    ....
  31. ncbi request reprint Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells
    Ting Zhang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute of The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Antiviral Res 73:132-9. 2007
    ..The P38 MAPK inhibitor (SB 203580) blocked NK SN-mediated HIV inhibition. These data provide compelling evidence that NK cells have a critical role in controlling HIV activation in the reservoirs...
  32. pmc Neurokinin-1 receptor antagonist (aprepitant) suppresses HIV-1 infection of microglia/macrophages
    Xu Wang
    Department of Pediatrics, Joseph Stokes, Jr Research Institute at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuroimmune Pharmacol 3:257-64. 2008
    ..These observations provide additional evidence to support the potential use of NK-1R antagonists as therapeutic and immunomodulatory agents for the treatment of HIV-1 infection...
  33. pmc Methamphetamine inhibits Toll-like receptor 9-mediated anti-HIV activity in macrophages
    Ping Cen
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    AIDS Res Hum Retroviruses 29:1129-37. 2013
    ..Collectively, our results provide further evidence that METH suppresses host cell innate immunity against HIV infection by down-regulating TLR9 expression and its signaling-mediated antiviral effect in macrophages...
  34. pmc Quantification of CCR5 mRNA in human lymphocytes and macrophages by real-time reverse transcriptase PCR assay
    Jian Ping Lai
    Divisions of Immunologic and Infectious Diseases, Joseph Stokes, Jr, Research Institute, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Clin Diagn Lab Immunol 10:1123-8. 2003
    ..MDM expressed higher levels of CCR5 mRNA than did PBL. Thus, this assay has the potential and a wide application for the investigation of the role of CCR5 in inflammatory diseases and viral infections, including HIV disease...
  35. pmc Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages
    Jieliang Li
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuroinflammation 8:15. 2011
    ..In this study, we examined whether BBI has the ability to inhibit LPS-mediated macrophage activation, reducing the release of pro-inflammatory cytokines and subsequent neurotoxicity in primary cortical neural cultures...
  36. ncbi request reprint HIV enhances substance P expression in human immune cells
    Wen Zhe Ho
    The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    FASEB J 16:616-8. 2002
    ..These data support the hypothesis that interaction of HIV and SP may have significant in vivo relevance to the immunopathogenesis of HIV infection and AIDS...
  37. ncbi request reprint Morphine inhibits intrahepatic interferon- alpha expression and enhances complete hepatitis C virus replication
    Yuan Li
    Division of Allergy and Immunology, Joseph Stokes, Jr, Research Institute, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Infect Dis 196:719-30. 2007
    ..These findings indicate that morphine plays a cofactor role in facilitating HCV persistence in human hepatocytes...
  38. ncbi request reprint Drug abuse, innate immunity and hepatitis C virus
    Ting Zhang
    Division of Allergy and Immunology, Joseph Stokes, Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Rev Med Virol 16:311-27. 2006
    ..This review paper focuses on the interplay between drug abuse (opiates and alcohol), innate immunity and HCV in the context of the development of HCV disease...
  39. pmc Quantification of substance p mRNA in human immune cells by real-time reverse transcriptase PCR assay
    Jian Ping Lai
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Clin Diagn Lab Immunol 9:138-43. 2002
    ..Since SP is a major modulator of neuroimmunoregulation, this assay has the potential for widespread application for basic and clinical investigations...
  40. ncbi request reprint Neurokinin-1 receptor antagonist (aprepitant) inhibits drug-resistant HIV-1 infection of macrophages in vitro
    Xu Wang
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Neuroimmune Pharmacol 2:42-8. 2007
    ..Aprepitant is in clinical use for the prevention of nausea and vomiting associated with cancer chemotherapy or following surgical procedures...
  41. pmc Real-time reverse transcription-PCR quantitation of substance P receptor (NK-1R) mRNA
    Jian Ping Lai
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Clin Diagn Lab Immunol 12:537-41. 2005
    ....
  42. pmc Drugs of abuse and HIV infection/replication: implications for mother-fetus transmission
    Xu Wang
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Life Sci 88:972-9. 2011
    ....
  43. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
    ..Together, these results indicate that CB₂ may offer a means to limit HIV-1 infection in macrophages...
  44. pmc Opioids and HIV/HCV infection
    Xu Wang
    Animal Biosafety Level 3 Laboratory, Wuhan University, Wuhan, Hubei 430071, People s Republic of China
    J Neuroimmune Pharmacol 6:477-89. 2011
    ..Thus, more extensive studies are needed in order to determine the effects of different conditions of opiate abuse and to define the understanding of the role of opiate in modulating HIV and/or HCV disease progression...
  45. ncbi request reprint Identification of new subtype of astrovirus type 3 from an infant with diarrhea in Wuhan, China
    Man Qing Liu
    Division of Virology, Wuhan Centers for Disease Prevention and Control, Wuhan 430022, Hubei, PR China
    Virology 375:301-6. 2008
    ..05 to the reference strains of HAstV-3, WH1859 represents a distinct subtype within HAstV-3 strains. Further studies are needed to determine the role of this new subtype strain of HAstV in viral gastroenteritis among young children...
  46. ncbi request reprint Substance P and neurokinin-1 receptor modulation of HIV
    Wen Zhe Ho
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuroimmunol 157:48-55. 2004
    ..Modulation of SP activity and SP receptor may offer a novel approach to the treatment of psychiatric disorders and to the design of new anti-HIV therapy...
  47. ncbi request reprint Deletion of N-glycosylation sites of hepatitis C virus envelope protein E1 enhances specific cellular and humoral immune responses
    Min Liu
    Department of Immunology, State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Medicine, Wuhan 430071, China
    Vaccine 25:6572-80. 2007
    ....
  48. pmc Lipopolysaccharide induces immune activation and SIV replication in rhesus macaques of Chinese origin
    Rong Bao
    Animal Biosafety Level III Laboratory at the Center for Animal Experiment, Wuhan University, Wuhan, Hubei, P R China
    PLoS ONE 9:e98636. 2014
    ..We thus investigate the impact of LPS on systemic immune activation in simian immunodeficiency virus (SIV)-infected rhesus macaques of Chinese origin...
  49. pmc Substance P up-regulates macrophage inflammatory protein-1beta expression in human T lymphocytes
    Chang Jiang Guo
    Division of Immunologic and Infectious Diseases, Joseph Stokes Jr Research Institute of The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuroimmunol 131:160-7. 2002
    ....
  50. ncbi request reprint Real-time RT-PCR for quantitation of hepatitis C virus RNA
    Ji Hong Yang
    Division of Immunologic and Infectious Diseases, Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    J Virol Methods 102:119-28. 2002
    ..Since HCV is a major pathogen of post-transfusion and community-transmitted non-A, non-B hepatitis, this assay has a broad application for basic and clinical investigations...

Research Grants22

  1. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2009
    ....
  2. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2006
    ....
  3. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2004
    ....
  4. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2009
    ....
  5. Drug Abuse, Sustance P and HIV
    Wenzhe Ho; Fiscal Year: 2010
    ..Our studies also will facilitate a rational basis for practical guidance towards the reduction of risk factors, such as heroin, that may potentiate HIV-1 infection and promote the development and progression of neuroAIDS. ..
  6. Drug Abuse, Sustance P and HIV
    Wenzhe Ho; Fiscal Year: 2009
    ..Our studies also will facilitate a rational basis for practical guidance towards the reduction of risk factors, such as heroin, that may potentiate HIV-1 infection and promote the development and progression of neuroAIDS. ..
  7. Opioids, LPS and HIV
    Wenzhe Ho; Fiscal Year: 2010
    ....
  8. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2009
    ....
  9. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2010
    ....
  10. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2007
    ..abstract_text> ..
  11. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2001
    ..These studies may also provide clues toward development of therapeutic strategies for HIV infection and AIDS. ..
  12. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2002
    ..These studies may also provide clues toward development of therapeutic strategies for HIV infection and AIDS. ..
  13. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2003
    ..These studies may also provide clues toward development of therapeutic strategies for HIV infection and AIDS. ..
  14. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2002
    ..These studies may also provide clues toward development of therapeutic strategies for HIV infection and AIDS. ..
  15. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2005
    ....
  16. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2006
    ....
  17. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2007
    ....
  18. Drug Abuse, Sustance P and HIV
    Wenzhe Ho; Fiscal Year: 2009
    ..Our studies also will facilitate a rational basis for practical guidance towards the reduction of risk factors, such as heroin, that may potentiate HIV-1 infection and promote the development and progression of neuroAIDS. ..