Alan H Gradman

Summary

Affiliation: Temple University
Country: USA

Publications

  1. doi request reprint Initial combination therapy reduces the risk of cardiovascular events in hypertensive patients: a matched cohort study
    Alan H Gradman
    Temple University School of Medicine, 1239 Shady Ave, Pittsburgh, PA 15232, USA
    Hypertension 61:309-18. 2013
  2. doi request reprint Strategies for combination therapy in hypertension
    Alan H Gradman
    Temple University School of Medicine Clinical Campus, Pittsburgh, Pennsylvania 15232, USA
    Curr Opin Nephrol Hypertens 21:486-91. 2012
  3. doi request reprint Combination therapy in hypertension
    Alan H Gradman
    The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania and Temple University School of Medicine, Philadelphia, PA 15224, USA
    J Am Soc Hypertens 4:42-50. 2010
  4. ncbi request reprint Hypertension and diastolic heart failure
    Alan H Gradman
    Division of Cardiovascular Disease, The Western Pennsylvania Hospital Suite 3411 NT, 4800 Friendship Avenue, Pittsburgh, PA 15224, USA
    Curr Cardiol Rep 11:422-9. 2009
  5. doi request reprint Combination therapy in hypertension
    Alan H Gradman
    Western Pennsylvania Hospital, Pittsburgh, PA, USA
    J Clin Hypertens (Greenwich) 13:146-54. 2011
  6. doi request reprint Combined renin-angiotensin-aldosterone system inhibition in patients with chronic heart failure secondary to left ventricular systolic dysfunction
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, Pittsburgh, PA15224 1722, USA
    Am Heart J 157:S17-23. 2009
  7. doi request reprint Current concepts: renin inhibition in the treatment of hypertension
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, 4800 Friendship Avenue, North Tower, Suite 3411, Pittsburgh, PA, USA
    Curr Opin Pharmacol 8:120-6. 2008
  8. doi request reprint Renin inhibition in hypertension
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania 15224, USA
    J Am Coll Cardiol 51:519-28. 2008
  9. ncbi request reprint The efficacy of aliskiren, a direct renin inhibitor, in the treatment of hypertension
    Alan H Gradman
    Division of Cardiovascular Diseases, Western Pennsylvania Hospital and Temple University School of Medicine Clinical Campus, Pittsburgh, Pennsylvania, USA
    Rev Cardiovasc Med 8:S22-30. 2007
  10. ncbi request reprint New drugs for hypertension: what do they offer?
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, 4800 Friendship Avenue, Suite 3411 N, Pittsburgh, PA 15224, USA
    Curr Hypertens Rep 8:425-32. 2006

Detail Information

Publications21

  1. doi request reprint Initial combination therapy reduces the risk of cardiovascular events in hypertensive patients: a matched cohort study
    Alan H Gradman
    Temple University School of Medicine, 1239 Shady Ave, Pittsburgh, PA 15232, USA
    Hypertension 61:309-18. 2013
    ..68-1.03]; P=0.0935). Initial combination therapy was associated with a significant risk reduction of cardiovascular events. More rapid achievement of target BP was found to be the main contributor to the estimated risk reduction...
  2. doi request reprint Strategies for combination therapy in hypertension
    Alan H Gradman
    Temple University School of Medicine Clinical Campus, Pittsburgh, Pennsylvania 15232, USA
    Curr Opin Nephrol Hypertens 21:486-91. 2012
    ..The topic is widely relevant given that more than 46  million ambulatory care visits are conducted in the United States annually for hypertension management...
  3. doi request reprint Combination therapy in hypertension
    Alan H Gradman
    The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania and Temple University School of Medicine, Philadelphia, PA 15224, USA
    J Am Soc Hypertens 4:42-50. 2010
    ..The advantages and disadvantages of single pill (fixed) drug combinations, and the implications of recent clinical trials involving specific combination strategies will also be discussed...
  4. ncbi request reprint Hypertension and diastolic heart failure
    Alan H Gradman
    Division of Cardiovascular Disease, The Western Pennsylvania Hospital Suite 3411 NT, 4800 Friendship Avenue, Pittsburgh, PA 15224, USA
    Curr Cardiol Rep 11:422-9. 2009
    ..In patients with established heart failure, diuretics and other empiric treatments are used to control symptoms...
  5. doi request reprint Combination therapy in hypertension
    Alan H Gradman
    Western Pennsylvania Hospital, Pittsburgh, PA, USA
    J Clin Hypertens (Greenwich) 13:146-54. 2011
    ..The advantages and disadvantages of single-pill (fixed) drug combinations and the implications of recent clinical trials involving specific combination strategies will also be discussed...
  6. doi request reprint Combined renin-angiotensin-aldosterone system inhibition in patients with chronic heart failure secondary to left ventricular systolic dysfunction
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, Pittsburgh, PA15224 1722, USA
    Am Heart J 157:S17-23. 2009
    ..This review discusses the clinical data supporting the use of angiotensin-converting enzyme inhibitors and angiotensin receptors blockers, alone or in combination, for improving outcomes in patients with HF...
  7. doi request reprint Current concepts: renin inhibition in the treatment of hypertension
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, 4800 Friendship Avenue, North Tower, Suite 3411, Pittsburgh, PA, USA
    Curr Opin Pharmacol 8:120-6. 2008
    ..Ongoing studies evaluating the long-term renal protective effects of aliskiren and its effects on ventricular remodeling are currently planned or underway...
  8. doi request reprint Renin inhibition in hypertension
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania 15224, USA
    J Am Coll Cardiol 51:519-28. 2008
    ..The effect of aliskiren on receptor-bound renin and pro-renin is the subject of active investigation...
  9. ncbi request reprint The efficacy of aliskiren, a direct renin inhibitor, in the treatment of hypertension
    Alan H Gradman
    Division of Cardiovascular Diseases, Western Pennsylvania Hospital and Temple University School of Medicine Clinical Campus, Pittsburgh, Pennsylvania, USA
    Rev Cardiovasc Med 8:S22-30. 2007
    ..Combinations with existing antihypertensives are producing promising additional blood pressure-lowering effects...
  10. ncbi request reprint New drugs for hypertension: what do they offer?
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, 4800 Friendship Avenue, Suite 3411 N, Pittsburgh, PA 15224, USA
    Curr Hypertens Rep 8:425-32. 2006
    ....
  11. ncbi request reprint Vaccination: a novel strategy for inhibiting the renin-angiotensin-aldosterone system
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, Pittsburgh, PA 15224, USA
    Curr Hypertens Rep 10:473-9. 2008
    ..No serious adverse events were attributed to vaccine administration. Although questions remain regarding efficacy and safety, RAAS immunization represents an innovative and promising approach to hypertension treatment...
  12. ncbi request reprint Newer combination therapies in the management of hypertension: an update
    Alan H Gradman
    Western Pennsylvania Hospital, Temple University School of Medicine Clinical Campus, Pittsburgh, PA, USA
    J Clin Hypertens (Greenwich) 10:398-405. 2008
    ..Participants included Matthew R. Weir, MD, University of Maryland School of Medicine, Baltimore, MD, and George L. Bakris, MD, University of Chicago, Chicago, IL...
  13. ncbi request reprint Managing high-risk patients with hypertension: focus on the renin-angiotensin system
    Alan H Gradman
    Division of Cardiovascular Diseases, Western Pennsylvania Hospital, 4800 Friendship Avenue, Pittsburgh, PA 15224, USA
    J Clin Hypertens (Greenwich) 6:501-8. 2004
    ..Agents that block the effects of angiotensin II are an important component of antihypertensive therapy because of their proven ability to lower the incidence of cardiovascular and renal events in high-risk hypertensive patients...
  14. ncbi request reprint Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
    Alan H Gradman
    The Western Pennsylvania Hospital, Pittsburgh, PA, USA
    Circulation 111:1012-8. 2005
    ..This study compares the antihypertensive efficacy and safety of the novel oral renin inhibitor aliskiren with placebo and an active comparator...
  15. ncbi request reprint New therapeutic perspectives with clevidipine: an ultra-short-acting intravenous Ca2+ channel blocker
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, Pittsburgh, PA 15224, USA
    Expert Opin Investig Drugs 16:1449-57. 2007
    ..Clevidipine constitutes a useful addition to available intravenous agents and could prove particularly valuable in circumstances that require the ability to rapidly terminate the blood pressure-lowering effects of administered agents...
  16. doi request reprint Role of angiotensin II type 1 receptor antagonists in the treatment of hypertension in patients aged >or=65 years
    Alan H Gradman
    Division of Cardiovascular Diseases, The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania 15224, USA
    Drugs Aging 26:751-67. 2009
    ..They also have the advantage of placebo-like tolerability, and this contributes favourably to patient compliance with long-term treatment, which is a prerequisite for reducing morbidity and mortality...
  17. doi request reprint Effect of intracoronary nicardipine on cardiac enzymes after elective percutaneous coronary intervention
    Sandeep Arora
    Department of Cardiovascular Disease, Western Pennsylvania Hospital Temple University Program, Pittsburgh, Pennsylvania 15224, USA
    Clin Cardiol 32:315-20. 2009
    ..Elevation in cardiac enzymes after percutaneous coronary intervention (PCI) is common and is associated with adverse clinical outcomes...
  18. ncbi request reprint From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease
    Alan H Gradman
    Western Pennsylvania Hospital, Pittsburgh, PA 15224, USA
    Prog Cardiovasc Dis 48:326-41. 2006
    ..In patients with established LVH, regression is both possible and desirable and results in a significant reduction in adverse clinical endpoints...
  19. ncbi request reprint Evolving strategies for the use of combination therapy in hypertension
    Alan H Gradman
    Temple University School of Medicine Clinical Campus, The Western Pennsylvania Hospital, Pittsburgh 15224, USA
    Curr Hypertens Rep 4:343-9. 2002
    ..Combinations of agents affecting the renin-angiotensin system by different mechanisms are currently the subject of active investigation...
  20. ncbi request reprint A multicenter, randomized, double-blind, placebo-controlled, 8-week trial of the efficacy and tolerability of once-daily losartan 100 mg/hydrochlorothiazide 25 mg and losartan 50 mg/hydrochlorothiazide 12.5 mg in the treatment of moderate-to-severe essent
    Alan H Gradman
    Western Pennsylvania Hospital, Pittsburgh, USA
    Clin Ther 24:1049-61. 2002
    ..Many patients with moderate-to-severe hypertension require multiple drug therapy to achieve blood-pressure goals. Fixed-dose combination therapy with losartan and hydrochlorothiazide may be useful in this population...
  21. ncbi request reprint Combination therapy in hypertension
    Alan H Gradman
    The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania and Temple University School of Medicine, Philadelphia, PA, USA
    J Am Soc Hypertens 4:90-8. 2010
    ..The advantages and disadvantages of single pill (fixed) drug combinations, and the implications of recent clinical trials involving specific combination strategies will also be discussed...