Thomas Gould

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus
    Justin W Kenney
    Department of Psychology, Temple University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e39939. 2012
  2. pmc Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear
    Thomas J Gould
    Department of Psychology, Weiss Hall, Neuroscience Program, Temple University, Philadelphia, PA 19122, USA Electronic address
    Brain Res 1559:1-10. 2014
  3. pmc Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, 1701 N 13th Street, Philadelphia, PA 19122, United States Electronic address
    Neurobiol Learn Mem 109:151-9. 2014
  4. pmc Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
    Thomas J Gould
    Temple University Department of Psychology, Neuroscience Program, Temple University, Philadelphia, PA 19122, United States Electronic address
    Neurobiol Learn Mem 107:108-32. 2014
  5. pmc The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, 6th Floor, Philadelphia, PA 19122, USA
    Neuropharmacology 62:2118-25. 2012
  6. ncbi request reprint Age-related deficits in the retention of memories for cued fear conditioning are reversed by galantamine treatment
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, Philadelphia, PA 19122, USA
    Behav Brain Res 165:160-71. 2005
  7. ncbi request reprint Atomoxetine and nicotine enhance prepulse inhibition of acoustic startle in C57BL/6 mice
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, Philadelphia, PA 19122, USA
    Neurosci Lett 377:85-90. 2005
  8. pmc Nicotine and hippocampus-dependent learning: implications for addiction
    Thomas J Gould
    Department of Psychology, Temple University, Philadelphia, PA, USA
    Mol Neurobiol 34:93-107. 2006
  9. pmc Addiction and cognition
    Thomas J Gould
    Department of Psychology and Center for Substance Abuse Research, Temple University, Philadelphia, Pennsylvania 19122, USA
    Addict Sci Clin Pract 5:4-14. 2010
  10. pmc Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioning
    Thomas J Gould
    Temple University, Psychology Department Neuroscience Program, Philadelphia, PA 19122, USA
    Learn Mem 12:389-98. 2005

Collaborators

Detail Information

Publications52

  1. pmc Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus
    Justin W Kenney
    Department of Psychology, Temple University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e39939. 2012
    ....
  2. pmc Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear
    Thomas J Gould
    Department of Psychology, Weiss Hall, Neuroscience Program, Temple University, Philadelphia, PA 19122, USA Electronic address
    Brain Res 1559:1-10. 2014
    ..These findings are discussed in terms of implications for development of therapeutics that target symptoms of nicotine addiction and for theories of addiction. ..
  3. pmc Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, 1701 N 13th Street, Philadelphia, PA 19122, United States Electronic address
    Neurobiol Learn Mem 109:151-9. 2014
    ....
  4. pmc Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
    Thomas J Gould
    Temple University Department of Psychology, Neuroscience Program, Temple University, Philadelphia, PA 19122, United States Electronic address
    Neurobiol Learn Mem 107:108-32. 2014
    ..e., adolescence) in these effects. ..
  5. pmc The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, 6th Floor, Philadelphia, PA 19122, USA
    Neuropharmacology 62:2118-25. 2012
    ..Thus, nicotine withdrawal-related deficits in contextual learning are time-limited changes that are associated with temporal changes in upregulation of high-affinity nAChR binding...
  6. ncbi request reprint Age-related deficits in the retention of memories for cued fear conditioning are reversed by galantamine treatment
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, Philadelphia, PA 19122, USA
    Behav Brain Res 165:160-71. 2005
    ..This retention deficit for cued fear conditioning is ameliorated by treatment with the AChE inhibitor galantamine...
  7. ncbi request reprint Atomoxetine and nicotine enhance prepulse inhibition of acoustic startle in C57BL/6 mice
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, Philadelphia, PA 19122, USA
    Neurosci Lett 377:85-90. 2005
    ..Thus, the newly available medication for ADHD, atomoxetine, could be a potential therapeutic agent for disorders associated with disrupted PPI such as withdrawal from nicotine...
  8. pmc Nicotine and hippocampus-dependent learning: implications for addiction
    Thomas J Gould
    Department of Psychology, Temple University, Philadelphia, PA, USA
    Mol Neurobiol 34:93-107. 2006
    ....
  9. pmc Addiction and cognition
    Thomas J Gould
    Department of Psychology and Center for Substance Abuse Research, Temple University, Philadelphia, Pennsylvania 19122, USA
    Addict Sci Clin Pract 5:4-14. 2010
    ..Patients with mental illness are at high risk for substance abuse, and the adverse impact on cognition may be particularly deleterious in combination with cognitive problems related to their mental disorders...
  10. pmc Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioning
    Thomas J Gould
    Temple University, Psychology Department Neuroscience Program, Philadelphia, PA 19122, USA
    Learn Mem 12:389-98. 2005
    ..These results suggest that nAChRs and glutamate receptors may support similar processes mediating acquisition of contextual fear conditioning and latent inhibition of fear conditioning...
  11. ncbi request reprint Nicotine enhances trace cued fear conditioning but not delay cued fear conditioning in C57BL/6 mice
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Behav Brain Res 155:167-73. 2004
    ..Taken together, the results of the present experiments suggest that nicotine enhances hippocampus-dependent versions of fear conditioning...
  12. ncbi request reprint Ethanol disrupts fear conditioning in C57BL/6 mice
    Thomas J Gould
    Department of Psychology, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    J Psychopharmacol 17:77-81. 2003
    ..Ethanol given on testing day only did not disrupt fear conditioning. The present results demonstrate that ethanol disrupts fear conditioning in C57BL/6 mice...
  13. ncbi request reprint Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training
    Thomas J Gould
    Neuroscience Program, Temple University, Weiss Hall, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 80:147-57. 2003
    ....
  14. ncbi request reprint Nicotine produces a within-subject enhancement of contextual fear conditioning in C57BL/6 mice independent of sex
    Thomas J Gould
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Integr Physiol Behav Sci 38:124-32. 2003
    ..These results suggest that nicotine enhanced acquisition and retrieval processes but did not produce state-dependent deficits when administered just for training or just for testing...
  15. ncbi request reprint Nicotine enhances contextual fear conditioning and ameliorates ethanol-induced deficits in contextual fear conditioning
    Thomas J Gould
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, Pennsylvania 19122, USA
    Behav Neurosci 117:1276-82. 2003
    ..Thus, nicotine both produces a long-lasting enhancement of contextual fear conditioning and protects against ethanol-associated deficits...
  16. ncbi request reprint Associative learning, the hippocampus, and nicotine addiction
    Jennifer A Davis
    Department of Psychology, Center for Substance Abuse Research, Temple University, Philadelphia, PA 19122, USA
    Curr Drug Abuse Rev 1:9-19. 2008
    ..Particular attention has been paid to research that describes the role of the hippocampus and hippocampus-dependent learning processes in nicotine addiction...
  17. pmc Hippocampal alpha4beta2 nicotinic acetylcholine receptor involvement in the enhancing effect of acute nicotine on contextual fear conditioning
    Jennifer A Davis
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurosci 27:10870-7. 2007
    ..The present results suggest a critical role for alpha4beta2 nAChRs in the dorsal hippocampus for mediating the enhancing effect of nicotine on contextual fear conditioning...
  18. pmc The hippocampus and cingulate cortex differentially mediate the effects of nicotine on learning versus on ethanol-induced learning deficits through different effects at nicotinic receptors
    Danielle Gulick
    Department of Psychology, Neuroscience Program, Center for Substance Abuse Research, Temple University, Philadelphia, PA 19122, USA
    Neuropsychopharmacology 34:2167-79. 2009
    ..These results suggest that nicotine acts in the hippocampus to enhance contextual learning, but acts in the cingulate to ameliorate ethanol-induced learning deficits through inactivation of high-affinity beta2 subunit-containing nAChRs...
  19. pmc beta2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice
    Jennifer A Davis
    Department of Psychology, Weiss Hall, Temple University, Philadelphia, PA, 19122, USA
    Psychopharmacology (Berl) 190:343-52. 2007
    ..Similarly, genetic deletion of the beta2 nAChR subunit but not the alpha7 nAChR subunit blocked the enhancing effect of nicotine on contextual fear conditioning...
  20. pmc Nicotine withdrawal disrupts both foreground and background contextual fear conditioning but not pre-pulse inhibition of the acoustic startle response in C57BL/6 mice
    Jessica M Andre
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, PA 19122, United States
    Behav Brain Res 190:174-81. 2008
    ..No effect of withdrawal from chronic nicotine was observed at any time point for PPI. Overall, these results demonstrate that nicotine withdrawal disrupts two methods of contextual learning but not sensory gating in C57BL/6J mice...
  21. pmc Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 89:106-13. 2008
    ..In addition, nicotine withdrawal selectively affects acquisition but not recall or expression of the learned response...
  22. pmc Atomoxetine reverses nicotine withdrawal-associated deficits in contextual fear conditioning
    Jennifer A Davis
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neuropsychopharmacology 32:2011-9. 2007
    ..These data suggest that atomoxetine may be efficacious for treating nicotine withdrawal-associated cognitive deficits that promote relapse in abstinent smokers...
  23. pmc Interactive effects of ethanol and nicotine on learning in C57BL/6J mice depend on both dose and duration of treatment
    Danielle Gulick
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, PA 19122, USA
    Psychopharmacology (Berl) 196:483-95. 2008
    ..Both drugs have dose-dependent effects on learning and memory. Thus, this study examined the interactive effects of acute ethanol and acute, chronic, or withdrawal from chronic nicotine on fear conditioning in C57BL/6J mice...
  24. pmc Nicotine withdrawal disrupts new contextual learning
    George S Portugal
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, PA 19122, USA
    Pharmacol Biochem Behav 92:117-23. 2009
    ..These data suggest that nicotine withdrawal disrupts new contextual learning, but does not alter contextual learning that occurred before withdrawal...
  25. pmc Involvement of hippocampal jun-N terminal kinase pathway in the enhancement of learning and memory by nicotine
    Justin W Kenney
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neuropsychopharmacology 35:483-92. 2010
    ..These data suggest that nicotine and learning interact to alter hippocampal JNK1 gene expression and related signaling processes, thus resulting in strengthened contextual memories...
  26. pmc Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits
    Jennifer A Davis
    Department of Psychology Neuroscience Program, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
    Eur Neuropsychopharmacol 19:551-61. 2009
    ..Therefore, the action of nicotine at hippocampal beta2 nAChRs mediates adaptations in hippocampal function that underlie withdrawal deficits in contextual fear conditioning...
  27. pmc Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice
    Jonathan D Raybuck
    Center for Substance Abuse Research, Temple University, Philadelphia, PA 19122, USA
    Behav Neurosci 122:1166-71. 2008
    ....
  28. pmc Nicotine enhances context learning but not context-shock associative learning
    Justin W Kenney
    Department of Psychology, Center for Substance Abuse Research, Temple University, Philadelphia, PA 19122, USA
    Behav Neurosci 122:1158-65. 2008
    ..Finally, the results are discussed in terms of a theory of how nicotine could alter hippocampal-cortical-amygdala interactions to facilitate contextual learning...
  29. ncbi request reprint Signal transduction mechanisms within the entorhinal cortex that support latent inhibition of cued fear conditioning
    Michael C Lewis
    Psychology Department Neuroscience Program, Weiss Hall, Temple University, 1701 N 13th Street, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 88:359-68. 2007
    ..These results are discussed in relation to the potential mechanisms of plasticity that support latent inhibition of cued fear conditioning...
  30. pmc Varenicline ameliorates ethanol-induced deficits in learning in C57BL/6 mice
    Danielle Gulick
    Department of Psychology, Neuroscience Program, Temple University, Weiss Hall, Rm 865, 1701 N 13th Street, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 90:230-6. 2008
    ..In addition, varenicline did not alter blood alcohol concentration. The smoking cessation aid varenicline may have therapeutic uses for treating ethanol-associated disruptions in cognitive processes...
  31. ncbi request reprint Latent inhibition of cued fear conditioning: an NMDA receptor-dependent process that can be established in the presence of anisomycin
    Michael C Lewis
    Temple University Neuroscience Program, Department of Psychology, Weiss Hall, Temple University, 1701 N 13th St, Philadelphia, PA 19122, USA
    Eur J Neurosci 20:818-26. 2004
    ..These findings suggest that latent inhibition of cued fear conditioning is a long-lasting NMDA receptor-dependent process that can develop during the inhibition of protein synthesis...
  32. pmc Age-related impairment in the 250-millisecond delay eyeblink classical conditioning procedure in C57BL/6 mice
    Richard W Vogel
    Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, Pennsylvania 19141, USA
    Learn Mem 9:321-36. 2002
    ..These results in mice support results in other species, indicating that cerebellar-dependent tasks show age-related deficits earlier in adulthood than do hippocampally dependent tasks...
  33. ncbi request reprint The interactive effects of nicotinic and muscarinic cholinergic receptor inhibition on fear conditioning in young and aged C57BL/6 mice
    Olivia Feiro
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Pharmacol Biochem Behav 80:251-62. 2005
    ..Co-administration of both antagonists did not disrupt fear conditioning in the aged mice, indicating that age-related alterations in the cholinergic receptor subtypes may occur...
  34. pmc Nicotine enhances both foreground and background contextual fear conditioning
    Jennifer A Davis
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Neurosci Lett 394:202-5. 2006
    ..These results demonstrate that nicotine enhances contextual fear conditioning regardless of whether the context is a background stimulus or a foreground stimulus during conditioning...
  35. ncbi request reprint Reversible inactivation of the entorhinal cortex disrupts the establishment and expression of latent inhibition of cued fear conditioning in C57BL/6 mice
    Michael C Lewis
    Psychology Department Neuroscience Program, Temple University, Philadelphia, Pennsylvania 19122, USA
    Hippocampus 17:462-70. 2007
    ....
  36. doi request reprint Of mice (Mus musculus) and toddlers (Homo sapiens): evidence for species-general spatial reorientation
    Alexandra D Twyman
    Psychology Department, Temple University, Philadelphia, PA 19122, USA
    J Comp Psychol 123:342-5. 2009
    ..These findings provide evidence that there is a homologous reorientation mechanism between mice and humans. Thus, future researchers can examine the genetic basis of this important cognitive ability...
  37. ncbi request reprint The effects of DHBE and MLA on nicotine-induced enhancement of contextual fear conditioning in C57BL/6 mice
    Jennifer A Davis
    Neuroscience Program, Temple University, Philadelphia, PA 19122, USA
    Psychopharmacology (Berl) 184:345-52. 2006
    ..This effect is blocked by mecamylamine, a noncompetitive, broad-spectrum nicotinic receptor antagonist...
  38. pmc Interactive effects of ethanol and nicotine on learning, anxiety, and locomotion in C57BL/6 mice in the plus-maze discriminative avoidance task
    Danielle Gulick
    Department of Psychology, Neuroscience Program, Center for Substance Abuse Research, Temple University, Philadelphia, PA 19122, USA
    Neuropharmacology 57:302-10. 2009
    ..Such a comparison would determine if the drugs produce independent effects on each behavior. The plus-maze discriminative avoidance task (PMDAT) allows within-subject measurement of these behaviors...
  39. pmc Modulation of hippocampus-dependent learning and synaptic plasticity by nicotine
    Justin W Kenney
    Department of Psychology, Center for Substance Abuse Research, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Mol Neurobiol 38:101-21. 2008
    ..This review compares and contrasts the effects of nicotine on hippocampus-dependent learning and LTP and briefly discusses how the effects of nicotine on learning could contribute to nicotine addiction...
  40. pmc Bupropion dose-dependently reverses nicotine withdrawal deficits in contextual fear conditioning
    George S Portugal
    Department of Psychology, Weiss Hall, Neuroscience Program, Temple University, Philadelphia, PA 19122, United States
    Pharmacol Biochem Behav 88:179-87. 2007
    ..Overall, these results indicate that a low dose of bupropion can reverse nicotine withdrawal deficits in contextual fear conditioning, but that high doses of bupropion produce deficits in fear conditioning...
  41. ncbi request reprint Nicotine and ethanol enhancements of acoustic startle reflex are mediated in part by dopamine in C57BL/6J mice
    Michael C Lewis
    Department of Psychology, Weiss Hall, Temple University, 1701 N 13th Street, Philadelphia, PA 19122, USA
    Pharmacol Biochem Behav 76:179-86. 2003
    ..It was found that the increase in acoustic startle responses observed with ethanol or nicotine was attenuated by haloperidol. Thus, ethanol or nicotine may enhance the acoustic startle reflex through a common dopaminergic mechanism...
  42. pmc Effects of ethanol and caffeine on behavior in C57BL/6 mice in the plus-maze discriminative avoidance task
    Danielle Gulick
    Department of Psychology, Neuroscience Program, Center for Substance Abuse Research, Temple University, Philadelphia, Pennsylvania 19122, USA
    Behav Neurosci 123:1271-8. 2009
    ..The plus-maze discriminative avoidance task (PMDAT) allows within-subject measurement of learning, anxiety, and locomotion...
  43. ncbi request reprint Inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase disrupts latent inhibition of cued fear conditioning in C57BL/6 mice
    Michael C Lewis
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Behav Neurosci 118:1444-9. 2004
    ..The results are discussed in relation to the molecular mechanisms that support latent inhibition of cued fear conditioning...
  44. ncbi request reprint Rolipram attenuates MK-801-induced deficits in latent inhibition
    Jennifer A Davis
    Temple University, Department of Psychology, Philadelphia, PA 19122, USA
    Behav Neurosci 119:595-602. 2005
    ....
  45. pmc Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine
    Jonathan D Raybuck
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Behav Neurosci 121:1119-24. 2007
    ..These results suggest that activation of ERK 1/2 by nicotine during acquisition leads to an enhancement of contextual fear conditioning...
  46. pmc Withdrawal from chronic nicotine administration impairs contextual fear conditioning in C57BL/6 mice
    Jennifer A Davis
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurosci 25:8708-13. 2005
    ..These findings provide a model of how the effects of nicotine on learning may contribute to the development and maintenance of nicotine addiction...
  47. pmc Acute ethanol has biphasic effects on short- and long-term memory in both foreground and background contextual fear conditioning in C57BL/6 mice
    Danielle Gulick
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 31:1528-37. 2007
    ..In addition, the present studies assessed the importance of stimulus salience in the effects of ethanol and directly compared the effects of ethanol on short-term and long-term memory...
  48. pmc The enhancement of contextual fear conditioning by ABT-418
    Justin W Kenney
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Behav Pharmacol 21:246-9. 2010
    ..ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner...
  49. pmc Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gs alpha
    Thomas J Gould
    Department of Psychology, Temple University, Weiss Hall, Philadelphia, PA, USA
    Neuropsychopharmacology 29:494-501. 2004
    ....
  50. pmc Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research
    George S Portugal
    Department of Psychology, Weiss Hall, Neuroscience Program, Temple University, Philadelphia, PA 19122, United States
    Behav Brain Res 193:1-16. 2008
    ..This review will examine the genetic factors that alter susceptibility to nicotine addiction, with an emphasis on the genes that encode nAChR proteins...
  51. doi request reprint Translating basic science to improve pharmacotherapy for nicotine dependence
    Jennifer M Phillips
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nicotine Tob Res 9:S583-98. 2007
    ....
  52. ncbi request reprint Neuronal nicotinic acetylcholine receptors: involvement in Alzheimer's disease and schizophrenia
    Diana S Woodruff-Pak
    Temple University and Albert Einstein Healthcare Network, USA
    Behav Cogn Neurosci Rev 1:5-20. 2002
    ..Therapy with 7 nAChR agonists relieves some schizophrenic symptoms. Despite disparities in etiology and symptomatology, AD and schizophrenia share a target for therapeutic intervention--7 nAChRs...

Research Grants10

  1. Nicotine Addiction: Learning, Neural & Genetic Process
    Thomas Gould; Fiscal Year: 2005
    ..Investigating the effects of nicotine on learning from the level of receptor activation to changes in cell signaling will enhance understanding of addiction and aid in development of treatments for nicotine addiction ..
  2. Genetic, Behavioral, & Neurobiological Substrates of Nicotine Withdrawal
    Thomas Gould; Fiscal Year: 2009
    ....
  3. Genetic, Behavioral, & Neurobiological Substrates of Nicotine Withdrawal
    Thomas Gould; Fiscal Year: 2009
    ....
  4. Nicotine Addiction: Learning, Neural & Genetic Process
    Thomas Gould; Fiscal Year: 2009
    ..Investigating the effects of nicotine on learning from the level of receptor activation to changes in cell signaling will enhance understanding of addiction and aid in development of treatments for nicotine addiction ..
  5. Nicotine Addiction: Learning, Neural & Genetic Process
    Thomas Gould; Fiscal Year: 2007
    ..Investigating the effects of nicotine on learning from the level of receptor activation to changes in cell signaling will enhance understanding of addiction and aid in development of treatments for nicotine addiction ..
  6. Nicotine & Ethanol Influences on Contextual Conditioning
    Thomas Gould; Fiscal Year: 2007
    ..Understanding the underlying neurobiology will not only further aid in this understanding but will also aid in developing treatments for alcoholism and nicotine addiction. ..
  7. Nicotine Addiction: Learning, Neural & Genetic Process
    Thomas Gould; Fiscal Year: 2006
    ..Investigating the effects of nicotine on learning from the level of receptor activation to changes in cell signaling will enhance understanding of addiction and aid in development of treatments for nicotine addiction ..
  8. Genetic, Behavioral, & Neurobiological Substrates of Nicotine Withdrawal
    Thomas J Gould; Fiscal Year: 2010
    ....