Research Topics
Genomes and Genes
| Antonio GiordanoSummaryAffiliation: Temple University Country: USA Publications
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Publications
Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastomaValentina Caracciolo
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Biochem 110:182-90. 2010..In turn, this "perturbation" may trigger a network of signals strictly connected with survival and apoptosis...- The burden of breast cancer in Italy: mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge recordsPrisco Piscitelli
Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology Temple University, BioLife Science, Bldg, Suite 431 1900 N 12th Street, Philadelphia, PA, 19122, USA
J Exp Clin Cancer Res 31:96. 2012..abstract:.. - The retinoblastoma family: twins or distant cousins?Pier Paolo Claudio
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technologies, Temple University, Philadelphia, PA 19122, USA
Genome Biol 3:reviews3012. 2002.... - Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysisElena Fiorio
Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, USA
BMC Cancer 8:305. 2008..Next, we studied if leptin/ObR can coexist with HER2 in breast cancer tissues, and if presence of these two systems correlates with specific clinicopathological features... 
Interaction between the Cdk2/cyclin A complex and a small molecule derived from the pRb2/p130 spacer domain: a theoretical modelAntonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cell Cycle 6:2591-3. 2007..We believe this model to be useful for the rational development of peptide or peptidomimetic kinase inhibitors for negative cell cycle modulation in cancer cells...- From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cellsAntonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania, USA
J Cell Physiol 211:27-35. 2007..Finally, we will provide information about biotech companies developing MSC therapy... - Carcinogenesis and environment: the cancer stem cell hypothesis and implications for the development of novel therapeutics and diagnosticsAntonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Front Biosci 12:3475-82. 2007.... 
Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and developmentValentina Caracciolo
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Cell Cycle 11:1202-16. 2012..This finding also shows that Cdk9 and Cdk7 pathways are not redundant and may have important implications in drug development and for studying the mechanism of chemoresistance in malignant cells...- The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cellsAlessandra Rossi
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia PA
Int J Cancer 125:235-43. 2009..Thus, using Abacavir, alone or in combination with current therapies, might be an effective therapeutic strategy for the treatment of medulloblastoma... - Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell linesValentina Caracciolo
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
J Cell Physiol 223:519-29. 2010..Our data indicate that overexpression of gamma-tubulin may be linked to phenotypic dedifferentiation (anaplasia) and tumor progression in medulloblastomas and may potentially serve as a promising tumor marker... - Androgen receptor serine 81 mediates Pin1 interaction and activityRaffaele La Montagna
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Cell Cycle 11:3415-20. 2012..Since Pin1 expression positively correlates with tumor grade, our results suggest that Pin1 can participate in this process by modulating AR function... - Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastomaMarcella Macaluso
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Cell Cycle 11:1841-50. 2012.... - pRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxolTiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
Clin Cancer Res 10:8085-93. 2004.... - IRS-1-Rad51 nuclear interaction sensitizes JCV T-antigen positive medulloblastoma cells to genotoxic treatmentJoanna Trojanek
Center for Neurovirology, Department of Neuroscience, Temple University, Philadelphia, PA 19122, USA
Int J Cancer 119:539-48. 2006..JCV T-antigen did not affect HRR directly. In the presence of JCV T-antigen, insulin receptor substrate 1 (IRS-1) translocated to the nucleus where it co-localized with Rad51, possibly attenuating HRR... - Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAgValentina Caracciolo
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 212:96-104. 2007..Moreover, Small interference RNA experiments directed toward silencing the Rb2/p130 gene demonstrated that pRb2/p130 does not play a predominant role in the nuclear transportation of E2F4 and E2F5... - NSP 5a3a's link to nuclear-cyto proteins B23 and hnRNP-L between normal and aberrant breast cell linesLuca D'Agostino
Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Cell Cycle 9:1131-42. 2010.... - Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin ATiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
Oncogene 23:4930-7. 2004..In this study, we propose a new mechanism for the functional inactivation of pRb2/p130 that ultimately contributes to cell cycle progression and malignant transformation... - CTCF and BORIS regulate Rb2/p130 gene transcription: a novel mechanism and a new paradigm for understanding the biology of lung cancerFrancesco Paolo Fiorentino
Sbarro Health Research Organization, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Mol Cancer Res 9:225-33. 2011.... - Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implicationsGiuseppe Russo
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122-6099, USA
Clin Cancer Res 11:3265-73. 2005..Additionally, E2F4 showed an identical localization pattern as to that of pRb2/p130. These data suggests an important role for pRb2/p130 in the pathogenesis and progression of certain salivary gland cancers... - MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regionsCristina Giacinti
Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 206:807-13. 2006.... - Cdk9 phosphorylates p53 on serine 392 independently of CKIIPier Paolo Claudio
Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 208:602-12. 2006..These studies demonstrate the existence of a feedback-loop between p53 and cdk9, pinpointing a novel mechanism by which p53 regulates the basal transcriptional machinery... - Cdk9-55: a new player in muscle regenerationCristina Giacinti
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, USA
J Cell Physiol 216:576-82. 2008..This alternative form is specifically induced in injured myofibers and its activity is strictly required for the completion of muscle regeneration process... - pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancerMarcella Macaluso
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA
Oncogene 22:3511-7. 2003.... - R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repairMario Federico
Sbarro Health Research Organization, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
Mol Cancer 9:208. 2010..To see if we could therapeutically block this switch, we analyzed the effects of the CDK-inhibitor R-Roscovitine on the expression levels of cyclin A1 under genotoxic stress and observed subsequent DNA damage and repair mechanisms... - Analysis of a mutant p53 protein arising in a medulloblastoma from a mouse transgenic for the JC virus early regionMartyn K White
Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19122, USA
Anticancer Res 26:4079-92. 2006..In T-negative clones, a novel mutant p53 was detected (p53(mt))... - New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cellsAlessandra Rossi
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, 1900 North 12th St, Philadelphia, PA 19122, USA
FASEB J 24:2881-92. 2010..In conclusion, our results suggest that S7, S29, and SI163 could be novel attractive candidates for the treatment of medulloblastoma or tumors characterized by high Src activity... - Possible functional role of NSPs in cancerLuca D'Agostino
Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology Temple University, Philadelphia, Pennsylvania 19122, USA
Cell Cycle 7:1810-27. 2008.... - Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptaseTiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Methods Mol Biol 285:155-7. 2004 - Dissecting Pin1 and phospho-pRb regulationFlavio Rizzolio
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 228:73-7. 2013.... - Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNATiziana Squillaro
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania, USA
FASEB J 24:1593-603. 2010..Nevertheless, MECP2 partial silencing did not change the methylation of promoters, whose expression is affected by MECP2 down-regulation... - Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR'sAndrew Puca
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University Philadelphia, PA, USA
Oncotarget 3:426-34. 2012.... - NSP 5a3a: a potential novel cancer target in head and neck carcinomaLuca D'Agostino
Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology Temple University, 1900 North 12th street room 431, Philadelphia, PA 19122, USA
Oncotarget 1:423-35. 2010..We propose NSP 5a3a as a potential therapeutic target for site directed cancer treatment in perhaps certain head and neck carcinomas by induction of apoptosis... - p53 gene mutational rate, Gleason score, and BK virus infection in prostate adenocarcinoma: Is there a correlation?Giuseppe Russo
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania
J Med Virol 80:2100-7. 2008..This study suggests that BKV acts as cofactor in the pathogenesis of prostate cancer. These observations emphasize previous studies regarding the cellular pathways that may be deregulated by BKV... - Insertional mutagenesis and development of malignancies induced by integrating gene delivery systems: implications for the design of safer gene-based interventions in patientsGaetano Romano
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Drug News Perspect 22:185-96. 2009..In this respect, a particular emphasis was placed on the engineering of enhancer-less self-inactivating retroviridae-based systems... - Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancerEliseo Mattioli
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 210:183-91. 2007..05). Altogether, these data may help shed some additional light on the pathogenetic mechanisms related to the two main gastric cancer histotypes and their invasive potentials... - Modulation of cell cycle components by epigenetic and genetic eventsMarcella Macaluso
Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Semin Oncol 32:452-7. 2005..This review focuses on the genetic and epigenetic alterations affecting the components of mechanisms regulating the progression of the cell cycle and leading to cancer formation and progression... - Frequent loss of pRb2/p130 in human ovarian carcinomaGiuseppina D'Andrilli
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Clin Cancer Res 10:3098-103. 2004..2, a region in which deletions have been found in several human neoplasms including breast, prostatic, and ovarian carcinoma. We sought to evaluate pRb2/p130 protein expression and function in ovarian carcinoma... - Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cellsTiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Methods Mol Biol 285:141-8. 2004 - Frequent loss of expression of the cyclin-dependent kinase inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomasValeria Masciullo
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Clin Cancer Res 9:5332-8. 2003..Low levels of p27 are associated with poor prognosis in a variety of gynecological tumors, including breast, ovarian, and cervical carcinomas. The role of p27 in endometrial cancer remains controversial... - Physical interaction between pRb and cdk9/cyclinT2 complexCristiano Simone
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA
Oncogene 21:4158-65. 2002.... - Human immunodeficiency virus type 1 (HIV-1) derived vectors: safety considerations and controversy over therapeutic applicationsGaetano Romano
Department of Neurosurgery, The Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, College Building, Suite 501, 1025 Walnut Street, Philadelphia, PA 19107, USA
Eur J Dermatol 13:424-9. 2003..On these grounds, it seems necessary to improve the design of other lentiviral vectors, which derive from viruses that are not pathogenic in humans and are distantly related to primate retroviridae... - pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulationBruna Pucci
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Oncogene 21:5897-905. 2002..Our data suggest a role for pRb2/p130 in glioblastoma gamma-radiation-induced cell death, indicating that the antitumoral action of pRb2/p130 can regulate both inhibition of cell cycle progression and induction of cell death... - Epigenetic modulation of estrogen receptor-alpha by pRb family proteins: a novel mechanism in breast cancerMarcella Macaluso
Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cancer Res 67:7731-7. 2007.... - From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathwayAng Sun
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, USA
J Cell Biochem 102:1400-4. 2007..This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression... - New players in ovarian cancerAlessandro Bovicelli
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
J Cell Physiol 226:2500-4. 2011..Together these studies can improve our knowledge of ovarian cancer tumorigenesis and diagnosis providing new tools to hopefully defeat this deadly disease... - A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinomaLuca D'Agostino
Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology Temple University, 1900 North 12th street room 431, Philadelphia PA 19122, USA
Oncotarget 2:1055-74. 2011..Interestingly, this novel mechanism appears independent of canonical caspases involved in the intrinsic mitochondrial pathway as well as those in the death receptor pathway thru TRAF2 and TRADD... - On the role of retinoblastoma family proteins in the establishment and maintenance of the epigenetic landscapeFrancesco Paolo Fiorentino
Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 228:276-84. 2013.... - Insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and AP-1 sites in breast cancer cellsSandra Cascio
Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia Pennsylvania 19122, USA
J Biol Chem 282:3498-506. 2007..IGF-1 potentiated the effects of E2 on ERE but not to AP-1 and increased E2-dependent pS2, but not cyclin D1, mRNA expression. In conclusion, E2 and IGF-1 differentially regulate ER transcription at ERE and AP-1 sites... - Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapyAntonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 213:403-6. 2007..This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment... - Chaotic dynamic stabilities and instabilities of hematopoietic stem cell growth plasticityAndrew Puca
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology College of Science and Technology, Temple University Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 213:672-8. 2007.... - CDK inhibitors: from the bench to clinical trialsFlavio Rizzolio
Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicines, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Curr Drug Targets 11:279-90. 2010..In this review, we discuss new strategies and methods to design more potent, selective and specific CDK inhibitors, starting from evidence emerging from animal and cancer cell models... - New insights in endometrial carcinogenesisGiuseppina D'Andrilli
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, PA 19122, USA
J Cell Physiol 227:2842-6. 2012..We focus on studies that describe markers with potential to progress from endometrial hyperplasia to invasive disease... - Expression profiles of micro RNA in proliferating and differentiating 32D murine myeloid cellsBin Shi
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Cell Physiol 207:706-10. 2006..We present here the data obtained with miR micro-arrays and identify the miR that are regulated by IGF-1 or G-CSF and are associated with either differentiation or indefinite cell proliferation of 32D murine myeloid cells... - How does DNA methylation mark the fate of cells?Marcella Macaluso
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA
Tumori 90:367-72. 2004..In this review we focus on the epigenetic molecular mechanisms during normal development and discuss how DNA methylation could affect the expression of genes leading to cancer transformation... - miRNAs: from biogenesis to networksGiuseppe Russo
Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Methods Mol Biol 563:303-52. 2009.... - Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf-1, p27, and PCNA in Barrett's esophagusElettra Merola
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122-6099, USA
J Cell Physiol 207:512-9. 2006.... - Overexpression of γ-tubulin in non-small cell lung cancerNicoletta F Maounis
Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134, USA
Histol Histopathol 27:1183-94. 2012..In both tumor cell lines increase in TUBG1 and TUBG2 transcripts was detected by RT-qPCR. Our results reveal for the first time an increased expression of γ-tubulin in lung cancer... - Determination of functional viral titer by drug-resistance colony assay, expression of green fluorescent protein, and beta-galactoside stainingTiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Methods Mol Biol 285:149-53. 2004 - Epigenetic information and estrogen receptor alpha expression in breast cancerLaura Giacinti
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania 19122-6009, USA
Oncologist 11:1-8. 2006..This paper reviews the current understanding of the role of epigenetic information in the development of cancer and its significance in breast cancer as predictive markers of ER status and as new targets of anticancer therapy... - Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokinesGiulia De Falco
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, PA 19122, USA
Oncogene 21:7464-70. 2002..We also observed that Cdk9 synergized with IL-6 in inducing the activation of an IL-6-responsive reporter plasmid. In summary, these results point to a previously undisclosed role for Cdk9 in signal transduction... - Advantages and limitations of microarray technology in human cancerGiuseppe Russo
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Oncogene 22:6497-507. 2003.... - The tumor suppressor role of CTCFFrancesco Paolo Fiorentino
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 227:479-92. 2012..Indeed, the ability of CTCF to bind their promoters strictly depends by cell-type features as DNA methylation, BORIS-binding and post-translational modifications as PARYlation... - Interaction of PP2A catalytic subunit with Rb2/p130 is required for all-trans retinoic acid suppression of ovarian carcinoma cell growthEnkhtsetseg Purev
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Cell Physiol 206:495-502. 2006..These studies suggest that ATRA treatment suppresses the growth of CAOV3 cells via a novel posttranscriptional mechanism involving PP2A... - Clinical trialsLaura Giacinti
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA
Front Biosci 11:2918-23. 2006..This paper reviews the principal phases of clinical trials and discusses the basic requirements needed to ensure a well-conducted experimental study... - Medulloblastoma: from molecular pathology to therapyAlessandra Rossi
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
Clin Cancer Res 14:971-6. 2008.... - Adenosine receptor ligands in clinical trialsFlavio Rizzolio
Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Curr Top Med Chem 10:1036-45. 2010..In this review, we highlight the mouse animal models that have been of use in designing new selective drugs as well as discuss the main adenosine receptor ligands in clinical trials... - Genetic and epigenetic alterations in breast cancer: what are the perspectives for clinical practice?Alfredo Fucito
Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
Int J Biochem Cell Biol 40:565-75. 2008..In this respect, the field of cancer research has placed a particular emphasis on the elucidation of genetic and epigenetic alterations that may lead to the pathogenesis of breast cancer and contribute to its progression... - pRB2/p130 target genes in non-small lung cancer cells identified by microarray analysisGiuseppe Russo
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Oncogene 22:6959-69. 2003..Our results may also contribute to identifying novel therapeutic biomarkers in lung carcinoma... - Identification of murine cdk10: association with Ets2 transcription factor and effects on the cell cycleLuigi Bagella
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Biochem 99:978-85. 2006..Murine cdk10 binds Ets2 transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed... - pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significancePier Paolo Claudio
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Clin Cancer Res 10:3509-17. 2004..Additional studies with larger numbers of patient data would allow the use of multivariable techniques and would be able to further identify patients with poorer survival... - Genetic and epigenetic alterations as hallmarks of the intricate road to cancerMarcella Macaluso
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA
Oncogene 22:6472-8. 2003..This review focuses on the genetic and epigenetic molecular mechanisms involved in cancer onset and progression, and discusses the possibility of new strategies in the development of anticancer treatments... - Prostaglandin E2: at the crossroads between stem cell development, inflammation and cancerCaitlin Marie Logan
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cancer Biol Ther 6:1517-20. 2007.... - Cell cycle genes in ovarian cancer: steps toward earlier diagnosis and novel therapiesChristine Kumar
Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Clin Cancer Res 10:8132-41. 2004..We sought to divide cell cycle-regulatory genes into four subgroups on the basis of their predominant role in a specific phase or during the transition between two phases of the cell cycle... - Helicobacter pylori as a class I carcinogen: physiopathology and management strategiesParaskevi Vogiatzi
Sbarro Institute for Cancer Research and Molecular Medicine, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Biochem 102:264-73. 2007.... - RB gene family: genome-wide ChIP approaches could open undiscovered roadsFlavio Rizzolio
Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Biochem 109:839-43. 2010..There are also new, possible directions that are suggested within the review that can be followed to further explore the role of each pRb members in the transcriptional networks of the cell... - Aging of the inceptive cellular population: the relationship between stem cells and agingCatherine E Symonds
Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, Temple University, Philadelphia, PA 19122, USA
Aging (Albany NY) 1:372-81. 2009..Here we will discuss the efforts of this research in the area of stem cells, delving into the regulatory mechanisms and how their de-regulation could be attributed to aging and age-related diseases... - Ubiquitin-mediated protein degradation and methylation-induced gene silencing cooperate in the inactivation of the INK4/ARF locus in Burkitt lymphoma cell linesAnnalisa Roberti
Sbarro Health Research Organization, and Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Cell Cycle 10:127-34. 2011.... - Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128aDavide Eletto
Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19112, USA
J Cell Physiol 216:764-70. 2008..Altogether, our data provide a novel mechanism by which HIV-Tat perturbs neuronal activity... - Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung cancerPier Paolo Claudio
Department of Biotechnology, Temple University, Philadelphia, PA, USA
Methods Mol Med 75:591-605. 2003 - Bacterial DNA microarrays for clinical microbiology: the early logarithmic phaseMarco Cassone
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122 6099, USA
Front Biosci 12:2658-69. 2007..Here, we provide an overview of the current use and the potential of DNA microarrays in clinical bacteriology, and several applications and technical solutions are discussed... - JC virus large T-antigen and IGF-I signaling system merge to affect DNA repair and genomic integrityKrzysztof Reiss
Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Biology Life Science Building, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 206:295-300. 2006.... - Detection of genetic elements carrying glycopeptide resistance clusters in Enterococcus by DNA microarraysMarco Cassone
LAMMB, Sezione di Microbiologia, Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
Mol Cell Probes 22:162-7. 2008.... - p53 and the malignant progression of Barrett's esophagusElettra Merola
Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Center for Biotechnology, Philadelphia 19122-6099, USA
J Cell Physiol 206:574-7. 2006..The aim of this review is to examine the published data regarding the role that assessment of p53 may play in the management of BE, trying to understand if it may be a useful marker to early diagnose BE malignant transformation... - Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseasesGaetano Romano
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cell Cycle 7:3664-8. 2008.... - The retinoblastoma family member pRb2/p130 is an independent predictor of survival in human soft tissue sarcomasValeria Masciullo
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19107 6799, USA
Clin Cancer Res 14:4775-9. 2008..We sought to evaluate pRb2/p130 protein expression and its clinical effect in patients affected with soft tissue sarcomas (STS)... - American Society of Gene Therapy--tenth annual meetingGaetano Romano
Temple University, 1801 North Broad Street, Philadelphia, PA 19122, USA
IDrugs 10:534-7. 2007 - Following the tracks of AKT1 geneParaskevi Vogiatzi
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cancer Biol Ther 6:1521-4. 2007..Here we give a critical appraisal of this finding and underline its clinical impact. We also discuss possible interventions for therapeutic development of AKT inhibitors to treat human cancer... - TMPRSS2:ERG gene fusion a new genetic marker for prostate cancer progressionMarcella Macaluso
Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cancer Biol Ther 6:46-7. 2007 - Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinomaPier Paolo Claudio
Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
Clin Cancer Res 8:1808-15. 2002.... - Interplay between cdk9 and NF-kappaB factors determines the level of HIV-1 gene transcription in astrocytic cellsShohreh Amini
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Room 203, Philadelphia, Pennsylvania, PA 19122, USA
Oncogene 21:5797-803. 2002..All of these observations led us to conclude that the interaction of cdk9 with the NF-kappaB factors can determine the ability of NF-kappaB to modulate HIV-1 gene transcription... - The bad and the good of mesenchymal stem cells in cancer: Boosters of tumor growth and vehicles for targeted delivery of anticancer agentsUmberto Galderisi
Umberto Galderisi, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, United States
World J Stem Cells 2:5-12. 2010..As with the two faces of Janus, this review will concisely explore the research activity in these two apparently conflicting fields... - Human polyomaviruses and brain tumorsMartyn K White
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015-96, Room 203, Philadelphia, PA 19122, USA
Brain Res Brain Res Rev 50:69-85. 2005.... - Activation of MyoD-dependent transcription by cdk9/cyclin T2Cristiano Simone
Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania, PA 19122, USA
Oncogene 21:4137-48. 2002..Finally, cdk9 can phosphorylate MyoD in vitro, suggesting the possibility that cdk9/cycT2a regulation of muscle differentiation includes the direct enzymatic activity of the kinase on MyoD... - Evidence for dysregulation of cell cycle by human polyomavirus, JCV, late auxiliary proteinArmine Darbinyan
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015-96, Philadelphia, Pennsylvania, PA 19122, USA
Oncogene 21:5574-81. 2002..Thus, the interaction of p53 and Agnoprotein can lead to a higher level of p21 expression and suppression of cell cycle progression during the cell cycle... - Adenoviral E1A: everlasting tool, versatile applications, continuous contributions and new hypothesesNianli Sang
Cardeza Foundation for Hematological Research, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
Front Biosci 7:d407-13. 2002.... - Tumor-specific exon 1 mutations could be the 'hit event' predisposing Rb2/p130 gene to epigenetic silencing in lung cancerCaterina Cinti
Institute of Clinical Physiology, CNR, Siena Unity, Italy
Oncogene 24:5821-6. 2005..Moreover, these homozygous mutations, found in different tumor histotypes, could represent tumor-specific markers... - Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approachGian Marco Tosi
Department of Ophthalmology and Neurosurgery, University of Siena, Italy
Oncogene 24:5827-36. 2005..Overall, our results highlight a crucial role of epigenetic events in sporadic retinoblastoma, which opens a perspective for new therapeutic approaches... - Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesisStefano Lazzi
Institute of Pathological Anatomy and Histology, University of Siena, Siena, Italy
Hum Pathol 33:723-31. 2002..In conclusion, our results seem to suggest that pRb2/p130 oncosuppressor protein may be a target in the interaction between the HIV-1 gene products and host proteins... - Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300Cristiano Simone
Laboratory of Gene Expression, Dulbecco Telethon Institute DTI at Fondazione A Cesalpino, University of Roma La Sapienza, Italy
Oncogene 23:2177-87. 2004.... - Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumorsMicaela Montanari
Istituto di Patologia Generale Centro di Ricerche Oncologiche Giovanni XXIII, Catholic University School of Medicine, Largo Francesco Vito 1, Rome, Italy
J Cell Physiol 202:215-22. 2005..These results demonstrate that expression of geminin is frequently deregulated in tumor cells and might play an important role in the regulation of cell growth in both normal and malignant cells... - The transcriptional co-activators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascadeRosalind Gusterson
Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, United Kingdom
J Biol Chem 277:2517-24. 2002..To our knowledge, this is the first report of a specific stimulus modulating the activity of CBP and p300 in cardiac cells and it suggests that these factors play an important role in the hypertrophic effect of PE...
Research Grants
- pRb2/p130: from the mechanisms to gene therapyAntonio Giordano; Fiscal Year: 2007..abstract_text> ..
- Interaction between HIV-1 and cell cycle proteinsAntonio Giordano; Fiscal Year: 2003..In particular, we will focus our attention on the cell cycle regulatory proteins, pRb2/pl30, Cdk9 and cycT1, which seem to be involved in AIDS-related tumorigenesis. ..
- MODULATION OF PRB2/P130 MEDIATED GROWTH SUPPRESSIONAntonio Giordano; Fiscal Year: 2002..To understand the regulatory function of pRb2/p130 phosphorylation, c. To define the role of the Rb2/p130 gene in human lung cancer development and progression, d. To prepare viral models for studying pRB2/p130 in vivo. ..