Antonio Giordano

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma
    Luca D'Agostino
    Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology Temple University, 1900 North 12th street room 431, Philadelphia PA 19122, USA
    Oncotarget 2:1055-74. 2011
  2. ncbi NSP 5a3a: a potential novel cancer target in head and neck carcinoma
    Luca D'Agostino
    Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology Temple University, 1900 North 12th street room 431, Philadelphia, PA 19122, USA
    Oncotarget 1:423-35. 2010
  3. ncbi Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 110:182-90. 2010
  4. ncbi Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 23:4930-7. 2004
  5. ncbi Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications
    Giuseppe Russo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122-6099, USA
    Clin Cancer Res 11:3265-73. 2005
  6. ncbi Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Cell Cycle 11:1202-16. 2012
  7. ncbi Frequent loss of pRb2/p130 in human ovarian carcinoma
    Giuseppina D'Andrilli
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Clin Cancer Res 10:3098-103. 2004
  8. ncbi IRS-1-Rad51 nuclear interaction sensitizes JCV T-antigen positive medulloblastoma cells to genotoxic treatment
    Joanna Trojanek
    Center for Neurovirology, Department of Neuroscience, Temple University, Philadelphia, PA 19122, USA
    Int J Cancer 119:539-48. 2006
  9. ncbi Cdk9 phosphorylates p53 on serine 392 independently of CKII
    Pier Paolo Claudio
    Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 208:602-12. 2006
  10. ncbi pRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Clin Cancer Res 10:8085-93. 2004

Detail Information

Publications86

  1. ncbi A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma
    Luca D'Agostino
    Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology Temple University, 1900 North 12th street room 431, Philadelphia PA 19122, USA
    Oncotarget 2:1055-74. 2011
    ..Interestingly, this novel mechanism appears independent of canonical caspases involved in the intrinsic mitochondrial pathway as well as those in the death receptor pathway thru TRAF2 and TRADD...
  2. ncbi NSP 5a3a: a potential novel cancer target in head and neck carcinoma
    Luca D'Agostino
    Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology Temple University, 1900 North 12th street room 431, Philadelphia, PA 19122, USA
    Oncotarget 1:423-35. 2010
    ..We propose NSP 5a3a as a potential therapeutic target for site directed cancer treatment in perhaps certain head and neck carcinomas by induction of apoptosis...
  3. ncbi Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 110:182-90. 2010
    ..In turn, this "perturbation" may trigger a network of signals strictly connected with survival and apoptosis...
  4. ncbi Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 23:4930-7. 2004
    ..In this study, we propose a new mechanism for the functional inactivation of pRb2/p130 that ultimately contributes to cell cycle progression and malignant transformation...
  5. ncbi Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications
    Giuseppe Russo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122-6099, USA
    Clin Cancer Res 11:3265-73. 2005
    ..Additionally, E2F4 showed an identical localization pattern as to that of pRb2/p130. These data suggests an important role for pRb2/p130 in the pathogenesis and progression of certain salivary gland cancers...
  6. ncbi Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Cell Cycle 11:1202-16. 2012
    ..This finding also shows that Cdk9 and Cdk7 pathways are not redundant and may have important implications in drug development and for studying the mechanism of chemoresistance in malignant cells...
  7. ncbi Frequent loss of pRb2/p130 in human ovarian carcinoma
    Giuseppina D'Andrilli
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Clin Cancer Res 10:3098-103. 2004
    ..2, a region in which deletions have been found in several human neoplasms including breast, prostatic, and ovarian carcinoma. We sought to evaluate pRb2/p130 protein expression and function in ovarian carcinoma...
  8. ncbi IRS-1-Rad51 nuclear interaction sensitizes JCV T-antigen positive medulloblastoma cells to genotoxic treatment
    Joanna Trojanek
    Center for Neurovirology, Department of Neuroscience, Temple University, Philadelphia, PA 19122, USA
    Int J Cancer 119:539-48. 2006
    ..JCV T-antigen did not affect HRR directly. In the presence of JCV T-antigen, insulin receptor substrate 1 (IRS-1) translocated to the nucleus where it co-localized with Rad51, possibly attenuating HRR...
  9. ncbi Cdk9 phosphorylates p53 on serine 392 independently of CKII
    Pier Paolo Claudio
    Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 208:602-12. 2006
    ..These studies demonstrate the existence of a feedback-loop between p53 and cdk9, pinpointing a novel mechanism by which p53 regulates the basal transcriptional machinery...
  10. ncbi pRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Clin Cancer Res 10:8085-93. 2004
    ....
  11. ncbi Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma
    Marcella Macaluso
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Cell Cycle 11:1841-50. 2012
    ....
  12. ncbi pRB2/p130 target genes in non-small lung cancer cells identified by microarray analysis
    Giuseppe Russo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 22:6959-69. 2003
    ..Our results may also contribute to identifying novel therapeutic biomarkers in lung carcinoma...
  13. ncbi Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
    J Cell Physiol 223:519-29. 2010
    ..Our data indicate that overexpression of gamma-tubulin may be linked to phenotypic dedifferentiation (anaplasia) and tumor progression in medulloblastomas and may potentially serve as a promising tumor marker...
  14. ncbi NSP 5a3a's link to nuclear-cyto proteins B23 and hnRNP-L between normal and aberrant breast cell lines
    Luca D'Agostino
    Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Cell Cycle 9:1131-42. 2010
    ....
  15. ncbi CTCF and BORIS regulate Rb2/p130 gene transcription: a novel mechanism and a new paradigm for understanding the biology of lung cancer
    Francesco Paolo Fiorentino
    Sbarro Health Research Organization, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Mol Cancer Res 9:225-33. 2011
    ....
  16. ncbi Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAg
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 212:96-104. 2007
    ..Moreover, Small interference RNA experiments directed toward silencing the Rb2/p130 gene demonstrated that pRb2/p130 does not play a predominant role in the nuclear transportation of E2F4 and E2F5...
  17. ncbi Androgen receptor serine 81 mediates Pin1 interaction and activity
    Raffaele La Montagna
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Cell Cycle 11:3415-20. 2012
    ..Since Pin1 expression positively correlates with tumor grade, our results suggest that Pin1 can participate in this process by modulating AR function...
  18. ncbi Dissecting Pin1 and phospho-pRb regulation
    Flavio Rizzolio
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 228:73-7. 2013
    ....
  19. ncbi pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significance
    Pier Paolo Claudio
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Clin Cancer Res 10:3509-17. 2004
    ..Additional studies with larger numbers of patient data would allow the use of multivariable techniques and would be able to further identify patients with poorer survival...
  20. ncbi pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer
    Marcella Macaluso
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Oncogene 22:3511-7. 2003
    ....
  21. ncbi Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cells
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:141-8. 2004
  22. ncbi New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells
    Alessandra Rossi
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, 1900 North 12th St, Philadelphia, PA 19122, USA
    FASEB J 24:2881-92. 2010
    ..In conclusion, our results suggest that S7, S29, and SI163 could be novel attractive candidates for the treatment of medulloblastoma or tumors characterized by high Src activity...
  23. ncbi Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA
    Tiziana Squillaro
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania, USA
    FASEB J 24:1593-603. 2010
    ..Nevertheless, MECP2 partial silencing did not change the methylation of promoters, whose expression is affected by MECP2 down-regulation...
  24. ncbi Analysis of a mutant p53 protein arising in a medulloblastoma from a mouse transgenic for the JC virus early region
    Martyn K White
    Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Anticancer Res 26:4079-92. 2006
    ..In T-negative clones, a novel mutant p53 was detected (p53(mt))...
  25. ncbi Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:155-7. 2004
  26. ncbi Cdk9-55: a new player in muscle regeneration
    Cristina Giacinti
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, USA
    J Cell Physiol 216:576-82. 2008
    ..This alternative form is specifically induced in injured myofibers and its activity is strictly required for the completion of muscle regeneration process...
  27. ncbi Possible functional role of NSPs in cancer
    Luca D'Agostino
    Sbarro Institute for Cancer Research and Molecular Medicine and Department of Biology, College of Science and Technology Temple University, Philadelphia, Pennsylvania 19122, USA
    Cell Cycle 7:1810-27. 2008
    ....
  28. ncbi Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancer
    Eliseo Mattioli
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 210:183-91. 2007
    ..05). Altogether, these data may help shed some additional light on the pathogenetic mechanisms related to the two main gastric cancer histotypes and their invasive potentials...
  29. ncbi Determination of functional viral titer by drug-resistance colony assay, expression of green fluorescent protein, and beta-galactoside staining
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:149-53. 2004
  30. ncbi R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair
    Mario Federico
    Sbarro Health Research Organization, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
    Mol Cancer 9:208. 2010
    ..To see if we could therapeutically block this switch, we analyzed the effects of the CDK-inhibitor R-Roscovitine on the expression levels of cyclin A1 under genotoxic stress and observed subsequent DNA damage and repair mechanisms...
  31. ncbi Modulation of cell cycle components by epigenetic and genetic events
    Marcella Macaluso
    Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Semin Oncol 32:452-7. 2005
    ..This review focuses on the genetic and epigenetic alterations affecting the components of mechanisms regulating the progression of the cell cycle and leading to cancer formation and progression...
  32. ncbi On the role of retinoblastoma family proteins in the establishment and maintenance of the epigenetic landscape
    Francesco Paolo Fiorentino
    Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 228:276-84. 2013
    ....
  33. ncbi Frequent loss of expression of the cyclin-dependent kinase inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas
    Valeria Masciullo
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 9:5332-8. 2003
    ..Low levels of p27 are associated with poor prognosis in a variety of gynecological tumors, including breast, ovarian, and cervical carcinomas. The role of p27 in endometrial cancer remains controversial...
  34. ncbi New players in ovarian cancer
    Alessandro Bovicelli
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    J Cell Physiol 226:2500-4. 2011
    ..Together these studies can improve our knowledge of ovarian cancer tumorigenesis and diagnosis providing new tools to hopefully defeat this deadly disease...
  35. ncbi Epigenetic modulation of estrogen receptor-alpha by pRb family proteins: a novel mechanism in breast cancer
    Marcella Macaluso
    Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Cancer Res 67:7731-7. 2007
    ....
  36. ncbi CDK inhibitors: from the bench to clinical trials
    Flavio Rizzolio
    Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicines, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Curr Drug Targets 11:279-90. 2010
    ..In this review, we discuss new strategies and methods to design more potent, selective and specific CDK inhibitors, starting from evidence emerging from animal and cancer cell models...
  37. ncbi From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway
    Ang Sun
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 102:1400-4. 2007
    ..This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression...
  38. ncbi Emerging molecular networks in Burkitt's lymphoma
    Davide Mangani
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    J Cell Biochem 114:35-8. 2013
    ..In this review, we integrate our discovery with the general view of BL and propose a new comprehensive approach to analyze and manage this aggressive disease...
  39. ncbi New insights in endometrial carcinogenesis
    Giuseppina D'Andrilli
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, PA 19122, USA
    J Cell Physiol 227:2842-6. 2012
    ..We focus on studies that describe markers with potential to progress from endometrial hyperplasia to invasive disease...
  40. ncbi pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation
    Bruna Pucci
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Oncogene 21:5897-905. 2002
    ..Our data suggest a role for pRb2/p130 in glioblastoma gamma-radiation-induced cell death, indicating that the antitumoral action of pRb2/p130 can regulate both inhibition of cell cycle progression and induction of cell death...
  41. ncbi miRNAs: from biogenesis to networks
    Giuseppe Russo
    Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 563:303-52. 2009
    ....
  42. ncbi Insertional mutagenesis and development of malignancies induced by integrating gene delivery systems: implications for the design of safer gene-based interventions in patients
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Drug News Perspect 22:185-96. 2009
    ..In this respect, a particular emphasis was placed on the engineering of enhancer-less self-inactivating retroviridae-based systems...
  43. ncbi Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy
    Antonio Giordano
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 213:403-6. 2007
    ..This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment...
  44. ncbi Human immunodeficiency virus type 1 (HIV-1) derived vectors: safety considerations and controversy over therapeutic applications
    Gaetano Romano
    Department of Neurosurgery, The Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, College Building, Suite 501, 1025 Walnut Street, Philadelphia, PA 19107, USA
    Eur J Dermatol 13:424-9. 2003
    ..On these grounds, it seems necessary to improve the design of other lentiviral vectors, which derive from viruses that are not pathogenic in humans and are distantly related to primate retroviridae...
  45. ncbi MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions
    Cristina Giacinti
    Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 206:807-13. 2006
    ....
  46. ncbi Epigenetic information and estrogen receptor alpha expression in breast cancer
    Laura Giacinti
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania 19122-6009, USA
    Oncologist 11:1-8. 2006
    ..This paper reviews the current understanding of the role of epigenetic information in the development of cancer and its significance in breast cancer as predictive markers of ER status and as new targets of anticancer therapy...
  47. ncbi Expression profiles of micro RNA in proliferating and differentiating 32D murine myeloid cells
    Bin Shi
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Physiol 207:706-10. 2006
    ..We present here the data obtained with miR micro-arrays and identify the miR that are regulated by IGF-1 or G-CSF and are associated with either differentiation or indefinite cell proliferation of 32D murine myeloid cells...
  48. ncbi The tumor suppressor role of CTCF
    Francesco Paolo Fiorentino
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 227:479-92. 2012
    ..Indeed, the ability of CTCF to bind their promoters strictly depends by cell-type features as DNA methylation, BORIS-binding and post-translational modifications as PARYlation...
  49. ncbi Overexpression of γ-tubulin in non-small cell lung cancer
    Nicoletta F Maounis
    Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134, USA
    Histol Histopathol 27:1183-94. 2012
    ..In both tumor cell lines increase in TUBG1 and TUBG2 transcripts was detected by RT-qPCR. Our results reveal for the first time an increased expression of γ-tubulin in lung cancer...
  50. ncbi Advantages and limitations of microarray technology in human cancer
    Giuseppe Russo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 22:6497-507. 2003
    ....
  51. ncbi Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung cancer
    Pier Paolo Claudio
    Department of Biotechnology, Temple University, Philadelphia, PA, USA
    Methods Mol Med 75:591-605. 2003
  52. ncbi How does DNA methylation mark the fate of cells?
    Marcella Macaluso
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Tumori 90:367-72. 2004
    ..In this review we focus on the epigenetic molecular mechanisms during normal development and discuss how DNA methylation could affect the expression of genes leading to cancer transformation...
  53. ncbi Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf-1, p27, and PCNA in Barrett's esophagus
    Elettra Merola
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122-6099, USA
    J Cell Physiol 207:512-9. 2006
    ....
  54. ncbi Genetic and epigenetic alterations in breast cancer: what are the perspectives for clinical practice?
    Alfredo Fucito
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Int J Biochem Cell Biol 40:565-75. 2008
    ..In this respect, the field of cancer research has placed a particular emphasis on the elucidation of genetic and epigenetic alterations that may lead to the pathogenesis of breast cancer and contribute to its progression...
  55. ncbi Identification of murine cdk10: association with Ets2 transcription factor and effects on the cell cycle
    Luigi Bagella
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 99:978-85. 2006
    ..Murine cdk10 binds Ets2 transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed...
  56. ncbi Interaction of PP2A catalytic subunit with Rb2/p130 is required for all-trans retinoic acid suppression of ovarian carcinoma cell growth
    Enkhtsetseg Purev
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Physiol 206:495-502. 2006
    ..These studies suggest that ATRA treatment suppresses the growth of CAOV3 cells via a novel posttranscriptional mechanism involving PP2A...
  57. ncbi Medulloblastoma: from molecular pathology to therapy
    Alessandra Rossi
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Department of Neuroscience, School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    Clin Cancer Res 14:971-6. 2008
    ....
  58. ncbi Helicobacter pylori as a class I carcinogen: physiopathology and management strategies
    Paraskevi Vogiatzi
    Sbarro Institute for Cancer Research and Molecular Medicine, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 102:264-73. 2007
    ....
  59. ncbi Human polyomaviruses and brain tumors
    Martyn K White
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015-96, Room 203, Philadelphia, PA 19122, USA
    Brain Res Brain Res Rev 50:69-85. 2005
    ....
  60. ncbi RB gene family: genome-wide ChIP approaches could open undiscovered roads
    Flavio Rizzolio
    Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 109:839-43. 2010
    ..There are also new, possible directions that are suggested within the review that can be followed to further explore the role of each pRb members in the transcriptional networks of the cell...
  61. ncbi The retinoblastoma family: twins or distant cousins?
    Pier Paolo Claudio
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technologies, Temple University, Philadelphia, PA 19122, USA
    Genome Biol 3:reviews3012. 2002
    ....
  62. ncbi Aging of the inceptive cellular population: the relationship between stem cells and aging
    Catherine E Symonds
    Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, Temple University, Philadelphia, PA 19122, USA
    Aging (Albany NY) 1:372-81. 2009
    ..Here we will discuss the efforts of this research in the area of stem cells, delving into the regulatory mechanisms and how their de-regulation could be attributed to aging and age-related diseases...
  63. ncbi Clinical trials
    Laura Giacinti
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Front Biosci 11:2918-23. 2006
    ..This paper reviews the principal phases of clinical trials and discusses the basic requirements needed to ensure a well-conducted experimental study...
  64. ncbi Ubiquitin-mediated protein degradation and methylation-induced gene silencing cooperate in the inactivation of the INK4/ARF locus in Burkitt lymphoma cell lines
    Annalisa Roberti
    Sbarro Health Research Organization, and Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Cell Cycle 10:127-34. 2011
    ....
  65. ncbi Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a
    Davide Eletto
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19112, USA
    J Cell Physiol 216:764-70. 2008
    ..Altogether, our data provide a novel mechanism by which HIV-Tat perturbs neuronal activity...
  66. ncbi Cell cycle genes in ovarian cancer: steps toward earlier diagnosis and novel therapies
    Christine Kumar
    Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Clin Cancer Res 10:8132-41. 2004
    ..We sought to divide cell cycle-regulatory genes into four subgroups on the basis of their predominant role in a specific phase or during the transition between two phases of the cell cycle...
  67. ncbi Bacterial DNA microarrays for clinical microbiology: the early logarithmic phase
    Marco Cassone
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122 6099, USA
    Front Biosci 12:2658-69. 2007
    ..Here, we provide an overview of the current use and the potential of DNA microarrays in clinical bacteriology, and several applications and technical solutions are discussed...
  68. ncbi Carcinogenesis and environment: the cancer stem cell hypothesis and implications for the development of novel therapeutics and diagnostics
    Antonio Giordano
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Front Biosci 12:3475-82. 2007
    ....
  69. ncbi Detection of genetic elements carrying glycopeptide resistance clusters in Enterococcus by DNA microarrays
    Marco Cassone
    LAMMB, Sezione di Microbiologia, Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    Mol Cell Probes 22:162-7. 2008
    ....
  70. ncbi American Society of Gene Therapy--tenth annual meeting
    Gaetano Romano
    Temple University, 1801 North Broad Street, Philadelphia, PA 19122, USA
    IDrugs 10:534-7. 2007
  71. ncbi Interaction between the Cdk2/cyclin A complex and a small molecule derived from the pRb2/p130 spacer domain: a theoretical model
    Antonio Giordano
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Cell Cycle 6:2591-3. 2007
    ..We believe this model to be useful for the rational development of peptide or peptidomimetic kinase inhibitors for negative cell cycle modulation in cancer cells...
  72. ncbi JC virus large T-antigen and IGF-I signaling system merge to affect DNA repair and genomic integrity
    Krzysztof Reiss
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Biology Life Science Building, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 206:295-300. 2006
    ....
  73. ncbi From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells
    Antonio Giordano
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania, USA
    J Cell Physiol 211:27-35. 2007
    ..Finally, we will provide information about biotech companies developing MSC therapy...
  74. ncbi A gene highly expressed in tumor cells encodes novel structure proteins
    Nianli Sang
    Program of Molecular Biology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 23:9438-46. 2004
    ..These results suggest that NSPs represent a new family of structure proteins with a possible role in nuclear dynamics during cell division, and that NSP5alpha3alpha may serve as a tumor marker...
  75. ncbi Adenosine receptor ligands in clinical trials
    Flavio Rizzolio
    Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Curr Top Med Chem 10:1036-45. 2010
    ..In this review, we highlight the mouse animal models that have been of use in designing new selective drugs as well as discuss the main adenosine receptor ligands in clinical trials...
  76. ncbi Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines
    Giulia De Falco
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, PA 19122, USA
    Oncogene 21:7464-70. 2002
    ..We also observed that Cdk9 synergized with IL-6 in inducing the activation of an IL-6-responsive reporter plasmid. In summary, these results point to a previously undisclosed role for Cdk9 in signal transduction...
  77. ncbi The retinoblastoma family member pRb2/p130 is an independent predictor of survival in human soft tissue sarcomas
    Valeria Masciullo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19107 6799, USA
    Clin Cancer Res 14:4775-9. 2008
    ..We sought to evaluate pRb2/p130 protein expression and its clinical effect in patients affected with soft tissue sarcomas (STS)...
  78. ncbi Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis
    Elena Fiorio
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, USA
    BMC Cancer 8:305. 2008
    ..Next, we studied if leptin/ObR can coexist with HER2 in breast cancer tissues, and if presence of these two systems correlates with specific clinicopathological features...
  79. ncbi Physical interaction between pRb and cdk9/cyclinT2 complex
    Cristiano Simone
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA
    Oncogene 21:4158-65. 2002
    ....
  80. ncbi Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma
    Pier Paolo Claudio
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Clin Cancer Res 8:1808-15. 2002
    ....
  81. ncbi Interplay between cdk9 and NF-kappaB factors determines the level of HIV-1 gene transcription in astrocytic cells
    Shohreh Amini
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Room 203, Philadelphia, Pennsylvania, PA 19122, USA
    Oncogene 21:5797-803. 2002
    ..All of these observations led us to conclude that the interaction of cdk9 with the NF-kappaB factors can determine the ability of NF-kappaB to modulate HIV-1 gene transcription...
  82. ncbi Activation of MyoD-dependent transcription by cdk9/cyclin T2
    Cristiano Simone
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania, PA 19122, USA
    Oncogene 21:4137-48. 2002
    ..Finally, cdk9 can phosphorylate MyoD in vitro, suggesting the possibility that cdk9/cycT2a regulation of muscle differentiation includes the direct enzymatic activity of the kinase on MyoD...
  83. ncbi Evidence for dysregulation of cell cycle by human polyomavirus, JCV, late auxiliary protein
    Armine Darbinyan
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015-96, Philadelphia, Pennsylvania, PA 19122, USA
    Oncogene 21:5574-81. 2002
    ..Thus, the interaction of p53 and Agnoprotein can lead to a higher level of p21 expression and suppression of cell cycle progression during the cell cycle...
  84. ncbi Prostaglandin E2: at the crossroads between stem cell development, inflammation and cancer
    Caitlin Marie Logan
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Cancer Biol Ther 6:1517-20. 2007
    ....
  85. ncbi Genetic and epigenetic alterations as hallmarks of the intricate road to cancer
    Marcella Macaluso
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Oncogene 22:6472-8. 2003
    ..This review focuses on the genetic and epigenetic molecular mechanisms involved in cancer onset and progression, and discusses the possibility of new strategies in the development of anticancer treatments...
  86. ncbi Adenoviral E1A: everlasting tool, versatile applications, continuous contributions and new hypotheses
    Nianli Sang
    Cardeza Foundation for Hematological Research, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Front Biosci 7:d407-13. 2002
    ....