Nae Dun

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Irisin-immunoreactivity in neural and non-neural cells of the rodent
    S L Dun
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuroscience 240:155-62. 2013
  2. ncbi request reprint Cocaine- and amphetamine-regulated transcript peptide and sympatho-adrenal axis
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Peptides 27:1949-55. 2006
  3. ncbi request reprint KiSS-1 expression and metastin-like immunoreactivity in the rat brain
    G Cristina Brailoiu
    Department of Pharmacology, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Comp Neurol 481:314-29. 2005
  4. ncbi request reprint G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor
    Mizuo Mifune
    Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 280:26592-9. 2005
  5. ncbi request reprint Neuropeptide B immunoreactivity in the central nervous system of the rat
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, USA
    Brain Res 1045:157-63. 2005
  6. ncbi request reprint Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat-induced Ca(2+) overload and neuronal death in cultured rat cortical neurons
    Eugen Brailoiu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Neurovirol 12:17-24. 2006
  7. ncbi request reprint Messenger-specific role for nicotinic acid adenine dinucleotide phosphate in neuronal differentiation
    Eugen Brailoiu
    Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania, USA
    J Biol Chem 281:15923-8. 2006
  8. ncbi request reprint Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Endocrinology 147:3243-8. 2006
  9. ncbi request reprint Expression and activity of cocaine- and amphetamine-regulated transcript peptide(1-39) in the rat
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, 3400 N Broad Street, Philadelphia, PA 19140, USA
    Regul Pept 140:47-54. 2007
  10. ncbi request reprint Smooth muscle-associated protein 8: distribution and biological activity in the rat brain
    G Cristina Brailoiu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Neurosci Res 85:1789-96. 2007

Research Grants

  1. NEUROBIOLOGY OF ENDOMORPHINS IN SPINAL DORSAL HORN
    Nae Dun; Fiscal Year: 2002
  2. ACTIVITY OF BRAINSTEM NEURONS
    Nae Dun; Fiscal Year: 2003
  3. ACTIVITY OF BRAINSTEM NEURONS
    Nae Dun; Fiscal Year: 2007
  4. ACTIVITY OF PREGANGLIONIC NEURONS IN VITRO
    Nae Dun; Fiscal Year: 2007
  5. ACTIVITY OF PREGANGLIONIC NEURONS IN VITRO
    Nae Dun; Fiscal Year: 2001
  6. ACTIVITY OF BRAINSTEM NEURONS
    Nae J Dun; Fiscal Year: 2010

Collaborators

  • Jun Yang
  • Sandip Patel
  • Larry Sklar
  • Peter J Dempsey
  • Hieronim Jakubowski
  • ERIC R contact PROSSNITZ
  • Hong Wang
  • S Inan
  • Eugen Brailoiu
  • G Cristina Brailoiu
  • Siok L Dun
  • Jaw Kang Chang
  • Phouangmala Scruggs
  • Catalin M Filipeanu
  • Xiaohua Jiang
  • Keisuke Mizuo
  • S L Dun
  • Masahiro Ohsawa
  • Mizuo Mifune
  • Michelle Chi
  • Garrett M Sparks
  • Su Ying Wu
  • Robin L Cooper
  • Benedito H Machado
  • J K Chang
  • Y H Chen
  • J J Luo
  • R M Lyu
  • Wei Kung Hsieh
  • Xiaofeng Yang
  • Chih Chia Lai
  • Tudor I Oprea
  • William Durante
  • Andrew I Schafer
  • Fan Yang
  • Bassel E Sawaya
  • Vinita Pandey
  • Antonina Dolei
  • Giuseppe Mameli
  • Dev Churamani
  • Lee Yuan Liu-Chen
  • Florin Tuluc
  • Yulin Wang
  • Walter G Thomas
  • Shigeki Higashiyama
  • Haruhiko Ohtsu
  • Tadashi Inagami
  • Chih C Lai
  • Andrea D Eckhart
  • Jesse E Scruggs
  • Jennifer L Hoard
  • Deling Yin
  • Hiroyuki Suzuki
  • Gerald D Frank
  • Hidekatsu Nakashima
  • Satoru Eguchi
  • Jennifer Hoard
  • Ramona Godbolde
  • Yoshitaka Ohtubo
  • Qiang Zeng
  • Xiangqun Chen
  • Amy Parsons
  • Jami Tabor
  • Eng Ang Ling
  • Sonya Castellino
  • Leni G H Bonagamba
  • Yee Kong Ng
  • Siok Le Dun
  • Ernest H Kwok

Detail Information

Publications34

  1. pmc Irisin-immunoreactivity in neural and non-neural cells of the rodent
    S L Dun
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuroscience 240:155-62. 2013
    ....
  2. ncbi request reprint Cocaine- and amphetamine-regulated transcript peptide and sympatho-adrenal axis
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Peptides 27:1949-55. 2006
    ....
  3. ncbi request reprint KiSS-1 expression and metastin-like immunoreactivity in the rat brain
    G Cristina Brailoiu
    Department of Pharmacology, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Comp Neurol 481:314-29. 2005
    ..The results show that metastin is biologically active in rat central neurons, and its anatomical distribution suggests a possible role in nociception and autonomic and neuroendocrine functions...
  4. ncbi request reprint G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor
    Mizuo Mifune
    Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 280:26592-9. 2005
    ....
  5. ncbi request reprint Neuropeptide B immunoreactivity in the central nervous system of the rat
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, USA
    Brain Res 1045:157-63. 2005
    ....
  6. ncbi request reprint Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat-induced Ca(2+) overload and neuronal death in cultured rat cortical neurons
    Eugen Brailoiu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Neurovirol 12:17-24. 2006
    ..The result led the authors to conclude that alcohol exposure significantly potentiates Tat-induced calcium overload and neuronal death...
  7. ncbi request reprint Messenger-specific role for nicotinic acid adenine dinucleotide phosphate in neuronal differentiation
    Eugen Brailoiu
    Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania, USA
    J Biol Chem 281:15923-8. 2006
    ..Thus, differential recruitment of intracellular Ca2+-mobilizing messengers and their target Ca2+ stores may represent a robust means of maintaining stimulus fidelity in the control of Ca2+-dependent cell function...
  8. ncbi request reprint Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Endocrinology 147:3243-8. 2006
    ..The concentration of irINSL5 in the hypothalamic-pituitary axis suggests a neuroendocrine function of this insulin superfamily member...
  9. ncbi request reprint Expression and activity of cocaine- and amphetamine-regulated transcript peptide(1-39) in the rat
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, 3400 N Broad Street, Philadelphia, PA 19140, USA
    Regul Pept 140:47-54. 2007
    ....
  10. ncbi request reprint Smooth muscle-associated protein 8: distribution and biological activity in the rat brain
    G Cristina Brailoiu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Neurosci Res 85:1789-96. 2007
    ..This is the first evidence of irSMAP8 in a population of VP/OT-containing hypothalamic neurons in the rat, and the peptide is biologically active in hypothalamic neurons, as evidenced by mobilization of extracellular Ca2+...
  11. ncbi request reprint Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system
    Eugen Brailoiu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Endocrinol 193:311-21. 2007
    ....
  12. ncbi request reprint Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain
    G Cristina Brailoiu
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Endocrinology 148:5088-94. 2007
    ....
  13. pmc State-dependent calcium mobilization by urotensin-II in cultured human endothelial cells
    Eugen Brailoiu
    Department of Pharmacology, 3420 N Broad Street, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Peptides 29:721-6. 2008
    ..The result demonstrates a state-dependent effect of U-II in cultured HAEC, which may explain the variable responses to U-II under different experimental conditions...
  14. ncbi request reprint Beacon-like immunoreactivity in the hypothalamus of Sprague-Dawley rats
    G Cristina Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577 Johnson City, TN 37614, USA
    Neurosci Lett 317:166-8. 2002
    ....
  15. ncbi request reprint Metastin-like immunoreactivity in the rat medulla oblongata and spinal cord
    Siok L Dun
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Neurosci Lett 335:197-201. 2003
    ..The pattern of distribution of MTS-LI in the medulla and spinal cord suggests that this novel peptide may participate in autonomic and sensory neural signaling...
  16. ncbi request reprint Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse
    G Cristina Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA
    Brain Res 984:215-23. 2003
    ..More interestingly, Blast search uncovered a 73-amino acid peptide, human ubiquitin-like 5, which has the same exact sequence as beacon. Thus, irBC observed in the mouse brain could be that of ubiquitin-like 5...
  17. ncbi request reprint Cocaine- and amphetamine-regulated transcript peptide-immunoreactivity in adrenergic C1 neurons projecting to the intermediolateral cell column of the rat
    Siok L Dun
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    J Chem Neuroanat 23:123-32. 2002
    ....
  18. ncbi request reprint Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats
    Phouangmala Scruggs
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1496-503. 2003
    ..The result suggests that endogenously released CARTp from primary afferents or exogenously administered CARTp modulates PE-induced baroreflex...
  19. ncbi request reprint Neuropeptide W-immunoreactivity in the hypothalamus and pituitary of the rat
    Siok L Dun
    James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Neurosci Lett 349:71-4. 2003
    ..The pattern of distribution of irNPW in the hypothalamus corroborates a possible role of NPW on prolactin release and feeding behavior reported by others...
  20. ncbi request reprint Urotensin-II regulates intracellular calcium in dissociated rat spinal cord neurons
    Catalin M Filipeanu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Neurochem 83:879-84. 2002
    ..Present results demonstrate that U-II modulates [Ca2+]i in rat spinal cord neurons via protein kinase A cascade...
  21. ncbi request reprint Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells
    Xiaohua Jiang
    Temple University School of Medicine, Department of Pharmacology, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 27:1976-83. 2007
    ..This study characterized and directly compared Hcy transport in cultured human aortic ECs (HAECs) and smooth muscle cells (HASMCs)...
  22. ncbi request reprint Pressor response to microinjection of orexin/hypocretin into rostral ventrolateral medulla of awake rats
    Benedito H Machado
    Department of Physiology, School of Medicine Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    Regul Pept 104:75-81. 2002
    ....
  23. ncbi request reprint Apelin-immunoreactivity in the rat hypothalamus and pituitary
    G Cristina Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Neurosci Lett 327:193-7. 2002
    ..The presence of irAP in certain hypothalamic nuclei and pituitary suggests that the peptide may be a signaling molecule released from the hypothalamic-hypophysial axis...
  24. ncbi request reprint Glutamate receptor subunit immunoreactivity in neurons of the rat rostral ventrolateral medulla
    G Cristina Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    Auton Neurosci 98:55-8. 2002
    ..Moreover, TH-negative neurons in the RVLM appear to bear similar subunits of ionotropic glutamate receptors...
  25. pmc Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction
    Eugen Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City 37614, USA
    Br J Pharmacol 136:1093-7. 2002
    ..The result provides the first evidence that S1-P acting intracellularly but not extracellularly enhances spontaneous transmitter release at the frog neuromuscular junction...
  26. ncbi request reprint Distribution and biological activity of obestatin in the rat
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Endocrinol 191:481-9. 2006
    ....
  27. pmc Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices
    Su Ying Wu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Br J Pharmacol 140:1088-96. 2003
    ....
  28. ncbi request reprint Effects of m-CPP in altering neuronal function: blocking depolarization in invertebrate motor and sensory neurons but exciting rat dorsal horn neurons
    Garrett M Sparks
    Department of Biology, University of Kentucky, Lexington, KY 40506 0225, USA
    Brain Res 969:14-26. 2003
    ..In the rat spinal cord, m-CPP enhances the occurrence of spontaneous excitatory postsynaptic potentials with no alteration in evoked currents...
  29. pmc Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP)
    Eugen Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Biochem J 373:313-8. 2003
    ..Asynchronous neurotransmitter release may therefore involve functional coupling of endoplasmic reticulum Ca(2+) stores with distinct Ca(2+) stores targeted by NAADP...
  30. ncbi request reprint Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings
    Eugen Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614 1708, USA
    Mol Pharmacol 63:1430-6. 2003
    ..The result provides the first electrophysiological evidence that SPC can modulate transmitter release by an extra- or intracellular action at the frog motor nerve ending...
  31. ncbi request reprint Cocaine- and amphetamine-regulated transcript peptide potentiates spinal glutamatergic sympathoexcitation in anesthetized rats
    Phouangmala Scruggs
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA
    Regul Pept 127:79-85. 2005
    ....
  32. ncbi request reprint Ultra low concentrations of morphine increase neurite outgrowth in cultured rat spinal cord and cerebral cortical neurons
    Eugen Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Neurosci Lett 365:10-3. 2004
    ..Pretreatment with naloxone did not prevent the morphine effect. The result shows that morphine at ultra low concentrations enhances neurite outgrowth of spinal and cortical neurons via a naloxone-independent mechanism...
  33. ncbi request reprint Interaction of ovokinin(2-7) with vascular bradykinin 2 receptors
    Phouangmala Scruggs
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City 37614, USA
    Regul Pept 120:85-91. 2004
    ..PA phosphohydrolase and phospholipase A2 inhibitors significantly reduced the responses as well. Our results show that ovokinin(2-7) modulates cardiovascular activity by interacting with B2 bradykinin receptors...
  34. ncbi request reprint Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth
    Eugen Brailoiu
    Department of Pharmacology, Temple University Medical School, Philadelphia, PA 19140, USA
    J Biol Chem 280:5646-50. 2005
    ..Interplay between NAADP receptors and more established intracellular Ca(2+) channels may therefore play important signaling roles in the nervous system...

Research Grants21

  1. NEUROBIOLOGY OF ENDOMORPHINS IN SPINAL DORSAL HORN
    Nae Dun; Fiscal Year: 2002
    ..abstract_text> ..
  2. ACTIVITY OF BRAINSTEM NEURONS
    Nae Dun; Fiscal Year: 2003
    ..Identification of the putative transmitters and the circuitry linking the hypothalamus to the autonomic nervous system will be a significant improvement in our understanding of the regulatory mechanisms underlying these disorders. ..
  3. ACTIVITY OF BRAINSTEM NEURONS
    Nae Dun; Fiscal Year: 2007
    ....
  4. ACTIVITY OF PREGANGLIONIC NEURONS IN VITRO
    Nae Dun; Fiscal Year: 2007
    ..abstract_text> ..
  5. ACTIVITY OF PREGANGLIONIC NEURONS IN VITRO
    Nae Dun; Fiscal Year: 2001
    ..Lastly, specific PACAP receptor antagonists and agonists may be targeted for new drug development in the management of cardiovascular disorders that have a neurogenic component, such as hypertension and stroke. ..
  6. ACTIVITY OF BRAINSTEM NEURONS
    Nae J Dun; Fiscal Year: 2010
    ....